{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:53:13Z","timestamp":1791208393331,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"vor","delay-in-days":6836,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2002,2]]},"DOI":"10.1074\/jbc.m109107200","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:03:26Z","timestamp":1027695806000},"page":"6017-6024","source":"Crossref","is-referenced-by-count":320,"title":["Hydrogen Peroxide Activates Endothelial Nitric-oxide Synthase through Coordinated Phosphorylation and Dephosphorylation via a Phosphoinositide 3-Kinase-dependent Signaling Pathway"],"prefix":"10.1016","volume":"277","author":[{"given":"Shane R.","family":"Thomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"John F.","family":"Keaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M109107200_bib1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1161\/01.CIR.88.1.43","volume":"88","author":"Lefroy","year":"1993","journal-title":"Circulation"},{"key":"10.1074\/jbc.M109107200_bib2","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1073\/pnas.86.9.3375","volume":"86","author":"Rees","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M109107200_bib3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1476-5381.1986.tb10218.x","volume":"88","author":"Azuma","year":"1986","journal-title":"Br. J. Pharmacol."},{"key":"10.1074\/jbc.M109107200_bib4","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1172\/JCI114081","volume":"83","author":"Garg","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M109107200_bib5","first-page":"F193","volume":"280","author":"Govers","year":"2001","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M109107200_bib6","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/21218","volume":"399","author":"Fulton","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M109107200_bib7","doi-asserted-by":"crossref","first-page":"16587","DOI":"10.1074\/jbc.M100229200","volume":"276","author":"Harris","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109107200_bib8","doi-asserted-by":"crossref","first-page":"17625","DOI":"10.1074\/jbc.C100122200","volume":"276","author":"Michell","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109107200_bib9","first-page":"E68","volume":"88","author":"Fleming","year":"2001","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M109107200_bib10","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0960-9822(99)80371-6","volume":"9","author":"Michell","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.M109107200_bib11","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1074\/jbc.M005036200","volume":"276","author":"Hisamoto","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109107200_bib12","doi-asserted-by":"crossref","first-page":"30392","DOI":"10.1074\/jbc.M103702200","volume":"276","author":"Montagnani","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109107200_bib13","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/21224","volume":"399","author":"Dimmeler","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M109107200_bib14","doi-asserted-by":"crossref","first-page":"30101","DOI":"10.1074\/jbc.274.42.30101","volume":"274","author":"Gallis","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109107200_bib15","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1161\/01.CIR.91.6.1732","volume":"91","author":"Panza","year":"1995","journal-title":"Circulation"},{"key":"10.1074\/jbc.M109107200_bib16","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1056\/NEJM198610233151702","volume":"315","author":"Ludmer","year":"1986","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M109107200_bib17","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1056\/NEJM199502233320807","volume":"332","author":"Levine","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M109107200_bib18","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1161\/01.RES.86.5.494","volume":"86","author":"Griendling","year":"2000","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M109107200_bib19","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1021\/tx970160x","volume":"10","author":"Kissner","year":"1997","journal-title":"Chemical Res. Toxicol."},{"key":"10.1074\/jbc.M109107200_bib20","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1172\/JCI116491","volume":"91","author":"Ohara","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M109107200_bib21","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1172\/JCI117953","volume":"95","author":"Keaney","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M109107200_bib22","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/S0891-5849(01)00665-7","volume":"31","author":"Liu","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1074\/jbc.M109107200_bib23","doi-asserted-by":"crossref","first-page":"17399","DOI":"10.1074\/jbc.M002248200","volume":"275","author":"Huang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109107200_bib24","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1073\/pnas.93.4.1480","volume":"93","author":"Moro","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M109107200_bib25","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1172\/JCI118804","volume":"98","author":"Keaney","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M109107200_bib26","doi-asserted-by":"crossref","first-page":"16349","DOI":"10.1074\/jbc.274.23.16349","volume":"274","author":"Fujio","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109107200_bib27","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1172\/JCI9419","volume":"106","author":"Luo","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M109107200_bib28","doi-asserted-by":"crossref","first-page":"6541","DOI":"10.1002\/j.1460-2075.1996.tb01045.x","volume":"15","author":"Alessi","year":"1996","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M109107200_bib29","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1128\/MCB.18.7.3708","volume":"18","author":"Kitamura","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M109107200_bib30","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0014-5793(98)01705-0","volume":"443","author":"Chen","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M109107200_bib31","doi-asserted-by":"crossref","first-page":"14624","DOI":"10.1074\/jbc.275.19.14624","volume":"275","author":"Wang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109107200_bib32","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev.biochem.67.1.481","volume":"67","author":"Fruman","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M109107200_bib33","doi-asserted-by":"crossref","first-page":"16045","DOI":"10.1074\/jbc.M011766200","volume":"276","author":"Chen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109107200_bib34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1042\/bj2970209","volume":"297","author":"Doan","year":"1994","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M109107200_bib35","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1161\/01.RES.86.3.347","volume":"86","author":"Drummond","year":"2000","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M109107200_bib36","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/sj.bjp.0701847","volume":"124","author":"Lopez-Ongil","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1074\/jbc.M109107200_bib37","first-page":"227","volume":"95","author":"Shimizu","year":"1997","journal-title":"Res. Commun. Mol. Pathol. Pharmacol."},{"key":"10.1074\/jbc.M109107200_bib38","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1476-5381.1993.tb13785.x","volume":"110","author":"Zembowicz","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1074\/jbc.M109107200_bib39","doi-asserted-by":"crossref","first-page":"22699","DOI":"10.1074\/jbc.274.32.22699","volume":"274","author":"Ushio-Fukai","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109107200_bib40","doi-asserted-by":"crossref","first-page":"12420","DOI":"10.1074\/jbc.M008375200","volume":"276","author":"Igarashi","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109107200_bib41","doi-asserted-by":"crossref","first-page":"36281","DOI":"10.1074\/jbc.M105628200","volume":"276","author":"Igarashi","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109107200_bib42","doi-asserted-by":"crossref","first-page":"32663","DOI":"10.1074\/jbc.M101371200","volume":"276","author":"Brouet","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109107200_bib43","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/01.RES.87.8.677","volume":"87","author":"Haynes","year":"2000","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M109107200_bib44","doi-asserted-by":"crossref","first-page":"19672","DOI":"10.1074\/jbc.M009993200","volume":"276","author":"Morales-Ruiz","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109107200_bib45","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.270.5234.296","volume":"270","author":"Sundaresan","year":"1995","journal-title":"Science"},{"key":"10.1074\/jbc.M109107200_bib46","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1074\/jbc.M107711200","volume":"277","author":"Colavitti","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109107200_bib47","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1172\/JCI10506","volume":"106","author":"Matoba","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M109107200_bib48","doi-asserted-by":"crossref","first-page":"11575","DOI":"10.1073\/pnas.201293198","volume":"98","author":"Paxinou","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819823700?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819823700?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M109107200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:37:33Z","timestamp":1641256653000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819823700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2002,2]]}},"alternative-id":["S0021925819823700"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m109107200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2002,2]]}}}