{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:33:54Z","timestamp":1790904834572,"version":"4.1.0"},"reference-count":75,"publisher":"Elsevier BV","issue":"46","license":[{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":7669,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[1999,11]]},"DOI":"10.1074\/jbc.274.46.32555","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:59:58Z","timestamp":1027695598000},"page":"32555-32564","source":"Crossref","is-referenced-by-count":124,"title":["Lethal Effects of Apidaecin on Escherichia coliInvolve Sequential Molecular Interactions with Diverse Targets"],"prefix":"10.1016","volume":"274","author":[{"given":"Madalyn","family":"Castle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpi","family":"Nazarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San San","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Tempst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.274.46.32555_bib1","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1128\/iai.12.6.1426-1438.1975","volume":"12","author":"Faye","year":"1975","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.274.46.32555_bib2","doi-asserted-by":"crossref","first-page":"7174","DOI":"10.1016\/S0021-9258(17)39590-X","volume":"260","author":"Okada","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.46.32555_bib3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev.mi.41.100187.000535","volume":"41","author":"Boman","year":"1987","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1074\/jbc.274.46.32555_bib4","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/0923-2494(90)90192-2","volume":"141","author":"Hoffmann","year":"1990","journal-title":"Res. Immunol."},{"key":"10.1074\/jbc.274.46.32555_bib5","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/0168-9525(93)90165-E","volume":"9","author":"Hultmark","year":"1993","journal-title":"Trends Genet."},{"key":"10.1074\/jbc.274.46.32555_bib6","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/0952-7915(95)80022-0","volume":"7","author":"Hoffmann","year":"1995","journal-title":"Curr. Opin. Immunol."},{"key":"10.1074\/jbc.274.46.32555_bib7","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1002\/j.1460-2075.1989.tb08368.x","volume":"8","author":"Casteels","year":"1989","journal-title":"EMBO J."},{"key":"10.1074\/jbc.274.46.32555_bib8","doi-asserted-by":"crossref","first-page":"24520","DOI":"10.1016\/S0021-9258(18)54260-5","volume":"266","author":"Bulet","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.46.32555_bib9","doi-asserted-by":"crossref","first-page":"14893","DOI":"10.1016\/S0021-9258(18)82417-6","volume":"268","author":"Bulet","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.46.32555_bib10","doi-asserted-by":"crossref","first-page":"7044","DOI":"10.1016\/S0021-9258(18)53143-4","volume":"268","author":"Casteels","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.46.32555_bib11","doi-asserted-by":"crossref","first-page":"26107","DOI":"10.1016\/S0021-9258(18)47165-7","volume":"269","author":"Casteels","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.46.32555_bib12","doi-asserted-by":"crossref","first-page":"28569","DOI":"10.1016\/S0021-9258(19)61943-5","volume":"269","author":"Casteels-Josson","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.46.32555_bib13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.iy.13.040195.000425","volume":"13","author":"Boman","year":"1995","journal-title":"Annu. Rev. Immunol."},{"key":"10.1074\/jbc.274.46.32555_bib14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0092-8674(91)90632-9","volume":"64","author":"Lehrer","year":"1991","journal-title":"Cell"},{"key":"10.1074\/jbc.274.46.32555_bib15","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.iy.11.040193.000541","volume":"11","author":"Lehrer","year":"1993","journal-title":"Annu. Rev. Immunol."},{"key":"10.1074\/jbc.274.46.32555_bib16","doi-asserted-by":"crossref","first-page":"5610","DOI":"10.1073\/pnas.86.14.5610","volume":"86","author":"Gabay","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.274.46.32555_bib17","doi-asserted-by":"crossref","first-page":"9573","DOI":"10.1016\/S0021-9258(19)81553-3","volume":"263","author":"Romeo","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.46.32555_bib18","doi-asserted-by":"crossref","first-page":"18871","DOI":"10.1016\/S0021-9258(17)30595-1","volume":"265","author":"Frank","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.46.32555_bib19","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1016\/S0021-9258(18)42830-X","volume":"267","author":"Selsted","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.46.32555_bib20","doi-asserted-by":"crossref","first-page":"6641","DOI":"10.1016\/S0021-9258(18)53298-1","volume":"268","author":"Selsted","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.46.32555_bib21","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/00062752-199704010-00009","volume":"4","author":"Ganz","year":"1997","journal-title":"Curr. Opin. Hematol."