{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:42:25Z","timestamp":1787852545795,"version":"build-2784847793"},"reference-count":57,"publisher":"Elsevier BV","issue":"44","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":6909,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2001,11]]},"DOI":"10.1074\/jbc.m104828200","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:49:43Z","timestamp":1027694983000},"page":"41435-41443","source":"Crossref","is-referenced-by-count":86,"title":["Crystal Structure of Bruton's Tyrosine Kinase Domain Suggests a Novel Pathway for Activation and Provides Insights into the Molecular Basis of X-linked Agammaglobulinemia"],"prefix":"10.1016","volume":"276","author":[{"given":"Chen","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih M.","family":"Uckun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M104828200_bib1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0006-2952(98)00122-1","volume":"56","author":"Uckun","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1074\/jbc.M104828200_bib2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1600-065X.1994.tb00849.x","volume":"138","author":"Rawlings","year":"1994","journal-title":"Immunol. Rev."},{"key":"10.1074\/jbc.M104828200_bib3","doi-asserted-by":"crossref","first-page":"15595","DOI":"10.1074\/jbc.272.25.15595","volume":"272","author":"Kurosaki","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M104828200_bib4","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1074\/jbc.274.3.1646","volume":"274","author":"Vassilev","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M104828200_bib5","doi-asserted-by":"crossref","first-page":"9587","DOI":"10.1074\/jbc.274.14.9587","volume":"274","author":"Mahajan","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M104828200_bib6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/978-1-4899-0987-9_24","volume":"365","author":"Tsukada","year":"1994","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1074\/jbc.M104828200_bib7","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/361226a0","volume":"361","author":"Vetrie","year":"1993","journal-title":"Nature"},{"key":"10.1074\/jbc.M104828200_bib8","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1126\/science.8332901","volume":"261","author":"Rawlings","year":"1993","journal-title":"Science"},{"key":"10.1074\/jbc.M104828200_bib9","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/0167-5699(95)80027-1","volume":"16","author":"Vihinen","year":"1995","journal-title":"Immunol. Today"},{"key":"10.1074\/jbc.M104828200_bib10","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/1074-7613(95)90115-9","volume":"3","author":"Kerner","year":"1995","journal-title":"Immunity"},{"key":"10.1074\/jbc.M104828200_bib11","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1093\/emboj\/16.12.3396","volume":"16","author":"Hyvonen","year":"1997","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M104828200_bib12","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1126\/science.271.5250.822","volume":"271","author":"Rawlings","year":"1996","journal-title":"Science"},{"key":"10.1074\/jbc.M104828200_bib13","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1073\/pnas.96.5.2221","volume":"96","author":"Nisitani","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M104828200_bib14","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1073\/pnas.050583597","volume":"97","author":"Nisitani","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M104828200_bib15","first-page":"1663","volume":"95","author":"Oda","year":"2000","journal-title":"Blood"},{"key":"10.1074\/jbc.M104828200_bib16","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S1074-7613(00)80417-3","volume":"4","author":"Park","year":"1996","journal-title":"Immunity"},{"key":"10.1074\/jbc.M104828200_bib17","doi-asserted-by":"crossref","first-page":"11526","DOI":"10.1073\/pnas.94.21.11526","volume":"94","author":"Wahl","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M104828200_bib18","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1128\/MCB.16.7.3465","volume":"16","author":"Afar","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M104828200_bib19","doi-asserted-by":"crossref","first-page":"5304","DOI":"10.1128\/MCB.15.10.5304","volume":"15","author":"Mahajan","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M104828200_bib20","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Otwinnowski","year":"1998","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M104828200_bib21","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1107\/S0907444994003112","volume":"50","author":"Collaborative Computational Project 4","year":"1994","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M104828200_bib22","doi-asserted-by":"crossref","first-page":"4438","DOI":"10.1021\/bi961947+","volume":"36","author":"Narayana","year":"1997","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M104828200_bib23","series-title":"First Map to Final Model","first-page":"59","author":"Kleywegt","year":"1994"},{"key":"10.1074\/jbc.M104828200_bib24","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1107\/S0907444993011333","volume":"50","author":"Kleywegt","year":"1994","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M104828200_bib25","series-title":"Molecular Replacement","first-page":"91","author":"Jones","year":"1992"},{"key":"10.1074\/jbc.M104828200_bib26","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1107\/S0907444999001031","volume":"55","author":"Kleywegt","year":"1999","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M104828200_bib27","series-title":"XPLOR, Version 3.1","author":"Br\u00fcnger","year":"1992"},{"key":"10.1074\/jbc.M104828200_bib28","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0263-7855(98)80040-4","volume":"6","author":"Sack","year":"1988","journal-title":"J. Mol. Graphics"},{"key":"10.1074\/jbc.M104828200_bib29","series-title":"Crystallographic Computing and Modeling Methods in Molecular Design","first-page":"120","author":"Jones","year":"1989"},{"key":"10.1074\/jbc.M104828200_bib30","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Crystallogr."