{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:30:48Z","timestamp":1791275448177,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":3097,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1074\/jbc.m111.292193","type":"journal-article","created":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T02:15:10Z","timestamp":1329790510000},"page":"11616-11628","source":"Crossref","is-referenced-by-count":109,"title":["Role of Osteoglycin in the Linkage between Muscle and Bone"],"prefix":"10.1016","volume":"287","author":[{"given":"Ken-ichiro","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Higashimaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takenobu","family":"Katagiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitsugu","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Seino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M111.292193_bib1","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1097\/gme.0b013e318164ee85","article-title":"Association between low lean body mass and osteoporotic fractures after menopause","volume":"15","author":"Capozza","year":"2008","journal-title":"Menopause"},{"key":"10.1074\/jbc.M111.292193_bib2","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/jbmr.5650110618","article-title":"Relationship between body composition and bone mass in women","volume":"11","author":"Khosla","year":"1996","journal-title":"J. Bone Miner Res."},{"key":"10.1074\/jbc.M111.292193_bib3","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1007\/s001980170075","article-title":"Determinants of bone mineral density and spinal fracture risk in postmenopausal Japanese women","volume":"12","author":"Nakaoka","year":"2001","journal-title":"Osteoporos Int."},{"key":"10.1074\/jbc.M111.292193_bib4","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.cellsig.2010.10.003","article-title":"Bone morphogenetic proteins. A critical review","volume":"23","author":"Bragdon","year":"2011","journal-title":"Cell. Signal."},{"key":"10.1074\/jbc.M111.292193_bib5","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/00005131-200307000-00007","article-title":"Influence of extensive muscle injury on fracture healing in rat tibia","volume":"17","author":"Utv\u00e5g","year":"2003","journal-title":"J. Orthop. Trauma"},{"key":"10.1074\/jbc.M111.292193_bib6","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.2106\/00004623-199173090-00006","article-title":"A comparison of the effects of skin coverage and muscle flap coverage on the early strength of union at the site of osteotomy after devascularization of a segment of canine tibia","volume":"73","author":"Richards","year":"1991","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1074\/jbc.M111.292193_bib7","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1073\/pnas.1018501108","article-title":"TNF-\u03b1 promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells","volume":"108","author":"Glass","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.292193_bib8","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1021\/pr060448k","article-title":"Identification of secreted proteins during skeletal muscle development","volume":"6","author":"Chan","year":"2007","journal-title":"J. Proteome Res."},{"key":"10.1074\/jbc.M111.292193_bib9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.berh.2007.11.007","article-title":"Fibrodysplasia ossificans progressiva","volume":"22","author":"Kaplan","year":"2008","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1074\/jbc.M111.292193_bib10","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ng1783","article-title":"A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva","volume":"38","author":"Shore","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M111.292193_bib11","doi-asserted-by":"crossref","first-page":"7149","DOI":"10.1074\/jbc.M801681200","article-title":"Constitutively activated ALK2 and increased SMAD1\/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva","volume":"284","author":"Fukuda","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.292193_bib12","doi-asserted-by":"crossref","first-page":"9787","DOI":"10.1074\/jbc.M110.179127","article-title":"Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway","volume":"286","author":"Hisa","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.292193_bib13","doi-asserted-by":"crossref","first-page":"36024","DOI":"10.1074\/jbc.M206030200","article-title":"Activations of ERK1\/2 and JNK by transforming growth factor \u03b2 negatively regulate Smad3-induced alkaline phosphatase activity and mineralization in mouse osteoblastic cells","volume":"277","author":"Sowa","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.292193_bib14","doi-asserted-by":"crossref","first-page":"40267","DOI":"10.1074\/jbc.M401312200","article-title":"Menin is required for bone morphogenetic protein 2- and transforming growth factor \u03b2-regulated osteoblastic differentiation through interaction with Smads and Runx2","volume":"279","author":"Sowa","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.292193_bib15","first-page":"758","article-title":"Analysis of transcriptional regulation of the small leucine-rich proteoglycans","volume":"10","author":"Tasheva","year":"2004","journal-title":"Mol. Vis."