{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:21:57Z","timestamp":1791328917228,"version":"4.3.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"39","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T00:00:00Z","timestamp":1603584000000},"content-version":"vor","delay-in-days":3707,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1074\/jbc.m110.131342","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T00:23:27Z","timestamp":1279844607000},"page":"29932-29940","source":"Crossref","is-referenced-by-count":182,"title":["A New Mode of Mineralocorticoid Receptor Antagonism by a Potent and Selective Nonsteroidal Molecule"],"prefix":"10.1016","volume":"285","author":[{"given":"J\u00e9r\u00f4me","family":"Fagart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Hillisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Huyet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"B\u00e4rfacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Fay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Pleiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Pook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Edith","family":"Rafestin-Oblin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kolkhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M110.131342_bib1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1161\/01.HYP.19.3.221","volume":"19","author":"Horisberger","year":"1992","journal-title":"Hypertension"},{"key":"10.1074\/jbc.M110.131342_bib2","first-page":"S49","volume":"65","author":"Bonvalet","year":"1998","journal-title":"Kidney Int. Suppl."},{"key":"10.1074\/jbc.M110.131342_bib3","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.3283939","volume":"240","author":"Evans","year":"1988","journal-title":"Science"},{"key":"10.1074\/jbc.M110.131342_bib4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/966","volume":"19","author":"Geller","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M110.131342_bib5","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1210\/me.2003-0408","volume":"18","author":"Sartorato","year":"2004","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M110.131342_bib6","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1681\/ASN.2005111188","volume":"17","author":"Geller","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1074\/jbc.M110.131342_bib7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/humu.20371","volume":"28","author":"Pujo","year":"2007","journal-title":"Hum. Mutat."},{"key":"10.1074\/jbc.M110.131342_bib8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1126\/science.289.5476.119","volume":"289","author":"Geller","year":"2000","journal-title":"Science"},{"key":"10.1074\/jbc.M110.131342_bib9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0008-6363(99)00088-7","volume":"43","author":"Delcayre","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1074\/jbc.M110.131342_bib10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jsbmb.2004.12.010","volume":"93","author":"Funder","year":"2005","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1074\/jbc.M110.131342_bib11","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1126\/science.126.3281.1015","volume":"126","author":"Kagawa","year":"1957","journal-title":"Science"},{"key":"10.1074\/jbc.M110.131342_bib12","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1126\/science.126.3281.1016","volume":"126","author":"Liddle","year":"1957","journal-title":"Science"},{"key":"10.1074\/jbc.M110.131342_bib13","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S0022-3565(25)22580-0","volume":"240","author":"de Gasparo","year":"1987","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1074\/jbc.M110.131342_bib14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0022-4731(89)90169-6","volume":"32","author":"de Gasparo","year":"1989","journal-title":"J. Steroid Biochem."},{"key":"10.1074\/jbc.M110.131342_bib15","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/0002-9149(87)91030-7","volume":"60","author":"Jeunemaitre","year":"1987","journal-title":"Am. J. Cardiol."},{"key":"10.1074\/jbc.M110.131342_bib16","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2165\/00129784-200505010-00007","volume":"5","author":"Croom","year":"2005","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"10.1074\/jbc.M110.131342_bib17","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","volume":"341","author":"Pitt","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M110.131342_bib18","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJMoa030207","volume":"348","author":"Pitt","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M110.131342_bib19","first-page":"691","volume":"5","author":"Corvol","year":"1976","journal-title":"Nouv. Presse Med."},{"key":"10.1074\/jbc.M110.131342_bib20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.mce.2003.10.005","volume":"217","author":"Garthwaite","year":"2004","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1074\/jbc.M110.131342_bib21","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0895-7061(02)02957-6","volume":"15","author":"Weinberger","year":"2002","journal-title":"Am. J. Hypertens."},{"key":"10.1074\/jbc.M110.131342_bib22","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1210\/me.2004-0537","volume":"19","author":"Hultman","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M110.131342_bib23","series-title":"Nuclear Receptors as Drug Targets","first-page":"409","author":"Kolkhof","year":"2008"},{"key":"10.1074\/jbc.M110.131342_bib24","first-page":"407","volume":"31","author":"Meyer","year":"1981","journal-title":"Arzneimittelforschung"},{"key":"10.1074\/jbc.M110.131342_bib25","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1093\/emboj\/17.12.3317","volume":"17","author":"Fagart","year":"1998","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M110.131342_bib26","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1124\/mol.58.4.684","volume":"58","author":"Auzou","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M110.131342_bib27","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1124\/mol.104.010710","volume":"67","author":"Fagart","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M110.131342_bib28","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nsmb939","volume":"12","author":"Fagart","year":"2005","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1074\/jbc.M110.131342_bib29","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1093\/nar\/19.7.1563","volume":"19","author":"Gouilleux","year":"1991","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M110.131342_bib30","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1124\/mol.107.036459","volume":"72","author":"Huyet","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M110.131342_bib31","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.vascn.2008.01.002","volume":"57","author":"Brandish","year":"2008","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1074\/jbc.M110.131342_bib32","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0014-5793(78)80197-5","volume":"88","author":"Claire","year":"1978","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M110.131342_bib33","unstructured":"Kuhl, A., Kolkhof, P., Heckroth, H., Schlemmer, K. H., Flamme, I., Perez, S. F., Gielen-Haertwig, H., Grosser, R., Erg\u00fcden, J. K., Lang, D., (2007) 4-CHROMENONYL-l,4-DIHYDROPYRIDINES AND THEIR USE. WO2007\/025604."},{"key":"10.1074\/jbc.M110.131342_bib34","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1097\/00004872-200409000-00002","volume":"22","author":"Meredith","year":"2004","journal-title":"J. Hypertens."},{"key":"10.1074\/jbc.M110.131342_bib35","doi-asserted-by":"crossref","first-page":"31283","DOI":"10.1074\/jbc.M504098200","volume":"280","author":"Bledsoe","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.131342_bib36","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.molcel.2005.06.026","volume":"19","author":"Li","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M110.131342_bib37","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jsbmb.2008.03.018","volume":"109","author":"Zhang","year":"2008","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1074\/jbc.M110.131342_bib38","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1210\/mend.12.6.0119","volume":"12","author":"Couette","year":"1998","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M110.131342_bib39","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1161\/HYPERTENSIONAHA.107.103580","volume":"51","author":"Dietz","year":"2008","journal-title":"Hypertension"},{"key":"10.1074\/jbc.M110.131342_bib40","first-page":"359","volume":"9","author":"Shiau","year":"2002","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.M110.131342_bib41","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1021\/jm0495879","volume":"48","author":"S\u00f6derholm","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M110.131342_bib42","doi-asserted-by":"crossref","first-page":"6201","DOI":"10.1073\/pnas.0500381102","volume":"102","author":"Bohl","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.131342_bib43","doi-asserted-by":"crossref","first-page":"37747","DOI":"10.1074\/jbc.M507464200","volume":"280","author":"Bohl","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.131342_bib44","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/ncpendmet0016","volume":"1","author":"Funder","year":"2005","journal-title":"Nat. Clin. Pract. Endocrinol. Metab."},{"key":"10.1074\/jbc.M110.131342_bib45","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1107\/S0907444993011333","volume":"50","author":"Kleywegt","year":"1994","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M110.131342_bib46","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1016\/0024-3205(82)90293-4","volume":"30","author":"Ehlert","year":"1982","journal-title":"Life Sci."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819890294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819890294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M110.131342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T07:41:51Z","timestamp":1740296511000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819890294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":46,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0021925819890294"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m110.131342","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}