{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:57:03Z","timestamp":1791255423973,"version":"4.1.0"},"reference-count":81,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":3510,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1074\/jbc.m110.154799","type":"journal-article","created":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T20:14:07Z","timestamp":1291148047000},"page":"3681-3692","source":"Crossref","is-referenced-by-count":100,"title":["Interferon Antagonist NSs of La Crosse Virus Triggers a DNA Damage Response-like Degradation of Transcribing RNA Polymerase II"],"prefix":"10.1016","volume":"286","author":[{"given":"Paul","family":"Verbruggen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Ruf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gjon","family":"Blakqori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna K.","family":"\u00d6verby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Heidemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Eick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedemann","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M110.154799_bib1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1056\/NEJM200103153441103","volume":"344","author":"McJunkin","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M110.154799_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/088307389901400101","volume":"14","author":"Rust","year":"1999","journal-title":"J. Child Neurol."},{"key":"10.1074\/jbc.M110.154799_bib3","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(02)07681-X","volume":"359","author":"Whitley","year":"2002","journal-title":"Lancet"},{"key":"10.1074\/jbc.M110.154799_bib4","author":"Centers for Disease Control and Prevention","year":"2005","journal-title":"Confirmed and Probable California Serogroup Viral (Mainly La Crosse) Encephalitis Cases, Human, United States, 1964\u20132005, by State"},{"key":"10.1074\/jbc.M110.154799_bib5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0891-5520(05)70410-4","volume":"12","author":"McJunkin","year":"1998","journal-title":"Infect. Dis. Clin. North. Am."},{"key":"10.1074\/jbc.M110.154799_bib6","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3201\/eid1605.100170","volume":"16","author":"Lambert","year":"2010","journal-title":"Emerg. Infect. Dis."},{"key":"10.1074\/jbc.M110.154799_bib7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S1286-4579(02)01547-2","volume":"4","author":"Borucki","year":"2002","journal-title":"Microbes Infect."},{"key":"10.1074\/jbc.M110.154799_bib8","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.3390\/v1031003","volume":"1","author":"Elliott","year":"2009","journal-title":"Viruses"},{"key":"10.1074\/jbc.M110.154799_bib9","doi-asserted-by":"crossref","first-page":"10420","DOI":"10.1128\/JVI.79.16.10420-10428.2005","volume":"79","author":"Blakqori","year":"2005","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M110.154799_bib10","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.1128\/JVI.01933-06","volume":"81","author":"Blakqori","year":"2007","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M110.154799_bib11","doi-asserted-by":"crossref","first-page":"7835","DOI":"10.1073\/pnas.0602460103","volume":"103","author":"Delhaye","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.154799_bib12","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.4049\/jimmunol.0804277","volume":"183","author":"Lienenklaus","year":"2009","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M110.154799_bib13","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1128\/CMR.14.4.778-809.2001","volume":"14","author":"Samuel","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1074\/jbc.M110.154799_bib14","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.immuni.2007.08.012","volume":"27","author":"Pichlmair","year":"2007","journal-title":"Immunity"},{"key":"10.1074\/jbc.M110.154799_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1099\/vir.0.83391-0","volume":"89","author":"Randall","year":"2008","journal-title":"J. Gen. Virol."},{"key":"10.1074\/jbc.M110.154799_bib16","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1600-065X.2008.00727.x","volume":"227","author":"Yoneyama","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1074\/jbc.M110.154799_bib17","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1084\/jem.20080091","volume":"205","author":"Kato","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M110.154799_bib18","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1126\/science.1132998","volume":"314","author":"Pichlmair","year":"2006","journal-title":"Science"},{"key":"10.1074\/jbc.M110.154799_bib19","doi-asserted-by":"crossref","first-page":"10761","DOI":"10.1128\/JVI.00770-09","volume":"83","author":"Pichlmair","year":"2009","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M110.154799_bib20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.immuni.2009.05.008","volume":"31","author":"Schlee","year":"2009","journal-title":"Immunity"},{"key":"10.1074\/jbc.M110.154799_bib21","doi-asserted-by":"crossref","first-page":"12067","DOI":"10.1073\/pnas.0900971106","volume":"106","author":"Schmidt","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.154799_bib22","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cytogfr.2007.06.002","volume":"18","author":"Hiscott","year":"2007","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1074\/jbc.M110.154799_bib23","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0092-8674(04)00132-1","volume":"116","author":"Le May","year":"2004","journal-title":"Cell"},{"key":"10.1074\/jbc.M110.154799_bib24","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1371\/journal.ppat.0040013","volume":"4","author":"Le