{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:35:55Z","timestamp":1782941755323,"version":"3.54.5"},"reference-count":52,"publisher":"Elsevier BV","issue":"21","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":3786,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1074\/jbc.m110.101543","type":"journal-article","created":{"date-parts":[[2010,3,16]],"date-time":"2010-03-16T03:24:37Z","timestamp":1268709877000},"page":"15916-15922","source":"Crossref","is-referenced-by-count":19,"title":["Prodrug Activation by Cryptosporidium Thymidine Kinase"],"prefix":"10.1016","volume":"285","author":[{"given":"Xin E.","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Sharling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mani","family":"Muthalagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devaraja G.","family":"Mudeppa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof W.","family":"Pankiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Felczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradipsinh K.","family":"Rathod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Mead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Striepen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizbeth","family":"Hedstrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M110.101543_bib1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.gtc.2006.03.006","volume":"35","author":"Huang","year":"2006","journal-title":"Gastroenterol. Clin. North Am."},{"key":"10.1074\/jbc.M110.101543_bib2","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.watres.2003.10.012","volume":"38","author":"Carey","year":"2004","journal-title":"Water Res."},{"key":"10.1074\/jbc.M110.101543_bib3","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1056\/NEJM199503303321304","volume":"332","author":"DuPont","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M110.101543_bib4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S1368-7646(02)00011-0","volume":"5","author":"Mead","year":"2002","journal-title":"Drug Resist. Updat."},{"key":"10.1074\/jbc.M110.101543_bib5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1126\/science.1094786","volume":"304","author":"Abrahamsen","year":"2004","journal-title":"Science"},{"key":"10.1074\/jbc.M110.101543_bib6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.molbiopara.2009.05.005","volume":"167","author":"Sauvage","year":"2009","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M110.101543_bib7","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.bmcl.2008.11.054","volume":"19","author":"Martucci","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1074\/jbc.M110.101543_bib8","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1021\/jm061027h","volume":"50","author":"Pelphrey","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M110.101543_bib9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0166-6851(96)02647-3","volume":"79","author":"V\u00e1squez","year":"1996","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M110.101543_bib10","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1126\/science.1143837","volume":"317","author":"Morrison","year":"2007","journal-title":"Science"},{"key":"10.1074\/jbc.M110.101543_bib11","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nature03291","volume":"433","author":"Loftus","year":"2005","journal-title":"Nature"},{"key":"10.1074\/jbc.M110.101543_bib12","series-title":"Cryptosporidium and Cryptosporidiosis","first-page":"57","author":"Zhu","year":"2008"},{"key":"10.1074\/jbc.M110.101543_bib13","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1073\/pnas.0304686101","volume":"101","author":"Striepen","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.101543_bib14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.2174\/1389557043403963","volume":"4","author":"Al-Madhoun","year":"2004","journal-title":"Mini. Rev. Med. Chem."},{"key":"10.1074\/jbc.M110.101543_bib15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1574-6968.1998.tb13255.x","volume":"168","author":"Woods","year":"1998","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1074\/jbc.M110.101543_bib16","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0008-6215(00)00089-6","volume":"327","author":"Pankiewicz","year":"2000","journal-title":"Carbohydr. Res."},{"key":"10.1074\/jbc.M110.101543_bib17","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.1021\/jm000975u","volume":"43","author":"Felczak","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M110.101543_bib18","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.molbiopara.2006.10.016","volume":"151","author":"Mudeppa","year":"2007","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M110.101543_bib19","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1110\/ps.2460102","volume":"11","author":"Kokoris","year":"2002","journal-title":"Protein Sci."},{"key":"10.1074\/jbc.M110.101543_bib20","first-page":"495","volume":"69","author":"Tung","year":"1996","journal-title":"Yale J. Biol. Med."},{"key":"10.1074\/jbc.M110.101543_bib21","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S0076-6879(78)51047-1","volume":"51","author":"Chen","year":"1978","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M110.101543_bib22","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0003-2697(63)90071-X","volume":"5","author":"Furlong","year":"1963","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M110.101543_bib23","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1006\/abio.2001.5191","volume":"295","author":"Schelling","year":"2001","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M110.101543_bib24","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.chembiol.2007.12.010","volume":"15","author":"Umejiego","year":"2008","journal-title":"Chem. Biol."