{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:37:33Z","timestamp":1790199453544,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":3088,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1074\/jbc.m111.304857","type":"journal-article","created":{"date-parts":[[2012,3,3]],"date-time":"2012-03-03T20:48:46Z","timestamp":1330807726000},"page":"13620-13632","source":"Crossref","is-referenced-by-count":46,"title":["Neutral Sphingomyelinase 2 Deficiency Increases Hyaluronan Synthesis by Up-regulation of Hyaluronan Synthase 2 through Decreased Ceramide Production and Activation of Akt"],"prefix":"10.1016","volume":"287","author":[{"given":"Jingdong","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny","family":"Berdyshev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Poirer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy B.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glyn","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M111.304857_bib1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/jmg.16.2.101","article-title":"Genetic heterogeneity in osteogenesis imperfecta","volume":"16","author":"Sillence","year":"1979","journal-title":"J. Med. Genet."},{"key":"10.1074\/jbc.M111.304857_bib2","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1359\/jbmr.2000.15.9.1650","article-title":"Type V osteogenesis imperfecta. A new form of brittle bone disease","volume":"15","author":"Glorieux","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"10.1074\/jbc.M111.304857_bib3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1359\/jbmr.2002.17.1.30","article-title":"Osteogenesis imperfecta type VI. A form of brittle bone disease with a mineralization defect","volume":"17","author":"Glorieux","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"10.1074\/jbc.M111.304857_bib4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S8756-3282(02)00790-1","article-title":"Osteogenesis imperfecta type VII. An autosomal recessive form of brittle bone disease","volume":"31","author":"Ward","year":"2002","journal-title":"Bone"},{"key":"10.1074\/jbc.M111.304857_bib5","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/ng1603","article-title":"A deletion in the gene encoding sphingomyelin phosphodiesterase 3 (Smpd3) results in osteogenesis and dentinogenesis imperfecta in the mouse","volume":"37","author":"Aubin","year":"2005","journal-title":"Nat Genet."},{"key":"10.1074\/jbc.M111.304857_bib6","doi-asserted-by":"crossref","first-page":"4554","DOI":"10.1073\/pnas.0406380102","article-title":"Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development","volume":"102","author":"Stoffel","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.304857_bib7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1083\/jcb.201102051","article-title":"A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization","volume":"194","author":"Khavandgar","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M111.304857_bib8","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0968-0004(99)01408-5","article-title":"Ceramide and apoptosis","volume":"24","author":"Kolesnick","year":"1999","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.M111.304857_bib9","doi-asserted-by":"crossref","first-page":"9868","DOI":"10.1074\/jbc.272.15.9868","article-title":"Anti-immunoglobulin-induced apoptosis in WEHI 231 cells involves the slow formation of ceramide from sphingomyelin and is blocked by Bcl-xL","volume":"272","author":"Wiesner","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.304857_bib10","doi-asserted-by":"crossref","first-page":"13775","DOI":"10.1074\/jbc.M212262200","article-title":"Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism","volume":"278","author":"Marchesini","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.304857_bib11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1083\/jcb.200307017","article-title":"Amyloid-\u03b2 peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway","volume":"164","author":"Lee","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M111.304857_bib12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/jnr.10816","article-title":"Regulation of sphingomyelinases in cells of the oligodendrocyte lineage","volume":"75","author":"Testai","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1074\/jbc.M111.304857_bib13","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1471-4159.2006.03774.x","article-title":"Amyloid \u03b2 peptide increases DP5 expression via activation of neutral sphingomyelinase and JNK in oligodendrocytes","volume":"97","author":"Chen","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M111.304857_bib14","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/42408","article-title":"Functional rafts in cell membranes","volume":"387","author":"Simons","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.304857_bib15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/35036052","article-title":"Lipid rafts and signal transduction","volume":"1","author":"Simons","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1074\/jbc.M111.304857_bib16","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/jnr.20549","article-title":"Differential regulation of ceramide in lipid-rich microdomains (rafts). Antagonistic role of palmitoyl:protein thioesterase and neutral sphingomyelinase 2","volume":"81","author":"Goswami","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1074\/jbc.M111.304857_bib17","doi-asserted-by":"crossref","first-page":"10047","DOI":"10.1074\/jbc.M611249200","article-title":"Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization","volume":"282","author":"Tani","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.304857_bib18","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1388-1981(02)00341-4","article-title":"Sphingosine kinase, sphingosine-1-phosphate, and apoptosis","volume":"1585","author":"Maceyka","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M111.304857_bib19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/380075a0","article-title":"Requirement for ceramide-initiated SAPK\/JNK signalling in stress-induced apoptosis","volume":"380","author":"Verheij","year":"1996","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.304857_bib20","doi-asserted-by":"crossref","first-page":"12587","DOI":"10.1074\/jbc.M112010200","article-title":"De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1","volume":"277","author":"Chalfant","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.304857_bib21","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/0-306-47931-1_12","article-title":"Acid sphingomyelinase-derived ceramide signaling in apoptosis","volume":"36","author":"Gulbins","year":"2002","journal-title":"Subcell. Biochem."