{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:16:06Z","timestamp":1791483366285,"version":"4.3.4"},"reference-count":51,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":3482,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1074\/jbc.m110.174037","type":"journal-article","created":{"date-parts":[[2011,1,5]],"date-time":"2011-01-05T21:59:06Z","timestamp":1294264746000},"page":"8655-8665","source":"Crossref","is-referenced-by-count":498,"title":["Klotho Inhibits Transforming Growth Factor-\u03b21 (TGF-\u03b21) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice"],"prefix":"10.1016","volume":"286","author":[{"given":"Shigehiro","family":"Doi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglong","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Togao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanne V.","family":"Pastor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George B.","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Shiizaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Gotschall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Schiavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Yorioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Boothman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Kuro-o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M110.174037_bib1","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1126\/science.1112766","volume":"309","author":"Kurosu","year":"2005","journal-title":"Science"},{"key":"10.1074\/jbc.M110.174037_bib2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/36285","volume":"390","author":"Kuro-o","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M110.174037_bib3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.febslet.2004.03.090","volume":"565","author":"Imura","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M110.174037_bib4","doi-asserted-by":"crossref","first-page":"19796","DOI":"10.1073\/pnas.0709805104","volume":"104","author":"Chen","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.174037_bib5","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1016\/j.febslet.2009.09.009","volume":"583","author":"Bloch","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M110.174037_bib6","doi-asserted-by":"crossref","first-page":"6120","DOI":"10.1074\/jbc.C500457200","volume":"281","author":"Kurosu","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.174037_bib7","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/nature05315","volume":"444","author":"Urakawa","year":"2006","journal-title":"Nature"},{"key":"10.1074\/jbc.M110.174037_bib8","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/81664","volume":"26","author":"White","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M110.174037_bib9","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1359\/JBMR.0301264","volume":"19","author":"Shimada","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"10.1074\/jbc.M110.174037_bib10","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.1210\/en.2005-0670","volume":"146","author":"Yu","year":"2005","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M110.174037_bib11","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1128\/MCB.02249-06","volume":"27","author":"Goetz","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"10.1074\/jbc.M110.174037_bib12","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1126\/science.1114245","volume":"310","author":"Chang","year":"2005","journal-title":"Science"},{"key":"10.1074\/jbc.M110.174037_bib13","doi-asserted-by":"crossref","first-page":"9805","DOI":"10.1073\/pnas.0803223105","volume":"105","author":"Cha","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.174037_bib14","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1124\/mol.109.055780","volume":"76","author":"Cha","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M110.174037_bib15","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1096\/fj.10-154765","volume":"24","author":"Hu","year":"2010","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M110.174037_bib16","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1126\/science.1143578","volume":"317","author":"Liu","year":"2007","journal-title":"Science"},{"key":"10.1074\/jbc.M110.174037_bib17","doi-asserted-by":"crossref","first-page":"7094","DOI":"10.1038\/onc.2008.292","volume":"27","author":"Wolf","year":"2008","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M110.174037_bib18","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1073\/pnas.0611079104","volume":"104","author":"Haruna","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.174037_bib19","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1172\/JCI0215518","volume":"110","author":"Iwano","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M110.174037_bib20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2353\/ajpath.2010.090517","volume":"176","author":"Humphreys","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.M110.174037_bib21","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","volume":"139","author":"Thiery","year":"2009","journal-title":"Cell"},{"key":"10.1074\/jbc.M110.174037_bib22","doi-asserted-by":"crossref","first-page":"L525","DOI":"10.1152\/ajplung.00163.2007","volume":"293","author":"Willis","year":"2007","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1074\/jbc.M110.174037_bib23","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1172\/JCI36183","volume":"119","author":"Zeisberg","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M110.174037_bib24","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/01.ASN.0000042168.43665.9B","volume":"14","author":"Ling","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1074\/jbc.M110.174037_bib25","doi-asserted-by":"crossref","first-page":"F1291","DOI":"10.1152\/ajprenal.00327.2005","volume":"292","author":"El Chaar","year":"2007","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1074\/jbc.M110.174037_bib26","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/1476-4598-9-122","volume":"9","author":"Ganapathy","year":"2010","journal-title":"Mol. Cancer"},{"key":"10.1074\/jbc.M110.174037_bib27","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1148\/radiol.10091735","volume":"255","author":"Togao","year":"2010","journal-title":"Radiology"},{"key":"10.1074\/jbc.M110.174037_bib28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/labinvest.2008.104","volume":"89","author":"Kawai","year":"2009","journal-title":"Lab. Invest."