{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:53:10Z","timestamp":1789739590373,"version":"4.0.1"},"reference-count":56,"publisher":"Elsevier BV","issue":"52","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":7248,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2000,12]]},"DOI":"10.1074\/jbc.m005590200","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:05:53Z","timestamp":1027695953000},"page":"41377-41388","source":"Crossref","is-referenced-by-count":84,"title":["Synergistic Adhesive Interactions and Signaling Mechanisms Operating between Platelet Glycoprotein Ib\/IX and Integrin \u03b1IIb\u03b23"],"prefix":"10.1016","volume":"275","author":[{"given":"Cindy L.","family":"Yap","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha C.","family":"Hughan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Cranmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warwick S.","family":"Nesbitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Rooney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Giuliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhasini","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sacha M.","family":"Dopheide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem H.","family":"Salem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun P.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M005590200_bib1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0092-8674(87)90233-9","volume":"48","author":"Hynes","year":"1987","journal-title":"Cell"},{"key":"10.1074\/jbc.M005590200_bib2","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1126\/science.2821619","volume":"238","author":"Ruoslathi","year":"1987","journal-title":"Science"},{"key":"10.1074\/jbc.M005590200_bib3","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/0092-8674(91)90393-D","volume":"65","author":"Lawrence","year":"1991","journal-title":"Cell"},{"key":"10.1074\/jbc.M005590200_bib4","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1182\/blood.V77.12.2553.2553","volume":"77","author":"Ley","year":"1991","journal-title":"Blood"},{"key":"10.1074\/jbc.M005590200_bib5","doi-asserted-by":"crossref","first-page":"7538","DOI":"10.1073\/pnas.88.17.7538","volume":"88","author":"von Andrian","year":"1991","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1074\/jbc.M005590200_bib6","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0092-8674(00)80983-6","volume":"84","author":"Savage","year":"1996","journal-title":"Cell"},{"key":"10.1074\/jbc.M005590200_bib7","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0092-8674(00)81607-4","volume":"94","author":"Savage","year":"1998","journal-title":"Cell"},{"key":"10.1074\/jbc.M005590200_bib8","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1172\/JCI111816","volume":"75","author":"De Marco","year":"1985","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M005590200_bib9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1172\/JCI111673","volume":"75","author":"Gralnick","year":"1985","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M005590200_bib10","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/0955-0674(93)90041-N","volume":"5","author":"Ruggeri","year":"1993","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1074\/jbc.M005590200_bib11","doi-asserted-by":"crossref","first-page":"11227","DOI":"10.1016\/S0021-9258(18)99152-0","volume":"266","author":"Savage","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M005590200_bib12","doi-asserted-by":"crossref","first-page":"11300","DOI":"10.1016\/S0021-9258(19)49910-9","volume":"267","author":"Savage","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M005590200_bib13","first-page":"537","volume":"101","author":"Moritz","year":"1983","journal-title":"J. Lab. Clin. Med."},{"key":"10.1074\/jbc.M005590200_bib14","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1182\/blood.V71.5.1366.1366","volume":"71","author":"Moake","year":"1988","journal-title":"Blood"},{"key":"10.1074\/jbc.M005590200_bib15","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1074\/jbc.271.6.2879","volume":"271","author":"MacKenzie","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M005590200_bib16","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1074\/jbc.273.4.2024","volume":"273","author":"Daniel","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M005590200_bib17","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1074\/jbc.273.4.2030","volume":"273","author":"Jin","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M005590200_bib18","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1182\/blood.V92.1.152.413k27_152_159","volume":"92","author":"Hechler","year":"1998","journal-title":"Blood"},{"key":"10.1074\/jbc.M005590200_bib19","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1055\/s-0038-1657538","volume":"78","author":"Gachet","year":"1997","journal-title":"Thromb. Haemostasis"},{"key":"10.1074\/jbc.M005590200_bib20","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1182\/blood.V94.4.1149","volume":"94","author":"Kuwahara","year":"1999","journal-title":"Blood"},{"key":"10.1074\/jbc.M005590200_bib21","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1055\/s-0038-1649652","volume":"70","author":"Francesconi","year":"1993","journal-title":"Thromb. Haemostasis"},{"key":"10.1074\/jbc.M005590200_bib22","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1006\/bbrc.1995.2262","volume":"214","author":"Francesconi","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M005590200_bib23","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1006\/bcmd.1996.0104","volume":"22","author":"Kermode","year":"1996","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1074\/jbc.M005590200_bib24","doi-asserted-by":"crossref","first-page":"36241","DOI":"10.1074\/jbc.274.51.36241","volume":"274","author":"Yuan","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M005590200_bib25","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0003-9861(61)90278-8","volume":"93","author":"Molnar","year":"1961","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1074\/jbc.M005590200_bib26","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1172\/JCI109070","volume":"61","author":"Montgomery","year":"1978","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M005590200_bib27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1021\/jm981072s","volume":"42","author":"Ingall","year":"1999","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M005590200_bib28","doi-asserted-by":"crossref","first-page":"27093","DOI":"10.1016\/S0021-9258(18)47130-X","volume":"269","author":"Jackson","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M005590200_bib29","doi-asserted-by":"crossref","first-page":"21847","DOI":"10.1074\/jbc.272.35.21847","volume":"272","author":"Yuan","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M005590200_bib30","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1074\/jbc.274.10.6097","volume":"274","author":"Cranmer","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M005590200_bib31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/mvre.1993.1004","volume":"45","author":"Cooke","year":"1993","journal-title":"Microvasc. Res."