{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:15:49Z","timestamp":1791180949579,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":3924,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1074\/jbc.m109.078626","type":"journal-article","created":{"date-parts":[[2009,11,18]],"date-time":"2009-11-18T03:59:09Z","timestamp":1258516749000},"page":"2562-2568","source":"Crossref","is-referenced-by-count":47,"title":["The Full-length Unprocessed Hedgehog Protein Is an Active Signaling Molecule"],"prefix":"10.1016","volume":"285","author":[{"given":"Robert","family":"Tokhunts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samer","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tehyen","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"D\u2019Angelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Baubet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Goetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Ascano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana","family":"Zavros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal P.","family":"Th\u00e9rond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Kunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Dahmane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Robbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M109.078626_bib1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ng1196-357","volume":"14","author":"Roessler","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M109.078626_bib2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00431-004-1459-0","volume":"163","author":"Hehr","year":"2004","journal-title":"Eur. J. Pediatr."},{"key":"10.1074\/jbc.M109.078626_bib3","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1093\/hmg\/8.9.1683","volume":"8","author":"Odent","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M109.078626_bib4","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1093\/hmg\/8.13.2479","volume":"8","author":"Nanni","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M109.078626_bib5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/ng1196-353","volume":"14","author":"Belloni","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M109.078626_bib6","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1074\/jbc.M511427200","volume":"281","author":"Goetz","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.078626_bib7","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0092-8674(02)00977-7","volume":"111","author":"Ma","year":"2002","journal-title":"Cell"},{"key":"10.1074\/jbc.M109.078626_bib8","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/35023008","volume":"406","author":"Taipale","year":"2000","journal-title":"Nature"},{"key":"10.1074\/jbc.M109.078626_bib9","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.reprotox.2004.11.013","volume":"19","author":"Scott","year":"2005","journal-title":"Reprod. Toxicol."},{"key":"10.1074\/jbc.M109.078626_bib10","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/35079648","volume":"411","author":"Zeng","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.M109.078626_bib11","doi-asserted-by":"crossref","first-page":"G99","DOI":"10.1152\/ajpgi.00389.2007","volume":"295","author":"Zavros","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1074\/jbc.M109.078626_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0092-8674(92)90264-D","volume":"71","author":"Lee","year":"1992","journal-title":"Cell"},{"key":"10.1074\/jbc.M109.078626_bib13","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0960-9822(95)00084-4","volume":"5","author":"Ingham","year":"1995","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.M109.078626_bib14","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1534-5807(03)00031-5","volume":"4","author":"Gallet","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1074\/jbc.M109.078626_bib15","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.devcel.2006.03.003","volume":"10","author":"Chu","year":"2006","journal-title":"Dev. Cell"},{"key":"10.1074\/jbc.M109.078626_bib16","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0092-8674(00)81677-3","volume":"99","author":"Burke","year":"1999","journal-title":"Cell"},{"key":"10.1074\/jbc.M109.078626_bib17","doi-asserted-by":"crossref","first-page":"8392","DOI":"10.1073\/pnas.90.18.8392","volume":"90","author":"Pear","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.078626_bib18","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0092-8674(95)90397-6","volume":"81","author":"Roelink","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.M109.078626_bib19","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/374363a0","volume":"374","author":"Porter","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.M109.078626_bib20","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1126\/science.280.5369.1603","volume":"280","author":"Cooper","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M109.078626_bib21","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1242\/dev.125.18.3553","volume":"125","author":"Incardona","year":"1998","journal-title":"Development"},{"key":"10.1074\/jbc.M109.078626_bib22","doi-asserted-by":"crossref","first-page":"12044","DOI":"10.1073\/pnas.220251997","volume":"97","author":"Incardona","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.078626_bib23","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/35049541","volume":"1","author":"Jessell","year":"2000","journal-title":"Nat. Rev. Genet."},{"key":"10.1074\/jbc.M109.078626_bib24","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/MED.0b013e328320a821","volume":"16","author":"El-Zaatari","year":"2009","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1074\/jbc.M109.078626_bib25","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0960-9822(95)00156-4","volume":"5","author":"L\u00f3pez-Mart\u00ednez","year":"1995","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.M109.078626_bib26","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1242\/dev.00534","volume":"130","author":"Pappu","year":"2003","journal-title":"Development"},{"key":"10.1074\/jbc.M109.078626_bib27","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/0092-8674(93)90535-X","volume":"75","author":"Heberlein","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.M109.078626_bib28","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0092-8674(00)80114-2","volume":"86","author":"Huang","year":"1996","journal-title":"Cell"},{"key":"10.1074\/jbc.M109.078626_bib29","doi-asserted-by":"crossref","first-page":"6548","DOI":"10.1073\/pnas.0600124103","volume":"103","author":"Li","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.078626_bib30","doi-asserted-by":"crossref","first-page":"5753","DOI":"10.1242\/dev.00178","volume":"129","author":"Kawakami","year":"2002","journal-title":"Development"},{"key":"10.1074\/jbc.M109.078626_bib31","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/S0960-9822(02)01147-8","volume":"12","author":"Caspary","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.M109.078626_bib32","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S1097-2765(00)80214-2","volume":"4","author":"The","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M109.078626_bib33","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/27932","volume":"394","author":"Bellaiche","year":"1998","journal-title":"Nature"},{"key":"10.1074\/jbc.M109.078626_bib34","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1101\/gad.938601","volume":"15","author":"Ingham","year":"2001","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M109.078626_bib35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrm1830","volume":"7","author":"Tickle","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1074\/jbc.M109.078626_bib36","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1093\/embo-reports\/kve255","volume":"2","author":"Sanson","year":"2001","journal-title":"EMBO Rep."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819637506?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819637506?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M109.078626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T01:51:52Z","timestamp":1641174712000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819637506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0021925819637506"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m109.078626","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}