{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T15:49:56Z","timestamp":1789919396957,"version":"4.0.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"44","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":2162,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1074\/jbc.c114.598946","type":"journal-article","created":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T03:15:17Z","timestamp":1410232517000},"page":"30190-30195","source":"Crossref","is-referenced-by-count":58,"title":["Isoniazid Induces Apoptosis Of Activated CD4+ T Cells"],"prefix":"10.1016","volume":"289","author":[{"given":"Sultan","family":"Tousif","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhiraj Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaheer","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashini","family":"Moodley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maitree","family":"Bhattacharyya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Van Kaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gobardhan","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.C114.598946_bib1","first-page":"237","article-title":"WHO global tuberculosis control report: Summary","volume":"18","author":"World Health Organization","year":"2010","journal-title":"Cent. Eur. J. Public Health"},{"key":"10.1074\/jbc.C114.598946_bib2","doi-asserted-by":"crossref","first-page":"e1002464","DOI":"10.1371\/journal.ppat.1002464","article-title":"Tuberculosis and HIV co-infection","volume":"8","author":"Pawlowski","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1074\/jbc.C114.598946_bib3","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1056\/NEJMra1200894","article-title":"Tuberculosis","volume":"368","author":"Zumla","year":"2013","journal-title":"N. Engl. J. Med"},{"issue":"Suppl. 3","key":"10.1074\/jbc.C114.598946_bib4","doi-asserted-by":"crossref","first-page":"S201","DOI":"10.1086\/651492","article-title":"HIV infection-associated tuberculosis: the epidemiology and the response","volume":"50","author":"Getahun","year":"2010","journal-title":"Clin. Infect. Dis"},{"key":"10.1074\/jbc.C114.598946_bib5","first-page":"165","article-title":"Impact of tuberculosis on HIV-1 replication, diversity, and disease progression","volume":"4","author":"Collins","year":"2002","journal-title":"AIDS Rev"},{"key":"10.1074\/jbc.C114.598946_bib6","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1001\/archinte.163.9.1009","article-title":"The growing burden of tuberculosis: global trends and interactions with the HIV epidemic","volume":"163","author":"Corbett","year":"2003","journal-title":"Arch. Intern. Med"},{"key":"10.1074\/jbc.C114.598946_bib7","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1056\/NEJM200104263441706","article-title":"Global trends in resistance to antituberculosis drugs: World Health Organization-International Union against Tuberculosis and Lung Disease Working Group on Anti-Tuberculosis Drug Resistance Surveillance","volume":"344","author":"Espinal","year":"2001","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.C114.598946_bib8","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1056\/NEJM199806043382301","article-title":"Global surveillance for antituberculosis-drug resistance, 1994\u20131997: World Health Organization-International Union against Tuberculosis and Lung Disease Working Group on Anti-Tuberculosis Drug Resistance Surveillance","volume":"338","author":"Pablos-M\u00e9ndez","year":"1998","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.C114.598946_bib9","series-title":"The WHO\/IUATLD Global Project on Anti-Tuberculosis Drug Resistance Surveillance Report No. 3","first-page":"16","article-title":"Anti-tuberculosis drug resistance in the world","author":"World Health Organization","year":"2004"},{"key":"10.1074\/jbc.C114.598946_bib10","first-page":"489","article-title":"Controlling multidrug-resistant tuberculosis and access to expensive drugs: a rational framework","volume":"80","author":"Pablos-Mendez","year":"2002","journal-title":"Bull. World Health Organ"},{"key":"10.1074\/jbc.C114.598946_bib11","first-page":"9","article-title":"Origins and evolution of antibiotic resistance","volume":"12","author":"Davies","year":"1996","journal-title":"Microbiologia"},{"key":"10.1074\/jbc.C114.598946_bib12","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1056\/NEJMra0908076","article-title":"MDR tuberculosis: critical steps for prevention and control","volume":"363","author":"Nathanson","year":"2010","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.C114.598946_bib13","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/S1473-3099(13)70130-0","article-title":"Universal access to care for multidrug-resistant tuberculosis: an analysis of surveillance data","volume":"13","author":"Falzon","year":"2013","journal-title":"Lancet Infect. Dis"},{"key":"10.1074\/jbc.C114.598946_bib14","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1378\/chest.08-2427","article-title":"Emergence of new forms of totally drug-resistant tuberculosis bacilli: super extensively drug-resistant tuberculosis or totally drug-resistant strains in Iran","volume":"136","author":"Velayati","year":"2009","journal-title":"Chest"},{"key":"10.1074\/jbc.C114.598946_bib15","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1440-1843.2012.02192.x","article-title":"Totally drug-resistant tuberculosis in India: who let the djinn out?","volume":"17","author":"Udwadia","year":"2012","journal-title":"Respirology"},{"key":"10.1074\/jbc.C114.598946_bib16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/cid\/cir889","article-title":"Totally drug-resistant tuberculosis in India","volume":"54","author":"Udwadia","year":"2012","journal-title":"Clin. Infect. Dis"},{"key":"10.1074\/jbc.C114.598946_bib17","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1378\/chest.128.1.116","article-title":"Isoniazid