{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:03:15Z","timestamp":1779188595095,"version":"3.51.4"},"reference-count":64,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":3248,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1074\/jbc.m111.305359","type":"journal-article","created":{"date-parts":[[2011,12,23]],"date-time":"2011-12-23T01:38:29Z","timestamp":1324604309000},"page":"5562-5573","source":"Crossref","is-referenced-by-count":50,"title":["FTY720 Normalizes Hyperglycemia by Stimulating \u03b2-Cell in Vivo Regeneration in db\/db Mice through Regulation of Cyclin D3 and p57KIP2"],"prefix":"10.1016","volume":"287","author":[{"given":"Zhengshan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinwoo","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongmin Alex","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M111.305359_bib1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.2337\/diab.40.2.166","article-title":"Banting lecture 1990. \u03b2-Cells in type II diabetes mellitus","volume":"40","author":"Porte","year":"1991","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M111.305359_bib2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2337\/diabetes.52.1.102","article-title":"\u03b2-Cell deficit and increased \u03b2-cell apoptosis in humans with type 2 diabetes","volume":"52","author":"Butler","year":"2003","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M111.305359_bib3","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1126\/science.1104345","article-title":"Type 2 diabetes, a matter of \u03b2-cell life and death?","volume":"307","author":"Rhodes","year":"2005","journal-title":"Science"},{"key":"10.1074\/jbc.M111.305359_bib4","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.1210\/jc.2010-0668","article-title":"Targeting \u03b2-cell function early in the course of therapy for type 2 diabetes mellitus","volume":"95","author":"Leahy","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1074\/jbc.M111.305359_bib5","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.2337\/db10-0084","article-title":"\u03b2-Cell growth and regeneration. Replication is only part of the story","volume":"59","author":"Bonner-Weir","year":"2010","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M111.305359_bib6","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1055\/s-2007-979040","article-title":"Adaptation of islets of Langerhans to pregnancy. \u03b2-Cell growth, enhanced insulin secretion and the role of lactogenic hormones","volume":"29","author":"Sorenson","year":"1997","journal-title":"Horm. Metab. Res."},{"key":"10.1074\/jbc.M111.305359_bib7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature02520","article-title":"Adult pancreatic \u03b2-cells are formed by self-duplication rather than stem-cell differentiation","volume":"429","author":"Dor","year":"2004","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.305359_bib8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cell.2007.12.015","article-title":"\u03b2-Cells can be generated from endogenous progenitors in injured adult mouse pancreas","volume":"132","author":"Xu","year":"2008","journal-title":"Cell"},{"key":"10.1074\/jbc.M111.305359_bib9","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1242\/jcs.065268","article-title":"Activation of pancreatic duct-derived progenitor cells during pancreas regeneration in adult rats","volume":"123","author":"Li","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M111.305359_bib10","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.2337\/diabetes.51.6.1834","article-title":"\u03b2-Cell neogenesis during prolonged hyperglycemia in rats","volume":"51","author":"Lipsett","year":"2002","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M111.305359_bib11","doi-asserted-by":"crossref","first-page":"15116","DOI":"10.1073\/pnas.0507567102","article-title":"Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells","volume":"102","author":"Minami","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.305359_bib12","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1172\/JCI29988","article-title":"Preexisting pancreatic acinar cells contribute to acinar cell, but not islet \u03b2-cell, regeneration","volume":"117","author":"Desai","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M111.305359_bib13","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/nature08894","article-title":"Conversion of adult pancreatic \u03b1-cells to \u03b2-cells after extreme \u03b2-cell loss","volume":"464","author":"Thorel","year":"2010","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.305359_bib14","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM200007273430401","article-title":"Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen","volume":"343","author":"Shapiro","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M111.305359_bib15","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/ncpendmet0647","article-title":"The replication of beta cells in normal physiology, in disease and for therapy","volume":"3","author":"Butler","year":"2007","journal-title":"Nat. Clin. Pract. Endocrinol. Metab."},{"key":"10.1074\/jbc.M111.305359_bib16","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1111\/j.1471-0528.1978.tb15835.x","article-title":"A morphological study of the endocrine pancreas in human pregnancy","volume":"85","author":"Van Assche","year":"1978","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"10.1074\/jbc.M111.305359_bib17","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.tem.2009.11.001","article-title":"Expansion of \u03b2-cell mass in response to pregnancy","volume":"21","author":"Rieck","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1074\/jbc.M111.305359_bib18","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1152\/physrev.00025.2004","article-title":"Regulation of pancreatic \u03b2-cell mass","volume":"85","author":"Bouwens","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1074\/jbc.M111.305359_bib19","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1399-5448.2008.00468.x","article-title":"Growth factor control of pancreatic islet regeneration and function","volume":"10","author":"Assmann","year":"2009","journal-title":"Pediatr. Diabetes"},{"key":"10.1074\/jbc.M111.305359_bib20","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.biochem.73.011303.073731","article-title":"Lysophospholipid receptors. Signaling and biology","volume":"73","author":"Ishii","year":"2004","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M111.305359_bib21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.molmed.2005.12.001","article-title":"Emerging medicinal roles for lysophospholipid signaling","volume":"12","author":"Gardell","year":"2006","journal-title":"Trends Mol. Med."