{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:47:34Z","timestamp":1791348454227,"version":"4.3.1"},"reference-count":59,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":3178,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1074\/jbc.m111.315432","type":"journal-article","created":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T04:41:03Z","timestamp":1324356063000},"page":"5059-5069","source":"Crossref","is-referenced-by-count":212,"title":["Mechanism of All-trans-retinal Toxicity with Implications for Stargardt Disease and Age-related Macular Degeneration"],"prefix":"10.1016","volume":"287","author":[{"given":"Yu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiichiro","family":"Okano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadao","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Golczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Palczewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M111.315432_bib1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1146\/annurev.biochem.75.103004.142743","article-title":"G protein-coupled receptor rhodopsin","volume":"75","author":"Palczewski","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M111.315432_bib2","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.tibs.2010.01.005","article-title":"The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision","volume":"35","author":"von Lintig","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.M111.315432_bib3","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1146\/annurev.pharmtox.47.120505.105225","article-title":"Diseases caused by defects in the visual cycle. Retinoids as potential therapeutic agents","volume":"47","author":"Travis","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1074\/jbc.M111.315432_bib4","author":"Kiser","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M111.315432_bib5","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.preteyeres.2010.03.002","article-title":"Membrane-binding and enzymatic properties of RPE65","volume":"29","author":"Kiser","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1074\/jbc.M111.315432_bib6","doi-asserted-by":"crossref","first-page":"9606","DOI":"10.1073\/pnas.86.23.9606","article-title":"Retinoid requirements for recovery of sensitivity after visual-pigment bleaching in isolated photoreceptors","volume":"86","author":"Jones","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.315432_bib7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0896-6273(02)00912-1","article-title":"Isomerization and oxidation of vitamin a in cone-dominant retinas. A novel pathway for visual-pigment regeneration in daylight","volume":"36","author":"Mata","year":"2002","journal-title":"Neuron"},{"key":"10.1074\/jbc.M111.315432_bib8","doi-asserted-by":"crossref","first-page":"8208","DOI":"10.1523\/JNEUROSCI.2367-08.2008","article-title":"Subfunctionalization of a retinoid-binding protein provides evidence for two parallel visual cycles in the cone-dominant zebrafish retina","volume":"28","author":"Fleisch","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M111.315432_bib9","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1562\/2004-11-13-IR-371","article-title":"Light-induced damage to the retina. Role of rhodopsin chromophore revisited","volume":"81","author":"R\u00f3zanowska","year":"2005","journal-title":"Photochem. Photobiol."},{"key":"10.1074\/jbc.M111.315432_bib10","doi-asserted-by":"crossref","first-page":"15173","DOI":"10.1074\/jbc.M900322200","article-title":"Involvement of all-trans-retinal in acute light-induced retinopathy of mice","volume":"284","author":"Maeda","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.315432_bib11","doi-asserted-by":"crossref","first-page":"7154","DOI":"10.1073\/pnas.130110497","article-title":"Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration","volume":"97","author":"Mata","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.315432_bib12","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.1074\/jbc.M708885200","article-title":"Retinyl ester formation by lecithin. Retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis","volume":"283","author":"Kim","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.315432_bib13","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1016\/j.bmc.2005.05.001","article-title":"On the mechanism of isomerization of all-trans-retinol esters to 11-cis-retinol in retinal pigment epithelial cells. 11-Fluoro-all-trans-retinol as substrate\/inhibitor in the visual cycle","volume":"13","author":"Fishkin","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1074\/jbc.M111.315432_bib14","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.ajo.2003.12.035","article-title":"Ophthalmic fundus imaging. Today and beyond","volume":"137","author":"Yannuzzi","year":"2004","journal-title":"Am. J. Ophthalmol."},{"key":"10.1074\/jbc.M111.315432_bib15","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/nm.2260","article-title":"Noninvasive multiphoton fluorescence microscopy resolves retinol and retinal condensation products in mouse eyes","volume":"16","author":"Palczewska","year":"2010","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M111.315432_bib16","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1086\/303018","article-title":"Further evidence for an association of ABCR alleles with age-related macular degeneration. The International ABCR Screening Consortium","volume":"67","author":"Allikmets","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"10.1074\/jbc.M111.315432_bib17","doi-asserted-by":"crossref","first-page":"11034","DOI":"10.1074\/jbc.275.15.11034","article-title":"Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol","volume":"275","author":"Rattner","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.315432_bib18","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/0-387-32442-9_64","article-title":"Binding of N-retinylidene-PE to ABCA4 and a model for its transport across membranes","volume":"572","author":"Molday","year":"2006","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1074\/jbc.M111.315432_bib19","doi-asserted-by":"crossref","first-page":"6855","DOI":"10.1021\/bi200774w","article-title":"Posttranslational modifications of the photoreceptor-specific ABC transporter ABCA4","volume":"50","author":"Tsybovsky","year":"2011","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M111.315432_bib20","doi-asserted-by":"crossref","first-page":"26684","DOI":"10.1074\/jbc.M804505200","article-title":"Retinopathy in mice induced by disrupted all-trans-retinal clearance","volume":"283","author":"Maeda","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.315432_bib21","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nchembio.759","volume":"8","author":"Maeda","year":"2011","journal-title":"Nature Chem. Biol."