{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:36:11Z","timestamp":1789803371769,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"43","license":[{"start":{"date-parts":[[2001,10,1]],"date-time":"2001-10-01T00:00:00Z","timestamp":1001894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":6940,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2001,10]]},"DOI":"10.1074\/jbc.m105206200","type":"journal-article","created":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T11:42:17Z","timestamp":1402486937000},"page":"40306-40312","source":"Crossref","is-referenced-by-count":76,"title":["Discovery and Structure of a Potent and Highly Specific Blocker of Insect Calcium Channels"],"prefix":"10.1016","volume":"276","author":[{"given":"Xiu-hong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry I.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham M.","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel P.","family":"Mackay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F.","family":"Alewood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macdonald J.","family":"Christie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn F.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M105206200_bib1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0378-4274(95)03470-6","volume":"82\u201383","author":"Feyereisen","year":"1995","journal-title":"Toxicol. Lett."},{"key":"10.1074\/jbc.M105206200_bib2","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1038\/81834","volume":"3","author":"Betarbet","year":"2000","journal-title":"Nat. Neurosci."},{"key":"10.1074\/jbc.M105206200_bib3","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/73804","volume":"18","author":"Shelton","year":"2000","journal-title":"Nat. Biotechnol."},{"key":"10.1074\/jbc.M105206200_bib4","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/370138a0","volume":"370","author":"Cory","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.M105206200_bib5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1146\/annurev.en.41.010196.001203","volume":"41","author":"Bonning","year":"1996","journal-title":"Annu. Rev. Entomol."},{"key":"10.1074\/jbc.M105206200_bib6","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/75921","volume":"7","author":"Wang","year":"2000","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.M105206200_bib7","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1046\/j.1432-1327.1999.00646.x","volume":"264","author":"Wang","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M105206200_bib8","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0041-0101(99)00174-9","volume":"38","author":"Szeto","year":"1999","journal-title":"Toxicon"},{"key":"10.1074\/jbc.M105206200_bib9","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S0969-2126(97)00301-8","volume":"5","author":"Fletcher","year":"1997","journal-title":"Structure"},{"key":"10.1074\/jbc.M105206200_bib10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00656997","volume":"391","author":"Hamill","year":"1981","journal-title":"Eur. J. Physiol."},{"key":"10.1074\/jbc.M105206200_bib11","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nsb0797-559","volume":"4","author":"Fletcher","year":"1997","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.M105206200_bib12","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1046\/j.1432-1327.1999.00659.x","volume":"264","author":"Fletcher","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M105206200_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00417486","volume":"5","author":"Bartels","year":"1995","journal-title":"J. Biomol. NMR"},{"key":"10.1074\/jbc.M105206200_bib14","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1006\/jmbi.1997.1284","volume":"273","author":"G\u00fcntert","year":"1997","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M105206200_bib15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF01875318","volume":"2","author":"Ludvigsen","year":"1992","journal-title":"J. Biomol. NMR"},{"key":"10.1074\/jbc.M105206200_bib16","series-title":"NMR of Proteins and Nucleic Acids","author":"W\u00fcthrich","year":"1986"},{"key":"10.1074\/jbc.M105206200_bib17","series-title":"X-PLOR Version 3.1","author":"Br\u00fcnger","year":"1992"},{"key":"10.1074\/jbc.M105206200_bib18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0263-7855(96)00009-4","volume":"14","author":"Koradi","year":"1996","journal-title":"J. Mol. Graph."},{"key":"10.1074\/jbc.M105206200_bib19","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/0076-6879(93)18026-9","volume":"218","author":"Frohman","year":"1993","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M105206200_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/protein\/10.1.1","volume":"10","author":"Nielsen","year":"1997","journal-title":"Protein Eng."},{"key":"10.1074\/jbc.M105206200_bib21","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0167-7799(00)88996-9","volume":"13","author":"Olivera","year":"1995","journal-title":"Trends Biotechnol."},{"key":"10.1074\/jbc.M105206200_bib22","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0041-0101(00)00157-4","volume":"39","author":"Olivera","year":"2001","journal-title":"Toxicon"},{"key":"10.1074\/jbc.M105206200_bib23","doi-asserted-by":"crossref","first-page":"15340","DOI":"10.1016\/S0021-9258(18)82260-8","volume":"268","author":"Diniz","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M105206200_bib24","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0965-1748(95)00070-4","volume":"26","author":"Leisy","year":"1996","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1074\/jbc.M105206200_bib25","doi-asserted-by":"crossref","first-page":"19259","DOI":"10.1016\/S0021-9258(19)47295-5","volume":"264","author":"Bougis","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M105206200_bib26","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/355827a0","volume":"355","author":"Mintz","year":"1992","journal-title":"Nature"},{"key":"10.1074\/jbc.M105206200_bib27","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Crystallogr."},{"key":"10.1074\/jbc.M105206200_bib28","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0041-0101(00)00160-4","volume":"39","author":"Craik","year":"2001","journal-title":"Toxicon"},{"key":"10.1074\/jbc.M105206200_bib29","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/pro.5560020205","volume":"2","author":"Le-Nguyen","year":"1993","journal-title":"Protein Sci."},{"key":"10.1074\/jbc.M105206200_bib30","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1006\/jmbi.1993.1489","volume":"233","author":"Holm","year":"1993","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M105206200_bib31","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1006\/jmbi.1995.0406","volume":"250","author":"Kim","year":"1995","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M105206200_bib32","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1098\/rstb.1998.0319","volume":"353","author":"French-Constant","year":"1998","journal-title":"Philos. Trans. R. Soc. Lond. B. Biol. Sci."},{"key":"10.1074\/jbc.M105206200_bib33","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1152\/jn.1999.82.5.2284","volume":"82","author":"Benquet","year":"1999","journal-title":"J. Neurophysiol."},{"key":"10.1074\/jbc.M105206200_bib34","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/0896-6273(89)90245-6","volume":"3","author":"Leung","year":"1989","journal-title":"Neuron"},{"key":"10.1074\/jbc.M105206200_bib35","doi-asserted-by":"crossref","first-page":"13123","DOI":"10.1021\/bi00211a022","volume":"32","author":"Yu","year":"1993","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M105206200_bib36","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/365496a0","volume":"365","author":"Branton","year":"1993","journal-title":"Nature"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820601120?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820601120?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M105206200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T02:41:49Z","timestamp":1639708909000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820601120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10]]},"references-count":36,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2001,10]]}},"alternative-id":["S0021925820601120"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m105206200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2001,10]]}}}