{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:54:31Z","timestamp":1790837671232,"version":"4.1.0"},"reference-count":71,"publisher":"Elsevier BV","issue":"47","license":[{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":7669,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[1999,11]]},"DOI":"10.1074\/jbc.274.47.33440","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:59:58Z","timestamp":1027695598000},"page":"33440-33448","source":"Crossref","is-referenced-by-count":108,"title":["Molecular Chlorine Generated by the Myeloperoxidase-Hydrogen Peroxide-Chloride System of Phagocytes Produces 5-Chlorocytosine in Bacterial RNA"],"prefix":"10.1016","volume":"274","author":[{"given":"Jeffrey P.","family":"Henderson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeman","family":"Byun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay W.","family":"Heinecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.274.47.33440_bib1","series-title":"The Neutrophil: Function and Clinical Disorders","author":"Klebanoff","year":"1978"},{"key":"10.1074\/jbc.274.47.33440_bib2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3109\/10409238909082555","volume":"24","author":"Hurst","year":"1989","journal-title":"CRC Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1074\/jbc.274.47.33440_bib3","series-title":"Heme Peroxidases","author":"Dunford","year":"1999"},{"key":"10.1074\/jbc.274.47.33440_bib4","series-title":"Blood Cell Biochemistry: Lymphocytes and Granulocytes","author":"Tobler","year":"1991"},{"key":"10.1074\/jbc.274.47.33440_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/13510002.1997.11747085","volume":"3","author":"Kettle","year":"1997","journal-title":"Redox. Rep."},{"key":"10.1074\/jbc.274.47.33440_bib6","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/S0021-9258(17)33749-3","volume":"251","author":"Harrison","year":"1976","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.47.33440_bib7","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/301715a0","volume":"301","author":"Foote","year":"1981","journal-title":"Nature"},{"key":"10.1074\/jbc.274.47.33440_bib8","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1172\/JCI119379","volume":"99","author":"Hazen","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.274.47.33440_bib9","doi-asserted-by":"crossref","first-page":"23080","DOI":"10.1074\/jbc.271.38.23080","volume":"271","author":"Hazen","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.47.33440_bib10","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0003-9861(92)90609-Z","volume":"296","author":"Winterbourn","year":"1992","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1074\/jbc.274.47.33440_bib11","doi-asserted-by":"crossref","first-page":"10127","DOI":"10.1021\/bi00199a041","volume":"33","author":"Heinecke","year":"1994","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.274.47.33440_bib12","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0076-6879(86)32042-1","volume":"132","author":"Thomas","year":"1986","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.274.47.33440_bib13","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1172\/JCI111544","volume":"74","author":"Test","year":"1984","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.274.47.33440_bib14","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/0006-291X(72)90690-0","volume":"48","author":"Patton","year":"1972","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.274.47.33440_bib15","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1096\/fasebj.5.3.1848195","volume":"5","author":"Bernofsky","year":"1991","journal-title":"FASEB J."},{"key":"10.1074\/jbc.274.47.33440_bib16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1006\/abbi.1997.0440","volume":"349","author":"Prutz","year":"1998","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1074\/jbc.274.47.33440_bib17","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1432-1033.1978.tb12748.x","volume":"92","author":"Stetmaszynska","year":"1978","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.274.47.33440_bib18","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.1074\/jbc.273.9.4997","volume":"273","author":"Hazen","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.47.33440_bib19","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1042\/bj3270275","volume":"327","author":"Carr","year":"1997","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.274.47.33440_bib20","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1172\/JCI116531","volume":"91","author":"Heinecke","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.274.47.33440_bib21","doi-asserted-by":"crossref","first-page":"30434","DOI":"10.1074\/jbc.270.51.30434","volume":"270","author":"Marquez","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.47.33440_bib22","doi-asserted-by":"crossref","first-page":"19950","DOI":"10.1074\/jbc.271.33.19950","volume":"271","author":"Jacob","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.47.33440_bib23","doi-asserted-by":"crossref","first-page":"20394","DOI":"10.1016\/S0021-9258(17)32005-7","volume":"269","author":"Savenkova","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.47.33440_bib24","doi-asserted-by":"crossref","first-page":"19199","DOI":"10.1074\/jbc.271.32.19199","volume":"271","author":"Eiserich","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.47.33440_bib25","doi-asserted-by":"crossref","first-page":"7617","DOI":"10.1074\/jbc.272.12.7617","volume":"272","author":"van