},{"key":"10.1074\/jbc.274.46.32555_bib22","doi-asserted-by":"crossref","first-page":"7472","DOI":"10.1016\/S0021-9258(18)68522-9","volume":"263","author":"Oppenheim","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.46.32555_bib23","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1126\/science.7886453","volume":"267","author":"Schonwetter","year":"1995","journal-title":"Science"},{"key":"10.1074\/jbc.274.46.32555_bib24","doi-asserted-by":"crossref","first-page":"9159","DOI":"10.1073\/pnas.86.23.9159","volume":"86","author":"Lee","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.274.46.32555_bib25","doi-asserted-by":"crossref","first-page":"3952","DOI":"10.1073\/pnas.88.9.3952","volume":"88","author":"Diamond","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.274.46.32555_bib26","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1432-1033.1991.tb16442.x","volume":"202","author":"Agerberth","year":"1991","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.274.46.32555_bib27","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1128\/iai.60.9.3556-3565.1992","volume":"60","author":"Eisenhauer","year":"1992","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.274.46.32555_bib28","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1083\/jcb.118.4.929","volume":"118","author":"Selsted","year":"1992","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.274.46.32555_bib29","doi-asserted-by":"crossref","first-page":"23216","DOI":"10.1016\/S0021-9258(18)50079-X","volume":"267","author":"Jones","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.46.32555_bib30","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1432-1033.1996.0086n.x","volume":"237","author":"Frohm","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.274.46.32555_bib31","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/S0140-6736(05)63574-X","volume":"350","author":"Fulton","year":"1997","journal-title":"Lancet"},{"key":"10.1074\/jbc.274.46.32555_bib32","doi-asserted-by":"crossref","first-page":"14961","DOI":"10.1073\/pnas.95.25.14961","volume":"95","author":"Singh","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.274.46.32555_bib33","doi-asserted-by":"crossref","first-page":"5072","DOI":"10.1073\/pnas.85.14.5072","volume":"85","author":"Christensen","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.274.46.32555_bib34","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1128\/iai.56.9.2324-2329.1988","volume":"56","author":"Viljanen","year":"1988","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.274.46.32555_bib35","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1172\/JCI114198","volume":"84","author":"Lehrer","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.274.46.32555_bib36","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1128\/iai.58.11.3724-3730.1990","volume":"58","author":"Skerlavaj","year":"1990","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.274.46.32555_bib37","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0922-4106(92)90045-W","volume":"226","author":"Cruciani","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"10.1074\/jbc.274.46.32555_bib38","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1073\/pnas.88.9.3792","volume":"88","author":"Cruciani","year":"1991","journal-title":"Proc. Natl. Acad. Sci U. S. A."},{"key":"10.1074\/jbc.274.46.32555_bib39","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1128\/iai.61.7.2978-2984.1993","volume":"61","author":"Boman","year":"1993","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.274.46.32555_bib40","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1073\/pnas.87.12.4761","volume":"87","author":"Wade","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.274.46.32555_bib41","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0014-5793(90)81351-N","volume":"274","author":"Besalle","year":"1990","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.274.46.32555_bib42","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1399-3011.1997.tb01121.x","volume":"49","author":"Vunnam","year":"1997","journal-title":"J. Pept. Res."},{"key":"10.1074\/jbc.274.46.32555_bib43","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1002\/j.1460-2075.1993.tb05801.x","volume":"12","author":"Casteels-Josson","year":"1993","journal-title":"EMBO J."},{"key":"10.1074\/jbc.274.46.32555_bib44","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1006\/bbrc.1994.1234","volume":"199","author":"Casteels","year":"1994","journal-title":"Bioch. Biophys. Res. Commun."},{"key":"10.1074\/jbc.274.46.32555_bib45","series-title":"Manual of Clinical Microbiology","author":"Barry","year":"1991"},{"key":"10.1074\/jbc.274.46.32555_bib46","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.1128\/aem.62.12.4652-4655.1996","volume":"62","author":"Taguchi","year":"1996","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1074\/jbc.274.46.32555_bib47","series-title":"Principles of Protein Structure","author":"Schulz","year":"1984"},{"key":"10.1074\/jbc.274.46.32555_bib48","series-title":"Understanding Antibacterial Action and