{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T17:52:32Z","timestamp":1765993952454},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":3541,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1074\/jbc.m110.101527","type":"journal-article","created":{"date-parts":[[2010,11,3]],"date-time":"2010-11-03T00:14:25Z","timestamp":1288743265000},"page":"410-419","source":"Crossref","is-referenced-by-count":49,"title":["Functional Gene Expression Profiling in Yeast Implicates Translational Dysfunction in Mutant Huntingtin Toxicity"],"prefix":"10.1016","volume":"286","author":[{"given":"Eran","family":"Tauber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonor","family":"Miller-Fleming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert P.","family":"Mason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanda","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jannine","family":"Clapp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola J.","family":"Butler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago F.","family":"Outeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Muchowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flaviano","family":"Giorgini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M110.101527_bib1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","volume":"72","author":"The Huntington's Disease Collaborative Research Group","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.M110.101527_bib2","doi-asserted-by":"crossref","first-page":"11884","DOI":"10.1073\/pnas.182276099","volume":"99","author":"Chen","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.101527_bib3","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1073\/pnas.0308679101","volume":"101","author":"Wexler","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.101527_bib4","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0076-6879(06)12013-3","volume":"412","author":"Giorgini","year":"2006","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M110.101527_bib5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-1-59745-540-4_9","volume":"548","author":"Giorgini","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1074\/jbc.M110.101527_bib6","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/ng1542","volume":"37","author":"Giorgini","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M110.101527_bib7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0014-5793(02)02585-1","volume":"517","author":"Panozzo","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M110.101527_bib8","first-page":"231","author":"Giorgini","year":"2008"},{"key":"10.1074\/jbc.M110.101527_bib9","doi-asserted-by":"crossref","first-page":"7390","DOI":"10.1074\/jbc.M708192200","volume":"283","author":"Giorgini","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.101527_bib10","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/nrd2681","volume":"7","author":"Kazantsev","year":"2008","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1074\/jbc.M110.101527_bib11","doi-asserted-by":"crossref","first-page":"44727","DOI":"10.1074\/jbc.M308632200","volume":"278","author":"Mallory","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.101527_bib12","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.1128\/MCB.18.9.4971","volume":"18","author":"Takemaru","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M110.101527_bib13","doi-asserted-by":"crossref","first-page":"7251","DOI":"10.1073\/pnas.94.14.7251","volume":"94","author":"Takemaru","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.101527_bib14","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1093\/brain\/awg155","volume":"126","author":"Stevanin","year":"2003","journal-title":"Brain"},{"key":"10.1074\/jbc.M110.101527_bib15","doi-asserted-by":"crossref","first-page":"4347","DOI":"10.1128\/MCB.21.13.4347-4368.2001","volume":"21","author":"Natarajan","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M110.101527_bib16","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1083\/jcb.200112104","volume":"157","author":"Meriin","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M110.101527_bib17","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.1093\/nar\/22.25.5767","volume":"22","author":"Mumberg","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M110.101527_bib18","series-title":"R: A Language and Environment for Statistical Computing","author":"The R Development Core Team","year":"2009"},{"key":"10.1074\/jbc.M110.101527_bib19","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/bioinformatics\/btl025","volume":"22","author":"Wettenhall","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1074\/jbc.M110.101527_bib20","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1198\/016214504000000683","volume":"99","author":"Wu","year":"2004","journal-title":"J. Am. Stat. Assoc."},{"key":"10.1074\/jbc.M110.101527_bib21","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","volume":"100","author":"Storey","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.101527_bib22","doi-asserted-by":"crossref","first-page":"R22","DOI":"10.1186\/gb-2003-4-3-r22","volume":"4","author":"Breitkreutz","year":"2003","journal-title":"Genome Biol."