{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:09:57Z","timestamp":1790870997728,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"49","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":3225,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1074\/jbc.m111.299727","type":"journal-article","created":{"date-parts":[[2011,10,15]],"date-time":"2011-10-15T00:15:29Z","timestamp":1318637729000},"page":"42162-42179","source":"Crossref","is-referenced-by-count":50,"title":["Carbohydrate Metabolism Is Perturbed in Peroxisome-deficient Hepatocytes Due to Mitochondrial Dysfunction, AMP-activated Protein Kinase (AMPK) Activation, and Peroxisome Proliferator-activated Receptor \u03b3 Coactivator 1\u03b1 (PGC-1\u03b1) Suppression"],"prefix":"10.1016","volume":"286","author":[{"given":"Annelies","family":"Peeters","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Fraisl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiel","family":"Ver Loren van Themaat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Van Kampen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Rider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Takemori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko Willems","family":"van Dijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul P.","family":"Van Veldhoven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Carmeliet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Baes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M111.299727_bib1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev.biochem.74.082803.133329","volume":"75","author":"Wanders","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M111.299727_bib2","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/j.bbamcr.2006.09.006","volume":"1763","author":"Schrader","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M111.299727_bib3","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.bbamcr.2006.09.010","volume":"1763","author":"Steinberg","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M111.299727_bib4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s100249900026","volume":"1","author":"Jevon","year":"1998","journal-title":"Pediatr. Dev. Pathol."},{"key":"10.1074\/jbc.M111.299727_bib5","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1126\/science.182.4107.62","volume":"182","author":"Goldfischer","year":"1973","journal-title":"Science"},{"key":"10.1074\/jbc.M111.299727_bib6","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1203\/00006450-198306000-00018","volume":"17","author":"Trijbels","year":"1983","journal-title":"Pediatr. Res."},{"key":"10.1074\/jbc.M111.299727_bib7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF00428229","volume":"384","author":"Pfeifer","year":"1979","journal-title":"Virchows Arch. A Pathol. Anat. Histol."},{"key":"10.1074\/jbc.M111.299727_bib8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3109\/01913128309141833","volume":"5","author":"Mooi","year":"1983","journal-title":"Ultrastruct. Pathol."},{"key":"10.1074\/jbc.M111.299727_bib9","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/0016-5085(80)90931-2","volume":"79","author":"Mathis","year":"1980","journal-title":"Gastroenterology"},{"key":"10.1074\/jbc.M111.299727_bib10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF01678985","volume":"416","author":"Hughes","year":"1990","journal-title":"Virchows Arch. A Pathol. Anat. Histopathol."},{"key":"10.1074\/jbc.M111.299727_bib11","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/hep.20628","volume":"41","author":"Dirkx","year":"2005","journal-title":"Hepatology"},{"key":"10.1074\/jbc.M111.299727_bib12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/gene.10047","volume":"32","author":"Baes","year":"2002","journal-title":"Genesis"},{"key":"10.1074\/jbc.M111.299727_bib13","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1074\/jbc.274.1.305","volume":"274","author":"Postic","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.299727_bib14","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1128\/MCB.15.6.3012","volume":"15","author":"Lee","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M111.299727_bib15","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/j.metabol.2010.03.008","volume":"59","author":"van den Berg","year":"2010","journal-title":"Metabolism"},{"key":"10.1074\/jbc.M111.299727_bib16","first-page":"23","volume":"16","author":"P\u00e9ronnet","year":"1991","journal-title":"Can. J. Sport Sci."},{"key":"10.1074\/jbc.M111.299727_bib17","doi-asserted-by":"crossref","first-page":"16329","DOI":"10.1074\/jbc.M001994200","volume":"275","author":"Baes","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.299727_bib18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature03354","volume":"434","author":"Rodgers","year":"2005","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.299727_bib19","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1111\/j.1742-4658.2006.05291.x","volume":"273","author":"Katoh","year":"2006","journal-title":"FEBS J."},{"key":"10.1074\/jbc.M111.299727_bib20","doi-asserted-by":"crossref","first-page":"E413","DOI":"10.1152\/ajpendo.00525.2009","volume":"299","author":"Uebi","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab"},{"key":"10.1074\/jbc.M111.299727_bib21","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1016\/S0021-9258(17)34850-0","volume":"253","author":"Jomain-Baum","year":"1978","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.299727_bib22","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.2337\/diabetes.49.7.1165","volume":"49","author":"Rajas","year":"2000","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M111.299727_bib23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1006\/abio.1996.0194","volume":"237","author":"Van Veldhoven","year":"1996","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.M111.299727_bib24","series-title":"Methods of Enzymatic Analysis. Metabolites 1: Carbohydrates","first-page":"11","author":"Keppler","year":"1984"},{"key":"10.1074\/jbc.M111.299727_bib25","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/0006-2952(84)90531-8","volume":"33","author":"Van Veldhoven","year":"1984","journal-title":"Biochem. Pharmacol."},{"key":"10.1074\/jbc.M111.299727_bib26","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1046-2023(02)00037-3","volume":"26","author":"Manfredi","year":"2002","journal-title":"Methods"},{"key":"10.1074\/jbc.M111.299727_bib27","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1432-1033.1982.tb07039.x","volume":"129","author":"Van Schaftingen","year":"1982","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M111.299727_bib28","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.bbrc.2007.03.198","volume":"357","author":"Dirkx","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M111.299727_bib29","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.cmet.2006.04.013","volume":"3","author":"Lerin","year":"2006","journal-title":"Cell Metab."