{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:26:06Z","timestamp":1761708366763},"reference-count":58,"publisher":"Elsevier BV","issue":"39","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":4020,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1074\/jbc.m109.034272","type":"journal-article","created":{"date-parts":[[2009,6,18]],"date-time":"2009-06-18T00:17:56Z","timestamp":1245284276000},"page":"26871-26881","source":"Crossref","is-referenced-by-count":25,"title":["The Lymphoma-associated Fusion Tyrosine Kinase ITK-SYK Requires Pleckstrin Homology Domain-mediated Membrane Localization for Activation and Cellular Transformation"],"prefix":"10.1016","volume":"284","author":[{"given":"Sue","family":"Rigby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanxue","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berthold","family":"Streubel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Chott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Qing","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne D.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris M.","family":"Bacon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M109.034272_bib1","first-page":"949","volume":"90","author":"Chalandon","year":"2005","journal-title":"Haematologica"},{"key":"10.1074\/jbc.M109.034272_bib2","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/sj.leu.2404125","volume":"20","author":"Turner","year":"2006","journal-title":"Leukemia"},{"key":"10.1074\/jbc.M109.034272_bib3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev.immunol.22.012703.104753","volume":"22","author":"Wong","year":"2004","journal-title":"Annu. Rev. Immunol."},{"key":"10.1074\/jbc.M109.034272_bib4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrc2291","volume":"8","author":"Chiarle","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/jbc.M109.034272_bib5","series-title":"World Health Organisation Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues.","author":"Jaffe","year":"2001"},{"key":"10.1074\/jbc.M109.034272_bib6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.blre.2007.03.001","volume":"21","author":"Savage","year":"2007","journal-title":"Blood Rev."},{"key":"10.1074\/jbc.M109.034272_bib7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/sj.leu.2404045","volume":"20","author":"Streubel","year":"2006","journal-title":"Leukemia"},{"key":"10.1074\/jbc.M109.034272_bib8","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1097\/PAS.0b013e3181971591","volume":"33","author":"Huang","year":"2009","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1074\/jbc.M109.034272_bib9","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1146\/annurev.immunol.22.012703.104743","volume":"23","author":"Berg","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1074\/jbc.M109.034272_bib10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0065-2776(06)93004-1","volume":"93","author":"Felices","year":"2007","journal-title":"Adv. Immunol."},{"key":"10.1074\/jbc.M109.034272_bib11","doi-asserted-by":"crossref","first-page":"11227","DOI":"10.1073\/pnas.94.21.11227","volume":"94","author":"August","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.034272_bib12","doi-asserted-by":"crossref","first-page":"6006","DOI":"10.4049\/jimmunol.163.11.6006","volume":"163","author":"Ching","year":"1999","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M109.034272_bib13","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1093\/emboj\/20.6.1232","volume":"20","author":"Woods","year":"2001","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M109.034272_bib14","doi-asserted-by":"crossref","first-page":"6638","DOI":"10.1073\/pnas.0609771104","volume":"104","author":"Bogin","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.034272_bib15","doi-asserted-by":"crossref","first-page":"25401","DOI":"10.1074\/jbc.272.40.25401","volume":"272","author":"Heyeck","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.034272_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1600-065X.2007.00534.x","volume":"218","author":"Gomez-Rodriguez","year":"2007","journal-title":"Immunol. Rev."},{"key":"10.1074\/jbc.M109.034272_bib17","doi-asserted-by":"crossref","first-page":"4758","DOI":"10.4049\/jimmunol.152.10.4758","volume":"152","author":"Chan","year":"1994","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M109.034272_bib18","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0167-5699(99)01574-1","volume":"21","author":"Turner","year":"2000","journal-title":"Immunol. Today"},{"key":"10.1074\/jbc.M109.034272_bib19","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1084\/jem.182.6.1815","volume":"182","author":"Kurosaki","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M109.034272_bib20","doi-asserted-by":"crossref","first-page":"11590","DOI":"10.1074\/jbc.270.19.11590","volume":"270","author":"Rowley","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.034272_bib21","doi-asserted-by":"crossref","first-page":"5276","DOI":"10.4049\/jimmunol.161.10.5276","volume":"161","author":"Keshvara","year":"1998","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M109.034272_bib22","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S1074-7613(00)80273-3","volume":"5","author":"Deckert","year":"1996","journal-title":"Immunity"},{"key":"10.1074\/jbc.M109.034272_bib23","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1128\/MCB.16.4.1305","volume":"16","author":"Law","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M109.034272_bib24","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1074-7613(00)80591-9","volume":"9","author":"Fu","year":"1998","journal-title":"Immunity"},{"key":"10.1074\/jbc.M109.034272_bib25","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1073\/pnas.051626198","volume":"98","author":"Baba","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.034272_bib26","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1182\/blood.V97.4.1050","volume":"97","author":"Kuno","year":"2001","journal-title":"Blood"},{"key":"10.1074\/jbc.M109.034272_bib27","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.semcancer.2005.01.008","volume":"15","author":"Bohlander","year":"2005","journal-title":"Semin. Cancer Biol."