},{"key":"10.1074\/jbc.M110.101527_bib23","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1093\/bioinformatics\/btl537","volume":"22","author":"Mendes","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1074\/jbc.M110.101527_bib24","doi-asserted-by":"crossref","first-page":"D132","DOI":"10.1093\/nar\/gkm976","volume":"36","author":"Monteiro","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M110.101527_bib25","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M110.101527_bib26","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/nar\/30.9.e36","volume":"30","author":"Pfaffl","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M110.101527_bib27","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/genetics\/147.2.507","volume":"147","author":"Derkatch","year":"1997","journal-title":"Genetics"},{"key":"10.1074\/jbc.M110.101527_bib28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0076-6879(06)11008-3","volume":"411","author":"Reimers","year":"2006","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M110.101527_bib29","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1074\/jbc.M110.101527_bib30","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/yea.1740","volume":"27","author":"Manogaran","year":"2010","journal-title":"Yeast"},{"key":"10.1074\/jbc.M110.101527_bib31","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0074-7696(05)24004-4","volume":"224","author":"Kassir","year":"2003","journal-title":"Int. Rev. Cytol."},{"key":"10.1074\/jbc.M110.101527_bib32","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0092-8674(00)80217-2","volume":"89","author":"Kadosh","year":"1997","journal-title":"Cell"},{"key":"10.1074\/jbc.M110.101527_bib33","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bbaexp.2005.09.005","volume":"1731","author":"Carrozza","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M110.101527_bib34","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1126\/science.1090389","volume":"302","author":"Willingham","year":"2003","journal-title":"Science"},{"key":"10.1074\/jbc.M110.101527_bib35","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1074\/mcp.M600381-MCP200","volume":"6","author":"Collins","year":"2007","journal-title":"Mol. Cell Proteomics"},{"key":"10.1074\/jbc.M110.101527_bib36","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nature04532","volume":"440","author":"Gavin","year":"2006","journal-title":"Nature"},{"key":"10.1074\/jbc.M110.101527_bib37","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S1097-2765(02)00579-8","volume":"10","author":"Grandi","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M110.101527_bib38","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1093\/hmg\/10.17.1829","volume":"10","author":"Wyttenbach","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M110.101527_bib39","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/hmg\/11.17.1953","volume":"11","author":"Sipione","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M110.101527_bib40","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.brainres.2006.02.102","volume":"1088","author":"Crocker","year":"2006","journal-title":"Brain Res."},{"key":"10.1074\/jbc.M110.101527_bib41","doi-asserted-by":"crossref","first-page":"9723","DOI":"10.1523\/JNEUROSCI.3044-08.2008","volume":"28","author":"Runne","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M110.101527_bib42","doi-asserted-by":"crossref","first-page":"e7275","DOI":"10.1371\/journal.pone.0007275","volume":"4","author":"Doumanis","year":"2009","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M110.101527_bib43","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.1073\/pnas.81.20.6442","volume":"81","author":"Hinnebusch","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.101527_bib44","doi-asserted-by":"crossref","first-page":"21661","DOI":"10.1074\/jbc.272.35.21661","volume":"272","author":"Hinnebusch","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.101527_bib45","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.cell.2008.02.037","volume":"133","author":"Steffen","year":"2008","journal-title":"Cell"},{"key":"10.1074\/jbc.M110.101527_bib46","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1083\/jcb.200408003","volume":"167","author":"Lu","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M110.101527_bib47","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1091\/mbc.e07-11-1173","volume":"19","author":"Mascarenhas","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M110.101527_bib48","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1016\/j.febslet.2005.03.043","volume":"579","author":"Matsuo","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M110.101527_bib49","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/nn.2372","volume":"12","author":"Tain","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1074\/jbc.M110.101527_bib50","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cell.2009.07.034","volume":"139","author":"Zid","year":"2009","journal-title":"Cell"},{"key":"10.1074\/jbc.M110.101527_bib51","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1124\/mol.107.043398","volume":"73","author":"King","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M110.101527_bib52","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/ng.337","volume":"41","author":"Yeger-Lotem","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M110.101527_bib53","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.1093\/hmg\/ddn276","volume":"17","author":"Liang","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M110.101527_bib54","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820542336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820542336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M110.101527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T23:34:24Z","timestamp":1711928064000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820542336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0021925820542336"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m110.101527","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}