{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:20:01Z","timestamp":1791181201501,"version":"4.1.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T00:00:00Z","timestamp":1601164800000},"content-version":"vor","delay-in-days":3802,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1074\/jbc.m109.081588","type":"journal-article","created":{"date-parts":[[2010,3,11]],"date-time":"2010-03-11T01:13:00Z","timestamp":1268269980000},"page":"16771-16781","source":"Crossref","is-referenced-by-count":37,"title":["Discovery of Potent and Selective Inhibitors of Trypanosoma brucei Ornithine Decarboxylase"],"prefix":"10.1016","volume":"285","author":[{"given":"David C.","family":"Smithson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongmi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anang A.","family":"Shelat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret A.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Kiplin","family":"Guy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M109.081588_bib1","series-title":"African Trypanosomiasis (Sleeping Sickness), Fact Sheet","year":"2006"},{"key":"10.1074\/jbc.M109.081588_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0166-6851(97)00183-7","volume":"91","author":"Pays","year":"1998","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M109.081588_bib3","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/sj.bjp.0707354","volume":"152","author":"Barrett","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1074\/jbc.M109.081588_bib4","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1073\/pnas.60.4.1420","volume":"60","author":"Russell","year":"1968","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.081588_bib5","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1021\/jm00250a016","volume":"17","author":"Abdel-Monem","year":"1974","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M109.081588_bib6","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nrd2243","volume":"6","author":"Casero","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1074\/jbc.M109.081588_bib7","first-page":"G308","volume":"258","author":"Iwami","year":"1990","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M109.081588_bib8","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1007\/s00018-003-2332-4","volume":"60","author":"Childs","year":"2003","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1074\/jbc.M109.081588_bib9","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.2174\/092986707780597899","volume":"14","author":"Amadasi","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"10.1074\/jbc.M109.081588_bib10","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/35056508","volume":"2","author":"Coffino","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1074\/jbc.M109.081588_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20031327","volume":"376","author":"Wallace","year":"2003","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M109.081588_bib12","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1021\/ja00476a050","volume":"100","author":"Metcalf","year":"1978","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.M109.081588_bib13","doi-asserted-by":"crossref","first-page":"15174","DOI":"10.1021\/bi9915115","volume":"38","author":"Grishin","year":"1999","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M109.081588_bib14","first-page":"3850","volume":"6","author":"Carbone","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"10.1074\/jbc.M109.081588_bib15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF00203544","volume":"5","author":"Griffin","year":"1987","journal-title":"Invest. New Drugs"},{"key":"10.1074\/jbc.M109.081588_bib16","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1158\/1940-6207.CAPR-08-0042","volume":"1","author":"Meyskens","year":"2008","journal-title":"Cancer Prev. Res."},{"key":"10.1074\/jbc.M109.081588_bib17","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1158\/1055-9965.EPI-07-0658","volume":"17","author":"Simoneau","year":"2008","journal-title":"Cancer Epidem. Biomark. Prev."},{"key":"10.1074\/jbc.M109.081588_bib18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00726-007-0531-2","volume":"33","author":"Shantz","year":"2007","journal-title":"Amino Acids"},{"key":"10.1074\/jbc.M109.081588_bib19","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1128\/EC.00047-09","volume":"8","author":"Xiao","year":"2009","journal-title":"Eukaryot. Cell"},{"key":"10.1074\/jbc.M109.081588_bib20","doi-asserted-by":"crossref","first-page":"11823","DOI":"10.1016\/S0021-9258(19)38472-8","volume":"265","author":"Ghoda","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.081588_bib21","doi-asserted-by":"crossref","first-page":"8721","DOI":"10.1016\/S0021-9258(18)47475-3","volume":"262","author":"Phillips","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.081588_bib22","doi-asserted-by":"crossref","first-page":"8275","DOI":"10.1073\/pnas.0701111104","volume":"104","author":"Willert","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.081588_bib23","doi-asserted-by":"crossref","first-page":"e1000183","DOI":"10.1371\/journal.ppat.1000183","volume":"4","author":"Willert","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1074\/jbc.M109.081588_bib24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0166-6851(87)90105-8","volume":"24","author":"Fairlamb","year":"1987","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M109.081588_bib25","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0140-6736(09)61117-X","volume":"374","author":"Priotto","year":"2009","journal-title":"Lancet"},{"key":"10.1074\/jbc.M109.081588_bib26","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/0140-6736(92)92180-N","volume":"340","author":"Milord","year":"1992","journal-title":"Lancet"},{"key":"10.1074\/jbc.M109.081588_bib27","first-page":"190","volume":"46","author":"Iten","year":"1995","journal-title":"Trop. Med. Parasitol."},{"key":"10.1074\/jbc.M109.081588_bib28","series-title":"Inhibition of Polyamine Metabolism, Biological Significance and Basis for New Therapies","first-page":"32","author":"Bey","year":"1987"},{"key":"10.1074\/jbc.M109.081588_bib29","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1042\/bj2080435","volume":"208","author":"Bitonti","year":"1982","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M109.081588_bib30","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0304-3940(02)00097-6","volume":"323","author":"Thyssen","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1074\/jbc.M109.081588_bib31","doi-asserted-by":"crossref","first-page":"13662","DOI":"10.1021\/bi00250a016","volume":"33","author":"Osterman","year":"1994","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M109.081588_bib32","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.cbpa.2007.05.003","volume":"11","author":"Shelat","year":"2007","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1074\/jbc.M109.081588_bib33","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1021\/ci990423o","volume":"39","author":"Hann","year":"1999","journal-title":"J. Chem. Inf. Comp. Sci."