{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T07:36:29Z","timestamp":1778225789331,"version":"3.51.4"},"reference-count":53,"publisher":"Elsevier BV","issue":"46","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":3237,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1074\/jbc.m110.201517","type":"journal-article","created":{"date-parts":[[2011,9,23]],"date-time":"2011-09-23T05:16:34Z","timestamp":1316754994000},"page":"39993-40001","source":"Crossref","is-referenced-by-count":41,"title":["Molecular Mechanisms of Disease for Mutations at Gly-90 in Rhodopsin"],"prefix":"10.1016","volume":"286","author":[{"given":"Darwin","family":"Toledo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Ramon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f2nica","family":"Aguil\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnau","family":"Cordom\u00ed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan J.","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo F.","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Cheetham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pere","family":"Garriga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M110.201517_bib1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1146\/annurev.biochem.75.103004.142743","volume":"75","author":"Palczewski","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M110.201517_bib2","doi-asserted-by":"crossref","first-page":"8114","DOI":"10.1074\/jbc.M109.063875","volume":"285","author":"Matsuyama","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.201517_bib3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0025-7753(03)73886-X","volume":"121","author":"Manyosa","year":"2003","journal-title":"Med. Clin. (Barc.)"},{"key":"10.1074\/jbc.M110.201517_bib4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev.genom.7.080505.115737","volume":"7","author":"Gregersen","year":"2006","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"10.1074\/jbc.M110.201517_bib5","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.tcb.2005.09.005","volume":"15","author":"Carrell","year":"2005","journal-title":"Trends Cell Biol."},{"key":"10.1074\/jbc.M110.201517_bib6","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jmb.2009.11.015","volume":"395","author":"Krebs","year":"2010","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M110.201517_bib7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.brainresbull.2009.09.015","volume":"81","author":"Surguchev","year":"2010","journal-title":"Brain Res. Bull."},{"key":"10.1074\/jbc.M110.201517_bib8","first-page":"1546","volume":"41","author":"Green","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1074\/jbc.M110.201517_bib9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.molmed.2005.02.007","volume":"11","author":"Mendes","year":"2005","journal-title":"Trends Mol. Med."},{"key":"10.1074\/jbc.M110.201517_bib10","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/ng0793-280","volume":"4","author":"Dryja","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M110.201517_bib11","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/367639a0","volume":"367","author":"Rao","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.M110.201517_bib12","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1021\/bi020613j","volume":"42","author":"Gross","year":"2003","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M110.201517_bib13","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1167\/iovs.08-1717","volume":"49","author":"Zeitz","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1074\/jbc.M110.201517_bib14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/978-1-4419-1399-9_30","volume":"664","author":"McAlear","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1074\/jbc.M110.201517_bib15","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1126\/science.2573154","volume":"246","author":"Zhukovsky","year":"1989","journal-title":"Science"},{"key":"10.1074\/jbc.M110.201517_bib16","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1167\/iovs.05-1317","volume":"47","author":"Neidhardt","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1074\/jbc.M110.201517_bib17","doi-asserted-by":"crossref","first-page":"8874","DOI":"10.1073\/pnas.84.24.8874","volume":"84","author":"Oprian","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.201517_bib18","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1242\/jcs.115.14.2907","volume":"115","author":"Saliba","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M110.201517_bib19","doi-asserted-by":"crossref","first-page":"4554","DOI":"10.1073\/pnas.93.10.4554","volume":"93","author":"Liu","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.201517_bib20","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1093\/hmg\/ddn202","volume":"17","author":"Mendes","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M110.201517_bib21","doi-asserted-by":"crossref","first-page":"8309","DOI":"10.1073\/pnas.86.21.8309","volume":"86","author":"Sakmar","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.201517_bib22","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.1074\/jbc.270.10.5073","volume":"270","author":"Farrens","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.201517_bib23","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1242\/jcs.055228","volume":"122","author":"Kosmaoglou","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M110.201517_bib24","doi-asserted-by":"crossref","first-page":"6427","DOI":"10.1074\/jbc.M210929200","volume":"278","author":"Ramon","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.201517_bib25","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1073\/pnas.92.3.880","volume":"92","author":"Sieving","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.201517_bib26","doi-asserted-by":"crossref","first-page":"7536","DOI":"10.1021\/bi960391n","volume":"35","author":"Zvyaga","year":"1996","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M110.201517_bib27","doi-asserted-by":"crossref","first-page":"8805","DOI":"10.1523\/JNEUROSCI.2751-07.2007","volume":"27","author":"Woodruff","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M110.201517_bib28","doi-asserted-by":"crossref","first-page":"34150","DOI":"10.1074\/jbc.M204955200","volume":"277","author":"Illing","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.201517_bib29","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1111\/j.1742-4658.2011.08066.x","volume":"278","author":"Bosch-Presegu\u00e9","year":"2011","journal-title":"FEBS J."