{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:52:51Z","timestamp":1791121971238,"version":"4.1.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":7494,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2000,4]]},"DOI":"10.1074\/jbc.275.14.9946","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:07:05Z","timestamp":1027696025000},"page":"9946-9956","source":"Crossref","is-referenced-by-count":51,"title":["Genuine Monovalent Ligands of TrkA Nerve Growth Factor Receptors Reveal a Novel Pharmacological Mechanism of Action"],"prefix":"10.1016","volume":"275","author":[{"given":"Sergei","family":"Maliartchouk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Debeir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Beglova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.Claudio","family":"Cuello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalle","family":"Gehring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.Uri","family":"Saragovi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.275.14.9946_bib1","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/0896-6273(92)90066-M","volume":"9","author":"Jing","year":"1992","journal-title":"Neuron"},{"key":"10.1074\/jbc.275.14.9946_bib2","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1126\/science.1850549","volume":"252","author":"Kaplan","year":"1991","journal-title":"Science"},{"key":"10.1074\/jbc.275.14.9946_bib3","doi-asserted-by":"crossref","first-page":"6884","DOI":"10.1016\/S0021-9258(17)37458-6","volume":"269","author":"Mahadeo","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.275.14.9946_bib4","doi-asserted-by":"crossref","first-page":"7859","DOI":"10.1073\/pnas.90.16.7859","volume":"90","author":"Benedetti","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.275.14.9946_bib5","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0166-2236(95)93922-K","volume":"18","author":"Chao","year":"1995","journal-title":"Trends Neurosci."},{"key":"10.1074\/jbc.275.14.9946_bib6","doi-asserted-by":"crossref","first-page":"6031","DOI":"10.1523\/JNEUROSCI.17-16-06031.1997","volume":"17","author":"Maliartchouk","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.275.14.9946_bib7","doi-asserted-by":"crossref","first-page":"23547","DOI":"10.1074\/jbc.272.38.23547","volume":"272","author":"MacPhee","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.275.14.9946_bib8","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/emboj\/18.3.616","volume":"18","author":"Bibel","year":"1999","journal-title":"EMBO J."},{"key":"10.1074\/jbc.275.14.9946_bib9","doi-asserted-by":"crossref","first-page":"34933","DOI":"10.1074\/jbc.273.52.34933","volume":"273","author":"Saragovi","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.275.14.9946_bib10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0166-2236(96)01049-1","volume":"20","author":"Bredesen","year":"1997","journal-title":"Trends Neurosci."},{"key":"10.1074\/jbc.275.14.9946_bib11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0165-0173(97)00036-2","volume":"26","author":"Chao","year":"1998","journal-title":"Brain Res. Rev."},{"key":"10.1074\/jbc.275.14.9946_bib12","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0896-6273(94)90469-3","volume":"13","author":"Hantzopoulos","year":"1994","journal-title":"Neuron"},{"key":"10.1074\/jbc.275.14.9946_bib13","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/350158a0","volume":"350","author":"Kaplan","year":"1991","journal-title":"Nature"},{"key":"10.1074\/jbc.275.14.9946_bib14","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0092-8674(95)90404-2","volume":"80","author":"Heldin","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.275.14.9946_bib15","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/2965","volume":"5","author":"Livnah","year":"1998","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.275.14.9946_bib16","doi-asserted-by":"crossref","first-page":"23247","DOI":"10.1074\/jbc.272.37.23247","volume":"272","author":"Arteaga","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.275.14.9946_bib17","doi-asserted-by":"crossref","first-page":"7431","DOI":"10.1021\/bi00148a001","volume":"31","author":"Taub","year":"1992","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.275.14.9946_bib18","doi-asserted-by":"crossref","first-page":"R568","DOI":"10.1016\/S0960-9822(99)80357-1","volume":"9","author":"Jiang","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.275.14.9946_bib19","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1523\/JNEUROSCI.16-04-01308.1996","volume":"16","author":"LeSauteur","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.275.14.9946_bib20","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1073\/pnas.96.7.4067","volume":"96","author":"Debeir","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.275.14.9946_bib21","doi-asserted-by":"crossref","first-page":"6564","DOI":"10.1074\/jbc.270.12.6564","volume":"270","author":"LeSauteur","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.275.14.9946_bib22","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/nbt0996-1120","volume":"14","author":"LeSauteur","year":"1996","journal-title":"Nat. Biotech."},{"key":"10.1074\/jbc.275.14.9946_bib23","first-page":"1915","volume":"10","author":"Bogenmann","year":"1995","journal-title":"Oncogene"},{"key":"10.1074\/jbc.275.14.9946_bib24","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/(SICI)1097-4695(199710)33:4<395::AID-NEU5>3.0.CO;2-5","volume":"33","author":"Kimpinski","year":"1997","journal-title":"J. Neurobiol."},{"key":"10.1074\/jbc.275.14.9946_bib25","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/(SICI)1096-9861(19970519)381:4<428::AID-CNE3>3.0.CO;2-4","volume":"381","author":"Molliver","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"10.1074\/jbc.275.14.9946_bib26","doi-asserted-by":"crossref","first-page":"8928","DOI":"10.1523\/JNEUROSCI.18-21-08928.1998","volume":"18","author":"Vogelbaum","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.275.14.9946_bib27","doi-asserted-by":"crossref","first-page":"23652","DOI":"10.1074\/jbc.273.37.23652","volume":"273","author":"Beglova","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.275.14.9946_bib28","doi-asserted-by":"crossref","first-page":"7566","DOI":"10.1021\/ja00133a039","volume":"117","author":"Altieri","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.275.14.9946_bib29","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/nbm.1940080704","volume":"8","author":"Szafer","year":"1995","journal-title":"NMR Biomed."