},{"key":"10.1074\/jbc.M111.299727_bib30","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ng.2007.62","volume":"40","author":"Aragon\u00e9s","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M111.299727_bib31","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.bbalip.2008.07.010","volume":"1781","author":"Martens","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M111.299727_bib32","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1016\/j.biochi.2011.06.034","volume":"93","author":"Peeters","year":"2011","journal-title":"Biochimie"},{"key":"10.1074\/jbc.M111.299727_bib33","doi-asserted-by":"crossref","first-page":"ii","DOI":"10.1155\/2010\/572405","volume":"2010","author":"Peeters","year":"2010","journal-title":"PPAR Res."},{"key":"10.1074\/jbc.M111.299727_bib34","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1126\/science.1079817","volume":"300","author":"Du","year":"2003","journal-title":"Science"},{"key":"10.1074\/jbc.M111.299727_bib35","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nm1044","volume":"10","author":"Koo","year":"2004","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M111.299727_bib36","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.3748\/wjg.15.2329","volume":"15","author":"Wang","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"10.1074\/jbc.M111.299727_bib37","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.2337\/db06-1448","volume":"56","author":"Okamoto","year":"2007","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M111.299727_bib38","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1042\/BJ20041425","volume":"386","author":"Iynedjian","year":"2005","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M111.299727_bib39","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/nature03967","volume":"437","author":"Koo","year":"2005","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.299727_bib40","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1748-1716.2009.01970.x","volume":"196","author":"Viollet","year":"2009","journal-title":"Acta Physiol."},{"key":"10.1074\/jbc.M111.299727_bib41","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1007\/s00018-010-0454-z","volume":"67","author":"Cant\u00f3","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1074\/jbc.M111.299727_bib42","doi-asserted-by":"crossref","first-page":"33902","DOI":"10.1074\/jbc.M802537200","volume":"283","author":"Horike","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.299727_bib43","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/35093050","volume":"413","author":"Yoon","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.299727_bib44","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nature01667","volume":"423","author":"Puigserver","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.299727_bib45","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1210\/er.2006-0037","volume":"27","author":"Handschin","year":"2006","journal-title":"Endocr. Rev."},{"key":"10.1074\/jbc.M111.299727_bib46","doi-asserted-by":"crossref","first-page":"14683","DOI":"10.1074\/jbc.M512636200","volume":"281","author":"Rhee","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.299727_bib47","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1006\/bbrc.2001.5608","volume":"287","author":"Wu","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M111.299727_bib48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0079-6603(01)70013-X","volume":"70","author":"Roche","year":"2001","journal-title":"Prog. Nucleic Acid Res. Mol. Biol."},{"key":"10.1074\/jbc.M111.299727_bib49","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cmet.2009.06.006","volume":"10","author":"Le Lay","year":"2009","journal-title":"Cell Metab."},{"key":"10.1074\/jbc.M111.299727_bib50","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.2337\/diabetes.52.7.1649","volume":"52","author":"She","year":"2003","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M111.299727_bib51","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s00018-007-7006-1","volume":"64","author":"Mandard","year":"2007","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1074\/jbc.M111.299727_bib52","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1113\/jphysiol.2006.108944","volume":"574","author":"Hardie","year":"2006","journal-title":"J. Physiol."},{"key":"10.1074\/jbc.M111.299727_bib53","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/S0960-9822(00)00742-9","volume":"10","author":"Marsin","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.M111.299727_bib54","doi-asserted-by":"crossref","first-page":"30778","DOI":"10.1074\/jbc.M205213200","volume":"277","author":"Marsin","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.299727_bib55","doi-asserted-by":"crossref","first-page":"891S","DOI":"10.3945\/ajcn.110.001925","volume":"93","author":"Hardie","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1074\/jbc.M111.299727_bib56","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1002\/hep.21710","volume":"45","author":"Lee","year":"2007","journal-title":"Hepatology"},{"key":"10.1074\/jbc.M111.299727_bib57","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0167-4889(89)90014-1","volume":"1012","author":"Carling","year":"1989","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M111.299727_bib58","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.1038\/onc.2010.206","volume":"29","author":"Jeninga","year":"2010","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M111.299727_bib59","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/nature07813","volume":"458","author":"Cant\u00f3","year":"2009","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.299727_bib60","doi-asserted-by":"crossref","first-page":"896","DOI":"10.2337\/diabetes.49.6.896","volume":"49","author":"Lochhead","year":"2000","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M111.299727_bib61","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.2337\/diabetes.54.5.1331","volume":"54","author":"Foretz","year":"2005","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M111.299727_bib62","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.diabres.2005.12.011","volume":"73","author":"Viana","year":"2006","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1074\/jbc.M111.299727_bib63","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.cmet.2009.02.006","volume":"9","author":"Purushotham","year":"2009","journal-title":"Cell Metab."},{"key":"10.1074\/jbc.M111.299727_bib64","doi-asserted-by":"crossref","first-page":"8466","DOI":"10.1073\/pnas.1032913100","volume":"100","author":"Patti","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.299727_bib65","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","volume":"34","author":"Mootha","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M111.299727_bib66","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.2337\/db08-0144","volume":"57","author":"Kumashiro","year":"2008","journal-title":"Diabetes"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820871075?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820871075?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M111.299727","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T22:50:06Z","timestamp":1641423006000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820871075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":66,"journal-issue":{"issue":"49","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0021925820871075"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m111.299727","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}