{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T12:26:15Z","timestamp":1768739175420,"version":"3.49.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"vor","delay-in-days":6759,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2002,5]]},"DOI":"10.1074\/jbc.m109882200","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:16:37Z","timestamp":1027696597000},"page":"15647-15653","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Transcriptional Activation of Cytochrome P450 CYP2C45 by Drugs Is Mediated by the Chicken Xenobiotic Receptor (CXR) Interacting with a Phenobarbital Response Enhancer Unit"],"prefix":"10.1016","volume":"277","author":[{"given":"Manuel","family":"Baader","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmela","family":"Gnerre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Stegeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urs A.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M109882200_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00008571-199602000-00002","volume":"6","author":"Nelson","year":"1996","journal-title":"Pharmacogenetics"},{"key":"10.1074\/jbc.M109882200_bib2","series-title":"Pharmacogenetics of Drug Metabolism","first-page":"549","author":"Okey","year":"1992"},{"key":"10.1074\/jbc.M109882200_bib3","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/j.1875-9114.1998.tb03830.x","volume":"18","author":"Michalets","year":"1998","journal-title":"Pharmacotherapy"},{"key":"10.1074\/jbc.M109882200_bib4","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/00008571-199312000-00003","volume":"3","author":"Yasumori","year":"1993","journal-title":"Pharmacogenetics"},{"key":"10.1074\/jbc.M109882200_bib5","first-page":"1327","volume":"28","author":"McGinnity","year":"2000","journal-title":"Drug Metab. Dispos."},{"key":"10.1074\/jbc.M109882200_bib6","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1111\/j.1528-1157.1995.tb06007.x","volume":"36","author":"Levy","year":"1995","journal-title":"Epilepsia"},{"key":"10.1074\/jbc.M109882200_bib7","first-page":"392","volume":"28","author":"Warrington","year":"2000","journal-title":"Drug Metab. Dispos."},{"key":"10.1074\/jbc.M109882200_bib8","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1021\/tx00025a009","volume":"5","author":"Rettie","year":"1992","journal-title":"Chem. Res. Toxicol."},{"key":"10.1074\/jbc.M109882200_bib9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/109158101317097746","volume":"20","author":"Czerniak","year":"2001","journal-title":"Int. J. Toxicol."},{"key":"10.1074\/jbc.M109882200_bib10","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1432-1033.1990.tb19140.x","volume":"191","author":"Morel","year":"1990","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M109882200_bib11","doi-asserted-by":"crossref","first-page":"5652","DOI":"10.1128\/MCB.18.10.5652","volume":"18","author":"Honkakoski","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M109882200_bib12","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1074\/jbc.274.10.6043","volume":"274","author":"Sueyoshi","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109882200_bib13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0092-8674(00)80900-9","volume":"92","author":"Kliewer","year":"1998","journal-title":"Cell"},{"key":"10.1074\/jbc.M109882200_bib14","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0009-2797(01)00163-6","volume":"134","author":"LeCluyse","year":"2001","journal-title":"Chem. Biol. Interact."},{"key":"10.1074\/jbc.M109882200_bib15","first-page":"615","volume":"29","author":"Quattrochi","year":"2001","journal-title":"Drug Metab. Dispos."},{"key":"10.1074\/jbc.M109882200_bib16","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0928-0987(00)00112-3","volume":"11","author":"Negishi","year":"2000","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1074\/jbc.M109882200_bib17","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/bj3470321","volume":"347","author":"Honkakoski","year":"2000","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M109882200_bib18","first-page":"23","volume":"61","author":"Kemper","year":"1998","journal-title":"Prog. Nucleic Acid Res. Mol. Biol."},{"key":"10.1074\/jbc.M109882200_bib19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.pharmtox.41.1.123","volume":"41","author":"Sueyoshi","year":"2001","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1074\/jbc.M109882200_bib20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/(SICI)1099-0461(1999)13:6<289::AID-JBT1>3.0.CO;2-N","volume":"13","author":"Klose","year":"1999","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1074\/jbc.M109882200_bib21","first-page":"242","volume":"29","author":"Gerbal-Chaloin","year":"2001","journal-title":"Drug Metab. Dispos."},{"key":"10.1074\/jbc.M109882200_bib22","doi-asserted-by":"crossref","first-page":"10769","DOI":"10.1073\/pnas.97.20.10769","volume":"97","author":"Handschin","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M109882200_bib23","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1210\/mend.15.9.0701","volume":"15","author":"Handschin","year":"2001","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M109882200_bib24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1006\/abbi.1999.1566","volume":"373","author":"Ourlin","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1074\/jbc.M109882200_bib25","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1006\/bbrc.2001.5111","volume":"285","author":"Meyer","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M109882200_bib26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0378-1119(89)90358-2","volume":"77","author":"Ho","year":"1989","journal-title":"Gene (Amst.)"},{"key":"10.1074\/jbc.M109882200_bib27","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1074\/jbc.272.7.4149","volume":"272","author":"Iniguez-Lluhi","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109882200_bib28","series-title":"Human CYP2C","first-page":"162","author":"Ioannides","year":"1996"},{"key":"10.1074\/jbc.M109882200_bib29","doi-asserted-by":"crossref","first-page":"13362","DOI":"10.1074\/jbc.275.18.13362","volume":"275","author":"Handschin","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109882200_bib30","doi-asserted-by":"crossref","first-page":"7559","DOI":"10.1074\/jbc.M008090200","volume":"276","author":"Kim","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109882200_bib31","first-page":"681","volume":"60","author":"Handschin","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M109882200_bib32","first-page":"63","volume":"49","author":"Schuetz","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M109882200_bib33","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1093\/nar\/18.14.4237","volume":"18","author":"Jaiswal","year":"1990","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M109882200_bib34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1089\/dna.1998.17.39","volume":"17","author":"Pereira","year":"1998","journal-title":"DNA Cell Biol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819357102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819357102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M109882200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T13:42:07Z","timestamp":1682170927000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819357102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":34,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["S0021925819357102"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m109882200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2002,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptional Activation of Cytochrome P450 CYP2C45 by Drugs Is Mediated by the Chicken Xenobiotic Receptor (CXR) Interacting with a Phenobarbital Response Enhancer Unit","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M109882200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2002 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}