},{"key":"10.1074\/jbc.M110.101543_bib25","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.1128\/AAC.49.11.4437-4442.2005","volume":"49","author":"Cai","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M110.101543_bib26","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1645\/0022-3395(2002)088[1014:STCPII]2.0.CO;2","volume":"88","author":"Campbell","year":"2002","journal-title":"J. Parasitol."},{"key":"10.1074\/jbc.M110.101543_bib27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1365-3024.2005.00736.x","volume":"27","author":"Ehigiator","year":"2005","journal-title":"Parasite Immunol."},{"key":"10.1074\/jbc.M110.101543_bib28","doi-asserted-by":"crossref","first-page":"89S","DOI":"10.1111\/j.1550-7408.1996.tb05015.x","volume":"43","author":"Arrowood","year":"1996","journal-title":"J. Eukaryot. Microbiol."},{"key":"10.1074\/jbc.M110.101543_bib29","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2307\/3283822","volume":"81","author":"Arrowood","year":"1995","journal-title":"J. Parasitol."},{"key":"10.1074\/jbc.M110.101543_bib30","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/sj.bjc.6600808","volume":"88","author":"de Bruin","year":"2003","journal-title":"Br. J. Cancer"},{"key":"10.1074\/jbc.M110.101543_bib31","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.molbiopara.2006.06.001","volume":"149","author":"Galazka","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1074\/jbc.M110.101543_bib32","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s11103-006-9101-3","volume":"63","author":"Islam","year":"2007","journal-title":"Plant Mol. Biol."},{"key":"10.1074\/jbc.M110.101543_bib33","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2174\/1389557043403981","volume":"4","author":"Lavie","year":"2004","journal-title":"Mini. Rev. Med. Chem."},{"key":"10.1074\/jbc.M110.101543_bib34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0065-2571(94)00014-T","volume":"35","author":"Munch-Petersen","year":"1995","journal-title":"Adv. Enzyme Regul."},{"key":"10.1074\/jbc.M110.101543_bib35","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.pep.2006.01.001","volume":"47","author":"Birringer","year":"2006","journal-title":"Protein Expr. Purif."},{"key":"10.1074\/jbc.M110.101543_bib36","first-page":"1435","volume":"28","author":"Shields","year":"1987","journal-title":"J. Nucl. Med."},{"key":"10.1074\/jbc.M110.101543_bib37","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0163-7258(95)00015-9","volume":"67","author":"Arn\u00e9r","year":"1995","journal-title":"Pharmacol. Ther."},{"key":"10.1074\/jbc.M110.101543_bib38","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0021-9258(18)51778-6","volume":"239","author":"Okazaki","year":"1964","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.101543_bib39","doi-asserted-by":"crossref","first-page":"15621","DOI":"10.1016\/S0021-9258(18)82301-8","volume":"268","author":"Munch-Petersen","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.101543_bib40","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0022-2836(67)90186-6","volume":"29","author":"Iwatsuki","year":"1967","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M110.101543_bib41","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1080\/15257770600894410","volume":"25","author":"Skovgaard","year":"2006","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10.1074\/jbc.M110.101543_bib42","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/med.20124","volume":"28","author":"P\u00e9rez-P\u00e9rez","year":"2008","journal-title":"Med. Res. Rev."},{"key":"10.1074\/jbc.M110.101543_bib43","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1128\/AAC.44.4.859-866.2000","volume":"44","author":"Markland","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M110.101543_bib44","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S0006-2952(00)00253-7","volume":"59","author":"Fukushima","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"10.1074\/jbc.M110.101543_bib45","first-page":"449","volume":"27","author":"Emura","year":"2005","journal-title":"Int. J. Oncol."},{"key":"10.1074\/jbc.M110.101543_bib46","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/j.1349-7006.2007.00477.x","volume":"98","author":"Temmink","year":"2007","journal-title":"Cancer Sci."},{"key":"10.1074\/jbc.M110.101543_bib47","first-page":"249","volume":"13","author":"Emura","year":"2004","journal-title":"Int. J. Mol. Med."},{"key":"10.1074\/jbc.M110.101543_bib48","first-page":"45","volume":"3","author":"Yin","year":"1991","journal-title":"Cancer Commun."},{"key":"10.1074\/jbc.M110.101543_bib49","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0163-7258(81)90068-1","volume":"13","author":"Danenberg","year":"1981","journal-title":"Pharmacol. Ther."},{"key":"10.1074\/jbc.M110.101543_bib50","doi-asserted-by":"crossref","first-page":"15086","DOI":"10.1021\/bi00254a018","volume":"33","author":"Eckstein","year":"1994","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M110.101543_bib51","doi-asserted-by":"crossref","first-page":"18314","DOI":"10.1074\/jbc.M400009200","volume":"279","author":"Atreya","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.101543_bib52","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1007\/s00436-007-0701-x","volume":"101","author":"Benitez","year":"2007","journal-title":"Parasitol. Res."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820494037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820494037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M110.101543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T18:10:51Z","timestamp":1641319851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820494037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":52,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0021925820494037"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m110.101543","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}