{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:06:29Z","timestamp":1790363189312,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"32","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T00:00:00Z","timestamp":1599868800000},"content-version":"vor","delay-in-days":3330,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1074\/jbc.m111.247924","type":"journal-article","created":{"date-parts":[[2011,6,15]],"date-time":"2011-06-15T00:18:04Z","timestamp":1308097084000},"page":"27998-28010","source":"Crossref","is-referenced-by-count":55,"title":["Alboserpin, a Factor Xa Inhibitor from the Mosquito Vector of Yellow Fever, Binds Heparin and Membrane Phospholipids and Exhibits Antithrombotic Activity"],"prefix":"10.1016","volume":"286","author":[{"given":"Eric","family":"Calvo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella M.","family":"Mizurini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson","family":"S\u00e1-Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.C.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben J.","family":"Mans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robson Q.","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michail","family":"Kotsyfakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo M.B.","family":"Francischetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M111.247924_bib1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1146\/annurev.ento.48.060402.102812","volume":"48","author":"Ribeiro","year":"2003","journal-title":"Annu. Rev. Entomol."},{"key":"10.1074\/jbc.M111.247924_bib2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1080\/00034983.1959.11685921","volume":"53","author":"Lavoipierre","year":"1959","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1074\/jbc.M111.247924_bib3","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.2174\/0929867043364603","volume":"11","author":"Stassen","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"10.1074\/jbc.M111.247924_bib4","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.toxicon.2009.12.003","volume":"56","author":"Francischetti","year":"2010","journal-title":"Toxicon"},{"key":"10.1074\/jbc.M111.247924_bib5","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ni.1923","volume":"11","author":"Ricklin","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1074\/jbc.M111.247924_bib6","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1161\/01.ATV.0000031340.68494.34","volume":"22","author":"Monroe","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1074\/jbc.M111.247924_bib7","doi-asserted-by":"crossref","first-page":"S287","DOI":"10.1097\/01.CCM.0000126364.46191.12","volume":"32","author":"Ruf","year":"2004","journal-title":"Crit. Care Med."},{"key":"10.1074\/jbc.M111.247924_bib8","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1128\/IAI.01507-08","volume":"77","author":"Guo","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.M111.247924_bib9","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1074\/jbc.M510359200","volume":"281","author":"Calvo","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.247924_bib10","doi-asserted-by":"crossref","first-page":"26928","DOI":"10.1074\/jbc.M705669200","volume":"282","author":"Calvo","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.247924_bib11","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1073\/pnas.91.1.138","volume":"91","author":"Champagne","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.247924_bib12","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.4049\/jimmunol.179.3.1497","volume":"179","author":"S\u00e1-Nunes","year":"2007","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M111.247924_bib13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1365-3024.2006.00807.x","volume":"28","author":"Titus","year":"2006","journal-title":"Parasite Immunol."},{"key":"10.1074\/jbc.M111.247924_bib14","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S1097-2765(00)80359-7","volume":"3","author":"Paesen","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M111.247924_bib15","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0020-7519(99)00042-9","volume":"29","author":"Wikel","year":"1999","journal-title":"Int. J. Parasitol."},{"key":"10.1074\/jbc.M111.247924_bib16","doi-asserted-by":"crossref","first-page":"e1001205","DOI":"10.1371\/journal.ppat.1001205","volume":"6","author":"Dai","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1074\/jbc.M111.247924_bib17","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1160\/TH09-04-0221","volume":"102","author":"Koh","year":"2009","journal-title":"Thromb. Haemost."},{"key":"10.1074\/jbc.M111.247924_bib18","doi-asserted-by":"crossref","first-page":"18717","DOI":"10.1074\/jbc.M001486200","volume":"275","author":"Valenzuela","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.247924_bib19","doi-asserted-by":"crossref","first-page":"16678","DOI":"10.1021\/bi991231p","volume":"38","author":"Francischetti","year":"1999","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M111.247924_bib20","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1182\/blood-2001-12-0237","volume":"99","author":"Francischetti","year":"2002","journal-title":"Blood"},{"key":"10.1074\/jbc.M111.247924_bib21","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.2741\/3363","volume":"14","author":"Francischetti","year":"2009","journal-title":"Front. Biosci."},{"key":"10.1074\/jbc.M111.247924_bib22","doi-asserted-by":"crossref","first-page":"20802","DOI":"10.1074\/jbc.273.33.20802","volume":"273","author":"Stark","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.247924_bib23","doi-asserted-by":"crossref","first-page":"4751","DOI":"10.1021\/cr010170+","volume":"102","author":"Gettins","year":"2002","journal-title":"Chem. Rev."},{"key":"10.1074\/jbc.M111.247924_bib24","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/nm0696-632","volume":"2","author":"Rubin","year":"1996","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M111.247924_bib25","doi-asserted-by":"crossref","first-page":"4841","DOI":"10.1111\/j.1742-4658.2005.04904.x","volume":"272","author":"Medcalf","year":"2005","journal-title":"FEBS J."},{"key":"10.1074\/jbc.M111.247924_bib26","series-title":"Molecular Cloning: A Laboratory Manual","author":"Sambrook","year":"1989"},{"key":"10.1074\/jbc.M111.247924_bib27","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0968-0004(98)01285-7","volume":"23","author":"Jeanmougin","year":"1998","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.M111.247924_bib28","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ibmb.2007.09.003","volume":"38","author":"Mans","year":"2008","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1074\/jbc.M111.247924_bib29","first-page":"189","volume":"10","author":"Kumar","year":"1994","journal-title":"Comput. Appl. Biosci."