der Vliet","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.47.33440_bib26","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/34923","volume":"391","author":"Eiserich","year":"1998","journal-title":"Nature"},{"key":"10.1074\/jbc.274.47.33440_bib27","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1074\/jbc.272.6.3520","volume":"272","author":"Leeuwenburgh","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.47.33440_bib28","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1074\/jbc.272.3.1433","volume":"272","author":"Leeuwenburgh","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.47.33440_bib29","doi-asserted-by":"crossref","first-page":"16990","DOI":"10.1074\/jbc.272.27.16990","volume":"272","author":"Hazen","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.47.33440_bib30","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1172\/JCI118914","volume":"98","author":"Hazen","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.274.47.33440_bib31","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1182\/blood.V76.4.655.655","volume":"76","author":"Weitzman","year":"1990","journal-title":"Blood"},{"key":"10.1074\/jbc.274.47.33440_bib32","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/bj3130017","volume":"313","author":"Wiseman","year":"1996","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.274.47.33440_bib33","doi-asserted-by":"crossref","first-page":"21167","DOI":"10.1074\/jbc.271.35.21167","volume":"271","author":"Luo","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.47.33440_bib34","doi-asserted-by":"crossref","first-page":"7876","DOI":"10.1021\/bi00486a014","volume":"29","author":"Gajewski","year":"1990","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.274.47.33440_bib35","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1021\/bi9822980","volume":"38","author":"Byun","year":"1999","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.274.47.33440_bib36","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0014-5793(95)01281-6","volume":"376","author":"Yermilov","year":"1995","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.274.47.33440_bib37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1021\/tx950126n","volume":"9","author":"Douki","year":"1996","journal-title":"Chem. Res. Toxicol."},{"key":"10.1074\/jbc.274.47.33440_bib38","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1126\/science.1948068","volume":"254","author":"Wink","year":"1991","journal-title":"Science"},{"key":"10.1074\/jbc.274.47.33440_bib39","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1021\/tx9600311","volume":"9","author":"Tamir","year":"1996","journal-title":"Chem. Res. Toxicol."},{"key":"10.1074\/jbc.274.47.33440_bib40","doi-asserted-by":"crossref","first-page":"6820","DOI":"10.1073\/pnas.82.20.6820","volume":"82","author":"Birnboim","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.274.47.33440_bib41","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/0006-291X(73)90591-3","volume":"53","author":"Hoyano","year":"1973","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.274.47.33440_bib42","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1021\/tx970086i","volume":"10","author":"Whiteman","year":"1997","journal-title":"Chem. Res. Toxicol."},{"key":"10.1074\/jbc.274.47.33440_bib43","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1126\/science.8079172","volume":"265","author":"Chaudhary","year":"1994","journal-title":"Science"},{"key":"10.1074\/jbc.274.47.33440_bib44","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1073\/pnas.89.8.3375","volume":"89","author":"Park","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.274.47.33440_bib45","doi-asserted-by":"crossref","first-page":"9697","DOI":"10.1073\/pnas.86.24.9697","volume":"86","author":"Shigenaga","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.274.47.33440_bib46","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1172\/JCI114342","volume":"84","author":"Jackson","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.274.47.33440_bib47","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1021\/bi00456a033","volume":"29","author":"Rakita","year":"1990","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.274.47.33440_bib48","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/oxfordjournals.jbchem.a135535","volume":"99","author":"Morita","year":"1986","journal-title":"J. Biochem. (Tokyo)"},{"key":"10.1074\/jbc.274.47.33440_bib49","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1074\/jbc.271.4.1861","volume":"271","author":"Hazen","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.47.33440_bib50","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.1021\/j100884a007","volume":"70","author":"Morris","year":"1966","journal-title":"J. Phys. Chem."