{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:57:08Z","timestamp":1791194228885,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"24","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":7431,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2000,6]]},"DOI":"10.1074\/jbc.m000040200","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:11:04Z","timestamp":1027696264000},"page":"18195-18200","source":"Crossref","is-referenced-by-count":269,"title":["Presenilin-1 Mutations Increase Levels of Ryanodine Receptors and Calcium Release in PC12 Cells and Cortical Neurons"],"prefix":"10.1016","volume":"275","author":[{"given":"Sic L.","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mayne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clark P.","family":"Holden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Geiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Mattson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M000040200_bib1","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1001\/jama.1997.03550160083043","volume":"278","author":"Small","year":"1997","journal-title":"JAMA"},{"key":"10.1074\/jbc.M000040200_bib2","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1152\/physrev.1997.77.4.1081","volume":"77","author":"Mattson","year":"1997","journal-title":"Physiol. Rev."},{"key":"10.1074\/jbc.M000040200_bib3","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0166-2236(96)01030-2","volume":"20","author":"Hardy","year":"1997","journal-title":"Trends Neurosci."},{"key":"10.1074\/jbc.M000040200_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1471-4159.1998.70010001.x","volume":"70","author":"Mattson","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M000040200_bib5","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0896-6273(93)90315-I","volume":"10","author":"Mattson","year":"1993","journal-title":"Neuron"},{"key":"10.1074\/jbc.M000040200_bib6","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0896-6273(00)80230-5","volume":"17","author":"Borchelt","year":"1996","journal-title":"Neuron"},{"key":"10.1074\/jbc.M000040200_bib7","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/383710a0","volume":"383","author":"Duff","year":"1996","journal-title":"Nature"},{"key":"10.1074\/jbc.M000040200_bib8","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nm0896-864","volume":"2","author":"Scheuner","year":"1996","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M000040200_bib9","doi-asserted-by":"crossref","first-page":"12341","DOI":"10.1074\/jbc.273.20.12341","volume":"273","author":"Guo","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M000040200_bib10","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1046\/j.1471-4159.1997.69062494.x","volume":"69","author":"Ancolio","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M000040200_bib11","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/00001756-199612200-00074","volume":"8","author":"Guo","year":"1996","journal-title":"NeuroReport"},{"key":"10.1074\/jbc.M000040200_bib12","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1523\/JNEUROSCI.17-11-04212.1997","volume":"17","author":"Guo","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M000040200_bib13","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/4789","volume":"5","author":"Guo","year":"1999","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M000040200_bib14","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.1073\/pnas.96.7.4125","volume":"96","author":"Guo","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M000040200_bib15","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1046\/j.1471-4159.1999.0721030.x","volume":"72","author":"Begley","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M000040200_bib16","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/nbdi.1998.0207","volume":"6","author":"Parent","year":"1999","journal-title":"Neurobiol. Dis."},{"key":"10.1074\/jbc.M000040200_bib17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(00)80510-3","volume":"21","author":"Berridge","year":"1998","journal-title":"Neuron"},{"key":"10.1074\/jbc.M000040200_bib18","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1523\/JNEUROSCI.13-07-03051.1993","volume":"13","author":"Sharp","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M000040200_bib19","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0014-2999(95)00797-0","volume":"298","author":"Padua","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"10.1074\/jbc.M000040200_bib20","first-page":"210","volume":"188","author":"Friel","year":"1995","journal-title":"Ciba Found. Symp."},{"key":"10.1074\/jbc.M000040200_bib21","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1126\/science.273.5274.503","volume":"273","author":"Khan","year":"1996","journal-title":"Science"},{"key":"10.1074\/jbc.M000040200_bib22","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1128\/MCB.17.6.3005","volume":"17","author":"Jayaraman","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M000040200_bib23","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1046\/j.1471-4159.1997.69041703.x","volume":"69","author":"Alcazar","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M000040200_bib24","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/j.1471-4159.1991.tb02031.x","volume":"56","author":"Frandsen","year":"1991","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M000040200_bib25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0091-679X(08)61930-5","volume":"46","author":"Mattson","year":"1995","journal-title":"Methods Cell Biol."},{"key":"10.1074\/jbc.M000040200_bib26","doi-asserted-by":"crossref","first-page":"5089","DOI":"10.1523\/JNEUROSCI.17-13-05089.1997","volume":"17","author":"Kruman","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M000040200_bib27","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1046\/j.1471-4159.1999.0730867.x","volume":"73","author":"Anderson","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M000040200_bib28","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/1531-8249(199905)45:5<633::AID-ANA12>3.0.CO;2-X","volume":"45","author":"Mayne","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1074\/jbc.M000040200_bib29","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1097\/00004647-199812000-00009","volume":"18","author":"Tasker","year":"1998","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1074\/jbc.M000040200_bib30","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1046\/j.1471-4159.1996.67062390.x","volume":"67","author":"Wei","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M000040200_bib31","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0304-3940(93)90623-S","volume":"158","author":"Zhang","year":"1993","journal-title":"Neurosci. Lett."},{"key":"10.1074\/jbc.M000040200_bib32","doi-asserted-by":"crossref","first-page":"674","DOI":"10.2307\/3579479","volume":"147","author":"Hagan","year":"1997","journal-title":"Radiat. Res."},{"key":"10.1074\/jbc.M000040200_bib33","first-page":"4933","volume":"54","author":"Lock","year":"1994","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M000040200_bib34","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0306-4522(99)00042-1","volume":"92","author":"Kelliher","year":"1999","journal-title":"Neuroscience"},{"key":"10.1074\/jbc.M000040200_bib35","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0950-3536(97)80035-2","volume":"10","author":"Erikson","year":"1997","journal-title":"Baillieres Clin. Haematol."},{"key":"10.1074\/jbc.M000040200_bib36","doi-asserted-by":"crossref","first-page":"21673","DOI":"10.1074\/jbc.274.31.21673","volume":"274","author":"Korkotian","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M000040200_bib37","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/emboj\/18.3.522","volume":"18","author":"Biswas","year":"1999","journal-title":"EMBO J."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819831721?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819831721?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M000040200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T01:07:15Z","timestamp":1641258435000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819831721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":37,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["S0021925819831721"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m000040200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2000,6]]}}}