hepatotoxicity associated with treatment of latent tuberculosis infection: a 7-year evaluation from a public health tuberculosis clinic","volume":"128","author":"Fountain","year":"2005","journal-title":"Chest"},{"key":"10.1074\/jbc.C114.598946_bib18","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1136\/bmj.39463.640787.BE","article-title":"Long term efficacy of DOTS regimens for tuberculosis: systematic review","volume":"336","author":"Cox","year":"2008","journal-title":"BMJ"},{"key":"10.1074\/jbc.C114.598946_bib19","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3201\/eid1308.051327","article-title":"High prevalence of tuberculosis in previously treated patients, Cape Town, South Africa","volume":"13","author":"den Boon","year":"2007","journal-title":"Emerg. Infect. Dis"},{"key":"10.1074\/jbc.C114.598946_bib20","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1056\/NEJM199910143411602","article-title":"Exogenous reinfection as a cause of recurrent tuberculosis after curative treatment","volume":"341","author":"van Rie","year":"1999","journal-title":"N. Engl. J. Med"},{"key":"10.1074\/jbc.C114.598946_bib21","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1002\/eji.1830230921","article-title":"Mycobacteria induce CD4+ T cells that are cytotoxic and display Th1-like cytokine secretion profile: heterogeneity in cytotoxic activity and cytokine secretion levels","volume":"23","author":"Mutis","year":"1993","journal-title":"Eur. J. Immunol"},{"key":"10.1074\/jbc.C114.598946_bib22","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1084\/jem.178.6.2249","article-title":"An essential role for interferon \u03b3 in resistance to Mycobacterium tuberculosis infection","volume":"178","author":"Flynn","year":"1993","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.C114.598946_bib23","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1084\/jem.174.3.583","article-title":"Selection of a human T helper type 1-like T cell subset by mycobacteria","volume":"174","author":"Haanen","year":"1991","journal-title":"J. Exp. Med"},{"key":"10.1074\/jbc.C114.598946_bib24","doi-asserted-by":"crossref","first-page":"16508","DOI":"10.1074\/jbc.M114.558098","article-title":"Small molecule-directed immunotherapy against recurrent infection by Mycobacterium tuberculosis","volume":"289","author":"Bhattacharya","year":"2014","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.C114.598946_bib25","doi-asserted-by":"crossref","first-page":"e1002378","DOI":"10.1371\/journal.ppat.1002378","article-title":"Early secreted antigen ESAT-6 of Mycobacterium tuberculosis promotes protective T helper 17 cell responses in a Toll-like receptor-2-dependent manner","volume":"7","author":"Chatterjee","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1074\/jbc.C114.598946_bib26","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/nm.2420","article-title":"A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis","volume":"17","author":"Sweeney","year":"2011","journal-title":"Nat Med"},{"key":"10.1074\/jbc.C114.598946_bib27","doi-asserted-by":"crossref","first-page":"120066","DOI":"10.1098\/rsob.120066","article-title":"Cancer drug pan-resistance: pumps, cancer stem cells, quiescence, epithelial to mesenchymal transition, blocked cell death pathways, persisters or what?","volume":"2","author":"Borst","year":"2012","journal-title":"Open Biol"},{"key":"10.1074\/jbc.C114.598946_bib28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.immuni.2006.06.011","article-title":"Granzyme B is critical for T cell receptor-induced cell death of type 2 helper T cells","volume":"25","author":"Devadas","year":"2006","journal-title":"Immunity"},{"key":"10.1074\/jbc.C114.598946_bib29","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1600-0463.2009.02458.x","article-title":"Interaction of Mycobacterium tuberculosis with the host: consequences for vaccine development","volume":"117","author":"Dietrich","year":"2009","journal-title":"APMIS"},{"key":"10.1074\/jbc.C114.598946_bib30","doi-asserted-by":"crossref","first-page":"e1002052","DOI":"10.1371\/journal.ppat.1002052","article-title":"A \u03b3 interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivo","volume":"7","author":"Gallegos","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1074\/jbc.C114.598946_bib31","doi-asserted-by":"crossref","first-page":"21653","DOI":"10.1073\/pnas.1007967107","article-title":"Mycobacterium tuberculosis evades host immunity by recruiting mesenchymal stem cells","volume":"107","author":"Raghuvanshi","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/jbc.C114.598946_bib32","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1002\/eji.1830241108","article-title":"Macrophage-T cell interaction in experimental mycobacterial infection: selective regulation of co-stimulatory molecules on Mycobacterium-infected macrophages and its implication in the suppression of cell-mediated immune response","volume":"24","author":"Saha","year":"1994","journal-title":"Eur. J. Immunol"},{"key":"10.1074\/jbc.C114.598946_bib33","doi-asserted-by":"crossref","first-page":"e19864","DOI":"10.1371\/journal.pone.0019864","article-title":"T cells from Programmed Death-1 deficient mice respond poorly to Mycobacterium tuberculosis infection","volume":"6","author":"Tousif","year":"2011","journal-title":"PLoS One"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820372276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820372276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.C114.598946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T08:37:05Z","timestamp":1641285425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820372276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":33,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0021925820372276"],"URL":"https:\/\/doi.org\/10.1074\/jbc.c114.598946","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]}}}