{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T04:27:42Z","timestamp":1774067262982,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"39","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"vor","delay-in-days":7349,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2000,9]]},"DOI":"10.1074\/jbc.m001782200","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:56:15Z","timestamp":1027695375000},"page":"30196-30201","source":"Crossref","is-referenced-by-count":18,"title":["Binding Properties of Agonists and Antagonists to Distinct Allosteric States of the Nicotinic Acetylcholine Receptor Are Incompatible with a Concerted Model"],"prefix":"10.1016","volume":"275","author":[{"given":"Michael","family":"Krauss","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Korr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinand","family":"Hucho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M001782200_bib1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/0896-6273(95)90004-7","volume":"15","author":"Karlin","year":"1995","journal-title":"Neuron"},{"key":"10.1074\/jbc.M001782200_bib2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1432-1033.1996.0539u.x","volume":"239","author":"Hucho","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M001782200_bib3","first-page":"21","volume":"4","author":"Changeux","year":"1990","journal-title":"FIDIA Res. Found. Neurosci. Award Lect."},{"key":"10.1074\/jbc.M001782200_bib4","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0896-6273(00)80616-9","volume":"21","author":"Changeux","year":"1998","journal-title":"Neuron"},{"key":"10.1074\/jbc.M001782200_bib5","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/0022-5193(67)90011-2","volume":"16","author":"Karlin","year":"1967","journal-title":"J. Theor. Biol."},{"key":"10.1074\/jbc.M001782200_bib6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1113\/jphysiol.1957.sp005838","volume":"138","author":"Katz","year":"1957","journal-title":"J. Physiol."},{"key":"10.1074\/jbc.M001782200_bib7","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/302528a0","volume":"302","author":"Noda","year":"1983","journal-title":"Nature"},{"key":"10.1074\/jbc.M001782200_bib8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0014-5793(86)80881-X","volume":"205","author":"Hucho","year":"1986","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M001782200_bib9","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1073\/pnas.87.7.2785","volume":"87","author":"Pedersen","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M001782200_bib10","doi-asserted-by":"crossref","first-page":"22603","DOI":"10.1016\/S0021-9258(18)54614-7","volume":"266","author":"Czajkowsky","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M001782200_bib11","doi-asserted-by":"crossref","first-page":"32940","DOI":"10.1074\/jbc.272.52.32940","volume":"272","author":"Chiara","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M001782200_bib12","doi-asserted-by":"crossref","first-page":"7282","DOI":"10.1073\/pnas.92.16.7282","volume":"92","author":"Machold","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M001782200_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/09687689609160569","volume":"13","author":"Arias","year":"1996","journal-title":"Mol. Membr. Biol."},{"key":"10.1074\/jbc.M001782200_bib14","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1002\/j.1460-2075.1986.tb04431.x","volume":"5","author":"Oberth\u00fcr","year":"1986","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M001782200_bib15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF01025243","volume":"7","author":"Oberth\u00fcr","year":"1988","journal-title":"J. Protein Chem."},{"key":"10.1074\/jbc.M001782200_bib16","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1073\/pnas.83.8.2719","volume":"83","author":"Giraudat","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M001782200_bib17","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1021\/bi00383a003","volume":"26","author":"Giraudat","year":"1987","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M001782200_bib18","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0014-5793(89)80957-3","volume":"253","author":"Giraudat","year":"1989","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M001782200_bib19","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1124\/mol.56.2.300","volume":"56","author":"Gallagher","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M001782200_bib20","doi-asserted-by":"crossref","first-page":"7238","DOI":"10.1016\/S0021-9258(18)48229-4","volume":"262","author":"Herz","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M001782200_bib21","doi-asserted-by":"crossref","first-page":"9070","DOI":"10.1021\/bi00197a007","volume":"33","author":"Johnson","year":"1994","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M001782200_bib22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0005-2760(97)00045-3","volume":"1347","author":"Arias","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M001782200_bib23","doi-asserted-by":"crossref","first-page":"6237","DOI":"10.1021\/bi00075a017","volume":"32","author":"Arias","year":"1993","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M001782200_bib24","doi-asserted-by":"crossref","first-page":"6330","DOI":"10.1021\/bi960123p","volume":"35","author":"Johnson","year":"1996","