{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:51:56Z","timestamp":1791593516853,"version":"4.3.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"28","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":3379,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1074\/jbc.m110.187591","type":"journal-article","created":{"date-parts":[[2011,3,26]],"date-time":"2011-03-26T00:25:43Z","timestamp":1301099143000},"page":"25108-25117","source":"Crossref","is-referenced-by-count":71,"title":["Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Associates with Huntingtin Protein and Promotes Its Atypical Ubiquitination to Enhance Aggregate Formation"],"prefix":"10.1016","volume":"286","author":[{"given":"Silvia","family":"Zucchelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Marcuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Codrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Agostoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Vilotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Biagioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisia","family":"Carnemolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Gustincich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Persichetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M110.187591_bib1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","volume":"72","author":"Huntington's Disease Collaborative Research Group","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.M110.187591_bib2","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1002\/ajmg.a.32901","volume":"149A","author":"Hendricks","year":"2009","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1074\/jbc.M110.187591_bib3","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1093\/hmg\/9.19.2789","volume":"9","author":"Hilditch-Maguire","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M110.187591_bib4","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nn884","volume":"5","author":"Panov","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1074\/jbc.M110.187591_bib5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/exnr.1998.6832","volume":"152","author":"Velier","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1074\/jbc.M110.187591_bib6","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1152\/physrev.00041.2009","volume":"90","author":"Zuccato","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1074\/jbc.M110.187591_bib7","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","volume":"277","author":"DiFiglia","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M110.187591_bib8","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1073\/pnas.97.6.2898","volume":"97","author":"Wyttenbach","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.187591_bib9","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nature06022","volume":"448","author":"Bennett","year":"2007","journal-title":"Nature"},{"key":"10.1074\/jbc.M110.187591_bib10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mcn.2006.09.006","volume":"34","author":"de Pril","year":"2007","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1074\/jbc.M110.187591_bib11","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.yexcr.2006.10.031","volume":"313","author":"Yang","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1074\/jbc.M110.187591_bib12","doi-asserted-by":"crossref","first-page":"11635","DOI":"10.1074\/jbc.M412042200","volume":"280","author":"Jana","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.187591_bib13","doi-asserted-by":"crossref","first-page":"22044","DOI":"10.1074\/jbc.M212235200","volume":"278","author":"Tsai","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.187591_bib14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.molcel.2009.01.014","volume":"33","author":"Chen","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M110.187591_bib15","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/embor.2008.93","volume":"9","author":"Ikeda","year":"2008","journal-title":"EMBO Rep."},{"key":"10.1074\/jbc.M110.187591_bib16","doi-asserted-by":"crossref","first-page":"10825","DOI":"10.1074\/jbc.M512786200","volume":"281","author":"Cripps","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.187591_bib17","doi-asserted-by":"crossref","first-page":"20365","DOI":"10.1074\/jbc.M414356200","volume":"280","author":"Shang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.187591_bib18","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.molcel.2006.10.022","volume":"24","author":"Ben-Saadon","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M110.187591_bib19","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/BJ20080067","volume":"411","author":"Al-Hakim","year":"2008","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M110.187591_bib20","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1091\/mbc.e08-05-0496","volume":"19","author":"Ikeda","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M110.187591_bib21","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ccr.2009.02.021","volume":"15","author":"Xu","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.M110.187591_bib22","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/ncb0805-758","volume":"7","author":"Chen","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M110.187591_bib23","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.molcel.2005.09.014","volume":"20","author":"Geetha","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M110.187591_bib24","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1074\/jbc.274.5.2597","volume":"274","author":"Khursigara","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.187591_bib25","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1471-4159.2005.03181.x","volume":"94","author":"Babu","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M110.187591_bib26","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1093\/hmg\/ddq290","volume":"19","author":"Zucchelli","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M110.187591_bib27","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1006\/nbdi.1999.0260","volume":"6","author":"Persichetti","year":"1999","journal-title":"Neurobiol. Dis."},{"key":"10.1074\/jbc.M110.187591_bib28","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ng1297-404","volume":"17","author":"White","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M110.187591_bib29","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/cdd.2008.169","volume":"16","author":"Zucchelli","year":"2009","journal-title":"Cell. Death Differ."},{"key":"10.1074\/jbc.M110.187591_bib30","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1093\/hmg\/11.19.2233","volume":"11","author":"Fossale","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M110.187591_bib31","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1074\/jbc.M110.187591_bib32","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/ncb2012","volume":"12","author":"Geisler","year":"2010","journal-title":"Nat. Cell. Biol."},{"key":"10.1074\/jbc.M110.187591_bib33","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1006\/exnr.1998.7005","volume":"156","author":"Sieradzan","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1074\/jbc.M110.187591_bib34","first-page":"ra42","volume":"3","author":"Shi","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1074\/jbc.M110.187591_bib35","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1083\/jcb.200507002","volume":"171","author":"Bj\u00f8rk\u00f8y","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M110.187591_bib36","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1471-4159.2004.02692.x","volume":"91","author":"Nagaoka","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M110.187591_bib37","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/sj.embor.7400822","volume":"7","author":"Chastagner","year":"2006","journal-title":"EMBO Rep."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819486729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819486729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M110.187591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T19:37:04Z","timestamp":1615491424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819486729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":37,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0021925819486729"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m110.187591","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}