{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:18:24Z","timestamp":1792124304678,"version":"4.4.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"38","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"vor","delay-in-days":4062,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1074\/jbc.m109.014340","type":"journal-article","created":{"date-parts":[[2009,7,21]],"date-time":"2009-07-21T01:46:14Z","timestamp":1248140774000},"page":"25697-25703","source":"Crossref","is-referenced-by-count":273,"title":["Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design"],"prefix":"10.1016","volume":"284","author":[{"given":"Iain D.","family":"Kerr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Farady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Marion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Rickert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Sajid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash C.","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor R.","family":"Caffrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Legac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Hansell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"McKerrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S.","family":"Craik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda S.","family":"Brinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M109.014340_bib1","series-title":"Principles and Practice of Travel Medicine","first-page":"91","author":"Balakrishnan","year":"2002"},{"key":"10.1074\/jbc.M109.014340_bib2","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1007\/s00436-002-0752-y","volume":"90","author":"Docampo","year":"2003","journal-title":"Parasitol Res"},{"key":"10.1074\/jbc.M109.014340_bib3","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4269\/ajtmh.2007.77.160","volume":"77","author":"Laufer","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1074\/jbc.M109.014340_bib4","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1046\/j.1365-3156.2001.00777.x","volume":"6","author":"Ouellette","year":"2001","journal-title":"Trop. Med. Int. Health"},{"key":"10.1074\/jbc.M109.014340_bib5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2174\/1389450003349290","volume":"1","author":"Caffrey","year":"2000","journal-title":"Curr. Drug Targets"},{"key":"10.1074\/jbc.M109.014340_bib6","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.ijpara.2004.10.003","volume":"34","author":"Rosenthal","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"10.1074\/jbc.M109.014340_bib7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0166-6851(01)00368-1","volume":"118","author":"Caffrey","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M109.014340_bib8","doi-asserted-by":"crossref","first-page":"7411","DOI":"10.1016\/S0021-9258(18)42533-1","volume":"267","author":"Eakin","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.014340_bib9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0924-8579(03)00096-7","volume":"22","author":"Nkemgu","year":"2003","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1074\/jbc.M109.014340_bib10","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.2174\/138955706778195207","volume":"6","author":"Steverding","year":"2006","journal-title":"Mini. Rev. Med. Chem."},{"key":"10.1074\/jbc.M109.014340_bib11","first-page":"171","volume":"59","author":"Engel","year":"1999","journal-title":"Medicina"},{"key":"10.1074\/jbc.M109.014340_bib12","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1016\/j.bmcl.2006.02.026","volume":"16","author":"Vicik","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1074\/jbc.M109.014340_bib13","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1084\/jem.188.4.725","volume":"188","author":"Engel","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M109.014340_bib14","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1242\/jcs.111.5.597","volume":"111","author":"Engel","year":"1998","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M109.014340_bib15","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1172\/JCI113766","volume":"82","author":"Rosenthal","year":"1988","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M109.014340_bib16","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.molbiopara.2006.06.013","volume":"150","author":"Sijwali","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M109.014340_bib17","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1073\/pnas.0307720101","volume":"101","author":"Sijwali","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.014340_bib18","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1002\/cmdc.200700070","volume":"2","author":"Schulz","year":"2007","journal-title":"ChemMedChem"},{"key":"10.1074\/jbc.M109.014340_bib19","doi-asserted-by":"crossref","first-page":"5860","DOI":"10.1016\/j.bmcl.2008.06.012","volume":"18","author":"Chen","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1074\/jbc.M109.014340_bib20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bmcl.2004.10.023","volume":"15","author":"Fujii","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1074\/jbc.M109.014340_bib21","doi-asserted-by":"crossref","first-page":"6697","DOI":"10.1016\/j.bmcl.2007.10.056","volume":"17","author":"Gonz\u00e1lez","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1074\/jbc.M109.014340_bib22","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1021\/jm030549j","volume":"47","author":"Greenbaum","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M109.014340_bib23","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1021\/jm701141u","volume":"51","author":"Ettari","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M109.014340_bib24","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.bmcl.2007.11.070","volume":"18","author":"Jaishankar","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1074\/jbc.M109.014340_bib25","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1021\/jm00017a002","volume":"38","author":"Palmer","year":"1995","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M109.014340_bib26","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1128\/AAC.40.7.1600","volume":"40","author":"Rosenthal","year":"1996","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M109.014340_bib27","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1128\/AAC.47.1.154-160.2003","volume":"47","author":"Shenai","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M109.014340_bib28","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/QCO.0b013e328315cca9","volume":"21","author":"McKerrow","year":"2008","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1074\/jbc.M109.014340_bib29","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nchembio837","volume":"2","author":"Renslo","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"10.1074\/jbc.M109.014340_bib30","doi-asserted-by":"crossref","first-page":"6115","DOI":"10.1016\/S0021-9258(18)53226-9","volume":"268","author":"Eakin","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.014340_bib31","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1002\/pro.5560060801","volume":"6","author":"Gillmor","year":"1997","journal-title":"Protein Sci."