{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:16:58Z","timestamp":1790756218819,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"28","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":7401,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2000,7]]},"DOI":"10.1074\/jbc.m000212200","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:07:12Z","timestamp":1027696032000},"page":"21309-21316","source":"Crossref","is-referenced-by-count":25,"title":["The Spider Toxin \u03c9-Aga IIIA Defines a High Affinity Site on Neuronal High Voltage-activated Calcium Channels"],"prefix":"10.1016","volume":"275","author":[{"given":"Lizhen","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M000212200_bib1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0166-2236(95)80030-6","volume":"18","author":"Dunlap","year":"1995","journal-title":"Trends Neurosci."},{"key":"10.1074\/jbc.M000212200_bib2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/367072a0","volume":"367","author":"Artalejo","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.M000212200_bib3","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1146\/annurev.bi.63.070194.004135","volume":"63","author":"Olivera","year":"1994","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M000212200_bib4","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0896-6273(00)81246-5","volume":"18","author":"Poncer","year":"1997","journal-title":"Neuron"},{"key":"10.1074\/jbc.M000212200_bib5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0165-6147(91)90595-J","volume":"12","author":"Tsien","year":"1991","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1074\/jbc.M000212200_bib6","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/0028-3908(93)90003-L","volume":"32","author":"Zhang","year":"1993","journal-title":"Neuropharmacoogy"},{"key":"10.1074\/jbc.M000212200_bib7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1254\/jjp.72.83","volume":"72","author":"Mori","year":"1996","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1074\/jbc.M000212200_bib8","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1523\/JNEUROSCI.15-04-02995.1995","volume":"15","author":"Randall","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M000212200_bib9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1126\/science.7832825","volume":"264","author":"Wheeler","year":"1994","journal-title":"Science"},{"key":"10.1074\/jbc.M000212200_bib10","doi-asserted-by":"crossref","first-page":"15353","DOI":"10.1021\/bi981255g","volume":"37","author":"Newcomb","year":"1998","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M000212200_bib11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.ne.17.030194.002151","volume":"17","author":"Hofmann","year":"1994","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1074\/jbc.M000212200_bib12","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1073\/pnas.87.9.3391","volume":"87","author":"Snutch","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M000212200_bib13","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1126\/science.8388125","volume":"260","author":"Soong","year":"1993","journal-title":"Science"},{"key":"10.1074\/jbc.M000212200_bib14","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1126\/science.1321501","volume":"257","author":"Williams","year":"1992","journal-title":"Science"},{"key":"10.1074\/jbc.M000212200_bib15","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0896-6273(92)90109-Q","volume":"8","author":"Williams","year":"1992","journal-title":"Neuron"},{"key":"10.1074\/jbc.M000212200_bib16","doi-asserted-by":"crossref","first-page":"22347","DOI":"10.1016\/S0021-9258(17)31796-9","volume":"269","author":"Williams","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M000212200_bib17","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1083\/jcb.123.4.949","volume":"123","author":"Hell","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M000212200_bib18","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/0028-3908(93)90006-O","volume":"32","author":"Tomlinson","year":"1993","journal-title":"Neuropharmacol."},{"key":"10.1074\/jbc.M000212200_bib19","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0896-6273(93)90162-K","volume":"10","author":"Fujita","year":"1993","journal-title":"Neuron"},{"key":"10.1074\/jbc.M000212200_bib20","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/0028-3908(93)90005-N","volume":"32","author":"Stea","year":"1993","journal-title":"Neuropharmacology"},{"key":"10.1074\/jbc.M000212200_bib21","doi-asserted-by":"crossref","first-page":"10576","DOI":"10.1073\/pnas.91.22.10576","volume":"91","author":"Stea","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M000212200_bib22","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/8070","volume":"2","author":"Bourinet","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1074\/jbc.M000212200_bib23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0014-5793(92)81038-N","volume":"308","author":"Niidome","year":"1992","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M000212200_bib24","first-page":"303","volume":"2","author":"Wakamori","year":"1994","journal-title":"Receptors Channels"},{"key":"10.1074\/jbc.M000212200_bib25","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1016\/S0021-9258(18)45925-X","volume":"267","author":"Venema","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M000212200_bib26","doi-asserted-by":"crossref","first-page":"6628","DOI":"10.1073\/pnas.88.15.6628","volume":"88","author":"Mintz","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M000212200_bib27","first-page":"947","volume":"42","author":"Cohen","year":"1992","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M000212200_bib28","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1085\/jgp.103.5.731","volume":"103","author":"Ertel","year":"1994","journal-title":"J. Gen. Physiol."