{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T15:04:47Z","timestamp":1793459087781,"version":"4.5.0"},"reference-count":77,"publisher":"Elsevier BV","issue":"32","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T00:00:00Z","timestamp":1599868800000},"content-version":"vor","delay-in-days":3330,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1074\/jbc.m111.237859","type":"journal-article","created":{"date-parts":[[2011,6,9]],"date-time":"2011-06-09T00:23:44Z","timestamp":1307579024000},"page":"28080-28088","source":"Crossref","is-referenced-by-count":168,"title":["\u03b1-Synuclein Interacts with Glucocerebrosidase Providing a Molecular Link between Parkinson and Gaucher Diseases"],"prefix":"10.1016","volume":"286","author":[{"given":"Thai Leong","family":"Yap","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Gruschus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Velayati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Westbroek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehud","family":"Goldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Moaven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Sidransky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M111.237859_bib1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuron.2006.09.026","volume":"52","author":"Lee","year":"2006","journal-title":"Neuron"},{"key":"10.1074\/jbc.M111.237859_bib2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0166-2236(97)01213-7","volume":"21","author":"Clayton","year":"1998","journal-title":"Trends Neurosci."},{"key":"10.1074\/jbc.M111.237859_bib3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1750-1326-4-9","volume":"4","author":"Cookson","year":"2009","journal-title":"Mol. Neurodegener."},{"key":"10.1074\/jbc.M111.237859_bib4","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2174\/138920309789351921","volume":"10","author":"Uversky","year":"2009","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1074\/jbc.M111.237859_bib5","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0028-3908(03)00140-0","volume":"45","author":"Dev","year":"2003","journal-title":"Neuropharmacol."},{"key":"10.1074\/jbc.M111.237859_bib6","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.M111.237859_bib7","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ng0298-106","volume":"18","author":"Kr\u00fcger","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M111.237859_bib8","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/ana.10795","volume":"55","author":"Zarranz","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1074\/jbc.M111.237859_bib9","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0140-6736(04)17103-1","volume":"364","author":"Chartier-Harlin","year":"2004","journal-title":"Lancet"},{"key":"10.1074\/jbc.M111.237859_bib10","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1090278","volume":"302","author":"Singleton","year":"2003","journal-title":"Science"},{"key":"10.1074\/jbc.M111.237859_bib11","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev.biochem.75.101304.123901","volume":"75","author":"Chiti","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M111.237859_bib12","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1021\/ar050073t","volume":"39","author":"Fink","year":"2006","journal-title":"Acc. Chem. Res."},{"key":"10.1074\/jbc.M111.237859_bib13","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/3311","volume":"4","author":"Conway","year":"1998","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M111.237859_bib14","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1021\/bi0120906","volume":"41","author":"Shtilerman","year":"2002","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M111.237859_bib15","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.jmb.2008.03.034","volume":"378","author":"Thirunavukkuarasu","year":"2008","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M111.237859_bib16","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.bpj.2009.12.4290","volume":"98","author":"Nath","year":"2010","journal-title":"Biophys. J."},{"key":"10.1074\/jbc.M111.237859_bib17","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1021\/bi2000824","volume":"50","author":"Yap","year":"2011","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M111.237859_bib18","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1523\/JNEUROSCI.08-08-02804.1988","volume":"8","author":"Maroteaux","year":"1988","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M111.237859_bib19","doi-asserted-by":"crossref","first-page":"44284","DOI":"10.1074\/jbc.M105343200","volume":"276","author":"Uversky","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.237859_bib20","doi-asserted-by":"crossref","first-page":"40186","DOI":"10.1074\/jbc.M305326200","volume":"278","author":"Zhu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.237859_bib21","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1021\/bi0600749","volume":"45","author":"Masuda","year":"2006","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M111.237859_bib22","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ymgme.2010.08.004","volume":"101","author":"Goldin","year":"2010","journal-title":"Mol. Genet. Metab."