{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:45:18Z","timestamp":1790797518810,"version":"4.1.0"},"reference-count":15,"publisher":"Elsevier BV","issue":"28","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":7401,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2000,7]]},"DOI":"10.1074\/jbc.m002522200","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:04:49Z","timestamp":1027695889000},"page":"21508-21513","source":"Crossref","is-referenced-by-count":212,"title":["Molecular Cloning and Characterization of a Human Mitochondrial Ceramidase"],"prefix":"10.1016","volume":"275","author":[{"given":"Samer","family":"El Bawab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Roddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja","family":"Bielawska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Lemasters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf A.","family":"Hannun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M002522200_bib1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0962-8924(99)01694-3","volume":"10","author":"Hannun","year":"2000","journal-title":"Trends Cell. Biol."},{"key":"10.1074\/jbc.M002522200_bib2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1042\/bj3350465","volume":"335","author":"Mathias","year":"1998","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M002522200_bib3","doi-asserted-by":"crossref","first-page":"18718","DOI":"10.1074\/jbc.272.30.18718","volume":"272","author":"Nikolova-Karakashian","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002522200_bib4","doi-asserted-by":"crossref","first-page":"7190","DOI":"10.1074\/jbc.274.11.7190","volume":"274","author":"Huwiler","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002522200_bib5","doi-asserted-by":"crossref","first-page":"21533","DOI":"10.1074\/jbc.274.31.21533","volume":"274","author":"Auge","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002522200_bib6","doi-asserted-by":"crossref","first-page":"23305","DOI":"10.1074\/jbc.270.40.23305","volume":"270","author":"Coroneos","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002522200_bib7","doi-asserted-by":"crossref","first-page":"27948","DOI":"10.1074\/jbc.274.39.27948","volume":"274","author":"El Bawab","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002522200_bib8","doi-asserted-by":"crossref","first-page":"12646","DOI":"10.1074\/jbc.271.21.12646","volume":"271","author":"Bielawska","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002522200_bib9","series-title":"Molecular Cloning: A Laboratory Manual","author":"Sambrook","year":"1989"},{"key":"10.1074\/jbc.M002522200_bib10","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1074\/jbc.M002522200_bib11","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/j.1432-1033.1996.00779.x","volume":"241","author":"Claros","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M002522200_bib12","doi-asserted-by":"crossref","first-page":"36616","DOI":"10.1074\/jbc.274.51.36616","volume":"274","author":"Okino","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002522200_bib13","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1074\/jbc.275.5.3462","volume":"275","author":"Tani","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002522200_bib14","doi-asserted-by":"crossref","first-page":"6876","DOI":"10.1074\/jbc.275.10.6876","volume":"275","author":"Mao","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002522200_bib15","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev.cellbio.15.1.269","volume":"15","author":"Budihardjo","year":"1999","journal-title":"Annu. Rev. Cell Dev. Biol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192581979783X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192581979783X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M002522200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T23:09:40Z","timestamp":1641251380000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192581979783X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":15,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["S002192581979783X"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m002522200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}