},{"key":"10.1074\/jbc.M000212200_bib29","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1523\/JNEUROSCI.14-05-02844.1994","volume":"14","author":"Mintz","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M000212200_bib30","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0028-3908(97)00086-5","volume":"36","author":"Randall","year":"1997","journal-title":"Neuropharmacology"},{"key":"10.1074\/jbc.M000212200_bib31","series-title":"Low-Voltage-Activated T-type Calcium Channels","first-page":"279","author":"Rock","year":"1998"},{"key":"10.1074\/jbc.M000212200_bib32","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/372272a0","volume":"372","author":"Ellinor","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.M000212200_bib33","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1432-1033.1992.tb16659.x","volume":"204","author":"Elshourbagy","year":"1992","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M000212200_bib34","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/0006-291X(88)90736-X","volume":"150","author":"Barhanin","year":"1988","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M000212200_bib35","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1523\/JNEUROSCI.08-09-03354.1988","volume":"8","author":"Wagner","year":"1988","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M000212200_bib36","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1006\/mcne.1994.1026","volume":"5","author":"Kristipati","year":"1994","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1074\/jbc.M000212200_bib37","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1523\/JNEUROSCI.14-08-05011.1994","volume":"14","author":"Boland","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M000212200_bib38","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0304-3940(93)90153-C","volume":"161","author":"Stoehr","year":"1993","journal-title":"Neurosci. Lett."},{"key":"10.1074\/jbc.M000212200_bib39","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/0006-291X(88)90684-5","volume":"154","author":"Feigenbaum","year":"1988","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M000212200_bib40","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1523\/JNEUROSCI.16-08-02612.1996","volume":"16","author":"McDonough","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M000212200_bib41","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0028-3908(05)80012-7","volume":"33","author":"Gaur","year":"1994","journal-title":"Neuropharmacology"},{"key":"10.1074\/jbc.M000212200_bib42","doi-asserted-by":"crossref","first-page":"12566","DOI":"10.1021\/bi00210a003","volume":"32","author":"Adams","year":"1993","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M000212200_bib43","first-page":"339","volume":"21","author":"McDonough","year":"1995","journal-title":"Soc. Neurosci. Abstr."},{"key":"10.1074\/jbc.M000212200_bib44","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1126\/science.1357749","volume":"258","author":"Turner","year":"1992","journal-title":"Science"},{"key":"10.1074\/jbc.M000212200_bib45","doi-asserted-by":"crossref","first-page":"9518","DOI":"10.1073\/pnas.90.20.9518","volume":"90","author":"Turner","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M000212200_bib46","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/366156a0","volume":"366","author":"Takahashi","year":"1993","journal-title":"Nature"},{"key":"10.1074\/jbc.M000212200_bib47","doi-asserted-by":"crossref","first-page":"5275","DOI":"10.1021\/bi00414a049","volume":"27","author":"Dunn","year":"1988","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M000212200_bib48","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1073\/pnas.95.8.4720","volume":"95","author":"Wu","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M000212200_bib49","doi-asserted-by":"crossref","first-page":"9235","DOI":"10.1523\/JNEUROSCI.19-21-09235.1999","volume":"19","author":"Wang","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M000212200_bib50","doi-asserted-by":"crossref","first-page":"11095","DOI":"10.1073\/pnas.88.24.11095","volume":"88","author":"McEnery","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M000212200_bib51","series-title":"Methods in Pharmacology","first-page":"3","author":"McEnery","year":"1993"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819797579?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819797579?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M000212200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T20:55:20Z","timestamp":1639688120000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819797579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":51,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["S0021925819797579"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m000212200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}