},{"key":"10.1074\/jbc.M111.237859_bib23","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1126\/science.1195227","volume":"329","author":"Burr\u00e9","year":"2010","journal-title":"Science"},{"key":"10.1074\/jbc.M111.237859_bib24","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1093\/brain\/awm318","volume":"131","author":"Pan","year":"2008","journal-title":"Brain"},{"key":"10.1074\/jbc.M111.237859_bib25","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nrn1868","volume":"7","author":"Abou-Sleiman","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1074\/jbc.M111.237859_bib26","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1126\/science.1101738","volume":"305","author":"Cuervo","year":"2004","journal-title":"Science"},{"key":"10.1074\/jbc.M111.237859_bib27","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1080\/13506120802193746","volume":"15","author":"Gruschus","year":"2008","journal-title":"Amyloid-J. Protein Fold. Disord."},{"key":"10.1074\/jbc.M111.237859_bib28","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/33416","volume":"392","author":"Kitada","year":"1998","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.237859_bib29","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.neuron.2004.11.005","volume":"44","author":"Zimprich","year":"2004","journal-title":"Neuron"},{"key":"10.1074\/jbc.M111.237859_bib30","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1126\/science.1096284","volume":"304","author":"Valente","year":"2004","journal-title":"Science"},{"key":"10.1074\/jbc.M111.237859_bib31","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1126\/science.1077209","volume":"299","author":"Bonifati","year":"2003","journal-title":"Science"},{"key":"10.1074\/jbc.M111.237859_bib32","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1136\/jmg.2004.024455","volume":"41","author":"Goker-Alpan","year":"2004","journal-title":"J. Med. Genet."},{"key":"10.1074\/jbc.M111.237859_bib33","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S1096-7192(03)00071-4","volume":"79","author":"Tayebi","year":"2003","journal-title":"Mol. Genet. Metab."},{"key":"10.1074\/jbc.M111.237859_bib34","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1056\/NEJMoa033277","volume":"351","author":"Aharon-Peretz","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M111.237859_bib35","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ymgme.2003.11.004","volume":"81","author":"Lwin","year":"2004","journal-title":"Mol. Genet. Metab."},{"key":"10.1074\/jbc.M111.237859_bib36","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1212\/01.wnl.0000230215.41296.18","volume":"67","author":"Goker-Alpan","year":"2006","journal-title":"Neurology"},{"key":"10.1074\/jbc.M111.237859_bib37","first-page":"691","volume":"89","author":"Neudorfer","year":"1996","journal-title":"QJM-Mon. J. Assoc. Physicians"},{"key":"10.1074\/jbc.M111.237859_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/JBB\/2006\/78549","volume":"2006","author":"Hruska","year":"2006","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1074\/jbc.M111.237859_bib39","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJMoa0901281","volume":"361","author":"Sidransky","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M111.237859_bib40","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00401-010-0741-7","volume":"120","author":"Goker-Alpan","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1074\/jbc.M111.237859_bib41","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.cbpa.2007.05.035","volume":"11","author":"Butters","year":"2007","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1074\/jbc.M111.237859_bib42","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/humu.20676","volume":"29","author":"Hruska","year":"2008","journal-title":"Hum. Mutat."},{"key":"10.1074\/jbc.M111.237859_bib43","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1089\/gte.1997.1.5","volume":"1","author":"Grabowski","year":"1997","journal-title":"Genet. Test."},{"key":"10.1074\/jbc.M111.237859_bib44","doi-asserted-by":"crossref","first-page":"13621","DOI":"10.1074\/jbc.M109.074617","volume":"285","author":"Mak","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.237859_bib45","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/hmg\/ddm289","volume":"17","author":"Settembre","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M111.237859_bib46","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.neuro.2009.06.009","volume":"30","author":"Manning-Bo\u011f","year":"2009","journal-title":"Neurotoxicology"},{"key":"10.1074\/jbc.M111.237859_bib47","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s11910-010-0102-x","volume":"10","author":"Velayati","year":"2010","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1074\/jbc.M111.237859_bib48","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.1111\/j.1742-4658.2008.06709.x","volume":"275","author":"Bras","year":"2008","journal-title":"FEBS J."