{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:40:43Z","timestamp":1791178843638,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"52","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T00:00:00Z","timestamp":1598659200000},"content-version":"vor","delay-in-days":3924,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1074\/jbc.m109.045336","type":"journal-article","created":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T20:14:15Z","timestamp":1255551255000},"page":"36137-36145","source":"Crossref","is-referenced-by-count":72,"title":["Chemical Validation of Trypanothione Synthetase"],"prefix":"10.1016","volume":"284","author":[{"given":"Leah S.","family":"Torrie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Wyllie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Spinks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra L.","family":"Oza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin R.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian H.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul G.","family":"Wyatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan H.","family":"Fairlamb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Frearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M109.045336_bib1","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1172\/JCI33945","volume":"118","author":"Stuart","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M109.045336_bib2","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.pt.2003.09.002","volume":"19","author":"Fairlamb","year":"2003","journal-title":"Trends Parasitol."},{"key":"10.1074\/jbc.M109.045336_bib3","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0169-4758(99)01414-3","volume":"15","author":"Barrett","year":"1999","journal-title":"Parasitol. Today"},{"key":"10.1074\/jbc.M109.045336_bib4","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1126\/science.1112181","volume":"309","author":"El-Sayed","year":"2005","journal-title":"Science"},{"key":"10.1074\/jbc.M109.045336_bib5","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1146\/annurev.mi.46.100192.003403","volume":"46","author":"Fairlamb","year":"1992","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1074\/jbc.M109.045336_bib6","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1515\/BC.2003.062","volume":"384","author":"Krauth-Siegel","year":"2003","journal-title":"Biol. Chem."},{"key":"10.1074\/jbc.M109.045336_bib7","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S1471-4922(03)00141-7","volume":"19","author":"M\u00fcller","year":"2003","journal-title":"Trends Parasitol."},{"key":"10.1074\/jbc.M109.045336_bib8","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.2174\/1381612013397564","volume":"7","author":"Augustyns","year":"2001","journal-title":"Curr. Pharm. Des."},{"key":"10.1074\/jbc.M109.045336_bib9","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1126\/science.3883489","volume":"227","author":"Fairlamb","year":"1985","journal-title":"Science"},{"key":"10.1074\/jbc.M109.045336_bib10","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1046\/j.1365-2958.2000.01721.x","volume":"35","author":"Krieger","year":"2000","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M109.045336_bib11","doi-asserted-by":"crossref","first-page":"31640","DOI":"10.1074\/jbc.M303035200","volume":"278","author":"Wilkinson","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.045336_bib12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0166-6851(03)00176-2","volume":"131","author":"Oza","year":"2003","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M109.045336_bib13","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1515\/BC.2003.072","volume":"384","author":"Comini","year":"2003","journal-title":"Biol. Chem."},{"key":"10.1074\/jbc.M109.045336_bib14","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.freeradbiomed.2004.02.008","volume":"36","author":"Comini","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1074\/jbc.M109.045336_bib15","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1042\/BJ20050911","volume":"391","author":"Ariyanayagam","year":"2005","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M109.045336_bib16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1365-2958.2009.06761.x","volume":"74","author":"Wyllie","year":"2009","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M109.045336_bib17","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.pt.2007.08.019","volume":"23","author":"Frearson","year":"2007","journal-title":"Trends Parasitol."},{"key":"10.1074\/jbc.M109.045336_bib18","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.1111\/j.1742-4658.2008.06670.x","volume":"275","author":"Oza","year":"2008","journal-title":"FEBS J."},{"key":"10.1074\/jbc.M109.045336_bib19","doi-asserted-by":"crossref","first-page":"17672","DOI":"10.1074\/jbc.M801850200","volume":"283","author":"Fyfe","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.045336_bib20","doi-asserted-by":"crossref","first-page":"35853","DOI":"10.1074\/jbc.M204403200","volume":"277","author":"Oza","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.045336_bib21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/abio.1999.4100","volume":"271","author":"Cogan","year":"1999","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M109.045336_bib22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0001-706X(97)00079-X","volume":"68","author":"R\u00e4z","year":"1997","journal-title":"Acta Trop."},{"key":"10.1074\/jbc.M109.045336_bib23","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1002\/cmdc.200900098","volume":"4","author":"Patterson","year":"2009","journal-title":"ChemMedChem"},{"key":"10.1074\/jbc.M109.045336_bib24","first-page":"807","volume":"134","author":"Shim","year":"1988","journal-title":"J. Gen. Microbiol."},{"key":"10.1074\/jbc.M109.045336_bib25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/108705719900400206","volume":"4","author":"Zhang","year":"1999","journal-title":"J. Biomol. Screen."},{"key":"10.1074\/jbc.M109.045336_bib26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1042\/bj2860009","volume":"286","author":"Benson","year":"1992","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M109.045336_bib27","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nchembio.118","volume":"4","author":"Hopkins","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1074\/jbc.M109.045336_bib28","unstructured":"Spinks, D., (7 8, 2009) United Kingdom Patent Application 909811.2."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582037424X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582037424X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M109.045336","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T01:54:20Z","timestamp":1641261260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192582037424X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":28,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S002192582037424X"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m109.045336","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1880958.1428056","asserted-by":"object"}]},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}