{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T07:17:44Z","timestamp":1789197464819,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":3178,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1074\/jbc.m111.315242","type":"journal-article","created":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T20:44:31Z","timestamp":1323895471000},"page":"4894-4903","source":"Crossref","is-referenced-by-count":37,"title":["Structural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in Nematodes"],"prefix":"10.1016","volume":"287","author":[{"given":"Xiaoyong","family":"Zhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. Edward","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Melcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Motola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Gelmedin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hawdon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Kliewer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Mangelsdorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Eric","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M111.315242_bib1","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.cell.2006.01.037","article-title":"Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans","volume":"124","author":"Motola","year":"2006","journal-title":"Cell"},{"key":"10.1074\/jbc.M111.315242_bib2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.devcel.2006.02.008","article-title":"Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase","volume":"10","author":"Rottiers","year":"2006","journal-title":"Dev. Cell"},{"key":"10.1074\/jbc.M111.315242_bib3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.biochem.72.121801.161712","article-title":"The enzymes, regulation, and genetics of bile acid synthesis","volume":"72","author":"Russell","year":"2003","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M111.315242_bib4","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/j.1474-9726.2011.00733.x","article-title":"The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity","volume":"10","author":"Wollam","year":"2011","journal-title":"Aging Cell"},{"key":"10.1074\/jbc.M111.315242_bib5","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1101\/gad.14.12.1512","article-title":"daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans","volume":"14","author":"Antebi","year":"2000","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M111.315242_bib6","unstructured":"Hu, P. J., (2007) The C. elegans Research Community, doi\/10.1895\/wormbook.1.144.1, www.wormbook.org"},{"key":"10.1074\/jbc.M111.315242_bib7","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1101\/gad.1701508","article-title":"C. elegans dauer formation and the molecular basis of plasticity","volume":"22","author":"Fielenbach","year":"2008","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M111.315242_bib8","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1101\/gad.312604","article-title":"A novel nuclear receptor\/coregulator complex controls C. elegans lipid metabolism, larval development, and aging","volume":"18","author":"Ludewig","year":"2004","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M111.315242_bib9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev.phyto.41.052102.104023","article-title":"Parasitic nematode interactions with mammals and plants","volume":"41","author":"Jasmer","year":"2003","journal-title":"Annu. Rev. Phytopathol."},{"key":"10.1074\/jbc.M111.315242_bib10","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.pt.2006.05.004","article-title":"New technologies for the control of human hookworm infection","volume":"22","author":"Hotez","year":"2006","journal-title":"Trends Parasitol."},{"key":"10.1074\/jbc.M111.315242_bib11","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/bies.200900010","article-title":"How did parasitic worms evolve","volume":"31","author":"Viney","year":"2009","journal-title":"BioEssays"},{"key":"10.1074\/jbc.M111.315242_bib12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.tig.2009.03.006","article-title":"How to become a parasite. Lessons from the genomes of nematodes","volume":"25","author":"Dieterich","year":"2009","journal-title":"Trends Genet."},{"key":"10.1074\/jbc.M111.315242_bib13","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.ijpara.2005.07.006","article-title":"TGF-\u03b2 and the evolution of nematode parasitism","volume":"35","author":"Viney","year":"2005","journal-title":"Int. J. Parasitol."},{"key":"10.1074\/jbc.M111.315242_bib14","doi-asserted-by":"crossref","first-page":"9138","DOI":"10.1073\/pnas.0904064106","article-title":"Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes","volume":"106","author":"Wang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.315242_bib15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cub.2008.11.063","article-title":"A conserved endocrine mechanism controls the formation of dauer and infective larvae in nematodes","volume":"19","author":"Ogawa","year":"2009","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.M111.315242_bib16","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1210\/me.2008-0415","article-title":"Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor","volume":"23","author":"Sharma","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.M111.315242_bib17","doi-asserted-by":"crossref","first-page":"9505","DOI":"10.1073\/pnas.0501204102","article-title":"Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner","volume":"102","author":"Li","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.315242_bib18","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S1097-2765(00)80326-3","article-title":"Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast","volume":"5","author":"Mossessova","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M111.315242_bib19","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1107\/S0108767390010224","article-title":"Improved methods for building protein models in electron density maps and the location of errors in these models","volume":"47","author":"Jones","year":"1991","journal-title":"Acta Crystallogr. A"},{"key":"10.1074\/jbc.M111.315242_bib20","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.molcel.2005.02.002","article-title":"Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1","volume":"17","author":"Li","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M111.315242_bib21","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0092-8674(04)00119-9","article-title":"Structural determinants of allosteric ligand activation in RXR heterodimers","volume":"116","author":"Shulman","year":"2004","journal-title":"Cell"},{"key":"10.1074\/jbc.M111.315242_bib22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1017\/S0031182000074953","article-title":"Observations on the feeding behavior of parasitic third-stage hookworm larvae","volume":"106","author":"Hawdon","year":"1993","journal-title":"Parasitology"},{"key":"10.1074\/jbc.M111.315242_bib23","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.cell.2005.01.024","article-title":"Structural analyses reveal phosphatidylinositols as ligands for the NR5 orphan receptors SF-1 and LRH-1","volume":"120","author":"Krylova","year":"2005","journal-title":"Cell"},{"key":"10.1074\/jbc.M111.315242_bib24","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.arr.2005.03.006","article-title":"C. elegans DAF-12, nuclear hormone receptors and human longevity and disease at old age","volume":"4","author":"Mooijaart","year":"2005","journal-title":"Ageing Res. Rev."},{"key":"10.1074\/jbc.M111.315242_bib25","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S1097-2765(03)00112-6","article-title":"Structural basis for bile acid binding and activation of the nuclear receptor FXR","volume":"11","author":"Mi","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M111.315242_bib26","doi-asserted-by":"crossref","first-page":"27138","DOI":"10.1074\/jbc.M302260200","article-title":"X-ray crystal structure of the liver X receptor \u03b2 ligand binding domain. Regulation by a histidine-tryptophan switch","volume":"278","author":"Williams","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.315242_bib27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1097-2765(00)80413-X","article-title":"The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand","volume":"5","author":"Rochel","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M111.315242_bib28","doi-asserted-by":"crossref","first-page":"5630","DOI":"10.3748\/wjg.14.5630","article-title":"Intestinal bile acid physiology and pathophysiology","volume":"14","author":"Martinez-Augustin","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1074\/jbc.M111.315242_bib29","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1172\/JCI2962","article-title":"Identification of a new inborn error in bile acid synthesis. Mutation of the oxysterol 7\u03b1-hydroxylase gene causes severe neonatal liver disease","volume":"102","author":"Setchell","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M111.315242_bib30","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1474-9726.2006.00218.x","article-title":"DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid","volume":"5","author":"Held","year":"2006","journal-title":"Aging Cell"},{"key":"10.1074\/jbc.M111.315242_bib31","doi-asserted-by":"crossref","first-page":"e005","DOI":"10.1621\/nrs.08005","article-title":"Deciphering the nuclear bile acid receptor FXR paradigm","volume":"8","author":"Modica","year":"2010","journal-title":"Nuclear Receptor Signal."},{"key":"10.1074\/jbc.M111.315242_bib32","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.pt.2004.08.001","article-title":"Drug resistance in nematodes of veterinary importance. A status report","volume":"20","author":"Kaplan","year":"2004","journal-title":"Trends Parasitol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820481438?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820481438?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M111.315242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T06:41:47Z","timestamp":1639982507000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820481438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0021925820481438"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m111.315242","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}