},{"key":"10.1074\/jbc.M111.247924_bib30","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/bioinformatics\/bti770","volume":"22","author":"Arnold","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1074\/jbc.M111.247924_bib31","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1242\/jeb.205.16.2429","volume":"205","author":"Francischetti","year":"2002","journal-title":"J. Exp. Biol."},{"key":"10.1074\/jbc.M111.247924_bib32","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1042\/bj3080243","volume":"308","author":"Ribeiro","year":"1995","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M111.247924_bib33","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1042\/BJ20041738","volume":"387","author":"Monteiro","year":"2005","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M111.247924_bib34","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1742-4658.2009.07494.x","volume":"277","author":"Calvo","year":"2010","journal-title":"FEBS J."},{"key":"10.1074\/jbc.M111.247924_bib35","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.thromres.2004.07.009","volume":"115","author":"Wang","year":"2005","journal-title":"Thromb. Res."},{"key":"10.1074\/jbc.M111.247924_bib36","doi-asserted-by":"crossref","first-page":"29256","DOI":"10.1074\/jbc.M703143200","volume":"282","author":"Kotsyfakis","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.247924_bib37","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ibmb.2006.10.007","volume":"37","author":"Arc\u00e0","year":"2007","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1074\/jbc.M111.247924_bib38","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0076-6879(79)63019-7","volume":"63","author":"Williams","year":"1979","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M111.247924_bib39","doi-asserted-by":"crossref","first-page":"7539","DOI":"10.1021\/bi00485a001","volume":"29","author":"Broze","year":"1990","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M111.247924_bib40","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/B978-0-12-385504-6.00005-1","volume":"99","author":"Olson","year":"2011","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1074\/jbc.M111.247924_bib41","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1538-7836.2004.01021.x","volume":"3","author":"Krishnaswamy","year":"2005","journal-title":"J. Thromb. Haemost."},{"key":"10.1074\/jbc.M111.247924_bib42","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S1050-1738(01)00070-6","volume":"10","author":"Rezaie","year":"2000","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1074\/jbc.M111.247924_bib43","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S1877-1173(10)93015-9","volume":"93","author":"Tollefsen","year":"2010","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1074\/jbc.M111.247924_bib44","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1161\/01.RES.0000265066.92923.ee","volume":"100","author":"Bouton","year":"2007","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M111.247924_bib45","doi-asserted-by":"crossref","first-page":"8740","DOI":"10.1074\/jbc.M110.188375","volume":"286","author":"Huang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.247924_bib46","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1021\/bi00057a035","volume":"32","author":"Gebbink","year":"1993","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M111.247924_bib47","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00018-008-8371-0","volume":"66","author":"Huntington","year":"2009","journal-title":"Cell Mol. Life Sci."},{"key":"10.1074\/jbc.M111.247924_bib48","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1161\/ATVBAHA.108.179663","volume":"29","author":"Ferrara","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1074\/jbc.M111.247924_bib49","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/00001721-199304050-00001","volume":"4","author":"Wesselschmidt","year":"1993","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"10.1074\/jbc.M111.247924_bib50","doi-asserted-by":"crossref","first-page":"11281","DOI":"10.1074\/jbc.273.18.11281","volume":"273","author":"Nishioka","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.247924_bib51","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1182\/blood-2006-09-046953","volume":"109","author":"Malleier","year":"2007","journal-title":"Blood"},{"key":"10.1074\/jbc.M111.247924_bib52","first-page":"85","volume":"31","author":"Maffey","year":"2001","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1074\/jbc.M111.247924_bib53","doi-asserted-by":"crossref","first-page":"13988","DOI":"10.1021\/bi00043a004","volume":"34","author":"Neuenschwander","year":"1995","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M111.247924_bib54","doi-asserted-by":"crossref","first-page":"18500","DOI":"10.1074\/jbc.270.31.18500","volume":"270","author":"Gilbert","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"Suppl. 2","key":"10.1074\/jbc.M111.247924_bib55","doi-asserted-by":"crossref","first-page":"S134","DOI":"10.1016\/S0049-3848(10)70031-1","volume":"125","author":"Thorpe","year":"2010","journal-title":"Thromb. Res."},{"key":"10.1074\/jbc.M111.247924_bib56","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.2174\/092986710791233706","volume":"17","author":"Rezaie","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1074\/jbc.M111.247924_bib57","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMp058118","volume":"353","author":"Berliner","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M111.247924_bib58","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/00041433-200310000-00002","volume":"14","author":"Leitinger","year":"2003","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1074\/jbc.M111.247924_bib59","doi-asserted-by":"crossref","first-page":"6987","DOI":"10.1021\/bi049655t","volume":"43","author":"Andersen","year":"2004","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M111.247924_bib60","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1097\/ALN.0b013e3181ebdb15","volume":"113","author":"Levy","year":"2010","journal-title":"Anesthesiology"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820575170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820575170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M111.247924","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T15:04:48Z","timestamp":1712502288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820575170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":60,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0021925820575170"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m111.247924","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}