{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:15:00Z","timestamp":1791321300716,"version":"4.3.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"28","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":3379,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1074\/jbc.m111.248864","type":"journal-article","created":{"date-parts":[[2011,5,14]],"date-time":"2011-05-14T00:24:14Z","timestamp":1305332654000},"page":"25246-25255","source":"Crossref","is-referenced-by-count":54,"title":["Phosphonoformic Acid Inhibits Viral Replication by Trapping the Closed Form of the DNA Polymerase"],"prefix":"10.1016","volume":"286","author":[{"given":"Karl E.","family":"Zahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egor P.","family":"Tchesnokov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"G\u00f6tte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Doubli\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M111.248864_bib1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/rmv.558","volume":"18","author":"Mercorelli","year":"2008","journal-title":"Rev. Med. Virol."},{"key":"10.1074\/jbc.M111.248864_bib2","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.4315\/0362-028X-70.11.2620","volume":"70","author":"Abou-Zeid","year":"2007","journal-title":"J. Food Prot."},{"key":"10.1074\/jbc.M111.248864_bib3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00005792-198405000-00002","volume":"63","author":"Lerner","year":"1984","journal-title":"Medicine"},{"key":"10.1074\/jbc.M111.248864_bib4","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/nrd1877","volume":"4","author":"De Clercq","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1074\/jbc.M111.248864_bib5","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1128\/AAC.27.4.600","volume":"27","author":"Spector","year":"1985","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M111.248864_bib6","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1128\/AAC.01172-07","volume":"52","author":"Magee","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M111.248864_bib7","doi-asserted-by":"crossref","first-page":"19039","DOI":"10.1016\/S0021-9258(19)47263-3","volume":"264","author":"Reardon","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.248864_bib8","doi-asserted-by":"crossref","first-page":"34218","DOI":"10.1074\/jbc.M806797200","volume":"283","author":"Tchesnokov","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.248864_bib9","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1074\/jbc.M607710200","volume":"282","author":"Marchand","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.248864_bib10","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.jmb.2009.03.025","volume":"388","author":"Beilhartz","year":"2009","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M111.248864_bib11","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1534\/genetics.104.040295","volume":"170","author":"Li","year":"2005","journal-title":"Genetics"},{"key":"10.1074\/jbc.M111.248864_bib12","doi-asserted-by":"crossref","first-page":"26439","DOI":"10.1074\/jbc.M109.012500","volume":"284","author":"Tchesnokov","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.248864_bib13","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1128\/JVI.80.3.1440-1450.2006","volume":"80","author":"Tchesnokov","year":"2006","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M111.248864_bib14","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1038\/sj.emboj.7600150","volume":"23","author":"Hogg","year":"2004","journal-title":"EMBO. J."},{"key":"10.1074\/jbc.M111.248864_bib15","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0092-8674(01)00367-1","volume":"105","author":"Franklin","year":"2001","journal-title":"Cell"},{"key":"10.1074\/jbc.M111.248864_bib16","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M111.248864_bib17","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0076-6879(97)76072-5","volume":"276","author":"Rould","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M111.248864_bib18","doi-asserted-by":"crossref","first-page":"10551","DOI":"10.1021\/bi7008807","volume":"46","author":"Zahn","year":"2007","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M111.248864_bib19","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1038\/nprot.2007.406","volume":"2","author":"Brunger","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1074\/jbc.M111.248864_bib20","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0076-6879(03)74014-2","volume":"374","author":"Winn","year":"2003","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M111.248864_bib21","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M111.248864_bib22","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1107\/S0021889893002729","volume":"26","author":"Howlin","year":"1993","journal-title":"J. Appl. Crystallogr."