{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:26:30Z","timestamp":1790979990763,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"29","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":3728,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1074\/jbc.m110.108514","type":"journal-article","created":{"date-parts":[[2010,5,7]],"date-time":"2010-05-07T20:13:16Z","timestamp":1273263196000},"page":"22403-22413","source":"Crossref","is-referenced-by-count":193,"title":["Impaired de Novo Choline Synthesis Explains Why Phosphatidylethanolamine N-Methyltransferase-deficient Mice Are Protected from Diet-induced Obesity"],"prefix":"10.1016","volume":"285","author":[{"given":"Ren\u00e9 L.","family":"Jacobs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debby P.Y.","family":"Koonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torunn","family":"Sletten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Lingrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Peake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Shang","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer D.","family":"Proctor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian P.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason R.B.","family":"Dyck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis E.","family":"Vance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M110.108514_bib1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.biochem.75.103004.142512","volume":"75","author":"Muoio","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M110.108514_bib2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.cmet.2005.03.001","volume":"1","author":"Kalaany","year":"2005","journal-title":"Cell Metab."},{"key":"10.1074\/jbc.M110.108514_bib3","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1053\/j.gastro.2006.02.012","volume":"130","author":"Hubbard","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1074\/jbc.M110.108514_bib4","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.cell.2007.08.047","volume":"131","author":"Pospisilik","year":"2007","journal-title":"Cell"},{"key":"10.1074\/jbc.M110.108514_bib5","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1126\/science.1126010","volume":"312","author":"Uno","year":"2006","journal-title":"Science"},{"key":"10.1074\/jbc.M110.108514_bib6","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nm995","volume":"10","author":"An","year":"2004","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M110.108514_bib7","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1073\/pnas.0707849104","volume":"105","author":"Wunderlich","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.108514_bib8","doi-asserted-by":"crossref","first-page":"33237","DOI":"10.1074\/jbc.R700028200","volume":"282","author":"Vance","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.108514_bib9","doi-asserted-by":"crossref","first-page":"29683","DOI":"10.1074\/jbc.274.42.29683","volume":"274","author":"DeLong","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.108514_bib10","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1096\/fasebj.5.7.2010061","volume":"5","author":"Zeisel","year":"1991","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M110.108514_bib11","series-title":"Biochemsitry of Lipids, Lipoproteins and Membranes","first-page":"213","author":"Vance","year":"2008"},{"key":"10.1074\/jbc.M110.108514_bib12","doi-asserted-by":"crossref","first-page":"13146","DOI":"10.1074\/jbc.272.20.13146","volume":"272","author":"Tang","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.108514_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1388-1981(03)00067-2","volume":"1633","author":"Karim","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M110.108514_bib14","doi-asserted-by":"crossref","first-page":"12880","DOI":"10.1073\/pnas.94.24.12880","volume":"94","author":"Walkey","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.108514_bib15","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/hep.510300305","volume":"30","author":"Agellon","year":"1999","journal-title":"Hepatology"},{"key":"10.1074\/jbc.M110.108514_bib16","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1194\/jlr.M700278-JLR200","volume":"48","author":"Verkade","year":"2007","journal-title":"J. Lipid Res."},{"key":"10.1074\/jbc.M110.108514_bib17","doi-asserted-by":"crossref","first-page":"42358","DOI":"10.1074\/jbc.M204542200","volume":"277","author":"Noga","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.108514_bib18","doi-asserted-by":"crossref","first-page":"21851","DOI":"10.1074\/jbc.M301982200","volume":"278","author":"Noga","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.108514_bib19","doi-asserted-by":"crossref","first-page":"35496","DOI":"10.1074\/jbc.M807433200","volume":"283","author":"Robichaud","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.108514_bib20","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1161\/ATVBAHA.109.188672","volume":"29","author":"Zhao","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1074\/jbc.M110.108514_bib21","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1194\/jlr.M800042-JLR200","volume":"49","author":"Rinella","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1074\/jbc.M110.108514_bib22","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jhep.2003.09.020","volume":"40","author":"Rinella","year":"2004","journal-title":"J. Hepatol."},{"key":"10.1074\/jbc.M110.108514_bib23","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1194\/jlr.M600198-JLR200","volume":"47","author":"Rizki","year":"2006","journal-title":"J. Lipid Res."},{"key":"10.1074\/jbc.M110.108514_bib24","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1126\/science.1071527","volume":"297","author":"Cohen","year":"2002","journal-title":"Science"},{"key":"10.1074\/jbc.M110.108514_bib25","doi-asserted-by":"crossref","first-page":"23356","DOI":"10.1074\/jbc.M502436200","volume":"280","author":"Dobrzyn","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.108514_bib26","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/BF02260773","volume":"28","author":"Kuksis","year":"1989","journal-title":"Adv. Chromatogr."