{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:07:49Z","timestamp":1783570069187,"version":"3.55.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"33","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T00:00:00Z","timestamp":1601596800000},"content-version":"vor","delay-in-days":7367,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2000,8]]},"DOI":"10.1074\/jbc.m003424200","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:04:49Z","timestamp":1027695889000},"page":"25681-25689","source":"Crossref","is-referenced-by-count":52,"title":["Activation of Serum Response Factor in the Depolarization Induction of Egr-1 Transcription in Pancreatic Islet \u03b2-Cells"],"prefix":"10.1016","volume":"275","author":[{"given":"Ernesto","family":"Bernal-Mizrachi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burton","family":"Wice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Alan","family":"Permutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M003424200_bib1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF00400917","volume":"35","author":"Swenne","year":"1992","journal-title":"Diabetologia"},{"key":"10.1074\/jbc.M003424200_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/dmr.5610090104","volume":"9","author":"Welsh","year":"1993","journal-title":"Diabetes Metab. Rev."},{"key":"10.1074\/jbc.M003424200_bib3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1210\/mend-3-1-165","volume":"3","author":"Nielsen","year":"1989","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M003424200_bib4","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1210\/endo-129-2-883","volume":"129","author":"Billestrup","year":"1991","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M003424200_bib5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1210\/endo-128-1-45","volume":"128","author":"Brelje","year":"1991","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M003424200_bib6","doi-asserted-by":"crossref","first-page":"288","DOI":"10.2337\/diab.36.3.288","volume":"36","author":"Swenne","year":"1987","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M003424200_bib7","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.2337\/diab.45.9.1223","volume":"45","author":"Beattie","year":"1996","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M003424200_bib8","doi-asserted-by":"crossref","first-page":"5781","DOI":"10.1073\/pnas.90.12.5781","volume":"90","author":"Polak","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M003424200_bib9","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1073\/pnas.94.11.5599","volume":"94","author":"Khoo","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M003424200_bib10","doi-asserted-by":"crossref","first-page":"7882","DOI":"10.1074\/jbc.270.14.7882","volume":"270","author":"Frodin","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M003424200_bib11","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1042\/bj3130119","volume":"313","author":"Persaud","year":"1996","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M003424200_bib12","doi-asserted-by":"crossref","first-page":"20936","DOI":"10.1074\/jbc.272.33.20936","volume":"272","author":"Macfarlane","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M003424200_bib13","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0896-6273(90)90106-P","volume":"4","author":"Sheng","year":"1990","journal-title":"Neuron"},{"key":"10.1074\/jbc.M003424200_bib14","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1096\/fasebj.12.12.1173","volume":"12","author":"Susini","year":"1998","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M003424200_bib15","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s001250051139","volume":"42","author":"Josefsen","year":"1999","journal-title":"Diabetologia"},{"key":"10.1074\/jbc.M003424200_bib16","doi-asserted-by":"crossref","first-page":"7857","DOI":"10.1073\/pnas.85.21.7857","volume":"85","author":"Christy","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M003424200_bib17","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1073\/pnas.85.13.4691","volume":"85","author":"Lemaire","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M003424200_bib18","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1126\/science.3672127","volume":"238","author":"Milbrandt","year":"1987","journal-title":"Science"},{"key":"10.1074\/jbc.M003424200_bib19","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1096\/fasebj.14.1.128","volume":"14","author":"Susini","year":"2000","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M003424200_bib20","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/BF00401058","volume":"36","author":"Ishihara","year":"1993","journal-title":"Diabetologia"},{"key":"10.1074\/jbc.M003424200_bib21","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M003424200_bib22","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1073\/pnas.81.7.1991","volume":"81","author":"Church","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M003424200_bib23","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/0169-328X(94)00243-8","volume":"29","author":"Mack","year":"1995","journal-title":"Mol. Brain. Res."