},{"key":"10.1074\/jbc.M110.174037_bib29","doi-asserted-by":"crossref","first-page":"26687","DOI":"10.1074\/jbc.M704165200","volume":"282","author":"Kurosu","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.174037_bib30","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1006\/bbrc.1999.2009","volume":"267","author":"Kato","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M110.174037_bib31","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1093\/ndt\/gfi165","volume":"20","author":"Sugiura","year":"2005","journal-title":"Nephrol. Dial Transplant"},{"key":"10.1074\/jbc.M110.174037_bib32","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1161\/01.HYP.0000013734.33441.EA","volume":"39","author":"Mitani","year":"2002","journal-title":"Hypertension"},{"key":"10.1074\/jbc.M110.174037_bib33","doi-asserted-by":"crossref","first-page":"F861","DOI":"10.1152\/ajprenal.00362.2001","volume":"283","author":"Klahr","year":"2002","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1074\/jbc.M110.174037_bib34","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/1522-2594(200006)43:6<828::AID-MRM8>3.0.CO;2-P","volume":"43","author":"Lyng","year":"2000","journal-title":"Magn. Reson. Med."},{"key":"10.1074\/jbc.M110.174037_bib35","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1172\/JCI38019","volume":"119","author":"Acloque","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M110.174037_bib36","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1038\/sj.emboj.7601421","volume":"25","author":"Boutet","year":"2006","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M110.174037_bib37","doi-asserted-by":"crossref","first-page":"21113","DOI":"10.1074\/jbc.M211304200","volume":"278","author":"Peinado","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.174037_bib38","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1146\/annurev.cellbio.21.022404.142018","volume":"21","author":"Feng","year":"2005","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1074\/jbc.M110.174037_bib39","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1073\/pnas.0902006107","volume":"107","author":"Goetz","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.174037_bib40","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1001\/jama.298.17.2038","volume":"298","author":"Coresh","year":"2007","journal-title":"JAMA"},{"key":"10.1074\/jbc.M110.174037_bib41","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1006\/bbrc.2000.4226","volume":"280","author":"Koh","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M110.174037_bib42","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/jmri.20979","volume":"26","author":"Xu","year":"2007","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1074\/jbc.M110.174037_bib43","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1476-4598-9-109","volume":"9","author":"Lee","year":"2010","journal-title":"Mol. Cancer"},{"key":"10.1074\/jbc.M110.174037_bib44","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1073\/pnas.022484299","volume":"99","author":"Arking","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.174037_bib45","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/onc.2009.301","volume":"29","author":"Wolf","year":"2010","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M110.174037_bib46","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S1535-6108(04)00050-9","volume":"5","author":"Mitsiades","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.M110.174037_bib47","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1242\/dev.126.20.4557","volume":"126","author":"DasGupta","year":"1999","journal-title":"Development"},{"key":"10.1074\/jbc.M110.174037_bib48","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s10911-008-9104-6","volume":"13","author":"Weroha","year":"2008","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"10.1074\/jbc.M110.174037_bib49","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/nature08356","volume":"461","author":"Huang","year":"2009","journal-title":"Nature"},{"key":"10.1074\/jbc.M110.174037_bib50","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/nrd1580","volume":"3","author":"Yingling","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1074\/jbc.M110.174037_bib51","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/labinvest.3700669","volume":"87","author":"Prud'homme","year":"2007","journal-title":"Lab. Invest."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820540052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820540052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M110.174037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T19:48:03Z","timestamp":1641325683000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820540052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S0021925820540052"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m110.174037","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}