},{"key":"10.1074\/jbc.M111.315432_bib22","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/ng0397-236","article-title":"A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy","volume":"15","author":"Allikmets","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M111.315432_bib23","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/hmg\/7.3.355","article-title":"Autosomal recessive retinitis pigmentosa and cone-rod dystrophy caused by splice site mutations in the Stargardt's disease gene ABCR","volume":"7","author":"Cremers","year":"1998","journal-title":"Hum Mol Genet"},{"key":"10.1074\/jbc.M111.315432_bib24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/ng0198-11","article-title":"Retinitis pigmentosa caused by a homozygous mutation in the Stargardt disease gene ABCR","volume":"18","author":"Mart\u00ednez-Mir","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M111.315432_bib25","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s00439-005-0054-4","article-title":"Severe autosomal recessive retinitis pigmentosa maps to chromosome 1p13.3-p21.2 between D1S2896 and D1S457 but outside ABCA4","volume":"118","author":"Zhang","year":"2005","journal-title":"Hum Genet"},{"key":"10.1074\/jbc.M111.315432_bib26","doi-asserted-by":"crossref","first-page":"23000","DOI":"10.1074\/jbc.M005359200","article-title":"Light-induced photoreceptor apoptosis in vivo requires neuronal nitric-oxide synthase and guanylate cyclase activity and is caspase-3-independent","volume":"276","author":"Donovan","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.315432_bib27","first-page":"1599","article-title":"Protection by dimethylthiourea against retinal light damage in rats","volume":"33","author":"Organisciak","year":"1992","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1074\/jbc.M111.315432_bib28","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0955-0674(03)00002-4","article-title":"Oxidant signals and oxidative stress","volume":"15","author":"Finkel","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1074\/jbc.M111.315432_bib29","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri1312","article-title":"NOX enzymes and the biology of reactive oxygen","volume":"4","author":"Lambeth","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1074\/jbc.M111.315432_bib30","doi-asserted-by":"crossref","first-page":"9397","DOI":"10.1073\/pnas.0808940106","article-title":"Depleting Rac1 in mouse rod photoreceptors protects them from photo-oxidative stress without affecting their structure or function","volume":"106","author":"Haruta","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.315432_bib31","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1111\/j.1471-4159.2009.06195.x","article-title":"NADPH oxidase plays a central role in cone cell death in retinitis pigmentosa","volume":"110","author":"Usui","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M111.315432_bib32","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1165\/ajrcmb.11.1.8018341","article-title":"Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol","volume":"11","author":"Stolk","year":"1994","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1074\/jbc.M111.315432_bib33","doi-asserted-by":"crossref","first-page":"7673","DOI":"10.1073\/pnas.83.20.7673","article-title":"All-trans-retinal stimulates superoxide release and phospholipase C activity in neutrophils without significantly blocking protein kinase C","volume":"83","author":"Lochner","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.315432_bib34","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/jcp.1041270206","article-title":"Retinoids stimulate the release of superoxide by neutrophils and change their morphology","volume":"127","author":"Badwey","year":"1986","journal-title":"J. Cell. Physiol."},{"key":"10.1074\/jbc.M111.315432_bib35","doi-asserted-by":"crossref","first-page":"16336","DOI":"10.1016\/S0021-9258(18)55302-3","article-title":"Arachidonate activation of the neutrophil NADPH-oxidase. Synergistic effects of protein phosphatase inhibitors compared with protein kinase activators","volume":"266","author":"Steinbeck","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.315432_bib36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1006\/scdb.2000.0211","article-title":"Calcium signaling. An overview","volume":"12","author":"Bootman","year":"2001","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1074\/jbc.M111.315432_bib37","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1023\/A:1027363730746","article-title":"A rise in ionized calcium activates the neutrophil NADPH-oxidase but is not sufficient to directly translocate cytosolic p47phox or p67phox to b cytochrome containing membranes","volume":"21","author":"Movitz","year":"1997","journal-title":"Inflammation"},{"key":"10.1074\/jbc.M111.315432_bib38","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1146\/annurev.biochem.70.1.281","article-title":"Regulation of phosphoinositide-specific phospholipase C","volume":"70","author":"Rhee","year":"2001","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M111.315432_bib39","doi-asserted-by":"crossref","first-page":"14609","DOI":"10.1073\/pnas.95.25.14609","article-title":"Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium","volume":"95","author":"Parish","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.315432_bib40","doi-asserted-by":"crossref","first-page":"8162","DOI":"10.1073\/pnas.0503318102","article-title":"Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle","volume":"102","author":"Golczak","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.315432_bib41","doi-asserted-by":"crossref","first-page":"18822","DOI":"10.1074\/jbc.M501757200","article-title":"Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo","volume":"280","author":"Maeda","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.315432_bib42","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1432-1033.1992.tb17159.x","article-title":"Diphenylene