},{"key":"10.1074\/jbc.M003424200_bib24","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1084\/jem.185.4.731","volume":"185","author":"Shao","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M003424200_bib25","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0076-6879(83)98149-1","volume":"98","author":"McDaniel","year":"1983","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M003424200_bib26","doi-asserted-by":"crossref","first-page":"12903","DOI":"10.1074\/jbc.271.22.12903","volume":"271","author":"Cohen","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M003424200_bib27","doi-asserted-by":"crossref","first-page":"3672","DOI":"10.1128\/MCB.15.7.3672","volume":"15","author":"Miranti","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M003424200_bib28","first-page":"647","volume":"6","author":"Walton","year":"1992","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M003424200_bib29","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/nar\/11.5.1475","volume":"11","author":"Dignam","year":"1983","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M003424200_bib30","first-page":"6260","volume":"13","author":"Rivera","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M003424200_bib31","series-title":"Current Protocols in Molecular Biology","first-page":"8.0.3","author":"Ausbel","year":"1989"},{"key":"10.1074\/jbc.M003424200_bib32","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1172\/JCI1129","volume":"101","author":"Taupenot","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M003424200_bib33","doi-asserted-by":"crossref","first-page":"5267","DOI":"10.1016\/S0021-9258(19)34116-X","volume":"265","author":"Chijiwa","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M003424200_bib34","first-page":"587","volume":"46","author":"Kuwada","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M003424200_bib35","doi-asserted-by":"crossref","first-page":"27489","DOI":"10.1074\/jbc.270.46.27489","volume":"270","author":"Alessi","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M003424200_bib36","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/376599a0","volume":"376","author":"Burgering","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.M003424200_bib37","doi-asserted-by":"crossref","first-page":"5241","DOI":"10.1016\/S0021-9258(17)37680-9","volume":"269","author":"Vlahos","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M003424200_bib38","doi-asserted-by":"crossref","first-page":"25715","DOI":"10.1074\/jbc.271.41.25715","volume":"271","author":"Pearman","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M003424200_bib39","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0968-0004(92)90013-Y","volume":"17","author":"Treisman","year":"1992","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.M003424200_bib40","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0959-437X(94)90097-3","volume":"4","author":"Treisman","year":"1994","journal-title":"Curr. Opin. Genetics Dev."},{"key":"10.1074\/jbc.M003424200_bib41","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/354531a0","volume":"354","author":"Hipskind","year":"1991","journal-title":"Nature"},{"key":"10.1074\/jbc.M003424200_bib42","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0092-8674(89)90579-5","volume":"56","author":"Shaw","year":"1989","journal-title":"Cell"},{"key":"10.1074\/jbc.M003424200_bib43","doi-asserted-by":"crossref","first-page":"25951","DOI":"10.1074\/jbc.272.41.25951","volume":"272","author":"Liao","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M003424200_bib44","doi-asserted-by":"crossref","first-page":"25483","DOI":"10.1016\/S0021-9258(18)47276-6","volume":"269","author":"Misra","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M003424200_bib45","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1128\/MCB.17.3.1513","volume":"17","author":"Bruning","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M003424200_bib46","doi-asserted-by":"crossref","first-page":"30222","DOI":"10.1074\/jbc.271.47.30222","volume":"271","author":"Harada","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M003424200_bib47","doi-asserted-by":"crossref","first-page":"7996","DOI":"10.1021\/bi00025a005","volume":"34","author":"Jhun","year":"1995","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M003424200_bib48","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0896-6273(90)90115-V","volume":"4","author":"Sheng","year":"1990","journal-title":"Neuron"},{"key":"10.1074\/jbc.M003424200_bib49","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1126\/science.8097062","volume":"260","author":"Ginty","year":"1993","journal-title":"Science"},{"key":"10.1074\/jbc.M003424200_bib50","first-page":"6799","volume":"10","author":"Knepel","year":"1990","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M003424200_bib51","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0143-4160(98)90111-7","volume":"23","author":"Hardingham","year":"1998","journal-title":"Cell Calcium"},{"key":"10.1074\/jbc.M003424200_bib52","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1083\/jcb.118.6.1489","volume":"118","author":"Vandromme","year":"1992","journal-title":"J. Cell Biol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819621368?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819621368?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M003424200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T01:01:38Z","timestamp":1641171698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819621368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":52,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["S0021925819621368"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m003424200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2000,8]]}}}