{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:13:05Z","timestamp":1790935985538,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"34","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":7016,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2001,8]]},"DOI":"10.1074\/jbc.m103285200","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:16:07Z","timestamp":1027696567000},"page":"32274-32281","source":"Crossref","is-referenced-by-count":170,"title":["The Crystal Structure of Tetanus Toxin Hc Fragment Complexed with a Synthetic GT1b Analogue Suggests Cross-linking between Ganglioside Receptors and the Toxin"],"prefix":"10.1016","volume":"276","author":[{"given":"Constantina","family":"Fotinou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Emsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isobel","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromune","family":"Ando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideharu","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Kiso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine A.","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil F.","family":"Fairweather","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil W.","family":"Isaacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M103285200_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2958.1994.tb00396.x","volume":"13","author":"Montecucco","year":"1994","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M103285200_bib2","series-title":"The Comprehensive Sourcebook of Bacterial Protein Toxins","first-page":"202","author":"Herreros","year":"1999"},{"key":"10.1074\/jbc.M103285200_bib3","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/359832a0","volume":"359","author":"Schiavo","year":"1992","journal-title":"Nature"},{"key":"10.1074\/jbc.M103285200_bib4","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1242\/jcs.112.16.2715","volume":"112","author":"Lalli","year":"1999","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M103285200_bib5","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0968-0004(86)90282-3","volume":"11","author":"Montecucco","year":"1986","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.M103285200_bib6","doi-asserted-by":"crossref","first-page":"11188","DOI":"10.1016\/S0021-9258(18)82109-3","volume":"268","author":"Halpern","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M103285200_bib7","first-page":"221","volume":"195","author":"Halpern","year":"1995","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1074\/jbc.M103285200_bib8","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/362318a0","volume":"362","author":"Sollner","year":"1993","journal-title":"Nature"},{"key":"10.1074\/jbc.M103285200_bib9","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1046\/j.1471-4159.2000.0741941.x","volume":"74","author":"Herreros","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M103285200_bib10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1042\/bj3470199","volume":"347","author":"Herreros","year":"2000","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M103285200_bib11","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s002490050079","volume":"26","author":"Janshoff","year":"1997","journal-title":"Eur. Biophys. J."},{"key":"10.1074\/jbc.M103285200_bib12","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1146\/annurev.micro.53.1.551","volume":"53","author":"Johnson","year":"1999","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1074\/jbc.M103285200_bib13","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1042\/bj2360845","volume":"236","author":"Pierce","year":"1986","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M103285200_bib14","first-page":"613","volume":"258","author":"Bakry","year":"1991","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1074\/jbc.M103285200_bib15","doi-asserted-by":"crossref","first-page":"10498","DOI":"10.1016\/S0021-9258(17)34087-5","volume":"269","author":"Nishiki","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M103285200_bib16","first-page":"215","volume":"7","author":"Li","year":"1998","journal-title":"J. Nat. Toxins"},{"key":"10.1074\/jbc.M103285200_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1006\/mpat.1998.0214","volume":"25","author":"Kozaki","year":"1998","journal-title":"Microb. Pathog."},{"key":"10.1074\/jbc.M103285200_bib18","doi-asserted-by":"crossref","first-page":"429","DOI":"10.18388\/abp.1998_4237","volume":"45","author":"Karlsson","year":"1998","journal-title":"Acta Biochim. Pol."},{"key":"10.1074\/jbc.M103285200_bib19","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1099\/00221287-24-1-107","volume":"24","author":"Van Heyningen","year":"1961","journal-title":"J. Gen. Microbiol."},{"key":"10.1074\/jbc.M103285200_bib20","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1111\/j.1471-4159.1971.tb00235.x","volume":"18","author":"Simpson","year":"1971","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M103285200_bib21","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/249415a0","volume":"249","author":"Van Heyningen","year":"1974","journal-title":"Nature"},{"key":"10.1074\/jbc.M103285200_bib22","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1432-1033.1980.tb04583.x","volume":"106","author":"Holmgren","year":"1980","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M103285200_bib23","doi-asserted-by":"crossref","first-page":"11859","DOI":"10.1073\/pnas.91.25.11859","volume":"91","author":"Angstrom","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M103285200_bib24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF01872268","volume":"69","author":"Fishman","year":"1982","journal-title":"J. Membr. Biol."