},{"key":"10.1074\/jbc.M104828200_bib31","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1126\/science.3291115","volume":"241","author":"Hanks","year":"1988","journal-title":"Science"},{"key":"10.1074\/jbc.M104828200_bib32","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/0076-6879(91)00126-H","volume":"200","author":"Hanks","year":"1991","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M104828200_bib33","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1096\/fasebj.9.8.7768349","volume":"9","author":"Hanks","year":"1995","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M104828200_bib34","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/384484a0","volume":"384","author":"Yamaguchi","year":"1996","journal-title":"Nature"},{"key":"10.1074\/jbc.M104828200_bib35","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1126\/science.1862342","volume":"253","author":"Knighton","year":"1991","journal-title":"Science"},{"key":"10.1074\/jbc.M104828200_bib36","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1093\/emboj\/16.18.5572","volume":"16","author":"Hubbard","year":"1997","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M104828200_bib37","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/372746a0","volume":"372","author":"Hubbard","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.M104828200_bib38","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0092-8674(00)80704-7","volume":"100","author":"Chen","year":"2000","journal-title":"Cell"},{"key":"10.1074\/jbc.M104828200_bib39","doi-asserted-by":"crossref","first-page":"14718","DOI":"10.1021\/bi991454f","volume":"38","author":"Skamnaki","year":"1999","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M104828200_bib40","doi-asserted-by":"crossref","first-page":"6646","DOI":"10.1093\/emboj\/16.22.6646","volume":"16","author":"Lowe","year":"1997","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M104828200_bib41","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0092-8674(00)81092-2","volume":"85","author":"Johnson","year":"1996","journal-title":"Cell"},{"key":"10.1074\/jbc.M104828200_bib42","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S1097-2765(00)80357-3","volume":"3","author":"Schindler","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M104828200_bib43","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1097-2765(00)80356-1","volume":"3","author":"Xu","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M104828200_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(98)00606-1","volume":"430","author":"Johnson","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M104828200_bib45","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/nar\/26.1.242","volume":"26","author":"Vihinen","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M104828200_bib46","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/(SICI)1098-1004(200001)15:1<117::AID-HUMU26>3.0.CO;2-H","volume":"15","author":"Orlandi","year":"2000","journal-title":"Hum. Mutat."},{"key":"10.1074\/jbc.M104828200_bib47","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/11468","volume":"6","author":"Hubbard","year":"1999","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.M104828200_bib48","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/385595a0","volume":"385","author":"Xu","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M104828200_bib49","first-page":"121","volume":"1287","author":"Brown","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M104828200_bib50","first-page":"205","volume":"5","author":"Ferracini","year":"1990","journal-title":"Oncogene Res."},{"key":"10.1074\/jbc.M104828200_bib51","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1006\/jmbi.1996.0429","volume":"260","author":"Schmitz","year":"1996","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M104828200_bib52","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/BF03348820","volume":"15","author":"Accili","year":"1992","journal-title":"J. Endocrinol. Invest."},{"key":"10.1074\/jbc.M104828200_bib53","first-page":"321","volume":"242","author":"Copley","year":"1994","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M104828200_bib54","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1107\/S0021889891004399","volume":"24","author":"Kraulis","year":"1991","journal-title":"J. Appl. Crystallogr."},{"key":"10.1074\/jbc.M104828200_bib55","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1107\/S0907444994006396","volume":"50","author":"Merritt","year":"1994","journal-title":"Acta Crystallogr. Sect D Biol. Crystallogr."},{"key":"10.1074\/jbc.M104828200_bib56","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/prot.340110407","volume":"11","author":"Nicholls","year":"1991","journal-title":"Proteins Struct. Funct. Genet."},{"key":"10.1074\/jbc.M104828200_bib57","unstructured":"(1997) Insight Version II, Molecular Simulations Inc., San Diego, CA."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820780075?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820780075?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M104828200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T17:43:41Z","timestamp":1641404621000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820780075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":57,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["S0021925820780075"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m104828200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2001,11]]}}}