},{"key":"10.1074\/jbc.M109.014340_bib32","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1107\/S0021889802016709","volume":"35","author":"Cohen","year":"2002","journal-title":"J. Appl. Crystallogr."},{"key":"10.1074\/jbc.M109.014340_bib33","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M109.014340_bib34","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1107\/S0021889897006766","volume":"30","author":"Vagin","year":"1997","journal-title":"J. Appl. Crystallogr."},{"key":"10.1074\/jbc.M109.014340_bib35","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M109.014340_bib36","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1107\/S0907444996012255","volume":"53","author":"Murshudov","year":"1997","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M109.014340_bib37","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1107\/S0108767393007597","volume":"50","author":"Navaza","year":"1994","journal-title":"Acta Crystallogr. A"},{"key":"10.1074\/jbc.M109.014340_bib38","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1042\/bj3600481","volume":"360","author":"Sijwali","year":"2001","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M109.014340_bib39","doi-asserted-by":"crossref","first-page":"9138","DOI":"10.1073\/pnas.0502368102","volume":"102","author":"Pandey","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.014340_bib40","series-title":"Preparation and Analysis of Protein Crystals","author":"McPherson","year":"1982"},{"key":"10.1074\/jbc.M109.014340_bib41","volume":"26","author":"Leslie","year":"1992","journal-title":"Joint CCP4 and ESF-EAMCB Newsletter on Protein Crystallography"},{"key":"10.1074\/jbc.M109.014340_bib42","first-page":"22","volume":"33","author":"Evans","year":"1997","journal-title":"Joint CCP4 and ESF-EAMCB Newsletter on protein Crystallography"},{"key":"10.1074\/jbc.M109.014340_bib43","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","volume":"40","author":"McCoy","year":"2007","journal-title":"J. Appl. Crystallogr."},{"key":"10.1074\/jbc.M109.014340_bib44","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1107\/S0907444998003254","volume":"54","author":"Br\u00fcnger","year":"1998","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M109.014340_bib45","doi-asserted-by":"crossref","first-page":"W375","DOI":"10.1093\/nar\/gkm216","volume":"35","author":"Davis","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M109.014340_bib46","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0076-6879(95)48007-2","volume":"248","author":"Bieth","year":"1995","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M109.014340_bib47","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.str.2007.03.012","volume":"15","author":"Wang","year":"2007","journal-title":"Structure"},{"key":"10.1074\/jbc.M109.014340_bib48","doi-asserted-by":"crossref","first-page":"11503","DOI":"10.1073\/pnas.0600489103","volume":"103","author":"Wang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.014340_bib49","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1074\/jbc.M310536200","volume":"279","author":"Pandey","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.014340_bib50","doi-asserted-by":"crossref","first-page":"14910","DOI":"10.1074\/jbc.M109680200","volume":"277","author":"Sijwali","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.014340_bib51","doi-asserted-by":"crossref","first-page":"12824","DOI":"10.1074\/jbc.M513331200","volume":"281","author":"Choe","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.014340_bib52","doi-asserted-by":"crossref","first-page":"28934","DOI":"10.1074\/jbc.M805824200","volume":"283","author":"O'Brien","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.014340_bib53","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0969-2126(00)00173-8","volume":"8","author":"Brinen","year":"2000","journal-title":"Structure"},{"key":"10.1074\/jbc.M109.014340_bib54","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0968-0896(02)00427-3","volume":"11","author":"Huang","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"10.1074\/jbc.M109.014340_bib55","doi-asserted-by":"crossref","first-page":"7754","DOI":"10.1073\/pnas.140132697","volume":"97","author":"Harris","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.014340_bib56","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0090-9556(24)15083-0","volume":"28","author":"Jacobsen","year":"2000","journal-title":"Drug Metab. Dispos."},{"key":"10.1074\/jbc.M109.014340_bib57","first-page":"360","volume":"26","author":"Zhang","year":"1998","journal-title":"Drug Metab. Dispos."},{"key":"10.1074\/jbc.M109.014340_bib58","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1021\/jm8013663","volume":"52","author":"Kerr","year":"2009","journal-title":"J. Med. Chem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818810444?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818810444?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M109.014340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T05:43:41Z","timestamp":1739252621000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925818810444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":58,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S0021925818810444"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m109.014340","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}