},{"key":"10.1074\/jbc.M110.108514_bib27","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1161\/01.RES.0000129255.19569.8f","volume":"94","author":"Dyck","year":"2004","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M110.108514_bib28","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1074\/jbc.M706628200","volume":"283","author":"Jacobs","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.108514_bib29","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.bbalip.2004.09.003","volume":"1686","author":"Liebisch","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M110.108514_bib30","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.bbalip.2007.05.007","volume":"1771","author":"Li","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M110.108514_bib31","doi-asserted-by":"crossref","first-page":"10048","DOI":"10.1074\/jbc.M708151200","volume":"283","author":"Chen","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.108514_bib32","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2337\/db08-1644","volume":"58","author":"Ahmadian","year":"2009","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M110.108514_bib33","doi-asserted-by":"crossref","first-page":"47402","DOI":"10.1074\/jbc.M404027200","volume":"279","author":"Jacobs","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.108514_bib34","doi-asserted-by":"crossref","first-page":"28299","DOI":"10.1074\/jbc.M501971200","volume":"280","author":"Jacobs","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.108514_bib35","doi-asserted-by":"crossref","first-page":"R182","DOI":"10.1152\/ajpregu.00406.2004","volume":"288","author":"Delgado-Reyes","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1074\/jbc.M110.108514_bib36","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1515\/CCLM.2005.187","volume":"43","author":"Ueland","year":"2005","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1074\/jbc.M110.108514_bib37","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1042\/bj1960261","volume":"196","author":"Pritchard","year":"1981","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M110.108514_bib38","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.bbrc.2008.02.003","volume":"368","author":"Kim","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M110.108514_bib39","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1111\/j.1572-0241.2001.04129.x","volume":"96","author":"Abdelmalek","year":"2001","journal-title":"Am. J. Gastroenterol."},{"key":"10.1074\/jbc.M110.108514_bib40","doi-asserted-by":"crossref","first-page":"G894","DOI":"10.1152\/ajpgi.00133.2007","volume":"293","author":"Song","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1074\/jbc.M110.108514_bib41","doi-asserted-by":"crossref","first-page":"e100","DOI":"10.1016\/j.atherosclerosis.2007.06.030","volume":"195","author":"Schwahn","year":"2007","journal-title":"Atherosclerosis"},{"key":"10.1074\/jbc.M110.108514_bib42","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1016\/S0021-9258(18)69166-5","volume":"263","author":"Yao","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.108514_bib43","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1111\/j.1440-1746.2006.04701.x","volume":"22","author":"Vetel\u00e4inen","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1074\/jbc.M110.108514_bib44","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/labinvest.3700489","volume":"87","author":"Leclercq","year":"2007","journal-title":"Lab. Invest."},{"key":"10.1074\/jbc.M110.108514_bib45","doi-asserted-by":"crossref","first-page":"9887","DOI":"10.1074\/jbc.M410310200","volume":"280","author":"Schattenberg","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.108514_bib46","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cmet.2007.05.005","volume":"6","author":"Monetti","year":"2007","journal-title":"Cell Metab."},{"key":"10.1074\/jbc.M110.108514_bib47","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/hep.20783","volume":"42","author":"Yu","year":"2005","journal-title":"Hepatology"},{"key":"10.1074\/jbc.M110.108514_bib48","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.2337\/db06-0097","volume":"55","author":"Raubenheimer","year":"2006","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M110.108514_bib49","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0197-0186(97)00127-7","volume":"32","author":"Klein","year":"1998","journal-title":"Neurochem. Int."},{"key":"10.1074\/jbc.M110.108514_bib50","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.neuint.2007.10.008","volume":"52","author":"Hartmann","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1074\/jbc.M110.108514_bib51","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/S0022-3565(24)36957-5","volume":"282","author":"K\u00f6ppen","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1074\/jbc.M110.108514_bib52","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1126\/science.1251187","volume":"191","author":"Cohen","year":"1976","journal-title":"Science"},{"key":"10.1074\/jbc.M110.108514_bib53","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cmet.2006.09.008","volume":"4","author":"Gautam","year":"2006","journal-title":"Cell Metab."},{"key":"10.1074\/jbc.M110.108514_bib54","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.cmet.2006.12.010","volume":"5","author":"Bernal-Mizrachi","year":"2007","journal-title":"Cell Metab."},{"key":"10.1074\/jbc.M110.108514_bib55","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ejphar.2008.05.017","volume":"589","author":"Cansev","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1074\/jbc.M110.108514_bib56","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1046\/j.1432-1033.2003.03472.x","volume":"270","author":"Ilcol","year":"2003","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M110.108514_bib57","first-page":"1399","volume":"22","author":"Buchman","year":"1995","journal-title":"Hepatology"},{"key":"10.1074\/jbc.M110.108514_bib58","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1096\/fj.06-5734com","volume":"20","author":"da Costa","year":"2006","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M110.108514_bib59","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1096\/fj.04-3580com","volume":"19","author":"Song","year":"2005","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M110.108514_bib60","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1093\/jn\/138.5.914","volume":"138","author":"Konstantinova","year":"2008","journal-title":"J. Nutr."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820602769?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820602769?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M110.108514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T13:19:39Z","timestamp":1740057579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820602769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":60,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0021925820602769"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m110.108514","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}