},{"key":"10.1074\/jbc.M111.292193_bib16","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1042\/bj3020527","article-title":"Interaction of the small interstitial proteoglycans biglycan, decorin, and fibromodulin with transforming growth factor \u03b2","volume":"302","author":"Hildebrand","year":"1994","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M111.292193_bib17","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1146\/annurev.biochem.67.1.609","article-title":"Matrix proteoglycans. From molecular design to cellular function","volume":"67","author":"Iozzo","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M111.292193_bib18","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/jcb.10515","article-title":"Phenotype discovery by gene expression profiling. Mapping of biological processes linked to BMP-2-mediated osteoblast differentiation","volume":"89","author":"Balint","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"10.1074\/jbc.M111.292193_bib19","doi-asserted-by":"crossref","first-page":"20805","DOI":"10.1016\/S0021-9258(19)47133-0","article-title":"Purification and characterization of a unique osteoinductive factor from bovine bone","volume":"264","author":"Bentz","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.292193_bib20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.heares.2007.12.006","article-title":"Expression studies of osteoglycin\/mimecan (OGN) in the cochlea and auditory phenotype of Ogn-deficient mice","volume":"237","author":"Williamson","year":"2008","journal-title":"Hear Res."},{"key":"10.1074\/jbc.M111.292193_bib21","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ygeno.2006.02.013","article-title":"Activation of genes for growth factor and cytokine pathways late in chondrogenic differentiation of ATDC5 cells","volume":"88","author":"Osawa","year":"2006","journal-title":"Genomics"},{"key":"10.1074\/jbc.M111.292193_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11010-008-9935-x","article-title":"The proteoglycan osteoglycin\/mimecan is correlated with arteriogenesis","volume":"322","author":"Kampmann","year":"2009","journal-title":"Mol. Cell. Biochem."},{"key":"10.1074\/jbc.M111.292193_bib23","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1745-7270.2008.00392.x","article-title":"High expression of osteoglycin decreases the metastatic capability of mouse hepatocarcinoma Hca-F cells to lymph nodes","volume":"40","author":"Cui","year":"2008","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1074\/jbc.M111.292193_bib24","doi-asserted-by":"crossref","first-page":"6117","DOI":"10.3748\/wjg.15.6117","article-title":"High expression of osteoglycin decreases gelatinase activity of murine hepatocarcinoma Hca-F cells","volume":"15","author":"Cui","year":"2009","journal-title":"World J. Gastroenterol"},{"key":"10.1074\/jbc.M111.292193_bib25","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M110.004804","article-title":"Identification of differentially regulated secretome components during skeletal myogenesis","volume":"10","author":"Chan","year":"2011","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/jbc.M111.292193_bib26","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1002\/jcb.20606","article-title":"Global gene expression analysis in the bones reveals involvement of several novel genes and pathways in mediating an anabolic response of mechanical loading in mice","volume":"96","author":"Xing","year":"2005","journal-title":"J. Cell. Biochem."},{"key":"10.1074\/jbc.M111.292193_bib27","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/jcb.21218","article-title":"Identification of mechanosensitive genes in osteoblasts by comparative microarray studies using the rotating wall vessel and the random positioning machine","volume":"101","author":"Patel","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"10.1074\/jbc.M111.292193_bib28","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1083\/jcb.200105052","article-title":"Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures","volume":"155","author":"Liu","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M111.292193_bib29","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1210\/jcem.86.5.7463","article-title":"Hypoadiponectinemia in obesity and type 2 diabetes. Close association with insulin resistance and hyperinsulinemia","volume":"86","author":"Weyer","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1074\/jbc.M111.292193_bib30","doi-asserted-by":"crossref","first-page":"12542","DOI":"10.1074\/jbc.M110.152405","article-title":"Adiponectin inhibits osteoclastogenesis and bone resorption via APPL1-mediated suppression of Akt1","volume":"286","author":"Tu","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.292193_bib31","first-page":"437","article-title":"Leptin in the regulation of immunity, inflammation, and hematopoiesis","volume":"68","author":"Fantuzzi","year":"2000","journal-title":"J. Leukoc. Biol."},{"key":"10.1074\/jbc.M111.292193_bib32","doi-asserted-by":"crossref","first-page":"37607","DOI":"10.1074\/jbc.M110.169714","article-title":"Leptin receptor (Lepr) is a negative modulator of bone mechanosensitivity, and genetic variations in Lepr may contribute to the differential osteogenic response to mechanical stimulation in the C57BL\/6J and C3H\/HeJ pair of mouse strains","volume":"285","author":"Kapur","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.292193_bib33","doi-asserted-by":"crossref","first-page":"4795","DOI":"10.1210\/jc.2010-1030","article-title":"The central regulation of bone mass, and the first link between bone remodeling and energy metabolism","volume":"95","author":"Karsenty","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1074\/jbc.M111.292193_bib34","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.2337\/diabetes.53.7.1643","article-title":"Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction","volume":"53","author":"Febbraio","year":"2004","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M111.292193_bib35","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1210\/jc.2002-021687","article-title":"Interleukin-6 stimulates lipolysis and fat oxidation in