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M001782200_bib25","doi-asserted-by":"crossref","first-page":"8202","DOI":"10.1073\/pnas.94.15.8202","volume":"94","author":"Watty","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M001782200_bib26","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0022-2836(65)80285-6","volume":"12","author":"Monod","year":"1965","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M001782200_bib27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1432-1033.1978.tb12211.x","volume":"85","author":"Schiebler","year":"1978","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M001782200_bib28","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1021\/bi00574a004","volume":"18","author":"Hartig","year":"1979","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M001782200_bib29","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1046\/j.1432-1327.1999.00787.x","volume":"265","author":"Saez-Briones","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M001782200_bib30","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1046\/j.1432-1327.2000.00971.x","volume":"267","author":"Bixel","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M001782200_bib31","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0014-2999(82)90085-1","volume":"80","author":"Sterz","year":"1982","journal-title":"Eur. J. Pharmacol."},{"key":"10.1074\/jbc.M001782200_bib32","doi-asserted-by":"crossref","first-page":"19623","DOI":"10.1074\/jbc.274.28.19623","volume":"274","author":"Prince","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M001782200_bib33","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1021\/bi00865a047","volume":"5","author":"Koshland","year":"1966","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M001782200_bib34","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/294462a0","volume":"294","author":"Hamill","year":"1981","journal-title":"Nature"},{"key":"10.1074\/jbc.M001782200_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-3495(83)84362-8","volume":"42","author":"Auerbach","year":"1983","journal-title":"Biophys. J."},{"key":"10.1074\/jbc.M001782200_bib36","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1073\/pnas.81.12.3901","volume":"81","author":"Jackson","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M001782200_bib37","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1113\/jphysiol.1996.sp021482","volume":"494","author":"Auerbach","year":"1996","journal-title":"J. Physiol."},{"key":"10.1074\/jbc.M001782200_bib38","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/376514a0","volume":"376","author":"Labarca","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.M001782200_bib39","first-page":"379","volume":"48","author":"Filatov","year":"1995","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M001782200_bib40","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0006-3495(98)77508-3","volume":"75","author":"Chen","year":"1998","journal-title":"Biophys. J."},{"key":"10.1074\/jbc.M001782200_bib41","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/353846a0","volume":"353","author":"Revah","year":"1991","journal-title":"Nature"},{"key":"10.1074\/jbc.M001782200_bib42","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1073\/pnas.89.4.1261","volume":"89","author":"Bertrand","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M001782200_bib43","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/0005-2736(95)80022-8","volume":"1235","author":"Moore","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M001782200_bib44","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1021\/bi962547p","volume":"36","author":"Lurtz","year":"1997","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M001782200_bib45","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/373037a0","volume":"373","author":"Unwin","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.M001782200_bib46","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0006-3495(92)81784-8","volume":"62","author":"Herz","year":"1992","journal-title":"Biophys. J."},{"key":"10.1074\/jbc.M001782200_bib47","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1006\/jmbi.1999.2721","volume":"288","author":"Miyazawa","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M001782200_bib48","first-page":"634","volume":"33","author":"Blanton","year":"1988","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M001782200_bib49","doi-asserted-by":"crossref","first-page":"16691","DOI":"10.1016\/S0021-9258(18)55356-4","volume":"266","author":"Herz","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M001782200_bib50","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF01872637","volume":"122","author":"Palma","year":"1991","journal-title":"J. Membr. Biol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818443542?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818443542?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M001782200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T06:56:13Z","timestamp":1639810573000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925818443542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":50,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["S0021925818443542"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m001782200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}