},{"key":"10.1074\/jbc.M111.237859_bib49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0014-5793(94)00395-5","volume":"345","author":"Jakes","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M111.237859_bib50","doi-asserted-by":"crossref","first-page":"6898","DOI":"10.1021\/ja711415b","volume":"130","author":"Lee","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.M111.237859_bib51","doi-asserted-by":"crossref","first-page":"16466","DOI":"10.1073\/pnas.0407307101","volume":"101","author":"Lee","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.237859_bib52","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0896-6273(02)01125-X","volume":"36","author":"Petrucelli","year":"2002","journal-title":"Neuron"},{"key":"10.1074\/jbc.M111.237859_bib53","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF00197809","volume":"6","author":"Delaglio","year":"1995","journal-title":"J. Biomol. NMR"},{"key":"10.1074\/jbc.M111.237859_bib54","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/prot.22102","volume":"73","author":"Bas","year":"2008","journal-title":"Proteins"},{"key":"10.1074\/jbc.M111.237859_bib55","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/sj.embor.embor873","volume":"4","author":"Dvir","year":"2003","journal-title":"EMBO Rep."},{"key":"10.1074\/jbc.M111.237859_bib56","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1515\/BC.2008.163","volume":"389","author":"Kacher","year":"2008","journal-title":"Biol. Chem."},{"key":"10.1074\/jbc.M111.237859_bib57","series-title":"Principles of Fluorescence Spectroscopy","author":"Lakowicz","year":"2006"},{"key":"10.1074\/jbc.M111.237859_bib58","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1006\/jmbi.2001.4538","volume":"307","author":"Eliezer","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M111.237859_bib59","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1074\/jbc.M110.150433","volume":"286","author":"Wei","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.237859_bib60","doi-asserted-by":"crossref","first-page":"23815","DOI":"10.1074\/jbc.M502799200","volume":"280","author":"Premkumar","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.237859_bib61","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.bbrc.2008.08.099","volume":"376","author":"Zaidi","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M111.237859_bib62","doi-asserted-by":"crossref","first-page":"4871","DOI":"10.1529\/biophysj.107.127464","volume":"95","author":"van Raaij","year":"2008","journal-title":"Biophys. J."},{"key":"10.1074\/jbc.M111.237859_bib63","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/pro.556","volume":"20","author":"Croke","year":"2011","journal-title":"Protein Sci."},{"key":"10.1074\/jbc.M111.237859_bib64","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nchembio850","volume":"3","author":"Lieberman","year":"2007","journal-title":"Nat. Chem. Biol."},{"key":"10.1074\/jbc.M111.237859_bib65","doi-asserted-by":"crossref","first-page":"19666","DOI":"10.1073\/pnas.0807826105","volume":"105","author":"Jao","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.237859_bib66","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.jmb.2009.05.066","volume":"390","author":"Bodner","year":"2009","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M111.237859_bib67","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1021\/jp908092e","volume":"114","author":"Pfefferkorn","year":"2010","journal-title":"J. Phys. Chem. B"},{"key":"10.1074\/jbc.M111.237859_bib68","doi-asserted-by":"crossref","first-page":"28261","DOI":"10.1074\/jbc.M110.157214","volume":"285","author":"Georgieva","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.237859_bib69","doi-asserted-by":"crossref","first-page":"14729","DOI":"10.1021\/bi0301338","volume":"42","author":"de Alba","year":"2003","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M111.237859_bib70","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.jmb.2004.12.045","volume":"346","author":"Hawkins","year":"2005","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M111.237859_bib71","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/S0021-9258(19)39921-1","volume":"265","author":"Morimoto","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.237859_bib72","doi-asserted-by":"crossref","first-page":"34328","DOI":"10.1074\/jbc.M004345200","volume":"275","author":"Jo","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.237859_bib73","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1021\/bi061749a","volume":"46","author":"Martinez","year":"2007","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M111.237859_bib74","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1471-4159.2009.06150.x","volume":"110","author":"Park","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M111.237859_bib75","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.bbamcr.2008.06.010","volume":"1783","author":"Zabrocki","year":"2008","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"key":"10.1074\/jbc.M111.237859_bib76","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1042\/bj3030377","volume":"303","author":"Meivar-Levy","year":"1994","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M111.237859_bib77","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1016\/S0021-9258(17)42166-1","volume":"269","author":"Grace","year":"1994","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582057525X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582057525X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M111.237859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T03:40:04Z","timestamp":1625024404000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192582057525X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":77,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S002192582057525X"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m111.237859","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}