{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:49:37Z","timestamp":1791218977466,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"52","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T00:00:00Z","timestamp":1598659200000},"content-version":"vor","delay-in-days":3924,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1074\/jbc.m109.075523","type":"journal-article","created":{"date-parts":[[2009,10,23]],"date-time":"2009-10-23T00:12:57Z","timestamp":1256256777000},"page":"36453-36461","source":"Crossref","is-referenced-by-count":112,"title":["Aminopyridines Potentiate Synaptic and Neuromuscular Transmission by Targeting the Voltage-activated Calcium Channel \u03b2 Subunit"],"prefix":"10.1016","volume":"284","author":[{"given":"Zi-Zhen","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Pei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Rui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Lin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M109.075523_bib1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/ana.410270215","volume":"27","author":"Davis","year":"1990","journal-title":"Ann. Neurol."},{"key":"10.1074\/jbc.M109.075523_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/neu.1993.10.1","volume":"10","author":"Hansebout","year":"1993","journal-title":"J. Neurotrauma"},{"key":"10.1074\/jbc.M109.075523_bib3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1136\/jnnp.42.2.171","volume":"42","author":"Lundh","year":"1979","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1074\/jbc.M109.075523_bib4","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1212\/WNL.54.3.603","volume":"54","author":"Sanders","year":"2000","journal-title":"Neurology"},{"key":"10.1074\/jbc.M109.075523_bib5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/clpt.2009.35","volume":"86","author":"Wirtz","year":"2009","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1074\/jbc.M109.075523_bib6","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.pharmthera.2005.10.006","volume":"111","author":"Judge","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1074\/jbc.M109.075523_bib7","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0022-3565(25)22023-7","volume":"227","author":"Thomsen","year":"1983","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1074\/jbc.M109.075523_bib8","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/283570a0","volume":"283","author":"Sherratt","year":"1980","journal-title":"Nature"},{"key":"10.1074\/jbc.M109.075523_bib9","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0002-9343(93)90314-F","volume":"95","author":"Hofer","year":"1993","journal-title":"Am. J. Med."},{"key":"10.1074\/jbc.M109.075523_bib10","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1126\/science.2447652","volume":"239","author":"Kim","year":"1988","journal-title":"Science"},{"key":"10.1074\/jbc.M109.075523_bib11","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1212\/01.WNL.0000125691.74109.53","volume":"62","author":"Strupp","year":"2004","journal-title":"Neurology"},{"key":"10.1074\/jbc.M109.075523_bib12","doi-asserted-by":"crossref","first-page":"18142","DOI":"10.1074\/jbc.M501229200","volume":"280","author":"Wu","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.075523_bib13","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1152\/jn.01267.2004","volume":"93","author":"Vydyanathan","year":"2005","journal-title":"J. Neurophysiol."},{"key":"10.1074\/jbc.M109.075523_bib14","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1471-4159.2008.05772.x","volume":"108","author":"Zhou","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M109.075523_bib15","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1113\/jphysiol.2002.020644","volume":"543","author":"Li","year":"2002","journal-title":"J. Physiol."},{"key":"10.1074\/jbc.M109.075523_bib16","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1152\/jn.1999.82.6.3030","volume":"82","author":"Moyer","year":"1999","journal-title":"J. Neurophysiol."},{"key":"10.1074\/jbc.M109.075523_bib17","doi-asserted-by":"crossref","first-page":"9280","DOI":"10.1016\/S0021-9258(17)39364-X","volume":"260","author":"Cruz","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.075523_bib18","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1523\/JNEUROSCI.15-04-02995.1995","volume":"15","author":"Randall","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M109.075523_bib19","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1124\/jpet.104.073429","volume":"311","author":"Wu","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1074\/jbc.M109.075523_bib20","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1113\/jphysiol.1992.sp018932","volume":"445","author":"Ficker","year":"1992","journal-title":"J. Physiol."},{"key":"10.1074\/jbc.M109.075523_bib21","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S0026-895X(25)10594-4","volume":"45","author":"Grissmer","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M109.075523_bib22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0306-3623(97)00034-7","volume":"30","author":"Mathie","year":"1998","journal-title":"Gen. Pharmacol."