},{"key":"10.1074\/jbc.M111.304857_bib22","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.2174\/1381612054367463","article-title":"Current status and perspectives in ceramide targeting molecular medicine","volume":"11","author":"Sawai","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"10.1074\/jbc.M111.304857_bib23","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.mito.2006.03.002","article-title":"Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations","volume":"6","author":"Siskind","year":"2006","journal-title":"Mitochondrion"},{"key":"10.1074\/jbc.M111.304857_bib24","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.4049\/jimmunol.177.2.1272","article-title":"Hyaluronan fragments act as an endogenous danger signal by engaging TLR2","volume":"177","author":"Scheibner","year":"2006","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M111.304857_bib25","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0304-4165(80)90388-8","article-title":"Synthesis of hyaluronic acid and collagen in skin fibroblasts cultured from patients with osteogenesis imperfecta","volume":"628","author":"Turakainen","year":"1980","journal-title":"Biochem. Biophys. Acta"},{"key":"10.1074\/jbc.M111.304857_bib26","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1042\/bj2130171","article-title":"Altered glycosaminoglycan production in cultured osteogenesis-imperfecta skin fibroblasts","volume":"213","author":"Turakainen","year":"1983","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M111.304857_bib27","first-page":"171","article-title":"Altered glycosaminoglycan production in cultured osteogenesis imperfecta skin fibroblasts","volume":"2","author":"Kapoor","year":"1983","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M111.304857_bib28","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00018-007-7360-z","article-title":"Hyaluronan synthesis and degradation in cartilage and bone","volume":"65","author":"Bastow","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1074\/jbc.M111.304857_bib29","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1111\/j.1742-4658.2011.08070.x","article-title":"Transcriptional and post-translational regulation of hyaluronan synthesis","volume":"278","author":"Tammi","year":"2011","journal-title":"FEBS J."},{"key":"10.1074\/jbc.M111.304857_bib30","doi-asserted-by":"crossref","first-page":"22901","DOI":"10.1074\/jbc.M109.088435","article-title":"Methyl-\u03b2-cyclodextrin suppresses hyaluronan synthesis by down-regulation of hyaluronan synthase 2 through inhibition of Akt","volume":"285","author":"Kultti","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.304857_bib31","doi-asserted-by":"crossref","first-page":"36777","DOI":"10.1074\/jbc.R700036200","article-title":"Hyaluronan synthases, a decade-plus of novel glycosyltransferases","volume":"282","author":"Weigel","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.304857_bib32","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1172\/JCI10272","article-title":"Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme","volume":"106","author":"Camenisch","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M111.304857_bib33","first-page":"S1","article-title":"Clustered conserved cysteines in hyaluronan synthase mediate cooperative activation by Mg2+ ions and serve inhibitory effects of divalent cations","author":"Tlapak-Simmons","year":"2011","journal-title":"J. Glycom. Lipidom."},{"key":"10.1074\/jbc.M111.304857_bib34","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1074\/jbc.274.7.4239","article-title":"Purification and lipid dependence of the recombinant hyaluronan synthases from Streptococcus pyogenes and Streptococcus equisimilis","volume":"274","author":"Tlapak-Simmons","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.304857_bib35","doi-asserted-by":"crossref","first-page":"36195","DOI":"10.1074\/jbc.M807772200","article-title":"Hyaluronan accumulation is elevated in cultures of low density lipoprotein receptor-deficient cells and is altered by manipulation of cell cholesterol content","volume":"283","author":"Sakr","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.304857_bib36","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/jnr.10549","article-title":"Ceramide in rafts (detergent-insoluble fraction) mediates cell death in neurotumor cell lines","volume":"72","author":"Kilkus","year":"2003","journal-title":"J Neurosci Res"},{"key":"10.1074\/jbc.M111.304857_bib37","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/o59-099","article-title":"A rapid method of tatal lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"key":"10.1074\/jbc.M111.304857_bib38","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0021-9673(00)85249-8","article-title":"A universal reagent for phospholipid analysis","volume":"114","author":"Vaskovsky","year":"1975","journal-title":"J. Chromatogr."},{"key":"10.1074\/jbc.M111.304857_bib39","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/j.cellsig.2006.01.018","article-title":"De novo biosynthesis of dihydrosphingosine 1-phosphate by sphingosine kinase 1 in mammalian cells","volume":"18","author":"Berdyshev","year":"2006","journal-title":"Cell. Signal."