},{"key":"10.1074\/jbc.M109.081588_bib34","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1021\/jm9602928","volume":"39","author":"Bemis","year":"1996","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M109.081588_bib35","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1073\/pnas.82.2.488","volume":"82","author":"Kunkel","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M109.081588_bib36","author":"Smithson","year":"2010","journal-title":"Assay Drug Dev. Technol."},{"key":"10.1074\/jbc.M109.081588_bib37","series-title":"R: A Language and Environment for Statistical Computing","author":"Team","year":"2007"},{"key":"10.1074\/jbc.M109.081588_bib38","author":"Rousseeuw","year":"2006","journal-title":"robustbase: Basic Robust Statistics"},{"key":"10.1074\/jbc.M109.081588_bib39","series-title":"Understanding Robust and Exploratory Data Analysis","first-page":"57","year":"1983"},{"key":"10.1074\/jbc.M109.081588_bib40","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/108705719900400206","volume":"4","author":"Zhang","year":"1999","journal-title":"J. Biomol. Screen."},{"key":"10.1074\/jbc.M109.081588_bib41","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/0005-2744(79)90310-3","volume":"568","author":"Pegg","year":"1979","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M109.081588_bib42","doi-asserted-by":"crossref","first-page":"27115","DOI":"10.1074\/jbc.M704066200","volume":"282","author":"Lee","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.081588_bib43","doi-asserted-by":"crossref","first-page":"21847","DOI":"10.1074\/jbc.M501100200","volume":"280","author":"Baldwin","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.081588_bib44","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1177\/1087057107304113","volume":"12","author":"Lor","year":"2007","journal-title":"J. Biomol. Screen."},{"key":"10.1074\/jbc.M109.081588_bib45","series-title":"Enzyme Kinetics, Behavior and Analysis of Rapid Equilibrium and Steady-state Enzyme Systems","first-page":"249","author":"Segel","year":"1975"},{"key":"10.1074\/jbc.M109.081588_bib46","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1006\/jmbi.1999.3331","volume":"295","author":"Almrud","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M109.081588_bib47","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1093-3263(98)00002-3","volume":"15","author":"Hendlich","year":"1997","journal-title":"J. Mol. Graphics"},{"key":"10.1074\/jbc.M109.081588_bib48","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1021\/cc800100g","volume":"10","author":"Lemoff","year":"2008","journal-title":"J. Comb. Chem."},{"key":"10.1074\/jbc.M109.081588_bib49","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1021\/ac061682x","volume":"79","author":"Yan","year":"2007","journal-title":"Anal. Chem."},{"key":"10.1074\/jbc.M109.081588_bib50","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.meegid.2005.05.004","volume":"6","author":"Steglich","year":"2006","journal-title":"Infect. Genet. Evol."},{"key":"10.1074\/jbc.M109.081588_bib51","doi-asserted-by":"crossref","first-page":"11797","DOI":"10.1074\/jbc.270.20.11797","volume":"270","author":"Osterman","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.081588_bib52","doi-asserted-by":"crossref","first-page":"12990","DOI":"10.1021\/bi048933l","volume":"43","author":"Jackson","year":"2004","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M109.081588_bib53","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1042\/bj2370685","volume":"237","author":"Bitonti","year":"1986","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M109.081588_bib54","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/0014-5793(85)81311-9","volume":"190","author":"Solano","year":"1985","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M109.081588_bib55","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/0006-2952(88)90427-3","volume":"37","author":"Henley","year":"1988","journal-title":"Biochem. Pharmacol."},{"key":"10.1074\/jbc.M109.081588_bib56","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1039\/jr9560004422","author":"Rose","year":"1956","journal-title":"J. Chem. Soc."},{"key":"10.1074\/jbc.M109.081588_bib57","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1128\/AAC.48.5.1561-1569.2004","volume":"48","author":"Ganendren","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M109.081588_bib58","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1158\/1535-7163.MCT-06-0134","volume":"5","author":"Yip","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"10.1074\/jbc.M109.081588_bib59","doi-asserted-by":"crossref","first-page":"22037","DOI":"10.1074\/jbc.M300188200","volume":"278","author":"Jackson","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.081588_bib60","doi-asserted-by":"crossref","first-page":"26669","DOI":"10.1016\/S0021-9258(18)47071-8","volume":"269","author":"Garvey","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109.081588_bib61","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1016\/j.bmc.2005.12.029","volume":"14","author":"Athri","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1074\/jbc.M109.081588_bib62","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1128\/AAC.00192-06","volume":"50","author":"Mathis","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M109.081588_bib63","doi-asserted-by":"crossref","first-page":"11247","DOI":"10.1021\/bi001209s","volume":"39","author":"Jackson","year":"2000","journal-title":"Biochemistry"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819356029?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819356029?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M109.081588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T13:46:52Z","timestamp":1641131212000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819356029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":63,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0021925819356029"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m109.081588","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}