{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:47:15Z","timestamp":1791175635915,"version":"4.1.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"27","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T00:00:00Z","timestamp":1599868800000},"content-version":"vor","delay-in-days":3726,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1074\/jbc.m110.119628","type":"journal-article","created":{"date-parts":[[2010,4,29]],"date-time":"2010-04-29T00:18:00Z","timestamp":1272500280000},"page":"20481-20491","source":"Crossref","is-referenced-by-count":21,"title":["Valproate Treatment of Human Cord Blood CD4-positive Effector T Cells Confers on Them the Molecular Profile (MicroRNA Signature and FOXP3 Expression) of Natural Regulatory CD4-positive Cells through Inhibition of Histone Deacetylase"],"prefix":"10.1016","volume":"285","author":[{"given":"Hussein","family":"Fayyad-Kazan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Redouane","family":"Rouas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makram","family":"Merimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil","family":"El Zein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lewalle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Jebbawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Mourtada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Badran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Ezzeddine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Salaun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ars\u00e8ne","family":"Burny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Martiat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassam","family":"Badran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M110.119628_bib1","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.jaci.2005.08.047","volume":"116","author":"Chatila","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1074\/jbc.M110.119628_bib2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jaci.2007.06.023","volume":"120","author":"Bacchetta","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1074\/jbc.M110.119628_bib3","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ni1455","volume":"8","author":"Zheng","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1074\/jbc.M110.119628_bib4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.0105-2896.2006.00427.x","volume":"212","author":"Sakaguchi","year":"2006","journal-title":"Immunol. Rev."},{"key":"10.1074\/jbc.M110.119628_bib5","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/art.22272","volume":"56","author":"Nguyen","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1074\/jbc.M110.119628_bib6","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jaci.2005.10.040","volume":"117","author":"Verhagen","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1074\/jbc.M110.119628_bib7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1365-2567.2005.02317.x","volume":"117","author":"Dejaco","year":"2006","journal-title":"Immunology"},{"key":"10.1074\/jbc.M110.119628_bib8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1365-2982.2006.00878.x","volume":"19","author":"Holm\u00e9n","year":"2007","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1074\/jbc.M110.119628_bib9","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4049\/jimmunol.174.1.164","volume":"174","author":"Sugiyama","year":"2005","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M110.119628_bib10","doi-asserted-by":"crossref","first-page":"660","DOI":"10.3324\/haematol.2009.015818","volume":"95","author":"Pidala","year":"2010","journal-title":"Haematologica"},{"key":"10.1074\/jbc.M110.119628_bib11","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.immuni.2006.08.003","volume":"25","author":"Shevach","year":"2006","journal-title":"Immunity."},{"key":"10.1074\/jbc.M110.119628_bib12","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.coi.2005.09.002","volume":"17","author":"Bluestone","year":"2005","journal-title":"Curr. Opin. Immunol."},{"key":"10.1074\/jbc.M110.119628_bib13","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.femsim.2004.10.017","volume":"44","author":"Raghavan","year":"2005","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1074\/jbc.M110.119628_bib14","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.4049\/jimmunol.172.9.5213","volume":"172","author":"Zheng","year":"2004","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M110.119628_bib15","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/intimm\/dxh126","volume":"16","author":"Schramm","year":"2004","journal-title":"Int. Immunol."},{"key":"10.1074\/jbc.M110.119628_bib16","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1093\/intimm\/dxh123","volume":"16","author":"Park","year":"2004","journal-title":"Int. Immunol."},{"key":"10.1074\/jbc.M110.119628_bib17","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.4049\/jimmunol.172.9.5149","volume":"172","author":"Fantini","year":"2004","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M110.119628_bib18","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1084\/jem.20030152","volume":"198","author":"Chen","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M110.119628_bib19","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1146\/annurev.immunol.24.021605.090547","volume":"24","author":"Ziegler","year":"2006","journal-title":"Annu. Rev. Immunol."},{"key":"10.1074\/jbc.M110.119628_bib20","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","volume":"4","author":"Fontenot","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1074\/jbc.M110.119628_bib21","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"10.1074\/jbc.M110.119628_bib22","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/38664","volume":"389","author":"Grunstein","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M110.119628_bib23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/47412","volume":"403","author":"Strahl","year":"2000","journal-title":"Nature"},{"key":"10.1074\/jbc.M110.119628_bib24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev.biochem.70.1.81","volume":"70","author":"Roth","year":"2001","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M110.119628_bib25","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1124\/mol.105.014167","volume":"68","author":"Acharya","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M110.119628_bib26","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.nbd.2007.03.008","volume":"26","author":"Gensert","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1074\/jbc.M110.119628_bib27","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1749-6632.1999.tb09416.x","volume":"886","author":"Kim","year":"1999","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1074\/jbc.M110.119628_bib28","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1002\/1097-0215(20001215)88:6<992::AID-IJC24>3.0.CO;2-9","volume":"88","author":"Suzuki","year":"2000","journal-title":"Int. J. Cancer"},{"key":"10.1074\/jbc.M110.119628_bib29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1006\/excr.1994.1248","volume":"214","author":"Hoshikawa","year":"1994","journal-title":"Exp. Cell Res."