{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:39:20Z","timestamp":1789735160143,"version":"4.0.1"},"reference-count":62,"publisher":"Elsevier BV","issue":"39","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":3309,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1074\/jbc.m111.247684","type":"journal-article","created":{"date-parts":[[2011,8,11]],"date-time":"2011-08-11T01:30:32Z","timestamp":1313026232000},"page":"34199-34214","source":"Crossref","is-referenced-by-count":27,"title":["The Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase\/Ribosomal S6 Protein Kinase 1 Cascade Phosphorylates cAMP Response Element-binding Protein to Induce MUC5B Gene Expression via d-Prostanoid Receptor Signaling"],"prefix":"10.1016","volume":"286","author":[{"given":"Yeon Ho","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Nam","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Aoyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasundo","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Yoon","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boryung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Min","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Geun","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo-Heon","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M111.247684_bib1","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1097\/MLG.0b013e3180383651","volume":"117","author":"Ali","year":"2007","journal-title":"Laryngoscope"},{"key":"10.1074\/jbc.M111.247684_bib2","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1183\/09031936.94.07091678","volume":"7","author":"Rogers","year":"1994","journal-title":"Eur. Respir. J."},{"key":"10.1074\/jbc.M111.247684_bib3","first-page":"L1203","volume":"273","author":"Yuta","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M111.247684_bib4","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1165\/rcmb.2006-0035SF","volume":"34","author":"Voynow","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1074\/jbc.M111.247684_bib5","first-page":"L549","volume":"276","author":"Borchers","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M111.247684_bib6","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bbrc.2009.05.136","volume":"386","author":"Binker","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M111.247684_bib7","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1165\/rcmb.2009-0205OC","volume":"43","author":"Kim","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1074\/jbc.M111.247684_bib8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0952-3278(97)90503-2","volume":"56","author":"Enss","year":"1997","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1074\/jbc.M111.247684_bib9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0090-6980(84)90115-1","volume":"28","author":"Marom","year":"1984","journal-title":"Prostaglandins"},{"key":"10.1074\/jbc.M111.247684_bib10","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1006\/bbrc.1998.8535","volume":"245","author":"van de Bovenkamp","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M111.247684_bib11","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/0016-5085(95)90380-1","volume":"109","author":"Ho","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1074\/jbc.M111.247684_bib12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1165\/rcmb.2003-0103OC","volume":"30","author":"Chen","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1074\/jbc.M111.247684_bib13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1042\/bj3240295","volume":"324","author":"Keates","year":"1997","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M111.247684_bib14","doi-asserted-by":"crossref","first-page":"23243","DOI":"10.1074\/jbc.M300096200","volume":"278","author":"Song","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.247684_bib15","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2353\/ajpath.2007.060452","volume":"170","author":"Yuan-Chen Wu","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.M111.247684_bib16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.pharmthera.2004.06.003","volume":"103","author":"Hata","year":"2004","journal-title":"Pharmacol. Ther."},{"key":"10.1074\/jbc.M111.247684_bib17","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S1471-4906(01)02154-8","volume":"23","author":"Harris","year":"2002","journal-title":"Trends Immunol."},{"key":"10.1074\/jbc.M111.247684_bib18","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.4049\/jimmunol.129.4.1627","volume":"129","author":"Lewis","year":"1982","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M111.247684_bib19","doi-asserted-by":"crossref","first-page":"11192","DOI":"10.1073\/pnas.91.23.11192","volume":"91","author":"Hirata","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.247684_bib20","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/sj.bjp.0704973","volume":"137","author":"Sawyer","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1074\/jbc.M111.247684_bib21","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.4049\/jimmunol.174.6.3703","volume":"174","author":"Spik","year":"2005","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M111.247684_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1172\/JCI200113416","volume":"108","author":"Tilley","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M111.247684_bib23","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.4049\/jimmunol.143.9.2982","volume":"143","author":"Urade","year":"1989","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M111.247684_bib24","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0021-9258(19)40239-1","volume":"265","author":"Urade","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.247684_bib25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0304-3940(96)12614-8","volume":"209","author":"Bl\u00f6dorn","year":"1996","journal-title":"Neurosci Lett."