May","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1074\/jbc.M110.154799_bib25","doi-asserted-by":"crossref","first-page":"31471","DOI":"10.1074\/jbc.M400938200","volume":"279","author":"Thomas","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.154799_bib26","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1128\/JVI.73.1.251-259.1999","volume":"73","author":"Buchholz","year":"1999","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M110.154799_bib27","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1101\/gad.6.3.426","volume":"6","author":"Peterson","year":"1992","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M110.154799_bib28","doi-asserted-by":"crossref","first-page":"789","DOI":"10.2144\/00284pf01","volume":"28","author":"Hernan","year":"2000","journal-title":"Biotechniques"},{"key":"10.1074\/jbc.M110.154799_bib29","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1099\/vir.0.18876-0","volume":"84","author":"Blakqori","year":"2003","journal-title":"J. Gen. Virol."},{"key":"10.1074\/jbc.M110.154799_bib30","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/emboj\/17.4.1087","volume":"17","author":"Yoneyama","year":"1998","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M110.154799_bib31","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1046\/j.1365-2443.2001.00426.x","volume":"6","author":"Iwamura","year":"2001","journal-title":"Genes Cells"},{"key":"10.1074\/jbc.M110.154799_bib32","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1128\/MCB.23.6.1961-1967.2003","volume":"23","author":"Cheng","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M110.154799_bib33","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1074\/jbc.M110.154799_bib34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1083\/jcb.122.2.283","volume":"122","author":"Wansink","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M110.154799_bib35","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1515\/bchm3.1995.376.8.473","volume":"376","author":"Kontermann","year":"1995","journal-title":"Biol. Chem. Hoppe-Seyler"},{"key":"10.1074\/jbc.M110.154799_bib36","doi-asserted-by":"crossref","first-page":"e2032","DOI":"10.1371\/journal.pone.0002032","volume":"3","author":"Habjan","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1074\/jbc.M110.154799_bib37","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1017\/S1355838299981190","volume":"5","author":"Clement","year":"1999","journal-title":"RNA"},{"key":"10.1074\/jbc.M110.154799_bib38","doi-asserted-by":"crossref","first-page":"827","DOI":"10.2337\/db06-1440","volume":"56","author":"Evans-Molina","year":"2007","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M110.154799_bib39","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1101\/SQB.1987.052.01.043","volume":"52","author":"Kolakofsky","year":"1987","journal-title":"Cold Spring Harbor Symp. Quant. Biol."},{"key":"10.1074\/jbc.M110.154799_bib40","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.molcel.2007.04.007","volume":"26","author":"Schneider","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M110.154799_bib41","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1146\/annurev.bi.55.070186.004101","volume":"55","author":"Sollner-Webb","year":"1986","journal-title":"Ann. Rev. Biochem."},{"key":"10.1074\/jbc.M110.154799_bib42","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.tig.2008.03.010","volume":"24","author":"Chapman","year":"2008","journal-title":"Trends Genet."},{"key":"10.1074\/jbc.M110.154799_bib43","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1126\/science.1145977","volume":"318","author":"Chapman","year":"2007","journal-title":"Science"},{"key":"10.1074\/jbc.M110.154799_bib44","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.molcel.2007.10.008","volume":"28","author":"Anindya","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M110.154799_bib45","doi-asserted-by":"crossref","first-page":"11586","DOI":"10.1073\/pnas.93.21.11586","volume":"93","author":"Bregman","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.154799_bib46","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1073\/pnas.072068399","volume":"99","author":"Lee","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.154799_bib47","doi-asserted-by":"crossref","first-page":"6897","DOI":"10.1074\/jbc.M707649200","volume":"283","author":"Malik","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.154799_bib48","doi-asserted-by":"crossref","first-page":"5184","DOI":"10.1074\/jbc.273.9.5184","volume":"273","author":"Ratner","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.154799_bib49","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cell.2007.01.046","volume":"129","author":"Somesh","year":"2007","journal-title":"Cell"},{"key":"10.1074\/jbc.M110.154799_bib50","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tibs.2007.02.005","volume":"32","author":"Svejstrup","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.M110.154799_bib51","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/pros.21114","volume":"70","author":"Zhang","year":"2010","journal-title":"Prostate"},{"key":"10.1074\/jbc.M110.154799_bib52","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/nrm2831","volume":"11","author":"Huen","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1074\/jbc.M110.154799_bib53","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1091\/mbc.e03-03-0139","volume":"14","author":"Col\u00f3n-Ramos","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M110.154799_bib54","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1743-422X-5-25","volume":"5","author":"Bennett","year":"2008","journal-title":"Virol. J."