{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:47:23Z","timestamp":1791064043966,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"39","license":[{"start":{"date-parts":[[2001,9,1]],"date-time":"2001-09-01T00:00:00Z","timestamp":999302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":6964,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2001,9]]},"DOI":"10.1074\/jbc.m104350200","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:59:12Z","timestamp":1027695552000},"page":"36788-36796","source":"Crossref","is-referenced-by-count":151,"title":["The Transmembrane Domain of the Alzheimer's \u03b2-Secretase (BACE1) Determines Its Late Golgi Localization and Access to \u03b2-Amyloid Precursor Protein (APP) Substrate"],"prefix":"10.1016","volume":"276","author":[{"given":"Riqiang","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyi","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Greengard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaxi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M104350200_bib1","doi-asserted-by":"crossref","first-page":"A23","DOI":"10.1038\/399a023","volume":"399","author":"Selkoe","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M104350200_bib2","first-page":"289","volume":"92","author":"Youkin","year":"1998","journal-title":"J. Physiol."},{"key":"10.1074\/jbc.M104350200_bib3","doi-asserted-by":"crossref","first-page":"D72","DOI":"10.2741\/Greenfield","volume":"5","author":"Greenfield","year":"2000","journal-title":"Front. Biosci."},{"key":"10.1074\/jbc.M104350200_bib4","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/0006-291X(84)91209-9","volume":"122","author":"Glenner","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M104350200_bib5","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0166-2236(96)01030-2","volume":"20","author":"Hardy","year":"1997","journal-title":"Trends Neurosci."},{"key":"10.1074\/jbc.M104350200_bib6","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1126\/science.1691865","volume":"248","author":"Sisodia","year":"1990","journal-title":"Science"},{"key":"10.1074\/jbc.M104350200_bib7","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1126\/science.286.5440.735","volume":"286","author":"Vassar","year":"1999","journal-title":"Science"},{"key":"10.1074\/jbc.M104350200_bib8","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1006\/mcne.1999.0811","volume":"14","author":"Hussain","year":"1999","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1074\/jbc.M104350200_bib9","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/990107","volume":"402","author":"Yan","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M104350200_bib10","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/990114","volume":"402","author":"Sinha","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M104350200_bib11","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1073\/pnas.97.4.1456","volume":"97","author":"Lin","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M104350200_bib12","doi-asserted-by":"crossref","first-page":"37712","DOI":"10.1074\/jbc.M005339200","volume":"275","author":"Bennett","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M104350200_bib13","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1074\/jbc.M006947200","volume":"276","author":"Creemers","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M104350200_bib14","doi-asserted-by":"crossref","first-page":"30849","DOI":"10.1074\/jbc.M003202200","volume":"275","author":"Capell","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M104350200_bib15","doi-asserted-by":"crossref","first-page":"14634","DOI":"10.1074\/jbc.M011116200","volume":"276","author":"Walter","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M104350200_bib16","doi-asserted-by":"crossref","first-page":"33729","DOI":"10.1074\/jbc.M004175200","volume":"275","author":"Huse","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M104350200_bib17","doi-asserted-by":"crossref","first-page":"10879","DOI":"10.1074\/jbc.M009899200","volume":"276","author":"Benjannet","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/jbc.M104350200_bib18","doi-asserted-by":"crossref","first-page":"10366","DOI":"10.1074\/jbc.M009200200","volume":"276","author":"Shi","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M104350200_bib19","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/nm0997-1021","volume":"3","author":"Cook","year":"1997","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M104350200_bib20","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/nm0997-1016","volume":"3","author":"Hartmann","year":"1997","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M104350200_bib21","doi-asserted-by":"crossref","first-page":"16085","DOI":"10.1074\/jbc.272.26.16085","volume":"272","author":"Wild-Bode","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M104350200_bib22","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1073\/pnas.96.2.742","volume":"96","author":"Greenfield","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M104350200_bib23","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.1073\/pnas.87.15.6003","volume":"87","author":"Buxbaum","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M104350200_bib24","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1083\/jcb.117.6.1171","volume":"117","author":"Wong","year":"1992","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M104350200_bib25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/bj3010069","volume":"301","author":"Horn","year":"1994","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M104350200_bib26","doi-asserted-by":"crossref","first-page":"17386","DOI":"10.1016\/S0021-9258(17)32449-3","volume":"269","author":"Koo","year":"1994","journal-title":".J. Biol. Chem."},{"key":"10.1074\/jbc.M104350200_bib27","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1083\/jcb.122.6.1169","volume":"122","author":"Xu","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M104350200_bib28","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.1073\/pnas.94.8.3748","volume":"94","author":"Xu","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M104350200_bib29","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1523\/JNEUROSCI.21-08-02561.2001","volume":"21","author":"Gasparini","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M104350200_bib30","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0092-8674(89)90177-3","volume":"57","author":"Weidemann","year":"1989","journal-title":"Cell"},{"key":"10.1074\/jbc.M104350200_bib31","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1016\/S0021-9258(19)39742-X","volume":"265","author":"Chen","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M104350200_bib32","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1093\/hmg\/7.13.2063","volume":"7","author":"Petris","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M104350200_bib33","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/85064","volume":"4","author":"Cai","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1074\/jbc.M104350200_bib34","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/85059","volume":"4","author":"Luo","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1074\/jbc.M104350200_bib35","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1126\/science.8362242","volume":"261","author":"Bretscher","year":"1993","journal-title":"Science"},{"key":"10.1074\/jbc.M104350200_bib36","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/0955-0674(93)90129-E","volume":"5","author":"Machamer","year":"1993","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1074\/jbc.M104350200_bib37","unstructured":"Yan, R., Munzner, J. B., Shuck, M. E., and Bienkowski, M. J. (June 22, 2001) J. Biol. Chem.10.1074\/jbc.M105583200"},{"key":"10.1074\/jbc.M104350200_bib38","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1074\/jbc.275.2.1261","volume":"275","author":"Watson","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M104350200_bib39","doi-asserted-by":"crossref","first-page":"36781","DOI":"10.1074\/jbc.274.51.36781","volume":"274","author":"Teuchert","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M104350200_bib40","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/71944","volume":"18","author":"Gruninger-Leitch","year":"2000","journal-title":"Nat. Biotechnol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820867647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820867647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M104350200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T04:29:07Z","timestamp":1639715347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820867647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9]]},"references-count":40,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["S0021925820867647"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m104350200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2001,9]]}}}