},{"key":"10.1074\/jbc.M005590200_bib32","doi-asserted-by":"crossref","first-page":"16364","DOI":"10.1016\/S0021-9258(18)49264-2","volume":"34","author":"Sage","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M005590200_bib33","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1055\/s-0038-1651640","volume":"69","author":"Ikeda","year":"1993","journal-title":"Thromb. Haemostasis"},{"key":"10.1074\/jbc.M005590200_bib34","doi-asserted-by":"crossref","first-page":"12579","DOI":"10.1016\/S0021-9258(18)67128-5","volume":"261","author":"Handa","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M005590200_bib35","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1182\/blood.V70.2.475.475","volume":"70","author":"Niiya","year":"1987","journal-title":"Blood"},{"key":"10.1074\/jbc.M005590200_bib36","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1126\/science.279.5349.381","volume":"279","author":"Campbell","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M005590200_bib37","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1056\/NEJM197108122850703","volume":"285","author":"Weiss","year":"1971","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M005590200_bib38","first-page":"203","volume":"22","author":"Ruggeri","year":"1985","journal-title":"Semin. Hematol."},{"key":"10.1074\/jbc.M005590200_bib39","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1182\/blood.V67.2.322.322","volume":"67","author":"Weiss","year":"1986","journal-title":"Blood"},{"key":"10.1074\/jbc.M005590200_bib40","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/j.1365-2141.1986.tb07552.x","volume":"63","author":"Sakariassen","year":"1986","journal-title":"Br. J. Haematol."},{"key":"10.1074\/jbc.M005590200_bib41","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1749-6632.1991.tb43698.x","volume":"614","author":"Weiss","year":"1991","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1074\/jbc.M005590200_bib42","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1182\/blood.V86.7.2606.2606","volume":"86","author":"Chen","year":"1995","journal-title":"Blood"},{"key":"10.1074\/jbc.M005590200_bib43","doi-asserted-by":"crossref","first-page":"12623","DOI":"10.1074\/jbc.273.20.12623","volume":"273","author":"Schaffner-Reckinger","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M005590200_bib44","doi-asserted-by":"crossref","first-page":"15868","DOI":"10.1016\/S0021-9258(18)82334-1","volume":"268","author":"Haimovich","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M005590200_bib45","doi-asserted-by":"crossref","first-page":"17817","DOI":"10.1074\/jbc.273.28.17817","volume":"273","author":"Heraud","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M005590200_bib46","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1182\/blood.V80.1.113.113","volume":"80","author":"Chow","year":"1992","journal-title":"Blood"},{"key":"10.1074\/jbc.M005590200_bib47","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1055\/s-0037-1615849","volume":"82","author":"Shattil","year":"1999","journal-title":"Thromb. Haemostasis"},{"key":"10.1074\/jbc.M005590200_bib48","doi-asserted-by":"crossref","first-page":"15781","DOI":"10.1016\/S0021-9258(18)98476-0","volume":"266","author":"Toullec","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M005590200_bib49","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1021\/jm00084a004","volume":"35","author":"Davis","year":"1992","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M005590200_bib50","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0092-8674(00)81607-4","volume":"94","author":"Savage","year":"1998","journal-title":"Cell"},{"key":"10.1074\/jbc.M005590200_bib51","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1182\/blood.V94.1.172.413k17_172_178","volume":"94","author":"Ruggeri","year":"1999","journal-title":"Blood"},{"key":"10.1074\/jbc.M005590200_bib52","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1172\/JCI7569","volume":"105","author":"Kulkarni","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M005590200_bib53","first-page":"1085","volume":"147","author":"Gu","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M005590200_bib54","doi-asserted-by":"crossref","first-page":"16779","DOI":"10.1074\/jbc.275.22.16779","volume":"275","author":"Zaffran","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M005590200_bib55","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1055\/s-0038-1649806","volume":"74","author":"Oda","year":"1995","journal-title":"Thromb. Haemostasis"},{"key":"10.1074\/jbc.M005590200_bib56","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1172\/JCI115468","volume":"88","author":"Kroll","year":"1991","journal-title":"J. Clin. Invest."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819556770?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819556770?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M005590200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T20:14:17Z","timestamp":1639685657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819556770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12]]},"references-count":56,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2000,12]]}},"alternative-id":["S0021925819556770"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m005590200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2000,12]]}}}