},{"key":"10.1074\/jbc.M110.119628_bib30","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/sj.bjc.6690493","volume":"80","author":"Qiu","year":"1999","journal-title":"Br. J. Cancer"},{"key":"10.1074\/jbc.M110.119628_bib31","first-page":"8492","volume":"61","author":"Munster","year":"2001","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M110.119628_bib32","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1093\/jnci\/92.15.1210","volume":"92","author":"Marks","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1074\/jbc.M110.119628_bib33","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0168-8278(01)00257-4","volume":"36","author":"Herold","year":"2002","journal-title":"J. Hepatol."},{"key":"10.1074\/jbc.M110.119628_bib34","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ijc.10699","volume":"103","author":"Yamashita","year":"2003","journal-title":"Int. J. Cancer"},{"key":"10.1074\/jbc.M110.119628_bib35","doi-asserted-by":"crossref","first-page":"s175","DOI":"10.2741\/1027","volume":"8","author":"Costello","year":"2003","journal-title":"Front. Biosci."},{"key":"10.1074\/jbc.M110.119628_bib36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.exphem.2004.09.008","volume":"33","author":"Sakajiri","year":"2005","journal-title":"Exp. Hematol."},{"key":"10.1074\/jbc.M110.119628_bib37","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/carcin\/bgi209","volume":"27","author":"Drucker","year":"2006","journal-title":"Carcinogenesis"},{"key":"10.1074\/jbc.M110.119628_bib38","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.4049\/jimmunol.176.6.3593","volume":"176","author":"Mantel","year":"2006","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M110.119628_bib39","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cellimm.2009.03.004","volume":"257","author":"Lucas","year":"2009","journal-title":"Cell. Immunol."},{"key":"10.1074\/jbc.M110.119628_bib40","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1097\/00001813-199711000-00007","volume":"8","author":"Cinatl","year":"1997","journal-title":"Anticancer Drugs"},{"key":"10.1074\/jbc.M110.119628_bib41","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.mce.2003.10.032","volume":"213","author":"Olsen","year":"2004","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1074\/jbc.M110.119628_bib42","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/sj.leu.2403390","volume":"18","author":"Tang","year":"2004","journal-title":"Leukemia"},{"key":"10.1074\/jbc.M110.119628_bib43","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","volume":"20","author":"G\u00f6ttlicher","year":"2001","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M110.119628_bib44","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","volume":"276","author":"Phiel","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.119628_bib45","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1158\/0008-5472.CAN-03-0799","volume":"64","author":"Gurvich","year":"2004","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M110.119628_bib46","doi-asserted-by":"crossref","first-page":"27586","DOI":"10.1074\/jbc.M303740200","volume":"278","author":"Detich","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.119628_bib47","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1158\/0008-5472.CAN-04-2478","volume":"65","author":"Marchion","year":"2005","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M110.119628_bib48","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0893-133X(99)00072-X","volume":"22","author":"Sands","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1074\/jbc.M110.119628_bib49","doi-asserted-by":"crossref","first-page":"17785","DOI":"10.1074\/jbc.M209430200","volume":"278","author":"Arinze","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.119628_bib50","doi-asserted-by":"crossref","first-page":"10309","DOI":"10.1073\/pnas.0504248102","volume":"102","author":"Achachi","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"Suppl. 2","key":"10.1074\/jbc.M110.119628_bib51","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1528-1167.2008.02005.x","volume":"50","author":"Temkin","year":"2009","journal-title":"Epilepsia"},{"key":"10.1074\/jbc.M110.119628_bib52","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1002\/eji.200838509","volume":"39","author":"Rouas","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"10.1074\/jbc.M110.119628_bib53","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1084\/jem.20061692","volume":"203","author":"Cobb","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M110.119628_bib54","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1089\/104303402320987888","volume":"13","author":"Abbas-Terki","year":"2002","journal-title":"Hum. Gene Ther."},{"key":"10.1074\/jbc.M110.119628_bib55","doi-asserted-by":"crossref","first-page":"e1612","DOI":"10.1371\/journal.pone.0001612","volume":"3","author":"Janson","year":"2008","journal-title":"PLoS. One."},{"key":"10.1074\/jbc.M110.119628_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-230X(08)60738-1","volume":"75","author":"Graves","year":"1998","journal-title":"Adv. Cancer Res."},{"key":"10.1074\/jbc.M110.119628_bib57","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.matbio.2005.04.001","volume":"24","author":"Colter","year":"2005","journal-title":"Matrix Biol."},{"key":"10.1074\/jbc.M110.119628_bib58","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/30764","volume":"393","author":"Nan","year":"1998","journal-title":"Nature"},{"key":"10.1074\/jbc.M110.119628_bib59","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nm1652","volume":"13","author":"Tao","year":"2007","journal-title":"Nat. Med."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820573316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820573316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M110.119628","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T03:16:01Z","timestamp":1641352561000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820573316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":59,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0021925820573316"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m110.119628","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}