},{"key":"10.1074\/jbc.M111.305359_bib22","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1095\/biolreprod.102.004051","article-title":"Increased production of bioactive lysophosphatidic acid by serum lysophospholipase D in human pregnancy","volume":"67","author":"Tokumura","year":"2002","journal-title":"Biol. Reprod."},{"key":"10.1074\/jbc.M111.305359_bib23","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.2337\/db06-0330","article-title":"Altered adipose and plasma sphingolipid metabolism in obesity. A potential mechanism for cardiovascular and metabolic risk","volume":"55","author":"Samad","year":"2006","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M111.305359_bib24","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1210\/endo-124-2-912","article-title":"The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. V. Interaction between the db gene and hepatic sex steroid sulfotransferases correlates with gender-dependent susceptibility to hyperglycemia","volume":"124","author":"Leiter","year":"1989","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M111.305359_bib25","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nrd3248","article-title":"Fingolimod (FTY720), discovery and development of an oral drug to treat multiple sclerosis","volume":"9","author":"Brinkmann","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1074\/jbc.M111.305359_bib26","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1056\/NEJMoa0907839","article-title":"Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis","volume":"362","author":"Cohen","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M111.305359_bib27","doi-asserted-by":"crossref","first-page":"21453","DOI":"10.1074\/jbc.C200176200","article-title":"The immune modulator FTY720 targets sphingosine 1-phosphate receptors","volume":"277","author":"Brinkmann","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.305359_bib28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10059-010-0041-z","article-title":"Sphingosine 1-phosphate receptors. Zooming in on ligand-induced intracellular trafficking and its functional implications","volume":"29","author":"Verzijl","year":"2010","journal-title":"Mol. Cells"},{"key":"10.1074\/jbc.M111.305359_bib29","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1210\/me.2004-0169","article-title":"Inhibition of Ca2+-independent phospholipase A2 results in insufficient insulin secretion and impaired glucose tolerance","volume":"19","author":"Song","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M111.305359_bib30","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1210\/en.2008-1342","article-title":"Advanced glycation end products inhibit glucose-stimulated insulin secretion through nitric oxide-dependent inhibition of cytochrome c oxidase and adenosine triphosphate synthesis","volume":"150","author":"Zhao","year":"2009","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M111.305359_bib31","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1210\/en.2010-0016","article-title":"Protection of pancreatic \u03b2-cells by group VIA phospholipase A2-mediated repair of mitochondrial membrane peroxidation","volume":"151","author":"Zhao","year":"2010","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M111.305359_bib32","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1242\/jcs.015834","article-title":"The increase of cell membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR","volume":"120","author":"Zhang","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M111.305359_bib33","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1242\/jcs.02821","article-title":"Disruption of G1 phase phospholipid turnover by inhibition of Ca2+-independent phospholipase A2 induces a p53-dependent cell-cycle arrest in G1 phase","volume":"119","author":"Zhang","year":"2006","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M111.305359_bib34","doi-asserted-by":"crossref","first-page":"22275","DOI":"10.1074\/jbc.M604330200","article-title":"Calcium-independent phospholipase A2 localizes in and protects mitochondria during apoptotic induction by staurosporine","volume":"281","author":"Seleznev","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.305359_bib35","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1111\/j.1600-6143.2007.01880.x","article-title":"Human islet function is not impaired by the sphingosine 1-phosphate receptor modulator FTY720","volume":"7","author":"Truong","year":"2007","journal-title":"Am. J. Transplant"},{"key":"10.1074\/jbc.M111.305359_bib36","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1210\/en.2006-0456","article-title":"Sphingosine 1-phosphate affects cytokine-induced apoptosis in rat pancreatic islet \u03b2-cells","volume":"147","author":"Laychock","year":"2006","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M111.305359_bib37","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S1097-2765(04)00237-0","article-title":"Clearance of apoptotic cells. Getting rid of the corpses","volume":"14","author":"Lauber","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M111.305359_bib38","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000315107","article-title":"Phosphorylation of the immunomodulator FTY720 inhibits programmed cell death of fibroblasts via the S1P3 receptor subtype and Bcl-2 activation","volume":"26","author":"Potteck","year":"2010","journal-title":"Cell Physiol. Biochem."},{"key":"10.1074\/jbc.M111.305359_bib39","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9","article-title":"The Ki67 protein. From the known and the unknown","volume":"182","author":"Scholzen","year":"2000","journal-title":"J. Cell Physiol."},{"key":"10.1074\/jbc.M111.305359_bib40","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nature05092","article-title":"p16INK4a induces an age-dependent decline in islet regenerative potential","volume":"443","author":"Krishnamurthy","year":"2006","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.305359_bib41","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1101\/gad.1742609","article-title":"Bmi-1 regulates the Ink4a\/Arf locus to control pancreatic \u03b2-cell proliferation","volume":"23","author":"Dhawan","year":"2009","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M111.305359_bib42","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1158\/1541-7786.MCR-09-0317","article-title":"p57KIP2, \u201cKip\u201ding the cell under control","volume":"7","author":"Pateras","year":"2009","journal-title":"Mol. Cancer Res."