iodonium as an inhibitor of the NADPH oxidase complex of bovine neutrophils. Factors controlling the inhibitory potency of diphenylene iodonium in a cell-free system of oxidase activation","volume":"208","author":"Doussi\u00e8re","year":"1992","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M111.315432_bib43","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S0022-3565(25)22967-6","article-title":"Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils","volume":"255","author":"Bleasdale","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1074\/jbc.M111.315432_bib44","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1093\/oxfordjournals.jbchem.a021780","article-title":"2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release","volume":"122","author":"Maruyama","year":"1997","journal-title":"J Biochem."},{"key":"10.1074\/jbc.M111.315432_bib45","doi-asserted-by":"crossref","first-page":"F650","DOI":"10.1152\/ajprenal.2000.278.4.F650","article-title":"5-HT(2A) receptors stimulate mitogen-activated protein kinase via H2O2 generation in rat renal mesangial cells","volume":"278","author":"Greene","year":"2000","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1074\/jbc.M111.315432_bib46","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S0893-133X(98)00037-2","article-title":"Effect of chronic serotonin-2 receptor agonist or antagonist administration on serotonin-1A receptor sensitivity","volume":"19","author":"Hensler","year":"1998","journal-title":"Neuropsychopharmacology"},{"key":"10.1074\/jbc.M111.315432_bib47","doi-asserted-by":"crossref","first-page":"7919","DOI":"10.1523\/JNEUROSCI.21-20-07919.2001","article-title":"Characterization of the functional heterologous desensitization of hypothalamic 5-HT(1A) receptors after 5-HT(2A) receptor activation","volume":"21","author":"Zhang","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M111.315432_bib48","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1124\/jpet.103.062224","article-title":"Desensitization of 5-HT1A receptors by 5-HT2A receptors in neuroendocrine neurons in vivo","volume":"310","author":"Zhang","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1074\/jbc.M111.315432_bib49","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1601-183X.2010.00581.x","article-title":"The role of 5-HT2A receptor and 5-HT2A\/5-HT1A receptor interaction in the suppression of catalepsy","volume":"9","author":"Naumenko","year":"2010","journal-title":"Genes Brain Behav"},{"key":"10.1074\/jbc.M111.315432_bib50","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1167\/iovs.10-6304","article-title":"Agonists at the serotonin receptor (5-HT(1A)) protect the retina from severe photo-oxidative stress","volume":"52","author":"Collier","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1074\/jbc.M111.315432_bib51","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0026-895X(25)14623-3","article-title":"[3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role","volume":"21","author":"Leysen","year":"1982","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M111.315432_bib52","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/S0026-895X(25)12558-3","article-title":"Receptor-binding properties in vitro and in vivo of ritanserin. A very potent and long acting serotonin-S2 antagonist","volume":"27","author":"Leysen","year":"1985","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M111.315432_bib53","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1021\/jm00140a002","article-title":"8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist","volume":"24","author":"Arvidsson","year":"1981","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.M111.315432_bib54","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0014-2999(89)90359-2","article-title":"Direct labeling of rat M3-muscarinic receptors by [3H]4-DAMP","volume":"166","author":"Michel","year":"1989","journal-title":"Eur. J. Pharmacol."},{"key":"10.1074\/jbc.M111.315432_bib55","doi-asserted-by":"crossref","first-page":"15543","DOI":"10.1074\/jbc.M111.228551","article-title":"Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice","volume":"286","author":"Shiose","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.315432_bib56","doi-asserted-by":"crossref","first-page":"14947","DOI":"10.1016\/S0021-9258(18)63794-9","article-title":"Paradoxical effects of retinal in neutrophil stimulation","volume":"264","author":"Badwey","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.315432_bib57","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0031-6997(25)06783-3","article-title":"International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin)","volume":"46","author":"Hoyer","year":"1994","journal-title":"Pharmacol. Rev."},{"key":"10.1074\/jbc.M111.315432_bib58","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1471-4159.1992.tb09273.x","article-title":"Inositol lipids and signal transduction in the nervous system. An update","volume":"58","author":"Fisher","year":"1992","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M111.315432_bib59","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.cellsig.2011.07.015","article-title":"Conjugated linoleic acid-induced apoptosis in mouse mammary tumor cells is mediated by both G protein coupled receptor-dependent activation of the AMP-activated protein kinase pathway and by oxidative stress","volume":"23","author":"Hsu","year":"2011","journal-title":"Cell Signal."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820481578?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820481578?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M111.315432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T04:29:49Z","timestamp":1742099389000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820481578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":59,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0021925820481578"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m111.315432","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}