{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:26:33Z","timestamp":1768292793395,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"29","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":7401,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2000,7]]},"DOI":"10.1074\/jbc.m002502200","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:04:49Z","timestamp":1027695889000},"page":"22069-22074","source":"Crossref","is-referenced-by-count":125,"title":["Altered Regulatory Properties of Human Cardiac Troponin I Mutants That Cause Hypertrophic Cardiomyopathy"],"prefix":"10.1016","volume":"275","author":[{"given":"Kathryn","family":"Elliott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles S.","family":"Redwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M002502200_bib1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1161\/01.CIR.92.4.785","volume":"92","author":"Maron","year":"1995","journal-title":"Circulation"},{"key":"10.1074\/jbc.M002502200_bib2","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/0092-8674(90)90274-I","volume":"62","author":"Geisterfer-Lowrance","year":"1990","journal-title":"Cell"},{"key":"10.1074\/jbc.M002502200_bib3","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1161\/01.RES.83.6.580","volume":"83","author":"Bonne","year":"1998","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M002502200_bib4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0008-6363(99)00213-8","volume":"44","author":"Redwood","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1074\/jbc.M002502200_bib5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/ng0897-379","volume":"16","author":"Kimura","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M002502200_bib6","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1146\/annurev.ph.58.030196.002311","volume":"58","author":"Tobacman","year":"1996","journal-title":"Annu. Rev. Physiol."},{"key":"10.1074\/jbc.M002502200_bib7","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1161\/01.RES.83.5.471","volume":"83","author":"Solaro","year":"1998","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M002502200_bib8","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/0022-2836(88)90208-2","volume":"203","author":"Herzberg","year":"1988","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M002502200_bib9","doi-asserted-by":"crossref","first-page":"12800","DOI":"10.1021\/bi00209a011","volume":"33","author":"Olah","year":"1994","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M002502200_bib10","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.1016\/S0021-9258(17)37679-2","volume":"269","author":"Farah","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002502200_bib11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0014-5793(90)81234-F","volume":"270","author":"Vallins","year":"1990","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M002502200_bib12","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1021\/bi00360a013","volume":"25","author":"Cachia","year":"1986","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M002502200_bib13","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0014-5793(93)81344-Y","volume":"323","author":"Van Eyk","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M002502200_bib14","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1006\/jmbi.1997.1200","volume":"271","author":"Tripet","year":"1997","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M002502200_bib15","doi-asserted-by":"crossref","first-page":"26887","DOI":"10.1074\/jbc.272.43.26887","volume":"272","author":"Rarick","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002502200_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1161\/01.RES.84.1.9","volume":"84","author":"McDonough","year":"1999","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M002502200_bib17","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1126\/science.287.5452.488","volume":"287","author":"Murphy","year":"2000","journal-title":"Science"},{"key":"10.1074\/jbc.M002502200_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.RES.84.1.1","volume":"84","author":"Huang","year":"1999","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M002502200_bib19","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1111\/j.1432-1033.1994.1195b.x","volume":"225","author":"al Hillawi","year":"1994","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M002502200_bib20","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1083\/jcb.109.2.593","volume":"109","author":"Way","year":"1989","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M002502200_bib21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/0076-6879(90)85008-C","volume":"185","author":"Studier","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M002502200_bib22","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1161\/01.RES.86.11.1146","volume":"86","author":"Redwood","year":"2000","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M002502200_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0076-6879(82)85009-X","volume":"85","author":"Margossian","year":"1982","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M002502200_bib24","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/0076-6879(82)85020-9","volume":"85","author":"Pardee","year":"1982","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M002502200_bib25","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1016\/S0021-9258(19)42382-X","volume":"249","author":"Eisenberg","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002502200_bib26","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M002502200_bib27","first-page":"1","volume":"40","author":"Bers","year":"1999","journal-title":"Methods Cell Biol."},{"key":"10.1074\/jbc.M002502200_bib28","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0021-9258(18)66180-0","volume":"202","author":"Taussky","year":"1953","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002502200_bib29","doi-asserted-by":"crossref","first-page":"13516","DOI":"10.1021\/bi980280j","volume":"37","author":"Reiffert","year":"1998","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M002502200_bib30","doi-asserted-by":"crossref","first-page":"12729","DOI":"10.1021\/bi00208a026","volume":"33","author":"Liao","year":"1994","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M002502200_bib31","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1016\/S0021-9258(19)77936-8","volume":"263","author":"Van Eyk","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002502200_bib32","doi-asserted-by":"crossref","first-page":"10529","DOI":"10.1074\/jbc.272.16.10529","volume":"272","author":"Van Eyk","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002502200_bib33","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0021-9258(17)42067-9","volume":"269","author":"Sweeney","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002502200_bib34","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/BF02332169","volume":"431","author":"Strauss","year":"1996","journal-title":"Pflugers. Arch."},{"key":"10.1074\/jbc.M002502200_bib35","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0021-9258(19)68355-9","volume":"257","author":"Robertson","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002502200_bib36","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1006\/jsbi.1998.3980","volume":"122","author":"Levine","year":"1998","journal-title":"J. Struct. Biol."},{"key":"10.1074\/jbc.M002502200_bib37","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1161\/01.RES.82.1.106","volume":"82","author":"Bottinelli","year":"1998","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M002502200_bib38","doi-asserted-by":"crossref","first-page":"28363","DOI":"10.1074\/jbc.274.40.28363","volume":"274","author":"Tobacman","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002502200_bib39","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1074\/jbc.275.1.624","volume":"275","author":"Szczesna","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002502200_bib40","doi-asserted-by":"crossref","first-page":"14406","DOI":"10.1073\/pnas.95.24.14406","volume":"95","author":"Sweeney","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M002502200_bib41","doi-asserted-by":"crossref","first-page":"18216","DOI":"10.1074\/jbc.272.29.18216","volume":"272","author":"Sia","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002502200_bib42","doi-asserted-by":"crossref","first-page":"8289","DOI":"10.1021\/bi9901679","volume":"38","author":"Li","year":"1999","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M002502200_bib43","doi-asserted-by":"crossref","first-page":"31382","DOI":"10.1074\/jbc.274.44.31382","volume":"274","author":"Dong","year":"1999","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819796380?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819796380?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M002502200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T23:05:10Z","timestamp":1641251110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819796380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":43,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["S0021925819796380"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m002502200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}