},{"key":"10.1074\/jbc.M111.305359_bib43","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/sj.bjp.0706872","article-title":"BML-241 fails to display selective antagonism at the sphingosine 1-phosphate receptor, S1P(3)","volume":"149","author":"Jongsma","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1074\/jbc.M111.305359_bib44","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.bcp.2007.12.018","article-title":"New players on the center stage. Sphingosine 1-phosphate and its receptors as drug targets","volume":"75","author":"Huwiler","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1074\/jbc.M111.305359_bib45","doi-asserted-by":"crossref","first-page":"5373","DOI":"10.1021\/jm050242f","article-title":"Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer","volume":"48","author":"Albert","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M111.305359_bib46","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/jcb.20094","article-title":"G protein-mediated signaling pathways in lysophospholipid induced cell proliferation and survival","volume":"92","author":"Radeff-Huang","year":"2004","journal-title":"J. Cell Biochem."},{"key":"10.1074\/jbc.M111.305359_bib47","doi-asserted-by":"crossref","first-page":"8292","DOI":"10.1073\/pnas.0707761105","article-title":"The p110\u03b2 isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma","volume":"105","author":"Guillermet-Guibert","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.305359_bib48","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrm2882","article-title":"The emerging mechanisms of isoform-specific PI3K signaling","volume":"11","author":"Vanhaesebroeck","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1074\/jbc.M111.305359_bib49","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/00006676-200403000-00001","article-title":"PDX-1 and the pancreas","volume":"28","author":"Ashizawa","year":"2004","journal-title":"Pancreas"},{"key":"10.1074\/jbc.M111.305359_bib50","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/MPA.0b013e318157753e","article-title":"Activation of phosphatidylinositol 3-kinase regulates pancreatic duodenal homeobox-1 in duct cells during pancreatic regeneration","volume":"36","author":"Watanabe","year":"2008","journal-title":"Pancreas"},{"key":"10.1074\/jbc.M111.305359_bib51","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bbrc.2008.03.012","article-title":"Regulation of pancreatic duct cell differentiation by phosphatidylinositol 3-kinase","volume":"370","author":"Watanabe","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M111.305359_bib52","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1128\/MCB.16.4.1722","article-title":"Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction","volume":"16","author":"Wymann","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M111.305359_bib53","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1021\/np2000528","article-title":"Fingolimod (FTY720), a recently approved multiple sclerosis drug based on a fungal secondary metabolite","volume":"74","author":"Strader","year":"2011","journal-title":"J. Nat. Prod."},{"key":"10.1074\/jbc.M111.305359_bib54","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nm.2277","article-title":"Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin","volume":"17","author":"Holland","year":"2011","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M111.305359_bib55","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tcb.2011.09.003","volume":"22","author":"Maceyka","year":"2012","journal-title":"Trends Cell Biol."},{"key":"10.1074\/jbc.M111.305359_bib56","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.2337\/diabetes.50.12.2763","article-title":"p57(KIP2) expression in normal islet cells and in hyperinsulinism of infancy","volume":"50","author":"Kassem","year":"2001","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M111.305359_bib57","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ydbio.2006.05.036","article-title":"p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors","volume":"298","author":"Georgia","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1074\/jbc.M111.305359_bib58","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1128\/MCB.01743-05","article-title":"E proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells","volume":"26","author":"Rothschild","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"10.1074\/jbc.M111.305359_bib59","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S1535-6108(03)00301-5","article-title":"Requirement for cyclin D3 in lymphocyte development and T cell leukemias","volume":"4","author":"Sicinska","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1074\/jbc.M111.305359_bib60","doi-asserted-by":"crossref","first-page":"20351","DOI":"10.1074\/jbc.M702182200","article-title":"Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK \u2192 Rac1 \u2192 Akt \u2192 endothelial nitric-oxide synthase pathway","volume":"282","author":"Levine","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.305359_bib61","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.canlet.2007.03.013","article-title":"FTY720, a synthetic compound from Isaria sinclairii, inhibits proliferation and induces apoptosis in pancreatic cancer cells","volume":"254","author":"Shen","year":"2007","journal-title":"Cancer Lett."},{"key":"10.1074\/jbc.M111.305359_bib62","doi-asserted-by":"crossref","first-page":"142","DOI":"10.2337\/db07-1294","article-title":"Partial pancreatectomy in adult humans does not provoke \u03b2-cell regeneration","volume":"57","author":"Menge","year":"2008","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M111.305359_bib63","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.2337\/db09-1776","article-title":"Induction of human beta-cell proliferation and engraftment using a single G1\/S regulatory molecule, cdk6","volume":"59","author":"Fiaschi-Taesch","year":"2010","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M111.305359_bib64","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1172\/JCI22098","article-title":"Beta cell replication is the primary mechanism for maintaining postnatal \u03b2-cell mass","volume":"114","author":"Georgia","year":"2004","journal-title":"J. Clin. Invest."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820612169?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820612169?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M111.305359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T05:52:11Z","timestamp":1641361931000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820612169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":64,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0021925820612169"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m111.305359","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}