},{"key":"10.1074\/jbc.M110.201517_bib30","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.1073\/pnas.87.13.4991","volume":"87","author":"Doi","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.201517_bib31","doi-asserted-by":"crossref","first-page":"6481","DOI":"10.1073\/pnas.88.15.6481","volume":"88","author":"Sung","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.201517_bib32","doi-asserted-by":"crossref","first-page":"8840","DOI":"10.1073\/pnas.88.19.8840","volume":"88","author":"Sung","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.201517_bib33","doi-asserted-by":"crossref","first-page":"6121","DOI":"10.1021\/bi00186a011","volume":"33","author":"Kaushal","year":"1994","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M110.201517_bib34","doi-asserted-by":"crossref","first-page":"4872","DOI":"10.1073\/pnas.061632798","volume":"98","author":"Hwa","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.201517_bib35","doi-asserted-by":"crossref","first-page":"16278","DOI":"10.1074\/jbc.M312101200","volume":"279","author":"Noorwez","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.201517_bib36","doi-asserted-by":"crossref","first-page":"14442","DOI":"10.1074\/jbc.M300087200","volume":"278","author":"Noorwez","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.201517_bib37","doi-asserted-by":"crossref","first-page":"16982","DOI":"10.1074\/jbc.M210567200","volume":"278","author":"Janz","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M110.201517_bib38","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0006-291X(03)00328-0","volume":"303","author":"Andr\u00e9s","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M110.201517_bib39","doi-asserted-by":"crossref","first-page":"9262","DOI":"10.1073\/pnas.1531970100","volume":"100","author":"Yan","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.201517_bib40","doi-asserted-by":"crossref","first-page":"10503","DOI":"10.1021\/ja0627848","volume":"128","author":"Vogel","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.M110.201517_bib41","doi-asserted-by":"crossref","first-page":"17795","DOI":"10.1073\/pnas.0804541105","volume":"105","author":"Mahalingam","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.201517_bib42","doi-asserted-by":"crossref","first-page":"991","DOI":"10.2174\/156802607780906799","volume":"7","author":"Deupi","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1074\/jbc.M110.201517_bib43","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/nar\/29.1.346","volume":"29","author":"Horn","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M110.201517_bib44","doi-asserted-by":"crossref","first-page":"140","DOI":"10.2174\/1874467210902020140","volume":"2","author":"Benned-Jensen","year":"2009","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1074\/jbc.M110.201517_bib45","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev.biophys.32.110601.142520","volume":"32","author":"Filipek","year":"2003","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"10.1074\/jbc.M110.201517_bib46","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1073\/pnas.92.8.3551","volume":"92","author":"Li","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.201517_bib47","doi-asserted-by":"crossref","first-page":"11662","DOI":"10.1523\/JNEUROSCI.4006-08.2008","volume":"28","author":"Dizhoor","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M110.201517_bib48","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nn1070","volume":"6","author":"Jin","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1074\/jbc.M110.201517_bib49","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1021\/ja066970p","volume":"129","author":"Sekharan","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.M110.201517_bib50","doi-asserted-by":"crossref","first-page":"13662","DOI":"10.1073\/pnas.2234461100","volume":"100","author":"Fan","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M110.201517_bib51","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1021\/bi020612r","volume":"42","author":"Gross","year":"2003","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M110.201517_bib52","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1002\/prot.21123","volume":"65","author":"Hornak","year":"2006","journal-title":"Proteins"},{"key":"10.1074\/jbc.M110.201517_bib53","series-title":"The PyMOL Molecular Graphics System, version 1.2r3pre","author":"DeLano","year":"2010"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820504973?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820504973?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M110.201517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T22:29:03Z","timestamp":1641335343000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820504973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":53,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0021925820504973"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m110.201517","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}