{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:14:43Z","timestamp":1791328483428,"version":"4.3.1"},"reference-count":60,"publisher":"Elsevier BV","issue":"43","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":3990,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1074\/jbc.m109.013193","type":"journal-article","created":{"date-parts":[[2009,8,27]],"date-time":"2009-08-27T00:18:22Z","timestamp":1251332302000},"page":"29427-29436","source":"Crossref","is-referenced-by-count":162,"title":["Phosphorylation of Threonine 3"],"prefix":"10.1016","volume":"284","author":[{"given":"Charity T.","family":"Aiken","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan S.","family":"Steffan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cortnie M.","family":"Guerrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Khashwji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamas","family":"Lukacsovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Simmons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy M.","family":"Purcell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimia","family":"Menhaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Zhen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"LaFerla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie Michels","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.Lawrence","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M109.013193_bib1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","volume":"72","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.M109.013193_bib2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0092-8674(00)80513-9","volume":"90","author":"Davies","year":"1997","journal-title":"Cell"},{"key":"10.1074\/jbc.M109.013193_bib3","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/35099568","volume":"413","author":"Steffan","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.M109.013193_bib4","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"10.1074\/jbc.M109.013193_bib5","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","volume":"277","author":"DiFiglia","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M109.013193_bib6","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.cell.2006.04.026","volume":"125","author":"Graham","year":"2006","journal-title":"Cell"},{"key":"10.1074\/jbc.M109.013193_bib7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/nen.0b013e318040b2c8","volume":"66","author":"Schilling","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1074\/jbc.M109.013193_bib8","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1093\/hmg\/ddm217","volume":"16","author":"Atwal","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M109.013193_bib9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/hmg\/ddl440","volume":"16","author":"Rockabrand","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M109.013193_bib10","doi-asserted-by":"crossref","first-page":"4842","DOI":"10.1523\/JNEUROSCI.22-12-04842.2002","volume":"22","author":"Gafni","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M109.013193_bib11","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/sj.cdd.4401358","volume":"11","author":"Hermel","year":"2004","journal-title":"Cell Death Differ."},{"key":"10.1074\/jbc.M109.013193_bib12","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S1534-5807(02)00188-0","volume":"2","author":"Humbert","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1074\/jbc.M109.013193_bib13","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1083\/jcb.200412071","volume":"169","author":"Luo","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M109.013193_bib14","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1523\/JNEUROSCI.3706-05.2006","volume":"26","author":"Pardo","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M109.013193_bib15","doi-asserted-by":"crossref","first-page":"23686","DOI":"10.1074\/jbc.M513507200","volume":"281","author":"Schilling","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.013193_bib16","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/hmg\/ddi165","volume":"14","author":"Warby","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M109.013193_bib17","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/nn1702","volume":"9","author":"Yanai","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1074\/jbc.M109.013193_bib18","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.cell.2009.03.018","volume":"137","author":"Jeong","year":"2009","journal-title":"Cell"},{"key":"10.1074\/jbc.M109.013193_bib19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/20446","volume":"399","author":"Ona","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M109.013193_bib20","doi-asserted-by":"crossref","first-page":"19385","DOI":"10.1074\/jbc.271.32.19385","volume":"271","author":"Kalchman","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.013193_bib21","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1126\/science.1092194","volume":"304","author":"Steffan","year":"2004","journal-title":"Science"},{"key":"10.1074\/jbc.M109.013193_bib22","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nsmb.1570","volume":"16","author":"Thakur","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1074\/jbc.M109.013193_bib23","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nature02998","volume":"431","author":"Arrasate","year":"2004","journal-title":"Nature"},{"key":"10.1074\/jbc.M109.013193_bib24","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.neuro.26.010302.081142","volume":"26","author":"Caughey","year":"2003","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1074\/jbc.M109.013193_bib25","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1074\/mcp.M500368-MCP200","volume":"5","author":"Tagwerker","year":"2006","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/jbc.M109.013193_bib26","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/exnr.2000.7551","volume":"167","author":"Ehrlich","year":"2001","journal-title":"Exp. Neurol."},{"key":"10.1074\/jbc.M109.013193_bib27","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1021\/pr0502020","volume":"4","author":"Schroeder","year":"2005","journal-title":"J. Proteome Res."