{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:55:09Z","timestamp":1783634109906,"version":"3.55.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"44","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":6909,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2001,11]]},"DOI":"10.1074\/jbc.m103424200","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:50:28Z","timestamp":1027695028000},"page":"40599-40605","source":"Crossref","is-referenced-by-count":38,"title":["The von Hippel-Lindau Gene Product Inhibits Renal Cell Apoptosis via Bcl-2-dependent Pathways"],"prefix":"10.1016","volume":"276","author":[{"given":"Prasad","family":"Devarajan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryely","family":"De Leon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farahnaz","family":"Talasazan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R.","family":"Schoenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliot J.","family":"Davidowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Burk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M103424200_bib1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0168-9525(98)01558-3","volume":"14","author":"Kaelin","year":"1998","journal-title":"Trends Genet."},{"key":"10.1074\/jbc.M103424200_bib2","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nm0895-822","volume":"1","author":"Iliopoulos","year":"1995","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M103424200_bib3","doi-asserted-by":"crossref","first-page":"8817","DOI":"10.1073\/pnas.95.15.8817","volume":"95","author":"Schoenfeld","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M103424200_bib4","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1126\/science.7660130","volume":"269","author":"Kibel","year":"1995","journal-title":"Science"},{"key":"10.1074\/jbc.M103424200_bib5","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1073\/pnas.94.6.2156","volume":"94","author":"Pause","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M103424200_bib6","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1126\/science.284.5414.657","volume":"284","author":"Kamura","year":"1999","journal-title":"Science"},{"key":"10.1074\/jbc.M103424200_bib7","doi-asserted-by":"crossref","first-page":"12436","DOI":"10.1073\/pnas.96.22.12436","volume":"96","author":"Iwai","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M103424200_bib8","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1128\/MCB.21.3.865-874.2001","volume":"21","author":"Davidowitz","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M103424200_bib9","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1073\/pnas.95.3.993","volume":"95","author":"Pause","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M103424200_bib10","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.1038\/sj.onc.1203985","volume":"19","author":"Schoenfeld","year":"2000","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M103424200_bib11","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1128\/MCB.19.2.1289","volume":"19","author":"Gorospe","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M103424200_bib12","doi-asserted-by":"crossref","first-page":"10595","DOI":"10.1073\/pnas.93.20.10595","volume":"93","author":"Iliopoulos","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M103424200_bib13","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/bjc.1972.33","volume":"26","author":"Kerr","year":"1972","journal-title":"Br. J. Cancer"},{"key":"10.1074\/jbc.M103424200_bib14","first-page":"F477","volume":"40","author":"Lieberthal","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M103424200_bib15","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0002-9343(00)00311-9","volume":"108","author":"Ueda","year":"2000","journal-title":"Am. J. Med."},{"key":"10.1074\/jbc.M103424200_bib16","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1056\/NEJM199507063330104","volume":"333","author":"Woo","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M103424200_bib17","first-page":"F837","volume":"276","author":"Feldenberg","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M103424200_bib18","first-page":"F000","volume":"280","author":"Erkan","year":"2001","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M103424200_bib19","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1126\/science.281.5381.1322","volume":"281","author":"Adams","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M103424200_bib20","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1126\/science.281.5381.1312","volume":"281","author":"Thornberry","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M103424200_bib21","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1126\/science.281.5381.1305","volume":"281","author":"Ashkenazi","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M103424200_bib22","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1101\/gad.13.15.1899","volume":"13","author":"Gross","year":"1999","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M103424200_bib23","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/sj.cdd.4400781","volume":"7","author":"Harris","year":"2000","journal-title":"Cell Death Differ."},{"key":"10.1074\/jbc.M103424200_bib24","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1681\/ASN.V113454","volume":"11","author":"Gob\u00e9","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1074\/jbc.M103424200_bib25","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1038\/sj.onc.1202579","volume":"17","author":"Saikumar","year":"1998","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M103424200_bib26","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1038\/sj.onc.1202590","volume":"17","author":"Saikumar","year":"1998","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M103424200_bib27","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1042\/bj3470669","volume":"347","author":"Dong","year":"2000","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M103424200_bib28","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/sj.cdd.4400783","volume":"7","author":"Korsmeyer","year":"2000","journal-title":"Cell Death Differ."},{"key":"10.1074\/jbc.M103424200_bib29","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/sj.cdd.4400778","volume":"7","author":"Vieira","year":"2000","journal-title":"Cell Death Differ."},{"key":"10.1074\/jbc.M103424200_bib30","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/sj.cdd.4400780","volume":"7","author":"Tsujimoto","year":"2000","journal-title":"Cell Death Differ."},{"key":"10.1074\/jbc.M103424200_bib31","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/sj.cdd.4400782","volume":"7","author":"Von Ahsen","year":"2000","journal-title":"Cell Death Differ."},{"key":"10.1074\/jbc.M103424200_bib32","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/35004029","volume":"2","author":"Goldstein","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M103424200_bib33","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1172\/JCI113380","volume":"81","author":"Venkatachalam","year":"1988","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M103424200_bib34","first-page":"F227","volume":"277","author":"Van Why","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M103424200_bib35","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1242\/jcs.107.12.3301","volume":"107","author":"Bacallao","year":"1994","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M103424200_bib36","doi-asserted-by":"crossref","first-page":"16133","DOI":"10.1074\/jbc.272.26.16133","volume":"272","author":"Tsukamoto","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M103424200_bib37","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1038\/ki.1997.240","volume":"51","author":"Hagar","year":"1997","journal-title":"Kidney Int."},{"key":"10.1074\/jbc.M103424200_bib38","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/1097-0215(20010215)91:4<457::AID-IJC1072>3.0.CO;2-P","volume":"91","author":"Schoenfeld","year":"2001","journal-title":"Int. J. Cancer"},{"key":"10.1074\/jbc.M103424200_bib39","first-page":"F315","volume":"274","author":"Lieberthal","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M103424200_bib40","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1042\/bj3380465","volume":"338","author":"Katoh","year":"1999","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M103424200_bib41","doi-asserted-by":"crossref","first-page":"11245","DOI":"10.1074\/jbc.274.16.11245","volume":"274","author":"Ackermann","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M103424200_bib42","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1084\/jem.185.8.1481","volume":"185","author":"Leist","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M103424200_bib43","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.1093\/emboj\/18.14.3990","volume":"18","author":"Mayo","year":"1999","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M103424200_bib44","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1128\/MCB.19.2.1486","volume":"19","author":"Lee","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M103424200_bib45","doi-asserted-by":"crossref","first-page":"30109","DOI":"10.1074\/jbc.274.42.30109","volume":"274","author":"Kroll","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M103424200_bib46","first-page":"2210","volume":"59","author":"Ananth","year":"1999","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M103424200_bib47","first-page":"4957","volume":"58","author":"Lieubeau-Teillet","year":"1998","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M103424200_bib48","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/carcin\/21.3.485","volume":"21","author":"Lowe","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1074\/jbc.M103424200_bib49","doi-asserted-by":"crossref","first-page":"6178","DOI":"10.1002\/j.1460-2075.1996.tb01006.x","volume":"15","author":"Macleod","year":"1996","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M103424200_bib50","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/371072a0","volume":"371","author":"Morgenbesser","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.M103424200_bib51","first-page":"32","volume":"15","author":"Haupt","year":"1996","journal-title":"Behring Inst. Mitt."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820778981?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820778981?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M103424200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T17:40:00Z","timestamp":1641404400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820778981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":51,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["S0021925820778981"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m103424200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2001,11]]}}}