},{"key":"10.1074\/jbc.M111.247684_bib26","first-page":"597","volume":"128","author":"Naclerio","year":"1983","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1074\/jbc.M111.247684_bib27","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1126\/science.287.5460.2013","volume":"287","author":"Matsuoka","year":"2000","journal-title":"Science"},{"key":"10.1074\/jbc.M111.247684_bib28","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1165\/ajrcmb.16.6.9191474","volume":"16","author":"Yoon","year":"1997","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1074\/jbc.M111.247684_bib29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1046\/j.1432-0436.2002.700202.x","volume":"70","author":"Yoon","year":"2002","journal-title":"Differentiation"},{"key":"10.1074\/jbc.M111.247684_bib30","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1165\/rcmb.2007-0377OC","volume":"40","author":"Choi","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1074\/jbc.M111.247684_bib31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1042\/BJ20071393","volume":"411","author":"Choi","year":"2008","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M111.247684_bib32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ajo.2009.07.030","volume":"149","author":"Kim","year":"2010","journal-title":"Am. J. Ophthalmol"},{"key":"10.1074\/jbc.M111.247684_bib33","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0022-3565(24)29398-8","volume":"298","author":"Arimura","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1074\/jbc.M111.247684_bib34","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.ejphar.2007.09.014","volume":"578","author":"Yasui","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1074\/jbc.M111.247684_bib35","doi-asserted-by":"crossref","first-page":"6174","DOI":"10.1021\/jm050519b","volume":"48","author":"Armer","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M111.247684_bib36","doi-asserted-by":"crossref","first-page":"10952","DOI":"10.1073\/pnas.90.23.10952","volume":"90","author":"Chen","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.247684_bib37","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0960-9822(00)00310-9","volume":"10","author":"Shimamura","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.M111.247684_bib38","doi-asserted-by":"crossref","first-page":"4258","DOI":"10.2741\/3003","volume":"13","author":"Carriere","year":"2008","journal-title":"Front. Biosci."},{"key":"10.1074\/jbc.M111.247684_bib39","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.273.5277.959","volume":"273","author":"Xing","year":"1996","journal-title":"Science"},{"key":"10.1074\/jbc.M111.247684_bib40","doi-asserted-by":"crossref","first-page":"18910","DOI":"10.1074\/jbc.270.32.18910","volume":"270","author":"Boie","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.247684_bib41","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/glia.20809","volume":"57","author":"Murray","year":"2009","journal-title":"Glia"},{"key":"10.1074\/jbc.M111.247684_bib42","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1165\/ajrcmb.25.4.4413","volume":"25","author":"Chen","year":"2001","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1074\/jbc.M111.247684_bib43","doi-asserted-by":"crossref","first-page":"6387","DOI":"10.1111\/j.1742-4658.2005.05035.x","volume":"272","author":"Chokki","year":"2005","journal-title":"FEBS J."},{"key":"10.1074\/jbc.M111.247684_bib44","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1161\/01.ATV.0000184757.50141.8d","volume":"25","author":"Hatoum","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1074\/jbc.M111.247684_bib45","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.prostaglandins.2003.12.002","volume":"73","author":"Nantel","year":"2004","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1074\/jbc.M111.247684_bib46","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00228-006-0211-2","volume":"63","author":"Van Hecken","year":"2007","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1074\/jbc.M111.247684_bib47","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S1526-0550(02)00007-0","volume":"3","author":"Voynow","year":"2002","journal-title":"Paediatr Respir. Rev."},{"key":"10.1074\/jbc.M111.247684_bib48","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s001090050063","volume":"74","author":"Whitmarsh","year":"1996","journal-title":"J. Mol. Med."},{"key":"10.1074\/jbc.M111.247684_bib49","doi-asserted-by":"crossref","first-page":"6566","DOI":"10.1038\/sj.onc.1210479","volume":"26","author":"Vincent","year":"2007","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M111.247684_bib50","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.4049\/jimmunol.0713637","volume":"182","author":"Chung","year":"2009","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M111.247684_bib51","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1126\/science.7716515","volume":"268","author":"Ghosh","year":"1995","journal-title":"Science"},{"key":"10.1074\/jbc.M111.247684_bib52","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1152\/physrev.00041.2005","volume":"88","author":"Mellstr\u00f6m","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1074\/jbc.M111.247684_bib53","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1096\/fj.04-1964fje","volume":"18","author":"McNamara","year":"2004","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M111.247684_bib54","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1128\/IAI.01355-08","volume":"77","author":"Pena","year":"2009","journal-title":"Infect Immun."},{"key":"10.1074\/jbc.M111.247684_bib55","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/1465-9921-7-105","volume":"7","author":"Isakson","year":"2006","journal-title":"Respir. Res."},{"key":"10.1074\/jbc.M111.247684_bib56","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/j.1471-4159.2009.06521.x","volume":"112","author":"Lam","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M111.247684_bib57","doi-asserted-by":"crossref","first-page":"8842","DOI":"10.1523\/JNEUROSCI.21-22-08842.2001","volume":"21","author":"Schinelli","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M111.247684_bib58","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1146\/annurev.biochem.68.1.821","volume":"68","author":"Shaywitz","year":"1999","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M111.247684_bib59","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.4049\/jimmunol.179.5.2766","volume":"179","author":"Chen","year":"2007","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M111.247684_bib60","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nrm2509","volume":"9","author":"Anjum","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1074\/jbc.M111.247684_bib61","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/30538","volume":"393","author":"Kawasaki","year":"1998","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.247684_bib62","first-page":"D1216","volume":"6","author":"Van Seuningen","year":"2001","journal-title":"Front. Biosci."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820739657?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820739657?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M111.247684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T14:21:04Z","timestamp":1741443664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820739657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":62,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0021925820739657"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m111.247684","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}