{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:02:10Z","timestamp":1791356530219,"version":"4.3.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T00:00:00Z","timestamp":1601596800000},"content-version":"vor","delay-in-days":5329,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1074\/jbc.c500451200","type":"journal-article","created":{"date-parts":[[2006,2,8]],"date-time":"2006-02-08T02:40:07Z","timestamp":1139366407000},"page":"8313-8316","source":"Crossref","is-referenced-by-count":212,"title":["TSC1 Stabilizes TSC2 by Inhibiting the Interaction between TSC2 and the HERC1 Ubiquitin Ligase"],"prefix":"10.1016","volume":"281","author":[{"given":"Huira","family":"Chong-Kopera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Inoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc R.","family":"Garcia-Gonzalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Luis","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Liang","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.C500451200_bib1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1469-1809.2003.00012.x","volume":"67","author":"Kwiatkowski","year":"2003","journal-title":"Ann. Hum. Genet"},{"key":"10.1074\/jbc.C500451200_bib2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.tcb.2003.12.006","volume":"14","author":"Pan","year":"2004","journal-title":"Trends Cell Biol."},{"key":"10.1074\/jbc.C500451200_bib3","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1101\/gad.1212704","volume":"18","author":"Hay","year":"2004","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.C500451200_bib4","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1038\/sj.onc.1207542","volume":"23","author":"Fingar","year":"2004","journal-title":"Oncogene"},{"key":"10.1074\/jbc.C500451200_bib5","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/hmg\/7.6.1053","volume":"7","author":"van Slegtenhorst","year":"1998","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.C500451200_bib6","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tibs.2003.11.007","volume":"29","author":"Li","year":"2004","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.C500451200_bib7","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.tibs.2003.09.003","volume":"28","author":"Manning","year":"2003","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.C500451200_bib8","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ncb839","volume":"4","author":"Inoki","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.C500451200_bib9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/sj.ejhg.5201276","volume":"13","author":"Nellist","year":"2005","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1074\/jbc.C500451200_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.onc.1201170","volume":"15","author":"Rosa","year":"1997","journal-title":"Oncogene"},{"key":"10.1074\/jbc.C500451200_bib11","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1002\/j.1460-2075.1996.tb00801.x","volume":"15","author":"Rosa","year":"1996","journal-title":"EMBO J."},{"key":"10.1074\/jbc.C500451200_bib12","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0898-6568(03)00040-8","volume":"15","author":"Krymskaya","year":"2003","journal-title":"Cell. Signal."},{"key":"10.1074\/jbc.C500451200_bib13","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.1038\/sj.onc.1204009","volume":"19","author":"Benvenuto","year":"2000","journal-title":"Oncogene"},{"key":"10.1074\/jbc.C500451200_bib14","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1093\/hmg\/10.25.2899","volume":"10","author":"Hodges","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.C500451200_bib15","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/hmg\/11.5.525","volume":"11","author":"Kwiatkowski","year":"2002","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/jbc.C500451200_bib16","doi-asserted-by":"crossref","first-page":"13571","DOI":"10.1073\/pnas.202476899","volume":"99","author":"Tee","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.C500451200_bib17","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/ncb847","volume":"4","author":"Gao","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.C500451200_bib18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1128\/MMBR.69.1.79-100.2005","volume":"69","author":"Inoki","year":"2005","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1074\/jbc.C500451200_bib19","doi-asserted-by":"crossref","first-page":"11413","DOI":"10.1073\/pnas.91.24.11413","volume":"91","author":"Yeung","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.C500451200_bib20","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1172\/JCI7319","volume":"104","author":"Onda","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.C500451200_bib21","doi-asserted-by":"crossref","first-page":"305","DOI":"10.4067\/S0716-97602002000200022","volume":"35","author":"Thomas","year":"2002","journal-title":"Biol. Res."},{"key":"10.1074\/jbc.C500451200_bib22","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/ncb999","volume":"5","author":"Zhang","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.C500451200_bib23","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.cellsig.2004.03.019","volume":"16","author":"Aspuria","year":"2004","journal-title":"Cell. Signal."},{"key":"10.1074\/jbc.C500451200_bib24","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1172\/JCI200317222","volume":"112","author":"Zhang","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.C500451200_bib25","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/ncb840","volume":"4","author":"Potter","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.C500451200_bib26","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1074\/jbc.M310208200","volume":"279","author":"Murthy","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.C500451200_bib27","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0962-8924(00)01834-1","volume":"10","author":"Jackson","year":"2000","journal-title":"Trends Cell Biol."},{"key":"10.1074\/jbc.C500451200_bib28","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/354080a0","volume":"354","author":"Bischoff","year":"1991","journal-title":"Nature"},{"key":"10.1074\/jbc.C500451200_bib29","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1007\/s00018-005-5119-y","volume":"62","author":"Garcia-Gonzalo","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1074\/jbc.C500451200_bib30","doi-asserted-by":"crossref","first-page":"35664","DOI":"10.1074\/jbc.M403385200","volume":"279","author":"Lu","year":"2004","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819565280?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819565280?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.C500451200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T22:25:50Z","timestamp":1641162350000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819565280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":30,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0021925819565280"],"URL":"https:\/\/doi.org\/10.1074\/jbc.c500451200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}