{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:34:22Z","timestamp":1790523262638,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"30","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T00:00:00Z","timestamp":1605312000000},"content-version":"vor","delay-in-days":4154,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1074\/jbc.c109.016931","type":"journal-article","created":{"date-parts":[[2009,6,11]],"date-time":"2009-06-11T00:13:08Z","timestamp":1244679188000},"page":"19786-19790","source":"Crossref","is-referenced-by-count":61,"title":["Inhibition of Human Steroid 5\u03b2-Reductase (AKR1D1) by Finasteride and Structure of the Enzyme-Inhibitor Complex"],"prefix":"10.1016","volume":"284","author":[{"given":"Jason E.","family":"Drury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Di Costanzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor M.","family":"Penning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Christianson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.C109.016931_bib1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.biochem.72.121801.161712","volume":"72","author":"Russell","year":"2003","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.C109.016931_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev.bi.63.070194.000325","volume":"63","author":"Russell","year":"1994","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.C109.016931_bib3","doi-asserted-by":"crossref","first-page":"12208","DOI":"10.1073\/pnas.95.21.12208","volume":"95","author":"Bertilsson","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.C109.016931_bib4","doi-asserted-by":"crossref","first-page":"15122","DOI":"10.1074\/jbc.M001215200","volume":"275","author":"Moore","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.C109.016931_bib5","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.1121435","volume":"312","author":"Huang","year":"2006","journal-title":"Science"},{"key":"10.1074\/jbc.C109.016931_bib6","first-page":"515","volume":"24","author":"Shimada","year":"1996","journal-title":"Drug Metab. Dispos."},{"key":"10.1074\/jbc.C109.016931_bib7","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0960-0760(90)90487-6","volume":"37","author":"Stoner","year":"1990","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1074\/jbc.C109.016931_bib8","first-page":"139","volume":"14","author":"Gormley","year":"1996","journal-title":"Semin. Urol. Oncol."},{"key":"10.1074\/jbc.C109.016931_bib9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1046\/j.1365-2265.1997.950908.x","volume":"46","author":"Habib","year":"1997","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1074\/jbc.C109.016931_bib10","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0090-4295(99)80021-1","volume":"45","author":"Andriole","year":"1995","journal-title":"Urology"},{"key":"10.1074\/jbc.C109.016931_bib11","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1056\/NEJMoa030660","volume":"349","author":"Thompson","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.C109.016931_bib12","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1073\/pnas.87.10.3640","volume":"87","author":"Andersson","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.C109.016931_bib13","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1021\/ja953069t","volume":"118","author":"Bull","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.C109.016931_bib14","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1042\/bj3260625","volume":"326","author":"Jez","year":"1997","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.C109.016931_bib15","doi-asserted-by":"crossref","first-page":"16830","DOI":"10.1074\/jbc.M801778200","volume":"283","author":"Di Costanzo","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.C109.016931_bib16","doi-asserted-by":"crossref","first-page":"8261","DOI":"10.1021\/bi800572s","volume":"47","author":"Faucher","year":"2008","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.C109.016931_bib17","doi-asserted-by":"crossref","first-page":"13537","DOI":"10.1021\/bi801276h","volume":"47","author":"Faucher","year":"2008","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.C109.016931_bib18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.mce.2008.09.013","volume":"301","author":"Di Costanzo","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1074\/jbc.C109.016931_bib19","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.C109.016931_bib20","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1107\/S0907444998003254","volume":"54","author":"Br\u00fcnger","year":"1998","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1074\/jbc.C109.016931_bib21","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1107\/S0907444905007894","volume":"61","author":"Afonine","year":"2005","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1074\/jbc.C109.016931_bib22","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1074\/jbc.C109.016931_bib23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0022-2860(98)00569-9","volume":"474","author":"Wawrzycka","year":"1999","journal-title":"J. Mol. Struct."},{"key":"10.1074\/jbc.C109.016931_bib24","first-page":"380","volume":"58","author":"Allen","year":"2002","journal-title":"Acta Crystallogr. B Biol. Crystallogr."},{"key":"10.1074\/jbc.C109.016931_bib25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/prot.340110307","volume":"11","author":"Herzberg","year":"1991","journal-title":"Proteins"},{"key":"10.1074\/jbc.C109.016931_bib26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1172\/JCI115574","volume":"89","author":"Jenkins","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.C109.016931_bib27","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/S0090-9556(25)06757-1","volume":"23","author":"Huskey","year":"1995","journal-title":"Drug Metab. Dispos."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817492611?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817492611?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.C109.016931","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T02:42:43Z","timestamp":1739155363000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925817492611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":27,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0021925817492611"],"URL":"https:\/\/doi.org\/10.1074\/jbc.c109.016931","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}