},{"key":"10.1074\/jbc.M109.013193_bib28","doi-asserted-by":"crossref","first-page":"13333","DOI":"10.1073\/pnas.0801870105","volume":"105","author":"Guerrero","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.013193_bib29","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1074\/mcp.D500002-MCP200","volume":"4","author":"Chalkley","year":"2005","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/jbc.M109.013193_bib30","doi-asserted-by":"crossref","first-page":"11563","DOI":"10.1073\/pnas.0505321102","volume":"102","author":"Wolfgang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.013193_bib31","doi-asserted-by":"crossref","first-page":"4906","DOI":"10.1073\/pnas.0811228106","volume":"106","author":"Simmons","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.013193_bib32","doi-asserted-by":"crossref","first-page":"11500","DOI":"10.1523\/JNEUROSCI.3203-08.2008","volume":"28","author":"Green","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M109.013193_bib33","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1006\/bbrc.2000.3682","volume":"277","author":"Hazeki","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M109.013193_bib34","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1073\/pnas.0611511104","volume":"104","author":"Bischof","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.013193_bib35","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1073\/pnas.0500055102","volume":"102","author":"Agrawal","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.013193_bib36","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/hmg\/11.17.1953","volume":"11","author":"Sipione","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M109.013193_bib37","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/cne.10776","volume":"465","author":"Menalled","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1074\/jbc.M109.013193_bib38","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF02290678","volume":"20","author":"Barnes","year":"1994","journal-title":"Somatic Cell Mol. Genet."},{"key":"10.1074\/jbc.M109.013193_bib39","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/BF03401575","volume":"1","author":"Persichetti","year":"1995","journal-title":"Mol. Med."},{"key":"10.1074\/jbc.M109.013193_bib40","unstructured":"Schutz-Geschwender, A., Zhang, Y., Holt, T., McDermitt, D., Olive, D. M., (2004) www.licor.com\/bio\/PDF\/IRquant.pdf, LI-COR Biosciences, Lincoln, NE"},{"key":"10.1074\/jbc.M109.013193_bib41","doi-asserted-by":"crossref","first-page":"R187","DOI":"10.1093\/hmg\/ddg271","volume":"12","author":"Marsh","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M109.013193_bib42","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1242\/dev.115.2.421","volume":"115","author":"Bayer","year":"1992","journal-title":"Development"},{"key":"10.1074\/jbc.M109.013193_bib43","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0092-8674(81)90343-3","volume":"24","author":"Jaenisch","year":"1981","journal-title":"Cell"},{"key":"10.1074\/jbc.M109.013193_bib44","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0092-8674(83)90369-0","volume":"34","author":"Lacy","year":"1983","journal-title":"Cell"},{"key":"10.1074\/jbc.M109.013193_bib45","series-title":"Pupil and Pseudopupil in the Compound Eye of Drosophila","author":"Franceschini","year":"1972"},{"key":"10.1074\/jbc.M109.013193_bib46","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.neuro.23.1.217","volume":"23","author":"Zoghbi","year":"2000","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1074\/jbc.M109.013193_bib47","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/hmg\/9.1.13","volume":"9","author":"Marsh","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M109.013193_bib48","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0896-6273(03)00258-7","volume":"38","author":"Emamian","year":"2003","journal-title":"Neuron"},{"key":"10.1074\/jbc.M109.013193_bib49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/bies.950030108","volume":"3","author":"Sherman","year":"1985","journal-title":"Bioessays"},{"key":"10.1074\/jbc.M109.013193_bib50","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1432-1033.1986.tb09378.x","volume":"154","author":"Flinta","year":"1986","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M109.013193_bib51","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/emboj\/18.2.396","volume":"18","author":"Petersen","year":"1999","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M109.013193_bib52","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3727\/000000005783992070","volume":"12","author":"Qu\u00e9lo","year":"2005","journal-title":"Gene Expr."},{"key":"10.1074\/jbc.M109.013193_bib53","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0022-2836(03)00713-7","volume":"330","author":"Reimer","year":"2003","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M109.013193_bib54","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1093\/emboj\/19.5.1010","volume":"19","author":"Rothb\u00e4cher","year":"2000","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M109.013193_bib55","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.neuroscience.2008.08.041","volume":"157","author":"Hickey","year":"2008","journal-title":"Neuroscience"},{"key":"10.1074\/jbc.M109.013193_bib56","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1073\/pnas.96.8.4604","volume":"96","author":"Scherzinger","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.013193_bib57","doi-asserted-by":"crossref","first-page":"41032","DOI":"10.1074\/jbc.M205809200","volume":"277","author":"Poirier","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.013193_bib58","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/nsmb860","volume":"11","author":"Wacker","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1074\/jbc.M109.013193_bib59","doi-asserted-by":"crossref","first-page":"11045","DOI":"10.1073\/pnas.0604547103","volume":"103","author":"Duennwald","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.013193_bib60","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrd892","volume":"1","author":"Hopkins","year":"2002","journal-title":"Nat. Rev. Drug Discov."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820381552?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820381552?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M109.013193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T01:15:53Z","timestamp":1639703753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820381552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":60,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0021925820381552"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m109.013193","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}