{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:25:18Z","timestamp":1791192318872,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"26","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"vor","delay-in-days":3021,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1074\/jbc.m111.304626","type":"journal-article","created":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T01:19:58Z","timestamp":1336094398000},"page":"21796-21805","source":"Crossref","is-referenced-by-count":64,"title":["The PP242 Mammalian Target of Rapamycin (mTOR) Inhibitor Activates Extracellular Signal-regulated Kinase (ERK) in Multiple Myeloma Cells via a Target of Rapamycin Complex 1 (TORC1)\/ Eukaryotic Translation Initiation Factor 4E (eIF-4E)\/RAF Pathway and Activation Is a Mechanism of Resistance"],"prefix":"10.1016","volume":"287","author":[{"given":"Bao","family":"Hoang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica","family":"Benavides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijiang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Frost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Gera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Lichtenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M111.304626_bib1","first-page":"1","article-title":"Early events of B cell activation by antigen","volume":"2","author":"Alessi","year":"2009","journal-title":"Science Signaling"},{"key":"10.1074\/jbc.M111.304626_bib2","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1158\/1535-7163.MCT-05-0068","article-title":"Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor\/insulin receptor substrate-1\/phosphatidylinositol 3-kinase cascade","volume":"4","author":"Shi","year":"2005","journal-title":"Mol. Cancer Ther."},{"key":"10.1074\/jbc.M111.304626_bib3","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1158\/0008-5472.CAN-05-2925","article-title":"mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt","volume":"66","author":"O'Reilly","year":"2006","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M111.304626_bib4","doi-asserted-by":"crossref","first-page":"7052","DOI":"10.1158\/0008-5472.CAN-05-0917","article-title":"Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition","volume":"65","author":"Sun","year":"2005","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M111.304626_bib5","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1182\/blood-2010-05-285726","article-title":"Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor","volume":"116","author":"Hoang","year":"2010","journal-title":"Blood"},{"key":"10.1074\/jbc.M111.304626_bib6","first-page":"3065","article-title":"Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer","volume":"118","author":"Carracedo","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M111.304626_bib7","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1126\/science.1106148","article-title":"Phosphorylation and regulation of Akt\/PKB by the rictor-mTOR complex","volume":"307","author":"Sarbassov","year":"2005","journal-title":"Science"},{"key":"10.1074\/jbc.M111.304626_bib8","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1158\/1078-0432.CCR-07-4153","article-title":"Involvement of hepcidin in the anemia of multiple myeloma","volume":"14","author":"Sharma","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1074\/jbc.M111.304626_bib9","first-page":"5027","article-title":"Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779","volume":"62","author":"Shi","year":"2002","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M111.304626_bib10","doi-asserted-by":"crossref","first-page":"10964","DOI":"10.1074\/jbc.M407874200","article-title":"Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK- and ERK-dependent pathway","volume":"280","author":"Shi","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.304626_bib11","doi-asserted-by":"crossref","first-page":"5030","DOI":"10.1038\/sj.onc.1203862","article-title":"A novel assay for the measurement of Raf-1 kinase activity","volume":"19","author":"Bondzi","year":"2000","journal-title":"Oncogene."},{"key":"10.1074\/jbc.M111.304626_bib12","doi-asserted-by":"crossref","first-page":"18239","DOI":"10.1074\/jbc.M400257200","article-title":"Vav1 transduces T cell receptor signals to the activation of the Ras\/ERK pathway via LAT, Sos, and RasGRP1","volume":"279","author":"Reynolds","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.304626_bib13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/332083a0","article-title":"Autocrine generation and requirement of BSF-2\/IL-6 for human multiple myelomas","volume":"332","author":"Kawano","year":"1988","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.304626_bib14","doi-asserted-by":"crossref","first-page":"5835","DOI":"10.1158\/0008-5472.CAN-08-4285","article-title":"Antimyeloma activity of the orally bioavailable dual phosphatidylinositol 3-kinase\/mammalian target of rapamycin inhibitor NVP-BEZ235","volume":"69","author":"McMillin","year":"2009","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M111.304626_bib15","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nature04304","article-title":"BRAF