},{"key":"10.1074\/jbc.274.47.33440_bib51","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0021-9258(19)50881-X","volume":"195","author":"Beers","year":"1952","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.47.33440_bib52","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/0076-6879(90)93450-Y","volume":"193","author":"Crain","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.274.47.33440_bib53","series-title":"Current Protocols in Molecular Biology","first-page":"4.4.1","author":"Ausubel","year":"1990"},{"key":"10.1074\/jbc.274.47.33440_bib54","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1074\/jbc.270.7.2906","volume":"270","author":"Thomas","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.47.33440_bib55","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/0167-4838(88)90297-X","volume":"956","author":"Kettle","year":"1988","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.274.47.33440_bib56","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0076-6879(96)71023-6","volume":"271","author":"Giese","year":"1996","journal-title":"Meth. Enzymol."},{"key":"10.1074\/jbc.274.47.33440_bib57","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0014-4827(88)90191-7","volume":"175","author":"Silver","year":"1988","journal-title":"Exp. Cell Res."},{"key":"10.1074\/jbc.274.47.33440_bib58","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1093\/infdis\/142.4.594","volume":"142","author":"Bryant","year":"1980","journal-title":"J. Infect. Dis."},{"key":"10.1074\/jbc.274.47.33440_bib59","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0035-9203(76)90180-2","volume":"70","author":"Ramachandran","year":"1976","journal-title":"Trans. Royal Soc. Trop. Med. Hyg."},{"key":"10.1074\/jbc.274.47.33440_bib60","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0360-3016(90)90544-T","volume":"19","author":"Santos","year":"1990","journal-title":"Int. J. Rad. Onc. Biol. Phys."},{"key":"10.1074\/jbc.274.47.33440_bib61","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1128\/AAC.22.3.431","volume":"22","author":"Fox","year":"1982","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.274.47.33440_bib62","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0027-5107(83)90051-9","volume":"109","author":"O'Neill","year":"1983","journal-title":"Mutat. Res."},{"key":"10.1074\/jbc.274.47.33440_bib63","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0165-1110(93)90006-9","volume":"297","author":"Morris","year":"1993","journal-title":"Mutat. Res."},{"key":"10.1074\/jbc.274.47.33440_bib64","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0024-3205(76)90237-X","volume":"19","author":"Penman","year":"1976","journal-title":"Life Sci."},{"key":"10.1074\/jbc.274.47.33440_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00928361","volume":"140","author":"Traut","year":"1994","journal-title":"Mol. Cell. Biochem."},{"key":"10.1074\/jbc.274.47.33440_bib66","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0167-4889(86)90027-3","volume":"888","author":"Iizasa","year":"1986","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.274.47.33440_bib67","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0006-2952(97)00040-3","volume":"53","author":"Ghoshal","year":"1997","journal-title":"Biochem. Pharmacol."},{"key":"10.1074\/jbc.274.47.33440_bib68","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/355273a0","volume":"355","author":"Maki","year":"1992","journal-title":"Nature"},{"key":"10.1074\/jbc.274.47.33440_bib69","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1073\/pnas.55.2.274","volume":"55","author":"Yanofsky","year":"1966","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.274.47.33440_bib70","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0921-8777(94)00062-B","volume":"336","author":"Tajiri","year":"1995","journal-title":"Mutat. Res."},{"key":"10.1074\/jbc.274.47.33440_bib71","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1126\/science.278.5335.128","volume":"278","author":"Taddei","year":"1997","journal-title":"Science"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817464842?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817464842?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.274.47.33440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T16:29:49Z","timestamp":1639672189000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925817464842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11]]},"references-count":71,"journal-issue":{"issue":"47","published-print":{"date-parts":[[1999,11]]}},"alternative-id":["S0021925817464842"],"URL":"https:\/\/doi.org\/10.1074\/jbc.274.47.33440","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[1999,11]]}}}