},{"key":"10.1074\/jbc.M109.075523_bib23","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1101\/SQB.1992.057.01.054","volume":"57","author":"Baldwin","year":"1992","journal-title":"Cold Spring Harbor Symp. Quant. Biol."},{"key":"10.1074\/jbc.M109.075523_bib24","doi-asserted-by":"crossref","first-page":"9855","DOI":"10.1523\/JNEUROSCI.0604-07.2007","volume":"27","author":"Chien","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M109.075523_bib25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0041-0101(00)00162-8","volume":"39","author":"Harvey","year":"2001","journal-title":"Toxicon"},{"key":"10.1074\/jbc.M109.075523_bib26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1113\/jphysiol.2005.097006","volume":"571","author":"Guan","year":"2006","journal-title":"J. Physiol."},{"key":"10.1074\/jbc.M109.075523_bib27","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/sj.bjp.0702283","volume":"126","author":"Diochot","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1074\/jbc.M109.075523_bib28","doi-asserted-by":"crossref","first-page":"6744","DOI":"10.1074\/jbc.273.12.6744","volume":"273","author":"Diochot","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.075523_bib29","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1540-8167.2006.00362.x","volume":"17","author":"Wang","year":"2006","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"10.1074\/jbc.M109.075523_bib30","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1124\/jpet.105.097618","volume":"317","author":"Rezazadeh","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1074\/jbc.M109.075523_bib31","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1023\/B:JOBB.0000008026.37790.5a","volume":"35","author":"Dolphin","year":"2003","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1074\/jbc.M109.075523_bib32","doi-asserted-by":"crossref","first-page":"5101","DOI":"10.1113\/jphysiol.2008.159384","volume":"586","author":"Catacuzzeno","year":"2008","journal-title":"J. Physiol."},{"key":"10.1074\/jbc.M109.075523_bib33","doi-asserted-by":"crossref","first-page":"C1589","DOI":"10.1152\/ajpcell.1994.267.6.C1589","volume":"267","author":"Robertson","year":"1994","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1074\/jbc.M109.075523_bib34","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1001\/archneur.1994.00540230074016","volume":"51","author":"Polman","year":"1994","journal-title":"Arch. Neurol."},{"key":"10.1074\/jbc.M109.075523_bib35","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1126\/science.1321501","volume":"257","author":"Williams","year":"1992","journal-title":"Science"},{"key":"10.1074\/jbc.M109.075523_bib36","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/372272a0","volume":"372","author":"Ellinor","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.M109.075523_bib37","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0896-6273(00)80881-8","volume":"25","author":"Bichet","year":"2000","journal-title":"Neuron"},{"key":"10.1074\/jbc.M109.075523_bib38","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.ne.17.030194.002151","volume":"17","author":"Hofmann","year":"1994","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1074\/jbc.M109.075523_bib39","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1523\/JNEUROSCI.17-04-01339.1997","volume":"17","author":"Ludwig","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M109.075523_bib40","doi-asserted-by":"crossref","first-page":"40342","DOI":"10.1074\/jbc.M203425200","volume":"277","author":"Murakami","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.075523_bib41","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1212\/WNL.44.6.1054","volume":"44","author":"Bever","year":"1994","journal-title":"Neurology"},{"key":"10.1074\/jbc.M109.075523_bib42","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1001\/archneur.1994.00540150090022","volume":"51","author":"Polman","year":"1994","journal-title":"Arch. Neurol."},{"key":"10.1074\/jbc.M109.075523_bib43","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1126\/science.1126308","volume":"312","author":"Kittel","year":"2006","journal-title":"Science"},{"key":"10.1074\/jbc.M109.075523_bib44","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/0896-6273(94)90414-6","volume":"13","author":"Haydon","year":"1994","journal-title":"Neuron"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820374561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820374561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M109.075523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T22:03:41Z","timestamp":1739397821000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820374561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":44,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0021925820374561"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m109.075523","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}