},{"key":"10.1074\/jbc.M111.248864_bib23","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/34593","volume":"391","author":"Doubli\u00e9","year":"1998","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.248864_bib24","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.str.2006.01.011","volume":"14","author":"Batra","year":"2006","journal-title":"Structure"},{"key":"10.1074\/jbc.M111.248864_bib25","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1177\/030089169408000310","volume":"80","author":"Stein","year":"1994","journal-title":"Tumori"},{"key":"10.1074\/jbc.M111.248864_bib26","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1021\/bi901488d","volume":"49","author":"Hogg","year":"2010","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M111.248864_bib27","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.dnarep.2007.03.005","volume":"6","author":"Garcia-Diaz","year":"2007","journal-title":"DNA Repair"},{"key":"10.1074\/jbc.M111.248864_bib28","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.1021\/bi049615p","volume":"43","author":"Zakharova","year":"2004","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M111.248864_bib29","doi-asserted-by":"crossref","first-page":"18193","DOI":"10.1074\/jbc.M602414200","volume":"281","author":"Liu","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.248864_bib30","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1107\/S0907444904026460","volume":"60","author":"Krissinel","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M111.248864_bib31","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","volume":"32","author":"Edgar","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M111.248864_bib32","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0092-8674(00)80296-2","volume":"89","author":"Wang","year":"1997","journal-title":"Cell"},{"key":"10.1074\/jbc.M111.248864_bib33","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1038\/sj.emboj.7600786","volume":"24","author":"Vaisman","year":"2005","journal-title":"EMBO. J."},{"key":"10.1074\/jbc.M111.248864_bib34","doi-asserted-by":"crossref","first-page":"e1000225","DOI":"10.1371\/journal.pbio.1000225","volume":"7","author":"Xu","year":"2009","journal-title":"PLoS Biol."},{"key":"10.1074\/jbc.M111.248864_bib35","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/j.1460-2075.1988.tb02781.x","volume":"7","author":"Wong","year":"1988","journal-title":"EMBO. J."},{"key":"10.1074\/jbc.M111.248864_bib36","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1093\/nar\/19.15.4045","volume":"19","author":"Ito","year":"1991","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M111.248864_bib37","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/protein\/3.6.461","volume":"3","author":"Delarue","year":"1990","journal-title":"Protein Eng."},{"key":"10.1074\/jbc.M111.248864_bib38","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1128\/jvi.67.1.60-66.1993","volume":"67","author":"Reha-Krantz","year":"1993","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M111.248864_bib39","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.1016\/S0021-9258(17)37508-7","volume":"269","author":"Reha-Krantz","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.248864_bib40","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/jac\/dkg354","volume":"52","author":"Baldanti","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1074\/jbc.M111.248864_bib41","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.humimm.2004.02.007","volume":"65","author":"Baldanti","year":"2004","journal-title":"Hum. Immunol."},{"key":"10.1074\/jbc.M111.248864_bib42","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S1368-7646(02)00021-3","volume":"5","author":"Gilbert","year":"2002","journal-title":"Drug Resist. Updat."},{"key":"10.1074\/jbc.M111.248864_bib43","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1128\/jvi.70.3.1390-1395.1996","volume":"70","author":"Baldanti","year":"1996","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M111.248864_bib44","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1086\/514041","volume":"176","author":"Smith","year":"1997","journal-title":"J. Infect. Dis."},{"key":"10.1074\/jbc.M111.248864_bib45","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1086\/517302","volume":"176","author":"Chou","year":"1997","journal-title":"J. Infect. Dis."},{"key":"10.1074\/jbc.M111.248864_bib46","doi-asserted-by":"crossref","first-page":"5927","DOI":"10.1128\/JVI.72.7.5927-5936.1998","volume":"72","author":"Cihlar","year":"1998","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M111.248864_bib47","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1086\/515648","volume":"178","author":"Chou","year":"1998","journal-title":"J. Infect. Dis."},{"key":"10.1074\/jbc.M111.248864_bib48","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1128\/AAC.00633-06","volume":"51","author":"Scott","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1074\/jbc.M111.248864_bib49","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/prot.21005","volume":"64","author":"Shi","year":"2006","journal-title":"Proteins"},{"key":"10.1074\/jbc.M111.248864_bib50","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/bioinformatics\/15.4.305","volume":"15","author":"Gouet","year":"1999","journal-title":"Bioinformatics"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819486833?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819486833?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M111.248864","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T19:20:25Z","timestamp":1641151225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819486833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":50,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0021925819486833"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m111.248864","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}