},{"key":"10.1074\/jbc.275.14.9946_bib30","doi-asserted-by":"crossref","first-page":"20175","DOI":"10.1074\/jbc.271.33.20175","volume":"271","author":"Segal","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.275.14.9946_bib31","doi-asserted-by":"crossref","first-page":"476","DOI":"10.4049\/jimmunol.141.2.476","volume":"141","author":"Saragovi","year":"1988","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.275.14.9946_bib32","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/0165-6147(93)90129-8","volume":"14","author":"Hoyer","year":"1993","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1074\/jbc.275.14.9946_bib33","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0165-6147(00)88963-4","volume":"16","author":"Milligan","year":"1995","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1074\/jbc.275.14.9946_bib34","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1126\/science.273.5274.449","volume":"273","author":"Wells","year":"1996","journal-title":"Science"},{"key":"10.1074\/jbc.275.14.9946_bib35","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1126\/science.283.5404.990","volume":"283","author":"Remy","year":"1999","journal-title":"Science"},{"key":"10.1074\/jbc.275.14.9946_bib36","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1126\/science.283.5404.987","volume":"283","author":"Livnah","year":"1999","journal-title":"Science"},{"key":"10.1074\/jbc.275.14.9946_bib37","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0960-9822(06)00323-X","volume":"7","author":"Germain","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.275.14.9946_bib38","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1600-065X.1998.tb01196.x","volume":"163","author":"Li","year":"1998","journal-title":"Immunol. Rev."},{"key":"10.1074\/jbc.275.14.9946_bib39","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/S0006-2952(99)00144-6","volume":"58","author":"Strange","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"10.1074\/jbc.275.14.9946_bib40","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1126\/science.273.5274.464","volume":"273","author":"Livnah","year":"1996","journal-title":"Science"},{"key":"10.1074\/jbc.275.14.9946_bib41","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1091\/mbc.5.5.549","volume":"5","author":"Clary","year":"1994","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.275.14.9946_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-4547(19971001)50:1<1::AID-JNR1>3.0.CO;2-N","volume":"50","author":"Gargano","year":"1997","journal-title":"J. Neurosci. Res."},{"key":"10.1074\/jbc.275.14.9946_bib43","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1083\/jcb.132.5.945","volume":"132","author":"Ross","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.275.14.9946_bib44","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1517\/13543776.9.6.737","volume":"9","author":"Saragovi","year":"1999","journal-title":"Expert Opin. Ther. Patents"},{"key":"10.1074\/jbc.275.14.9946_bib45","doi-asserted-by":"crossref","first-page":"28133","DOI":"10.1074\/jbc.270.47.28133","volume":"270","author":"Windisch","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.275.14.9946_bib46","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/mcne.1995.1010","volume":"6","author":"Perez","year":"1995","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1074\/jbc.275.14.9946_bib47","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1006\/mcne.1996.0027","volume":"7","author":"MacDonald","year":"1996","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1074\/jbc.275.14.9946_bib48","doi-asserted-by":"crossref","first-page":"25296","DOI":"10.1074\/jbc.272.40.25296","volume":"272","author":"Haniu","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.275.14.9946_bib49","first-page":"4202","volume":"10","author":"Coulier","year":"1990","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.275.14.9946_bib50","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.1128\/MCB.18.9.5371","volume":"18","author":"Burke","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.275.14.9946_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-4547(19970401)48:1<1::AID-JNR1>3.0.CO;2-K","volume":"48","author":"Longo","year":"1997","journal-title":"J. Neurosci. Res."},{"key":"10.1074\/jbc.275.14.9946_bib52","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0896-6273(00)80432-8","volume":"20","author":"Frade","year":"1998","journal-title":"Neuron"},{"key":"10.1074\/jbc.275.14.9946_bib53","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1021\/jm00022a008","volume":"38","author":"Jaen","year":"1995","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.275.14.9946_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1471-4159.1997.68062348.x","volume":"68","author":"Farooqui","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.275.14.9946_bib55","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1021\/jm970031d","volume":"40","author":"Kaneko","year":"1997","journal-title":"J Med. Chem."},{"key":"10.1074\/jbc.275.14.9946_bib56","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1126\/science.281.5374.257","volume":"281","author":"Tian","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.275.14.9946_bib57","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1126\/science.284.5416.974","volume":"284","author":"Zhang","year":"1999","journal-title":"Science"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819898642?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819898642?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.275.14.9946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T06:17:27Z","timestamp":1704349047000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819898642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":57,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["S0021925819898642"],"URL":"https:\/\/doi.org\/10.1074\/jbc.275.14.9946","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2000,4]]}}}