},{"key":"10.1074\/jbc.M111.304857_bib40","doi-asserted-by":"crossref","first-page":"14134","DOI":"10.1074\/jbc.M109.076810","article-title":"Neurons and oligodendrocytes recycle sphingosine 1-phosphate to ceramide. Significance for apoptosis and multiple sclerosis","volume":"285","author":"Qin","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.304857_bib41","doi-asserted-by":"crossref","first-page":"25001","DOI":"10.1074\/jbc.R600010200","article-title":"When do Lasses (longevity assurance genes) become CerS (ceramide synthases)? Insights into the regulation of ceramide synthesis","volume":"281","author":"Pewzner-Jung","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.304857_bib42","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/ng0795-288","article-title":"Acid sphingomyelinase deficient mice. A model of types A and B Niemann-Pick disease","volume":"10","author":"Horinouchi","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M111.304857_bib43","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0092-8674(05)80010-8","article-title":"Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease)","volume":"81","author":"Otterbach","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.M111.304857_bib44","doi-asserted-by":"crossref","first-page":"19605","DOI":"10.1016\/S0021-9258(17)32212-3","article-title":"Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction","volume":"269","author":"Wolff","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.304857_bib45","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1002\/(SICI)1097-4547(19990915)57:6<884::AID-JNR14>3.0.CO;2-A","article-title":"Overexpression of Akt (protein kinase B) confers protection against apoptosis and prevents formation of ceramide in response to pro-apoptotic stimuli","volume":"57","author":"Goswami","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"10.1074\/jbc.M111.304857_bib46","doi-asserted-by":"crossref","first-page":"16568","DOI":"10.1074\/jbc.273.26.16568","article-title":"Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis","volume":"273","author":"Zhou","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.304857_bib47","doi-asserted-by":"crossref","first-page":"27879","DOI":"10.1074\/jbc.M503002200","article-title":"Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-\u03b1","volume":"280","author":"Osawa","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.304857_bib48","doi-asserted-by":"crossref","first-page":"35622","DOI":"10.1074\/jbc.M105673200","article-title":"Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3","volume":"276","author":"Banno","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.304857_bib49","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/254065a0","article-title":"Increased hyaluronic acid production on stimulation of DNA synthesis in chick embryo fibroblasts","volume":"254","author":"Moscatelli","year":"1975","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.304857_bib50","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0309-1651(85)90023-2","article-title":"Growth coupled changes in glucosaminoglycans (heparan sulfate and hyaluronic acid) in normal and transformed human fibroblasts","volume":"9","author":"Matuoka","year":"1985","journal-title":"Cell Biol. Int. Rep."},{"key":"10.1074\/jbc.M111.304857_bib51","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1242\/jcs.90.2.275","article-title":"Hyaluronic acid-dependent change in the extracellular matrix of mouse dermal fibroblasts that is conducive to cell proliferation","volume":"90","author":"Yoneda","year":"1988","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M111.304857_bib52","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0014-4827(89)90428-X","article-title":"The effect of hyaluronate and its oligosaccharides on endothelial cell proliferation and monolayer integrity","volume":"183","author":"West","year":"1989","journal-title":"Exp. Cell Res."},{"key":"10.1074\/jbc.M111.304857_bib53","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1091\/mbc.e07-05-0439","article-title":"Anomalous surface distribution of glycosyl phosphatidyl inositol-anchored proteins in neurons lacking acid sphingomyelinase","volume":"19","author":"Galvan","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M111.304857_bib54","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1074\/jbc.M110.155234","article-title":"A novel mechanism of lysosomal acid sphingomyelinase maturation. Requirement for carboxyl-terminal proteolytic processing","volume":"286","author":"Jenkins","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.304857_bib55","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrm2329","article-title":"Principles of bioactive lipid signaling. Lessons from sphingolipids","volume":"9","author":"Hannun","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1074\/jbc.M111.304857_bib56","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1023\/B:APPT.0000045801.15585.dd","article-title":"PI3K-Akt pathway. Its functions and alterations in human cancer","volume":"9","author":"Osaki","year":"2004","journal-title":"Apoptosis"},{"key":"10.1074\/jbc.M111.304857_bib57","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/jnr.20550","article-title":"Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines","volume":"81","author":"Goswami","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1074\/jbc.M111.304857_bib58","doi-asserted-by":"crossref","first-page":"24639","DOI":"10.1074\/jbc.M110.134536","article-title":"Proinflammatory cytokines induce hyaluronan synthesis and monocyte adhesion in human endothelial cells through hyaluronan synthase 2 (HAS2) and the nuclear factor-\u03baB (NF-\u03baB) pathway","volume":"285","author":"Vigetti","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.304857_bib59","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrm1103","article-title":"Sphingosine-1-phosphate. An enigmatic signalling lipid","volume":"4","author":"Spiegel","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1074\/jbc.M111.304857_bib60","first-page":"881","article-title":"Divide, accumulate, differentiate. Cell condensation in skeletal development revisited","volume":"3","author":"Hall","year":"1995","journal-title":"Int. J. Dev. Biol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820529359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820529359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M111.304857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T12:25:11Z","timestamp":1624623911000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820529359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":60,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0021925820529359"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m111.304857","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}