},{"key":"10.1074\/jbc.M110.154799_bib55","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.biochi.2007.01.005","volume":"89","author":"Weber","year":"2007","journal-title":"Biochimie"},{"key":"10.1074\/jbc.M110.154799_bib56","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1128\/JVI.52.1.215-222.1984","volume":"52","author":"Patterson","year":"1984","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M110.154799_bib57","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1128\/JVI.62.1.27-32.1988","volume":"62","author":"Raju","year":"1988","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M110.154799_bib58","doi-asserted-by":"crossref","first-page":"9667","DOI":"10.1128\/JVI.00822-06","volume":"80","author":"L\u00e9onard","year":"2006","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M110.154799_bib59","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.biochi.2007.08.002","volume":"89","author":"Casamassimi","year":"2007","journal-title":"Biochimie"},{"key":"10.1074\/jbc.M110.154799_bib60","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.molcel.2005.06.029","volume":"19","author":"Yang","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M110.154799_bib61","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1128\/JVI.80.7.3567-3581.2006","volume":"80","author":"Dai-Ju","year":"2006","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M110.154799_bib62","doi-asserted-by":"crossref","first-page":"5091","DOI":"10.1128\/JVI.00184-07","volume":"81","author":"Fraser","year":"2007","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M110.154799_bib63","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.1128\/JVI.02129-06","volume":"81","author":"Rodriguez","year":"2007","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M110.154799_bib64","doi-asserted-by":"crossref","first-page":"11166","DOI":"10.1128\/JVI.01439-09","volume":"83","author":"Rodriguez","year":"2009","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M110.154799_bib65","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.virol.2009.10.003","volume":"396","author":"Vreede","year":"2010","journal-title":"Virology"},{"key":"10.1074\/jbc.M110.154799_bib66","doi-asserted-by":"crossref","first-page":"6972","DOI":"10.1128\/MCB.19.10.6972","volume":"19","author":"Beaudenon","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M110.154799_bib67","doi-asserted-by":"crossref","first-page":"20705","DOI":"10.1073\/pnas.0907052106","volume":"106","author":"Harreman","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.154799_bib68","doi-asserted-by":"crossref","first-page":"9555","DOI":"10.1074\/jbc.M707700200","volume":"283","author":"Heine","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.154799_bib69","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.cell.2005.04.010","volume":"121","author":"Somesh","year":"2005","journal-title":"Cell"},{"key":"10.1074\/jbc.M110.154799_bib70","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1101\/gad.1398206","volume":"20","author":"Gomes","year":"2006","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M110.154799_bib71","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.tim.2007.01.003","volume":"15","author":"Lilley","year":"2007","journal-title":"Trends Microbiol."},{"key":"10.1074\/jbc.M110.154799_bib72","doi-asserted-by":"crossref","first-page":"11379","DOI":"10.1128\/JVI.76.22.11379-11386.2002","volume":"76","author":"Andrejeva","year":"2002","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M110.154799_bib73","doi-asserted-by":"crossref","first-page":"13434","DOI":"10.1128\/JVI.79.21.13434-13441.2005","volume":"79","author":"Precious","year":"2005","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M110.154799_bib74","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1006\/viro.2002.1773","volume":"304","author":"Ulane","year":"2002","journal-title":"Virology"},{"key":"10.1074\/jbc.M110.154799_bib75","doi-asserted-by":"crossref","first-page":"e1491","DOI":"10.1371\/journal.pone.0001491","volume":"3","author":"Li","year":"2008","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M110.154799_bib76","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/embor.2009.221","volume":"10","author":"Brookes","year":"2009","journal-title":"EMBO Rep."},{"key":"10.1074\/jbc.M110.154799_bib77","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nature08449","volume":"461","author":"Fuda","year":"2009","journal-title":"Nature"},{"key":"10.1074\/jbc.M110.154799_bib78","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cell.2007.05.042","volume":"130","author":"Guenther","year":"2007","journal-title":"Cell"},{"key":"10.1074\/jbc.M110.154799_bib79","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1038\/ng.2007.21","volume":"39","author":"Muse","year":"2007","journal-title":"Nature Genet."},{"key":"10.1074\/jbc.M110.154799_bib80","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nrm1981","volume":"7","author":"Saunders","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1074\/jbc.M110.154799_bib81","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cell.2009.05.047","volume":"138","author":"Hargreaves","year":"2009","journal-title":"Cell"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820540714?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820540714?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M110.154799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T14:33:16Z","timestamp":1617201196000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820540714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":81,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0021925820540714"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m110.154799","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}