{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:17:43Z","timestamp":1791220663370,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"44","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":3236,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1074\/jbc.m111.257055","type":"journal-article","created":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T10:06:17Z","timestamp":1316081177000},"page":"38095-38102","source":"Crossref","is-referenced-by-count":194,"title":["HDAC4 Protein Regulates HIF1\u03b1 Protein Lysine Acetylation and Cancer Cell Response to Hypoxia"],"prefix":"10.1016","volume":"286","author":[{"given":"Hao","family":"Geng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris T.","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Pittsenbarger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz M.","family":"Beer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhui","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Z.","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M111.257055_bib1","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrc1187","volume":"3","author":"Semenza","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/jbc.M111.257055_bib2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.semcancer.2008.11.009","volume":"19","author":"Semenza","year":"2009","journal-title":"Semin. Cancer Biol."},{"key":"10.1074\/jbc.M111.257055_bib3","doi-asserted-by":"crossref","first-page":"17771","DOI":"10.1074\/jbc.271.30.17771","volume":"271","author":"Jiang","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.257055_bib4","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1074\/jbc.270.3.1230","volume":"270","author":"Wang","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.257055_bib5","doi-asserted-by":"crossref","first-page":"cm8","DOI":"10.1126\/stke.4072007cm8","volume":"2007","author":"Semenza","year":"2007","journal-title":"Sci. STKE"},{"key":"10.1074\/jbc.M111.257055_bib6","doi-asserted-by":"crossref","first-page":"41966","DOI":"10.1074\/jbc.M406320200","volume":"279","author":"Kato","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.257055_bib7","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/sj.emboj.7601025","volume":"25","author":"Yoo","year":"2006","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M111.257055_bib8","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/82146","volume":"6","author":"Kung","year":"2000","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M111.257055_bib9","doi-asserted-by":"crossref","first-page":"12969","DOI":"10.1073\/pnas.93.23.12969","volume":"93","author":"Arany","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.257055_bib10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/20459","volume":"399","author":"Maxwell","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.257055_bib11","doi-asserted-by":"crossref","first-page":"29936","DOI":"10.1074\/jbc.M204733200","volume":"277","author":"Isaacs","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.257055_bib12","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.molcel.2007.01.001","volume":"25","author":"Liu","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M111.257055_bib13","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1074\/jbc.M109.068577","volume":"285","author":"Luo","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.257055_bib14","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0092-8674(02)01085-1","volume":"111","author":"Jeong","year":"2002","journal-title":"Cell"},{"key":"10.1074\/jbc.M111.257055_bib15","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.molcel.2010.05.023","volume":"38","author":"Lim","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M111.257055_bib16","doi-asserted-by":"crossref","first-page":"8814","DOI":"10.1158\/0008-5472.CAN-05-4598","volume":"66","author":"Qian","year":"2006","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M111.257055_bib17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.gene.2005.09.010","volume":"363","author":"Glozak","year":"2005","journal-title":"Gene"},{"key":"10.1074\/jbc.M111.257055_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/emm.2004.1","volume":"36","author":"Lee","year":"2004","journal-title":"Exp. Mol. Med."},{"key":"10.1074\/jbc.M111.257055_bib19","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1128\/MCB.26.6.2019-2028.2006","volume":"26","author":"Kong","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M111.257055_bib20","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/86507","volume":"7","author":"Kim","year":"2001","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M111.257055_bib21","doi-asserted-by":"crossref","first-page":"6626","DOI":"10.1158\/0008-5472.CAN-04-0540","volume":"64","author":"Qian","year":"2004","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M111.257055_bib22","first-page":"647","volume":"17","author":"Kim","year":"2007","journal-title":"Oncol. Rep."},{"key":"10.1074\/jbc.M111.257055_bib23","doi-asserted-by":"crossref","first-page":"19579","DOI":"10.1073\/pnas.0809763105","volume":"105","author":"Zhang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.257055_bib24","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1158\/0008-5472.CAN-09-3186","volume":"70","author":"Geng","year":"2010","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M111.257055_bib25","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/978-1-59745-190-1_19","volume":"523","author":"Yuan","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1074\/jbc.M111.257055_bib26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.molcel.2007.05.033","volume":"27","author":"Zhang","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M111.257055_bib27","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1158\/1535-7163.MCT-08-0198","volume":"7","author":"Sullivan","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"10.1074\/jbc.M111.257055_bib28","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1535-6108(04)00118-7","volume":"5","author":"Semenza","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.M111.257055_bib29","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.canlet.2008.11.012","volume":"280","author":"Ellis","year":"2009","journal-title":"Cancer Lett."},{"key":"10.1074\/jbc.M111.257055_bib30","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1126\/science.1166226","volume":"323","author":"Chen","year":"2009","journal-title":"Science"},{"key":"10.1074\/jbc.M111.257055_bib31","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1172\/JCI27438","volume":"116","author":"Backs","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M111.257055_bib32","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cell.2004.10.024","volume":"119","author":"Vega","year":"2004","journal-title":"Cell"},{"key":"10.1074\/jbc.M111.257055_bib33","doi-asserted-by":"crossref","first-page":"7816","DOI":"10.1128\/MCB.19.11.7816","volume":"19","author":"Wang","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M111.257055_bib34","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1093\/nar\/29.16.3439","volume":"29","author":"Miska","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M111.257055_bib35","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1126\/science.1147949","volume":"318","author":"Semenza","year":"2007","journal-title":"Science"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820506522?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820506522?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M111.257055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T22:34:19Z","timestamp":1641335659000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820506522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":35,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0021925820506522"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m111.257055","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}