mutation predicts sensitivity to MEK inhibition","volume":"439","author":"Solit","year":"2006","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.304626_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0014-5793(01)02651-5","article-title":"Effects of MAP kinase cascade inhibitors on the MKK5\/ERK5 pathway","volume":"502","author":"Mody","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M111.304626_bib17","doi-asserted-by":"crossref","first-page":"7099","DOI":"10.1158\/0008-5472.CAN-04-1443","article-title":"BAY 43\u20139006 exhibits broad spectrum oral antitumor activity and targets the RAF\/MEK\/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis","volume":"64","author":"Wilhelm","year":"2004","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M111.304626_bib18","doi-asserted-by":"crossref","first-page":"4853","DOI":"10.1158\/0008-5472.CAN-07-6787","article-title":"Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma","volume":"68","author":"Montagut","year":"2008","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M111.304626_bib19","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1038\/sj.leu.2403052","article-title":"Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation","volume":"17","author":"Shelton","year":"2003","journal-title":"Leukemia"},{"key":"10.1074\/jbc.M111.304626_bib20","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0898-6568(02)00139-0","article-title":"Mechanisms of regulating the Raf kinase family","volume":"15","author":"Chong","year":"2003","journal-title":"Cellular Signalling"},{"key":"10.1074\/jbc.M111.304626_bib21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.molcel.2004.11.055","article-title":"Regulation of Raf-1 by direct feedback phosphorylation","volume":"17","author":"Dougherty","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M111.304626_bib22","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.cell.2009.12.040","article-title":"Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF","volume":"140","author":"Heidorn","year":"2010","journal-title":"Cell"},{"key":"10.1074\/jbc.M111.304626_bib23","doi-asserted-by":"crossref","first-page":"8023","DOI":"10.1074\/jbc.M900301200","article-title":"An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1","volume":"284","author":"Thoreen","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.304626_bib24","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1371\/journal.pbio.1000038","article-title":"Active site inhibitors of mTOR target rapamycin-resistant outputs of TORC1 and TORC2","volume":"7","author":"Feldman","year":"2009","journal-title":"PLoS Biol."},{"key":"10.1074\/jbc.M111.304626_bib25","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1158\/1535-7163.MCT-08-1177","article-title":"Effect of autophagy on multiple myeloma cell viability","volume":"8","author":"Hoang","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"10.1074\/jbc.M111.304626_bib26","doi-asserted-by":"crossref","first-page":"13975","DOI":"10.1073\/pnas.1008908107","article-title":"Mnk earmarks eIF4E for cancer therapy","volume":"107","author":"Hay","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.304626_bib27","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1101\/gad.1604407","article-title":"Dissecting eIF4E action in tumorigenesis","volume":"21","author":"Wendel","year":"2007","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M111.304626_bib28","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1182\/blood-2010-04-278788","article-title":"A mechanistic rationale for MEK inhibitor therapy in myeloma based on blockade of MAF oncogene expression","volume":"117","author":"Annunziata","year":"2011","journal-title":"Blood"},{"key":"10.1074\/jbc.M111.304626_bib29","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1126\/science.270.5240.1326","article-title":"Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis","volume":"270","author":"Xia","year":"1995","journal-title":"Science"},{"key":"10.1074\/jbc.M111.304626_bib30","doi-asserted-by":"crossref","first-page":"31108","DOI":"10.1074\/jbc.274.43.31108","article-title":"Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK\/Erk kinase","volume":"274","author":"Scheid","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.304626_bib31","first-page":"469","article-title":"Regulation of cell cycle progression and apoptosis by the Ras\/Raf\/MEK\/ERK pathway (Review)","volume":"22","author":"Chang","year":"2003","journal-title":"Int. J. Oncol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820497108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820497108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M111.304626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T18:29:10Z","timestamp":1641320950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820497108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":31,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0021925820497108"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m111.304626","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}