},{"key":"10.1074\/jbc.M103285200_bib25","doi-asserted-by":"crossref","first-page":"25173","DOI":"10.1074\/jbc.274.35.25173","volume":"274","author":"Williamson","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M103285200_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1388-1981(99)00140-7","volume":"1441","author":"Kitamura","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M103285200_bib27","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nsb1097-788","volume":"4","author":"Umland","year":"1997","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.M103285200_bib28","doi-asserted-by":"crossref","first-page":"8889","DOI":"10.1074\/jbc.275.12.8889","volume":"275","author":"Emsley","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M103285200_bib29","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/2338","volume":"5","author":"Lacy","year":"1998","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.M103285200_bib30","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1128\/iai.63.8.3218-3221.1995","volume":"63","author":"Figueiredo","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M103285200_bib31","doi-asserted-by":"crossref","first-page":"30380","DOI":"10.1074\/jbc.272.48.30380","volume":"272","author":"Shapiro","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M103285200_bib32","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1016\/S0957-4166(00)80396-1","volume":"5","author":"Ishida","year":"1994","journal-title":"Tetrahedron Asymmetry"},{"key":"10.1074\/jbc.M103285200_bib33","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1046\/j.1365-2958.2000.02091.x","volume":"37","author":"Sinha","year":"2000","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M103285200_bib34","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1107\/S0108767393007597","volume":"50","author":"Navaza","year":"1994","journal-title":"Acta Cryst. Sec. A"},{"key":"10.1074\/jbc.M103285200_bib35","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1107\/S0907444996012255","volume":"53","author":"Murshudov","year":"1997","journal-title":"Acta Cryst. Sec. D"},{"key":"10.1074\/jbc.M103285200_bib36","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/pro.5560030202","volume":"3","author":"Merritt","year":"1994","journal-title":"Protein Sci."},{"key":"10.1074\/jbc.M103285200_bib37","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1107\/S0907444992008886","volume":"49","author":"Lamzin","year":"1993","journal-title":"Acta Cryst. Sec. D"},{"key":"10.1074\/jbc.M103285200_bib38","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Cryst."},{"key":"10.1074\/jbc.M103285200_bib39","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/prot.340110407","volume":"11","author":"Nicholls","year":"1991","journal-title":"Proteins"},{"key":"10.1074\/jbc.M103285200_bib40","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s008940050068","volume":"4","author":"Bohne","year":"1998","journal-title":"J. Mol. Model."},{"key":"10.1074\/jbc.M103285200_bib41","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1107\/S0907444994003112","volume":"50","author":"Collaborative Computational Project Number 4","year":"1994","journal-title":"Acta Cryst. Sec. D"},{"key":"10.1074\/jbc.M103285200_bib42","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0263-7855(93)87009-T","volume":"11","author":"Evans","year":"1993","journal-title":"J. Mol. Graph."},{"key":"10.1074\/jbc.M103285200_bib43","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1146\/annurev.bb.24.060195.003003","volume":"24","author":"Rini","year":"1995","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"10.1074\/jbc.M103285200_bib44","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.bi.65.070196.002301","volume":"65","author":"Weis","year":"1996","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M103285200_bib45","doi-asserted-by":"crossref","first-page":"5139","DOI":"10.1093\/emboj\/16.16.5139","volume":"16","author":"Stehle","year":"1997","journal-title":"The EMBO J."},{"key":"10.1074\/jbc.M103285200_bib46","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0009-3084(91)90001-R","volume":"59","author":"Acquotti","year":"1991","journal-title":"Chem. Phys. Lipids"},{"key":"10.1074\/jbc.M103285200_bib47","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0144-8617(84)90050-X","volume":"4","author":"Veluraja","year":"1984","journal-title":"Carbohydr. Polymers"},{"key":"10.1074\/jbc.M103285200_bib48","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/S0041-0101(97)00027-5","volume":"35","author":"Kamata","year":"1997","journal-title":"Toxicon"},{"key":"10.1074\/jbc.M103285200_bib49","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1006\/jmbi.1999.2945","volume":"291","author":"Lacy","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M103285200_bib50","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1128\/aem.63.4.1214-1218.1997","volume":"63","author":"Kubota","year":"1997","journal-title":"Appl. Envirom. Microbiol."},{"key":"10.1074\/jbc.M103285200_bib51","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/78005","volume":"7","author":"Swaminathan","year":"2000","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.M103285200_bib52","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0014-5793(01)02273-6","volume":"493","author":"Sutton","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M103285200_bib53","series-title":"Joint CCP4 and ESF-EACMD Newsletter on Protein Crystallography","author":"Leslie","year":"1992"},{"key":"10.1074\/jbc.M103285200_bib54","series-title":"Proceedings of the CCP4 Study Weekend","first-page":"114","author":"Evans","year":"1993"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819315467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819315467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M103285200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T11:48:42Z","timestamp":1641124122000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819315467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":54,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["S0021925819315467"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m103285200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2001,8]]}}}