humans","volume":"88","author":"van Hall","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1074\/jbc.M111.292193_bib36","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1172\/JCI23606","article-title":"FGF-21 as a novel metabolic regulator","volume":"115","author":"Kharitonenkov","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M111.292193_bib37","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1016\/j.febslet.2008.10.021","article-title":"FGF21 is an Akt-regulated myokine","volume":"582","author":"Izumiya","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M111.292193_bib38","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1152\/japplphysiol.00734.2009","article-title":"Edward F. Adolph distinguished lecture. Muscle as an endocrine organ. IL-6 and other myokines","volume":"107","author":"Pedersen","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"10.1074\/jbc.M111.292193_bib39","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1152\/japplphysiol.00080.2007","article-title":"Role of myokines in exercise and metabolism","volume":"103","author":"Pedersen","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"10.1074\/jbc.M111.292193_bib40","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1210\/er.2004-0001","article-title":"Transforming growth factor-\u03b21 to the bone","volume":"26","author":"Janssens","year":"2005","journal-title":"Endocr. Rev."},{"key":"10.1074\/jbc.M111.292193_bib41","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1146\/annurev.cellbio.21.022404.142018","article-title":"Specificity and versatility in TGF-\u03b2 signaling through Smads","volume":"21","author":"Feng","year":"2005","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1074\/jbc.M111.292193_bib42","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1101\/gad.1350705","article-title":"Smad transcription factors","volume":"19","author":"Massagu\u00e9","year":"2005","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M111.292193_bib43","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1359\/jbmr.2002.17.7.1190","article-title":"Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells","volume":"17","author":"Sowa","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"10.1074\/jbc.M111.292193_bib44","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1359\/jbmr.2001.16.10.1754","article-title":"The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis","volume":"16","author":"Borton","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1074\/jbc.M111.292193_bib45","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/jcb.22252","article-title":"Role of Smad3, acting independently of transforming growth factor-\u03b2, in the early induction of Wnt-\u03b2-catenin signaling by parathyroid hormone in mouse osteoblastic cells","volume":"108","author":"Inoue","year":"2009","journal-title":"J. Cell. Biochem."},{"key":"10.1074\/jbc.M111.292193_bib46","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1161\/01.ATV.17.11.2437","article-title":"Identification of osteoglycin as a component of the vascular matrix. Differential expression by vascular smooth muscle cells during neointima formation and in atherosclerotic plaques","volume":"17","author":"Shanahan","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1074\/jbc.M111.292193_bib47","doi-asserted-by":"crossref","first-page":"18693","DOI":"10.1074\/jbc.274.26.18693","article-title":"The bovine mimecan gene. Molecular cloning and characterization of two major RNA transcripts generated by alternative use of two splice acceptor sites in the third exon","volume":"274","author":"Tasheva","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.292193_bib48","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0167-4781(02)00245-2","article-title":"Analysis of the promoter region of human mimecan gene","volume":"1575","author":"Tasheva","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M111.292193_bib49","first-page":"277","article-title":"Interferon-\u03b3 regulation of the human mimecan promoter","volume":"9","author":"Tasheva","year":"2003","journal-title":"Mol. Vis."},{"key":"10.1074\/jbc.M111.292193_bib50","doi-asserted-by":"crossref","first-page":"41626","DOI":"10.1074\/jbc.M406630200","article-title":"Bone morphogenetic protein-1\/tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis","volume":"279","author":"Ge","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.292193_bib51","first-page":"407","article-title":"Mimecan\/osteoglycin-deficient mice have collagen fibril abnormalities","volume":"8","author":"Tasheva","year":"2002","journal-title":"Mol. Vis."},{"key":"10.1074\/jbc.M111.292193_bib52","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1089\/dna.1990.9.303","article-title":"Molecular cloning of a novel bone-forming compound. Osteoinductive factor","volume":"9","author":"Madisen","year":"1990","journal-title":"DNA Cell Biol."},{"key":"10.1074\/jbc.M111.292193_bib53","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1167\/iovs.05-0325","article-title":"An x-ray diffraction study of corneal structure in mimecan-deficient mice","volume":"46","author":"Beecher","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820530895?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820530895?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M111.292193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:10:51Z","timestamp":1641341451000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820530895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":53,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0021925820530895"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m111.292193","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}