{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:57:51Z","timestamp":1790006271413,"version":"4.0.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2001,5,1]],"date-time":"2001-05-01T00:00:00Z","timestamp":988675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T00:00:00Z","timestamp":1601078400000},"content-version":"vor","delay-in-days":7088,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2001,5]]},"DOI":"10.1074\/jbc.m101072200","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:09:24Z","timestamp":1027696164000},"page":"17455-17460","source":"Crossref","is-referenced-by-count":13,"title":["Functional Uncoupling of T-cell Receptor Engagement and Lck Activation in Anergic Human Thymic CD4+T Cells"],"prefix":"10.1016","volume":"276","author":[{"given":"Wakae","family":"Fujimaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makio","family":"Iwashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Yagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisako","family":"Yagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuharu","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken'ichi","family":"Imanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M101072200_bib1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1084\/jem.185.1.141","volume":"185","author":"Res","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M101072200_bib2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4049\/jimmunol.160.1.112","volume":"160","author":"Imanishi","year":"1998","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M101072200_bib3","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.4049\/jimmunol.155.11.5213","volume":"155","author":"Takahashi","year":"1995","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M101072200_bib4","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.4049\/jimmunol.142.8.2617","volume":"142","author":"Mueller","year":"1989","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M101072200_bib5","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.4049\/jimmunol.155.11.5083","volume":"155","author":"Migita","year":"1995","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M101072200_bib6","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1126\/science.271.5253.1272","volume":"271","author":"Li","year":"1996","journal-title":"Science"},{"key":"10.1074\/jbc.M101072200_bib7","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1126\/science.271.5253.1276","volume":"271","author":"Fields","year":"1996","journal-title":"Science"},{"key":"10.1074\/jbc.M101072200_bib8","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1084\/jem.183.5.2017","volume":"183","author":"DeSilva","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M101072200_bib9","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1126\/science.257.5073.1134","volume":"257","author":"Kang","year":"1992","journal-title":"Science"},{"key":"10.1074\/jbc.M101072200_bib10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1073\/pnas.91.1.38","volume":"91","author":"Gajewski","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M101072200_bib11","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1126\/science.278.5335.124","volume":"278","author":"Boussiotis","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M101072200_bib12","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1002\/eji.1830250707","volume":"25","author":"Gajewski","year":"1995","journal-title":"Eur. J. Immunol."},{"key":"10.1074\/jbc.M101072200_bib13","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1365-2249.1994.tb06045.x","volume":"96","author":"Akatsuka","year":"1994","journal-title":"Clin. Exp. Immunol."},{"key":"10.1074\/jbc.M101072200_bib14","first-page":"638","volume":"68","author":"Uchiyama","year":"1987","journal-title":"Clin. Exp. Immunol."},{"key":"10.1074\/jbc.M101072200_bib15","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/j.1460-2075.1993.tb05659.x","volume":"12","author":"Sieh","year":"1993","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M101072200_bib16","doi-asserted-by":"crossref","first-page":"8941","DOI":"10.1073\/pnas.86.22.8941","volume":"86","author":"Choi","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M101072200_bib17","first-page":"985","volume":"64","author":"Kato","year":"1994","journal-title":"J. Tokyo Womens Med. College"},{"key":"10.1074\/jbc.M101072200_bib18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0092-8674(93)90221-B","volume":"73","author":"Weiss","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.M101072200_bib19","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0092-8674(92)90428-F","volume":"70","author":"Straus","year":"1992","journal-title":"Cell"},{"key":"10.1074\/jbc.M101072200_bib20","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1073\/pnas.85.12.4247","volume":"85","author":"Amrein","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M101072200_bib21","first-page":"540","volume":"8","author":"Marth","year":"1988","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M101072200_bib22","first-page":"1455","volume":"5","author":"Veillette","year":"1990","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M101072200_bib23","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0092-8674(91)90639-G","volume":"64","author":"Cantley","year":"1991","journal-title":"Cell"},{"key":"10.1074\/jbc.M101072200_bib24","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.1708916","volume":"252","author":"Koch","year":"1991","journal-title":"Science"},{"key":"10.1074\/jbc.M101072200_bib25","doi-asserted-by":"crossref","first-page":"6302","DOI":"10.1073\/pnas.86.16.6302","volume":"86","author":"Mustelin","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M101072200_bib26","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/42408","volume":"387","author":"Simons","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M101072200_bib27","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S1074-7613(00)80606-8","volume":"9","author":"Zhang","year":"1998","journal-title":"Immunity"},{"key":"10.1074\/jbc.M101072200_bib28","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S1074-7613(00)80069-2","volume":"10","author":"Leitenberg","year":"1999","journal-title":"Immunity"},{"key":"10.1074\/jbc.M101072200_bib29","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1083\/jcb.135.6.1515","volume":"135","author":"Rodgers","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M101072200_bib30","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1126\/science.283.5402.680","volume":"283","author":"Viola","year":"1999","journal-title":"Science"},{"key":"10.1074\/jbc.M101072200_bib31","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1126\/science.285.5425.221","volume":"285","author":"Grakoui","year":"1999","journal-title":"Science"},{"key":"10.1074\/jbc.M101072200_bib32","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/25764","volume":"395","author":"Monks","year":"1998","journal-title":"Nature"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819319350?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819319350?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M101072200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T13:25:45Z","timestamp":1682169945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819319350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5]]},"references-count":32,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2001,5]]}},"alternative-id":["S0021925819319350"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m101072200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2001,5]]}}}