{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:09:30Z","timestamp":1791835770703,"version":"4.3.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"27","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":7204,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2001,1]]},"DOI":"10.1074\/jbc.m007383200","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T11:16:07Z","timestamp":1027682167000},"page":"25096-25100","source":"Crossref","is-referenced-by-count":483,"title":["Leptin Induces Mitochondrial Superoxide Production and Monocyte Chemoattractant Protein-1 Expression in Aortic Endothelial Cells by Increasing Fatty Acid Oxidation via Protein Kinase A"],"prefix":"10.1016","volume":"276","author":[{"given":"Sho-ichi","family":"Yamagishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Edelstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-liang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasufumi","family":"Kaneda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Guzm\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Brownlee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M007383200_bib1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1126\/science.7624777","volume":"269","author":"Halaas","year":"1995","journal-title":"Science"},{"key":"10.1074\/jbc.M007383200_bib2","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1126\/science.7624776","volume":"269","author":"Pelleymounter","year":"1995","journal-title":"Science"},{"key":"10.1074\/jbc.M007383200_bib3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1530\/eje.0.1360173","volume":"136","author":"Nyholm","year":"1997","journal-title":"Eur. J. Endocrinol."},{"key":"10.1074\/jbc.M007383200_bib4","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1159\/000023294","volume":"50","author":"Rudberg","year":"1998","journal-title":"Horm. Res."},{"key":"10.1074\/jbc.M007383200_bib5","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/nm1195-1155","volume":"1","author":"Maffei","year":"1995","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M007383200_bib6","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1056\/NEJM198708063170605","volume":"317","author":"Ferrannini","year":"1987","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M007383200_bib7","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.2337\/diab.37.12.1595","volume":"37","author":"Reaven","year":"1988","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M007383200_bib8","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1126\/science.281.5383.1683","volume":"281","author":"Sierra-Honigmann","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M007383200_bib9","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1096\/fasebj.13.10.1231","volume":"13","author":"Bouloumi\u00e9","year":"1999","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M007383200_bib10","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1172\/JCI117936","volume":"95","author":"Hotamisligil","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M007383200_bib11","first-page":"4196","volume":"82","author":"Mohamed-Ali","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1074\/jbc.M007383200_bib12","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1210\/jcem.84.9.5987","volume":"84","author":"Crandall","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1074\/jbc.M007383200_bib13","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/nm0796-800","volume":"2","author":"Shimomura","year":"1996","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M007383200_bib14","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1097\/00019501-199610000-00005","volume":"7","author":"Panahloo","year":"1996","journal-title":"Coron. Artery Dis."},{"key":"10.1074\/jbc.M007383200_bib15","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/35008121","volume":"404","author":"Nishikawa","year":"2000","journal-title":"Nature"},{"key":"10.1074\/jbc.M007383200_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.RES.81.1.1","volume":"81","author":"Wung","year":"1997","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M007383200_bib17","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2337\/diab.42.1.80","volume":"42","author":"Kaiser","year":"1993","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M007383200_bib18","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1042\/bj3180615","volume":"318","author":"Civelek","year":"1996","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M007383200_bib19","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/sj.gt.3300711","volume":"5","author":"Saeki","year":"1998","journal-title":"Gene Ther."},{"key":"10.1074\/jbc.M007383200_bib20","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1042\/bj2870487","volume":"287","author":"Guzm\u00e1n","year":"1992","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M007383200_bib21","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1046\/j.1471-4159.1998.71041597.x","volume":"71","author":"Blazquez","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M007383200_bib22","first-page":"273","volume":"918","author":"Bijleveld","year":"1987","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M007383200_bib23","doi-asserted-by":"crossref","first-page":"21497","DOI":"10.1074\/jbc.273.34.21497","volume":"273","author":"Velasco","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M007383200_bib24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S1043-2760(99)00223-4","volume":"11","author":"Guzm\u00e1n","year":"2000","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1074\/jbc.M007383200_bib25","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/(SICI)1099-0895(199812)14:4<263::AID-DMR233>3.0.CO;2-C","volume":"14","author":"Randle","year":"1998","journal-title":"Diabetes Metab. Rev."},{"key":"10.1074\/jbc.M007383200_bib26","first-page":"E1","volume":"276","author":"Ruderman","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M007383200_bib27","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1073\/pnas.81.11.3317","volume":"81","author":"Stralfors","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M007383200_bib28","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/362801a0","volume":"362","author":"Ross","year":"1993","journal-title":"Nature"},{"key":"10.1074\/jbc.M007383200_bib29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1050-1738(97)00133-3","volume":"8","author":"Abe","year":"1998","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1074\/jbc.M007383200_bib30","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1172\/JCI116778","volume":"92","author":"Marui","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M007383200_bib31","first-page":"1229","volume":"136","author":"Rollins","year":"1990","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.M007383200_bib32","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1172\/JCI115411","volume":"88","author":"Nelken","year":"1991","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M007383200_bib33","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/29788","volume":"394","author":"Boring","year":"1998","journal-title":"Nature"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582079589X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582079589X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M007383200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T13:51:48Z","timestamp":1641390708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192582079589X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":33,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["S002192582079589X"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m007383200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}