Resistance","author":"Russell","year":"1990"},{"key":"10.1074\/jbc.274.46.32555_bib49","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0014-5793(81)80777-6","volume":"129","author":"Vaara","year":"1981","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.274.46.32555_bib50","doi-asserted-by":"crossref","first-page":"3706","DOI":"10.1128\/iai.58.11.3706-3710.1990","volume":"58","author":"Miller","year":"1990","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.274.46.32555_bib51","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1128\/AAC.36.7.1460","volume":"36","author":"Ohta","year":"1992","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.274.46.32555_bib52","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1146\/annurev.bi.55.070186.002145","volume":"55","author":"Ames","year":"1986","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.274.46.32555_bib53","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0076-6879(86)25024-7","volume":"125","author":"Furlong","year":"1986","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.274.46.32555_bib54","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0076-6879(86)25031-4","volume":"125","author":"Higgins","year":"1986","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.274.46.32555_bib55","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1073\/pnas.70.5.1514","volume":"70","author":"Berger","year":"1973","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.274.46.32555_bib56","doi-asserted-by":"crossref","first-page":"7747","DOI":"10.1016\/S0021-9258(19)42031-0","volume":"249","author":"Berger","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.46.32555_bib57","series-title":"Antibiotics in Laboratory Medicine","first-page":"432","author":"Eliopoulos","year":"1991"},{"key":"10.1074\/jbc.274.46.32555_bib58","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1128\/AAC.40.1.115","volume":"40","author":"Shi","year":"1996","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.274.46.32555_bib59","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0304-4157(83)90014-X","volume":"737","author":"Lugtenberg","year":"1983","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.274.46.32555_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/mr.49.1.1-32.1985","volume":"49","author":"Nikaido","year":"1985","journal-title":"Microbiol. Rev."},{"key":"10.1074\/jbc.274.46.32555_bib61","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1046\/j.1365-2958.1998.00764.x","volume":"28","author":"Linton","year":"1998","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.274.46.32555_bib62","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0168-6445(05)80008-7","volume":"6","author":"Ames","year":"1990","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1074\/jbc.274.46.32555_bib63","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1046\/j.1365-2958.1997.4071742.x","volume":"24","author":"Driessen","year":"1997","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.274.46.32555_bib64","doi-asserted-by":"crossref","first-page":"5300","DOI":"10.1016\/S0021-9258(17)33161-7","volume":"251","author":"Jackson","year":"1976","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.46.32555_bib65","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF01872157","volume":"106","author":"Wood","year":"1988","journal-title":"J. Membr. Biol."},{"key":"10.1074\/jbc.274.46.32555_bib66","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1128\/jb.122.3.1200-1207.1975","volume":"122","author":"Barak","year":"1975","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.274.46.32555_bib67","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1128\/jb.155.3.1434-1438.1983","volume":"155","author":"Higgins","year":"1983","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.274.46.32555_bib68","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1128\/jb.161.2.484-492.1985","volume":"161","author":"Andrew","year":"1985","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.274.46.32555_bib69","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1128\/jb.168.2.775-779.1986","volume":"168","author":"Guyer","year":"1986","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.274.46.32555_bib70","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1126\/science.8202710","volume":"264","author":"Tame","year":"1994","journal-title":"Science"},{"key":"10.1074\/jbc.274.46.32555_bib71","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev.mi.36.100182.001013","volume":"36","author":"Konisky","year":"1982","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1074\/jbc.274.46.32555_bib72","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.mi.41.100187.001355","volume":"41","author":"Kleinkauf","year":"1987","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1074\/jbc.274.46.32555_bib73","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev.mi.43.100189.001133","volume":"43","author":"Martin","year":"1989","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1074\/jbc.274.46.32555_bib74","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1128\/AAC.27.5.791","volume":"27","author":"Garcia-Bustos","year":"1985","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.274.46.32555_bib75","doi-asserted-by":"crossref","first-page":"23520","DOI":"10.1074\/jbc.270.40.23520","volume":"270","author":"Guijarro","year":"1995","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817465471?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817465471?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.274.46.32555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T13:57:26Z","timestamp":1640959046000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925817465471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11]]},"references-count":75,"journal-issue":{"issue":"46","published-print":{"date-parts":[[1999,11]]}},"alternative-id":["S0021925817465471"],"URL":"https:\/\/doi.org\/10.1074\/jbc.274.46.32555","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[1999,11]]}}}