},{"key":"10.1074\/jbc.M109.034272_bib28","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1084\/jem.20060967","volume":"203","author":"Wossning","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M109.034272_bib29","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.1128\/MCB.19.6.4279","volume":"19","author":"Wennstr\u00f6m","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M109.034272_bib30","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1432-1033.1997.00447.x","volume":"246","author":"Couture","year":"1997","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M109.034272_bib31","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1073\/pnas.94.5.1919","volume":"94","author":"El-Hillal","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.034272_bib32","doi-asserted-by":"crossref","first-page":"35442","DOI":"10.1074\/jbc.M004549200","volume":"275","author":"Zhang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.034272_bib33","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1096\/fasebj.9.8.7768349","volume":"9","author":"Hanks","year":"1995","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M109.034272_bib34","doi-asserted-by":"crossref","first-page":"29697","DOI":"10.1016\/S0021-9258(18)43936-1","volume":"269","author":"Oliver","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.034272_bib35","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0003-2697(03)00026-5","volume":"315","author":"Yamamoto","year":"2003","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M109.034272_bib36","doi-asserted-by":"crossref","first-page":"6241","DOI":"10.1002\/j.1460-2075.1996.tb01014.x","volume":"15","author":"Salim","year":"1996","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M109.034272_bib37","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1074\/jbc.275.3.2219","volume":"275","author":"Bunnell","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.034272_bib38","doi-asserted-by":"crossref","first-page":"10983","DOI":"10.1074\/jbc.274.16.10983","volume":"274","author":"V\u00e1rnai","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.034272_bib39","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0092-8674(94)90104-X","volume":"76","author":"Resh","year":"1994","journal-title":"Cell"},{"key":"10.1074\/jbc.M109.034272_bib40","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1242\/jcs.110.5.673","volume":"110","author":"Zlatkine","year":"1997","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M109.034272_bib41","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-2141.2005.05883.x","volume":"132","author":"Rinaldi","year":"2006","journal-title":"Br. J. Haematol."},{"key":"10.1074\/jbc.M109.034272_bib42","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/leu.2008.77","volume":"22","author":"Feldman","year":"2008","journal-title":"Leukemia"},{"key":"10.1074\/jbc.M109.034272_bib43","doi-asserted-by":"crossref","first-page":"8078","DOI":"10.1073\/pnas.0601192103","volume":"103","author":"Stover","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.034272_bib44","doi-asserted-by":"crossref","first-page":"15445","DOI":"10.1074\/jbc.273.25.15445","volume":"273","author":"Zeitlmann","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.034272_bib45","doi-asserted-by":"crossref","first-page":"4924","DOI":"10.1128\/MCB.25.12.4924-4933.2005","volume":"25","author":"Brdicka","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M109.034272_bib46","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.cell.2007.03.039","volume":"129","author":"Deindl","year":"2007","journal-title":"Cell"},{"key":"10.1074\/jbc.M109.034272_bib47","doi-asserted-by":"crossref","first-page":"7231","DOI":"10.1158\/0008-5472.CAN-04-4167","volume":"65","author":"Delaval","year":"2005","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M109.034272_bib48","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.molcel.2008.05.005","volume":"31","author":"De Keersmaecker","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M109.034272_bib49","doi-asserted-by":"crossref","first-page":"6945","DOI":"10.1128\/MCB.20.18.6945-6957.2000","volume":"20","author":"Shan","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M109.034272_bib50","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0092-8674(93)90304-9","volume":"74","author":"Kolanus","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.M109.034272_bib51","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/emboj.2008.62","volume":"27","author":"Kulathu","year":"2008","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M109.034272_bib52","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1006\/jmbi.2000.4091","volume":"302","author":"Brazin","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M109.034272_bib53","doi-asserted-by":"crossref","first-page":"38529","DOI":"10.1074\/jbc.M609180200","volume":"281","author":"Qi","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.034272_bib54","doi-asserted-by":"crossref","first-page":"16201","DOI":"10.1074\/jbc.M100873200","volume":"276","author":"Saito","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.034272_bib55","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1371\/journal.pbio.0050095","volume":"5","author":"Calleja","year":"2007","journal-title":"PLoS Biol."},{"key":"10.1074\/jbc.M109.034272_bib56","doi-asserted-by":"crossref","first-page":"6071","DOI":"10.1038\/sj.onc.1207813","volume":"23","author":"Armstrong","year":"2004","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M109.034272_bib57","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1182\/blood-2003-12-4290","volume":"105","author":"Maeda","year":"2005","journal-title":"Blood"},{"key":"10.1074\/jbc.M109.034272_bib58","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1038\/sj.onc.1210979","volume":"27","author":"Tao","year":"2008","journal-title":"Oncogene"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820385185?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820385185?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M109.034272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T18:14:31Z","timestamp":1710440071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820385185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":58,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S0021925820385185"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m109.034272","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}